Targeting pathogenic fibroblast-like synoviocyte subsets in rheumatoid arthritis by Hongyan Qian, Chaoqiong Deng, Shiju Chen, Xinwei Zhang, Yan He, Jingying Lan, Aodi Wang, Guixiu Shi, Yuan Liu

“…However, fibroblasts perform many essential functions that are required for sustaining tissue homeostasis. …”
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Phylogeography and genomic analysis of SARS-CoV-2 delta variant in Morocco by Safae El Mazouri, Houda Bendani, Nasma Boumajdi, Tarik Aanniz, Ilham Kandoussi, Saaïd Amzazi, Lahcen Belyamani, Azeddine Ibrahimi, Mouna Ouadghiri

“…Conclusions: We conclude that these mutations might have functional consequences on the S protein of SARS-CoV-2. …”
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Molecular basis for the enzymatic inactivity of class III glutaredoxin ROXY9 on standard glutathionylated substrates by Pascal Mrozek, Stephan Grunewald, Katrin Treffon, Gereon Poschmann, Fabian Rabe von Pappenheim, Kai Tittmann, Christiane Gatz

“…Thus, structural alterations in the GSH binding site leading to an altered GSH binding mode likely explain the enzymatic inactivity of ROXY9. This might have evolved to avoid overlapping functions with class I GRXs and raises questions of whether ROXY9 regulates TGA substrates through redox regulation.…”
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Magnetic Resonance Imaging Studies of Postpartum Depression: An Overview by Marco Fiorelli, Franca Aceti, Isabella Marini, Nicoletta Giacchetti, Enrica Macci, Emanuele Tinelli, Valentina Calistri, Valentina Meuti, Francesca Caramia, Massimo Biondi

“…In this review we synthesize the results from studies on postpartum depression in the context of structural, functional, and spectroscopic magnetic resonance studies of major depression as a whole. …”
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Effect of Exportin 1/XPO1 Nuclear Export Pathway Inhibition on Coronavirus Replication by Masmudur M. Rahman, Bereket Estifanos, Honor L. Glenn, Ami D. Gutierrez-Jensen, Karen Kibler, Yize Li, Bertram Jacobs, Grant McFadden, Brenda G. Hogue

“…These results indicate that XPO1-mediated nuclear export pathway inhibition might affect coronavirus replication depending on cell types and virus origin.…”
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Proinsulin Promotes Self-Renewal of a Hematopoietic Progenitor Cell Line In Vitro by Yuewen Han, Tingting Liu, Yunding Zou, Ling Ji, Yuanyuan Li, Jing Li, Jing Wang, Guopin Chen, Jieping Chen, Liang Chen, Zhijia Ye

“…Overexpression of proINS was confirmed via real-time PCR and Western blotting. The functional activity of the human proINS secreted by EML cells was elucidated by analyzing the activation of insulin receptor and its downstream signaling. …”
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An Inducible Expression System of the Calcium-Activated Potassium Channel 4 to Study the Differential Impact on Embryonic Stem Cells by Stefan Liebau, Michael Tischendorf, Daniel Ansorge, Leonhard Linta, Marianne Stockmann, Clair Weidgang, Michelina Iacovino, Tobias Boeckers, Götz von Wichert, Michael Kyba, Alexander Kleger

“…Distinct SK channel subtype expression in ES cells might elucidate their precise impact during cardiac development. …”
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Controlling Assistive Machines in Paralysis Using Brain Waves and Other Biosignals by Paulo Rogério de Almeida Ribeiro, Fabricio Lima Brasil, Matthias Witkowski, Farid Shiman, Christian Cipriani, Nicola Vitiello, Maria Chiara Carrozza, Surjo Raphael Soekadar

“…Thus, using brain waves in combination with other biosignals might significantly enhance the ability of people with a compromised motor system to interact with assistive machines. …”
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Dact1 induces Dishevelled oligomerization to facilitate binding partner switch and signalosome formation during convergent extension by Allyson Angermeier, Deli Yu, Yali Huang, Sylvie Marchetto, Jean-Paul Borg, Chenbei Chang, Jianbo Wang

“…Existing evidence suggests that adopting PCP for CE might be a vertebrate-specific adaptation with incorporation of new regulators. …”
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Prediction of hearing aid cognitive outcomes in age-related hearing loss by Patrice Voss, Zaida Escila Martinez-Moreno, Francois Prévost, Anthony Zeitouni, Alejandro Lopez Valdes, Alejandro Lopez Valdes, Alejandro Lopez Valdes, Alejandro Lopez Valdes, Etienne de Villers-Sidani

