Identification of low-molecular compounds that inhibit envelope formation of hepatitis B virus by Kosuke Sato, Jun Inoue, Masashi Ninomiya, Akitoshi Sano, Mio Tsuruoka, Masazumi Onuki, Satoko Sawahashi, Keishi Ouchi, Kotaro Doi, Kengo Watanabe, Atsushi Masamune

“…Abstract Agents with novel mechanisms are clinically needed for the functional cure of chronic hepatitis B virus (HBV) infection. …”
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Bisphenol A Does Not Mimic Estrogen in the Promotion of the In Vitro Response of Murine Dendritic Cells to Toll-Like Receptor Ligands by Marita Chakhtoura, Uma Sriram, Michelle Heayn, Joshua Wonsidler, Christopher Doyle, Joudy-Ann Dinnall, Stefania Gallucci, Rebecca A. Roberts

“…Sex hormones affect immune responses and might promote autoimmunity. Endocrine disrupting chemicals such as bisphenol A (BPA) may mimic their immune effects. …”
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The reaction specificity of mammalian ALOX15B orthologs does not depend on the evolutionary ranking of the animals by Eda Gündem, Sabine Stehling, Astrid Borchert, Hartmut Kuhn

“…For human and mouse ALOX15B orthologs similar functional differences have been reported but for the time being it was unclear whether these differences might also be a consequence of targeted enzyme evolution. …”
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Kininogen enhances seizure susceptibility in mice possibly through bradykinin-induced modulation of calcium transients in glutamatergic and GABAergic neurons by Arijit Ghosh, Arijit Ghosh, Jiwen Huang, Jiwen Huang, Qian Wang, Qian Wang, Yanling Gong, Yanling Gong, Srishti Jain, Srishti Jain, Abhimanyu Thakur, Abhimanyu Thakur, Amiyangshu De, Amiyangshu De, Meixi Gong, Meixi Gong, Yoshie Kiyohara, Yoshie Kiyohara, Jingtai Hu, Lingyan Jin, Sharba Bandyopadhyay, Sharba Bandyopadhyay, Fang Chen, Shengtian Li

“…Next, to understand its functional role, kininogen was overexpressed in the hippocampal CA1 area via its AAV-mediated gene delivery, and bradykinin was administered through the fourth ventricle in mice. …”
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Colder environments are associated with a greater cancer incidence in the female population of the United States by Ankit Sharma, Tanu Sharma, Mahaveer S Panwar, Devesh Sharma, Rashmi Bundel, Ryan T Hamilton, James A Radosevich, Chandi C Mandal

“…Similarly, environmental temperature modulates many biological functions. To study the effect of environment temperature on cancer incidence, the US population was selected. …”
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HLA-E: Presentation of a Broader Peptide Repertoire Impacts the Cellular Immune Response—Implications on HSCT Outcome by Thomas Kraemer, Alexander A. Celik, Trevor Huyton, Heike Kunze-Schumacher, Rainer Blasczyk, Christina Bade-Döding

“…The HLA-E locus encodes a nonclassical class Ib molecule that serves many immune functions from inhibiting NK cells to activating CTLs. …”
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Epithelial-Mesenchymal Transition and Inflammation in Head and Neck Squamous Cell Carcinoma by Habib Sadeghi Rad, Abbas Shakoori Garakani, Ghodratolah Panahi, Saman Mehrabi, Mohammad reza Noori daloii

“…The current study aimed at investigating the mRNA expression of the three major factors in tumor specimens to define their functional and pathological roles in this malignancy. …”
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Partial Purification of <i>Bacillus cereus</i> Enzyme Expression for Bio-Pulping of Lignin Degraders Isolated from <i>Coptotermus curvignathus</i> by Sharfina Mutia Syarifah, Ashuvila Mohd Aripin, Nadiah Ishak, Nosa Septiana Anindita, Mohd Firdaus Abdul-Wahab, Angzzas Sari Mohd Kassim

“…Also, the peptides sequenced in this study identified various uncharacterized proteins and hypothetical proteins that might not be discovered for their protein functions. …”
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Oligodendrocyte-astrocyte crosstalk in Parkinson’s disease mediates neuronal ferroptosis via the FGF signaling pathway by Sen Zhang, Min Yan, Xing Jiang, Youhan Liu, Wen Ma, Ling Ding, Zhimin Lu, Ying Luo, Xuewen Tian, Qinglu Wang

