Genomic hotspots for adaptation: the population genetics of Müllerian mimicry in the Heliconius melpomene clade. by Simon W Baxter, Nicola J Nadeau, Luana S Maroja, Paul Wilkinson, Brian A Counterman, Anna Dawson, Margarita Beltran, Silvia Perez-Espona, Nicola Chamberlain, Laura Ferguson, Richard Clark, Claire Davidson, Rebecca Glithero, James Mallet, W Owen McMillan, Marcus Kronforst, Mathieu Joron, Richard H Ffrench-Constant, Chris D Jiggins

“…In contrast, at HmB a single peak of association indicates the likely position of functional sites at three genes, encoding a kinesin, a G-protein coupled receptor, and an mRNA splicing factor. …”
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Additive genetic effect of GCKR, G6PC2, and SLC30A8 variants on fasting glucose levels and risk of type 2 diabetes. by Guanjie Chen, Daniel Shriner, Jianhua Zhang, Jie Zhou, Poorni Adikaram, Ayo P Doumatey, Amy R Bentley, Adebowale Adeyemo, Charles N Rotimi

“…Fine mapping, genome-wide conditional analysis, and functional annotation indicated that the three loci were independently associated with fasting glucose. …”
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Mechanism of intestinal tight junction transmembrane proteins interaction with egg white peptides RVPSL and QIGLF by Zhipeng Yu, Di Liu, Long Ding, Zhiyang Du, Wenzhu Zhao

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Clonidine in respiratory panic disorder subtype Clonidina no subtipo respiratório de transtorno de pânico by Alexandre M. Valença, Antonio E. Nardi, Marco A. Mezzasalma, Isabella Nascimento, Fabiana L. Lopes, Walter A. Zin, Marcio Versiani

“…RESULTS: Patients obtained panic free status, reduced anxiety levels and better functioning after clonidine administration (0.30-0.45 mg/day) for 6 weeks. …”
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The Timing of Femur Fracture Fixation is an Important Factor for Prolonged Mechanical Ventilation by Hyung Chul Choi, Kwang Hwan Jung, Kyu Hyouck Kyoung, Seong Ho Choi

“…Early fixation of femur fractures might prevent PMV and its associated complications.…”
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Nas frestas entre a ciência e a arte: uma série de ilustrações de barbeiros do Instituto Oswaldo Cruz In the gap between science and art: a series of illustrations of triatomine bu... by Ricardo Lourenço de Oliveira, Roberto Conduru

“…We have investigated their history in an effort to discover what might have led science to condemn the series. We also undertook a brief historical analysis of verisimilitude in scientific drawing. …”
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Detection of Toxicity of heavy metal pollution in soils based on their respiratory activity in native soils and simulated substrates (a case-study of the protected area “YAMSKAYA s... by N. O. Bakunovich, O. S. Khokhlova, T. N. Myakshina, A. V. Rusakov, A. S. Shapovalov

“…Only in two soils of the whole 21 soils from the investigated MA the signs of disturbance of functioning of microbial community were revealed. The measurement of the bulk forms of HM showed relative increase in concentrations of Сu, Zn, Zr, Sn, Pb, As on these MA. …”
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Invariant NKT cell response to dengue virus infection in human. by Ponpan Matangkasombut, Wilawan Chan-In, Anunya Opasawaschai, Pisut Pongchaikul, Nattaya Tangthawornchaikul, Sirijitt Vasanawathana, Wannee Limpitikul, Prida Malasit, Thaneeya Duangchinda, Gavin Screaton, Juthathip Mongkolsapaya

“…Furthermore, these iNKT cells had altered functional response to subsequent ex vivo stimulation with α-GalCer. …”
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The systemic inflammation markers as potential predictors of disease progression and survival time in amyotrophic lateral sclerosis by Ye Hong, Jian-Quan Shi, Shuai Feng, Shi-Qi Huang, Zhen-Hua Yuan, Shen Liu, Xiao-Hao Zhang, Jun-Shan Zhou, Teng Jiang, Hong-Dong Zhao, Ying-Dong Zhang

“…The rate of disease progression was calculated as the change of Revised ALS Functional Rating Scale (ALSFRS-R) score per month. …”
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Genome-Wide Identification of the GPAT Family in <i>Medicago sativa</i> L. and Expression Profiling Under Abiotic Stress by Jianzhi Ma, Mingyang Du, Huiyan Xiong, Ruijun Duan