“…Future studies with larger sample sizes are warranted, in particular, to explore a wider array of cognitive functions, investigate a greater range of potential predictors, and better quantify their relative contribution to outcome measure estimates.…”
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Suppressing Syndecan-1 Shedding Ameliorates Intestinal Epithelial Inflammation through Inhibiting NF-κB Pathway and TNF-α by Yan Zhang, Zhongqiu Wang, Jun Liu, Zhenyu Zhang, Ye Chen

“…These results indicate that the ectodomain of SDC1 might be the optional therapy for intestinal inflammation.…”
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A potential dermal substitute using decellularized dermis extracellular matrix derived bio-ink by Joo-Yun Won, Mi-Hee Lee, Mi-Jeong Kim, Kyung-Hyun Min, Geunseon Ahn, Ji-Seok Han, Songwan Jin, Won-Soo Yun, Jin-Hyung Shim

“…Skin dECM was extracted by treating the dermis with chemicals and enzymes; the basic structural and functional proteins of the ECM, including collagen, glycosaminoglycans (GAGs), bioreactive materials and growth factors, were preserved, whereas the resident cells that might cause immune rejection or inflammatory responses were removed. …”
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Impact of Two Hexaploidizations on Distribution, Codon Bias, and Expression of Transcription Factors in Tomato Fruit Ripeness by Yating Han, Wanjie Hu, Xiuling Wu, Xinyu Li, Junxi Luo, Ziying Zhu, Zhenyi Wang, Ying Liu

“…Additionally, our research uncovered that WGD events might maintain expression activity during fruit ripening by generating duplicate TF family members. …”
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PM2.5 affected ciliary beat frequency of axonemes via the cyclic AMP-dependent protein kinase a pathway by Jinyan Pang, Jinyan Pang, Zhiqin Xiong, Zhiqin Xiong, Kexin Zhang, Kexin Zhang, Yang Li, Yang Li

“…Low concentrations and short-term exposure to PM2.5 stimulated CBF elevation, however, high concentration and prolonged exposure to PM2.5 might damage respiratory cilia, thereby increasing the risk of respiratory diseases.…”
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Comparative genomic analysis revealed that dietary habits affected the adaptation of Bifidobacterium bifidum to the intestinal tract in different geographic populations by Min Li, Jie Yu, Weicheng Li, Qiong Wu, Jiaqi Sun, Zhihong Sun

“…The phylogenetic tree, based on 919 core genes showed that B. bifidum might be related to the geographical characteristics of isolation region. …”
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Marked elevation of circulating CD19+CD38hiCD24hi transitional B cells give protection against neonatal sepsis by Sitao Li, Fei Ma, Hu Hao, Desheng Wang, Yu Gao, Jialiang Zhou, Fei Li, Hung-Chih Lin, Xin Xiao, Qiyi Zeng

“…Adequate functions of immunoregulation, mediated by regulatory cells such as IL-10 producing CD19+CD38hiCD24hi transitional B cells (Trans), play an important role in control of excessive inflammatory response. …”
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All arthroscopic management of an Hoffa fracture of the medial femoral condyle: case report by Catarina Silva Souto, Diana Bicas Machado, Nuno Rodrigues, Nuno Tavares

“…Diagnosis of this fracture might be challenging as standard radiographic studies may appear normal. …”
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Human Acquired Aplastic Anemia Patients’ Bone-Marrow-Derived Mesenchymal Stem Cells Are Not Influenced by Hematopoietic Compartment and Maintain Stemness and Immune Properties by Vandana Sharma, Sonali Rawat, Suchi Gupta, Sweta Tamta, Rinkey Sharma, Tulika Seth, Sujata Mohanty

“…Our data suggest that BM-MSCs from aAA patients might not be involved in disease pathogenesis. However, owing to a smaller number of samples, it is not conclusive, and future studies with more exhaustive investigation at transcriptome level are warranted.…”
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Adjunct psychomotor trauma exposure in the treatment of post-traumatic stress disorder: a case series by Claire Guépin, Stéphane Duhem, Nicolas Gaud, Frédérique Warembourg, Guillaume Vaiva, Arnaud Leroy

“…However, many patients remain resistant to treatment, with significant levels of residual symptoms, a high dropout rate, and poor functional prognosis despite a reduction in psychotraumatic symptoms. …”
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Rapamycin Attenuated Cardiac Hypertrophy Induced by Isoproterenol and Maintained Energy Homeostasis via Inhibiting NF-κB Activation by Xi Chen, Siyu Zeng, Jian Zou, Yanfang Chen, Zhongbao Yue, Ying Gao, Luankun Zhang, Weiwei Cao, Peiqing Liu

“…Rapa was demonstrated to attenuate isoproterenol-induced cardiac hypertrophy, maintain the structure integrity and functional performance of mitochondria, and upregulate genes related to fatty acid metabolism in hypertrophied hearts. …”
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