“…Recent studies have shown that oligodendrocytes also exhibit functional abnormalities in the brains of PD patients and are involved in the ferroptotic process. …”
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Antagonist actions of CMK-1/CaMKI and TAX-6/calcineurin along the C. elegans thermal avoidance circuit orchestrate adaptation of nociceptive response to repeated stimuli by Martina Rudgalvyte, Zehan Hu, Dieter Kressler, Jörn Dengjel, Dominique A Glauser

“…Since CMK-1 and TAX-6 act in distinct cell types, the phosphorylation observed in vitro might not directly underlie the behavioral phenotype. …”
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Production and characterization of sophorolipid under yeast-mediated submerged fermentation utilizing Agro-industrial waste by Aishwary Purohit, Amar Jyoti Das, Debashish Ghosh

“…FTIR spectroscopy identified characteristic functional groups, while LC-MS revealed distinct sophorolipid congeners with varying lipid chain lengths and acetylation. …”
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Effects of therapeutic alliance on patients with major depressive disorder: a literature review by Giovanni Videtta, Silvia Busilacchi, Giulia Bartoccioni, Luisa Cirella, Ylenia Barone, Giuseppe Delvecchio

“…Seven of the reviewed studies highlighted that therapeutic alliance is a strong predictor of clinical outcomes, contributing to symptom improvement, relapse prevention, and more adaptive functioning in patients with MDD. However, three studies supported the hypothesis that clinical improvement itself might influence the therapeutic alliance between a therapist and a patient at different stages of treatment. …”
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Marital dissolution and cognition: The mediating effect of Aβ neuropathology by Avinash Chandra, Rifah Anjum, Sheena Waters, Petroula Proitsi, Laura J. Smith, Charles R. Marshall, for the Alzheimer's Disease Neuroimaging Initiative

“…DISCUSSION Findings suggest that stressful life events, such as the dissolution of one's marriage, might exert an effect on Alzheimer's disease proteinopathy, which may subsequently influence poor cognition. …”
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Suppressed Accretion onto Massive Black Hole Binaries Surrounded by Thin Disks by Christopher Tiede, Jonathan Zrake, Andrew MacFadyen, Zoltán Haiman

“…We demonstrate that gas disks around binary systems might deliver gas to the binary components only when the circumbinary disk is relatively warm. …”
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Ovotransferrin-depleted egg white hydrolysate reduces blood pressure in spontaneously hypertensive rats by Fatemeh Ashkar, Hongbing Fan, Zihan Wang, Ilekuttige Priyan Shanura Fernando, Jianping Wu

“…These findings demonstrate the potential of OD-EWH as a functional food ingredient against hypertension.…”
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Making sense of the evidence in population health intervention research: building a dry stone wall by David Ogilvie, Jenna Panter, Adrian Bauman, David Humphreys, Louise Foley, Cornelia Guell

“…In this way we might channel a spirit of pragmatic pluralism into making sense of complex sets of evidence, robust enough to support more plausible causal inference to guide action, while accepting and adapting to the reality of the public health landscape rather than wishing it were otherwise. …”
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Gastric Microbiota Associated with Gastric Precancerous Lesions in <i>Helicobacter pylori</i>-Negative Patients by Han-Na Kim, Min-Jeong Kim, Jonathan P. Jacobs, Hyo-Joon Yang

“…<i>Prevotella jejuni</i> and the genus <i>Parvimonas</i> were enriched in the IM group. A predictive functional analysis revealed enrichment of the ornithine degradation pathway in the IM and dysplasia groups, suggesting its role in persistent gastric mucosal inflammation associated with gastric precancerous lesions. …”
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Nanocarrier-based insulin delivery: A leap towards a needle-free future by Saranya Balasubramaniyam, Thirumalaikumaran Rathinam, Mohanakrishnan Srinivasan, Sowmiya Jayarani

“…Nanomedicine's role is poised to shift diabetes care from symptom management to functional cure, with global implications for improving patient quality of life.…”
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Consumption of only wild foods induces large scale, partially persistent alterations to the gut microbiome by Simone Rampelli, Diederik Pomstra, Monica Barone, Marco Fabbrini, Silvia Turroni, Marco Candela, Amanda G. Henry

“…This analysis highlighted structural and functional shifts in microbial interactions, underscoring diet’s role in shaping the gut ecosystem.…”
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CRISPR activation identifies a novel miR-2861 binding site that facilitates the osteogenesis of human mesenchymal stem cells by Seong-Ho Park, Jungwoo Kim, Hee-Jin Yang, Ju Yeon Lee, Chi Heon Kim, Junho K. Hur, Sung Bae Park

“…Therefore, miRNAmiR-2861 with the CRISPRa methods might be a good biomaterial for osteogenesis augmentation.…”
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