“…It was also ascertained that these <i>GPAT</i> genes might assume a crucial role in salt and drought stress. …”
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IMMUNE DISTURBANCES IN PATIENTS WITH EPILEPSY AND OPPORTUNITY OF IMMUNOMODULATION BY RECOMBINANT HUMAN IL-2 by L. V. Lipatova, N. B. Serebryanya, N. A. Sivakova, A. V. Vasilenko, T. V. Kapustina

“…Changes of these immunological parameters correlated with clinical improvement of PE: reduction of seizure frequency and positive EEG changes. These results might be used to optimize treatment of PE due to modulation of inflammatory process and increase of neurotrophic factors production required for the processes of brain neuroplasticity and neurogenesis.…”
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Multiple mechanisms contribute to leakiness of a frameshift mutation in canine cone-rod dystrophy. by Keiko Miyadera, Ian Brierley, Jesús Aguirre-Hernández, Cathryn S Mellersh, David R Sargan

“…The study was designed to discover mechanisms that might allow such leakiness.<h4>Methods</h4>We analysed alternate start sites and splicing of RPGRIP1 transcripts; variability of polyA(n) length in the insertion and slippage at polyA(n) during transcription/translation.…”
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Quantifying conformational heterogeneity of 3D genome organization in fruit fly. by Samira Mali, Igor S Tolokh, Erik Cross, Alexey V Onufriev

“…Within our computational approach, depletion of nuclear lamins leads to increased structural heterogeneity at nearly all genomic separations, with the potential implication that cell functions that depend on chromatin structure might be more variable within lamins depleted nuclei compared to the wild type.…”
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JAK inhibitor withdrawal causes a transient pro-inflammatory cascade: A potential mechanism for major adverse cardiac events. by Ilya Gurevic, Loic Meudec, Xavier Mariette, Gaetane Nocturne, Sara S McCoy

“…<h4>Conclusions</h4>Type I JAKinibs paradoxically accumulate functionally defective pJAK. Upon withdrawal, the primed pJAKs are de-repressed and initiate a pSTAT signaling cascade, resulting in high interferon and urokinase. …”
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miR-199a-5p Relieves Obstructive Sleep Apnea Syndrome-Related Hypertension by Targeting HIF-1α by Chunyan Guo, Minghui Zhang, Wei Su, Min Xu, Shumei Zhao

“…Vascular remodeling is both the pathogenesis and the structural change basis of OSAS-related hypertension. Exploring miRNA functioning in OSAS-related hypertension may offer novel diagnostic and therapeutic targets for controlling hypertension-associated cardiovascular diseases. …”
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Mediodorsal thalamic nucleus mediates resistance to ethanol through Cav3.1 T-type Ca2+ regulation of neural activity by Charles-francois V Latchoumane, Joon-Hyuk Lee, Seong-Wook Kim, Jinhyun Kim, Hee-Sup Shin

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Eco‐Friendly Biomass‐Based Carbon Dots, Carbon Nanotubes, Graphene, and Their Derivatives for Enhanced Oil Recovery: A New Horizon for Petroleum Industry by Ruhul Amin Foisal, Prof. Dr. Abu Bin Imran, Prof. Dr. Al‐Nakib Chowdhury

“…An environmentally friendly and more resilient energy future may be possible if research and development in this area are allowed to continue. This might completely change how oil resources are found and used.…”
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Late life bipolar disorder evolving into frontotemporal dementia mimic by Dols A, Krudop W, Moeller C, Shulman K, Sajatovic M, Pijnenburg Y

“…An alternative neurodegenerative nature seems unlikely based on repeated normal neuroimaging and the absence of clinical progression. Functional involvement of the frontal-subcortical networks might play a role. …”
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Multi-Omics Pan-Cancer Profiling of <i>HSD17B10</i> Unveils Its Prognostic Potential, Metabolic Regulation, and Immune Microenvironment Interactions by Tao Qi, Xiao Chang, Yiming Wang

“…Functional enrichment analysis revealed that <i>HSD17B10</i> participated in tumor progression by regulating oxidative phosphorylation, mitochondrial metabolism, and RNA methylation. …”
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Adsorption Properties of Fishbone and Fishbone-Derived Biochar for Cadmium in Aqueous Solution by Nan Pei, Wenwen Luo, Qingqing Huang, Yuebing Sun

“…Moreover, the potential adsorption mechanisms of Cd²⁺ on FBM and fishbone-derived biochar might be related to pore filling, ion exchange, complexation with oxygen functional groups, and precipitation with the minerals on the biochar surface. …”
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