Optimization of a bearing geometry for a cervical total disc replacement by Lucia Kölle, Markus Flohr, Gregory Pryce, Andrew R. Beadling, Michael Bryant, Richard M. Hall, Stephen J. Ferguson, Benedikt Helgason

“…The design optimization aims to functionally replace the structures that are commonly excised (removed) or dissected (cut) during TDR implantation in the anterior column.ResultsThe optimized bearing geometry was able to replicate the moment-rotation curve of the anterior column of the natural C6/C7 level during coupled flexion/extension-anterior/posterior translation movement. …”
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Association between medication adherence and health-related quality of life among type 2 diabetic adults in Mexico by Sara I. Olvera-Cruz, Araceli Cano-Estrada, José Á. Hernández-Mariano, Ana C. Castañeda-Márquez, Yaneth C. O. Orihuela, María A. Mejía-Blanquel

“…Purpose Previous evidence suggests that non-adherence to medication among patients with chronic diseases might negatively affect their health-related quality of life (HRQoL); however, the evidence in adults with type 2 diabetes (T2D) is not conclusive, and information is scarce in the Mexican context. …”
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<i>NAC</i> Gene Family in <i>Lagerstroemia indica</i>: Genome-Wide Identification, Characterization, Expression Analysis, and Key Regulators Involved in Anthocyanin Biosynthesis by Zilong Gao, Zhuomei Chen, Jinfeng Wang, Weixin Liu

“…Our results provided novel insights and could help in the functional identification of <i>LiNACs</i> in <i>L. indica</i> and the regulation of anthocyanin synthesis.…”
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Activation-induced cytidine deaminase (AID)-associated multigene signature to assess impact of AID in etiology of diseases with inflammatory component. by Diana Mechtcheriakova, Yury Sobanov, Gabriele Holtappels, Erika Bajna, Martin Svoboda, Markus Jaritz, Claus Bachert, Erika Jensen-Jarolim

“…Thus, the algorithm presented herein including the multigene signature approach, analysis of co-regularities and creation of AID-associated functional network gives an integrated view of biological processes and might be further applied to assess role of altered AID expression in etiology of other diseases, in particular, aberrant immunity and cancer.…”
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Mariner Transposons Contain a Silencer: Possible Role of the Polycomb Repressive Complex 2. by Solenne Bire, Sophie Casteret, Benoît Piégu, Linda Beauclair, Nathalie Moiré, Peter Arensbuger, Yves Bigot

“…Here, we describe a silencer situated in the last 300 bp of the Mos1 transposase open reading frame (ORF) which functions in vertebrate and arthropod cells. Functional silencers are also found at similar locations within three other animal mariner elements, i.e. …”
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Deciphering the role of molecular mimicry in the etiopathogenesis of Autoimmune Hemolytic Anemia using an immunoinformatics approach. by Pratyusha Patidar, Arihant Jain, Tulika Prakash

“…Additionally, many B-cell and T-cell epitopes exhibited exact homologies with various human gut microbial proteins. The functional annotation highlighted the involvement of specialized RBC functions, such as cytoskeleton organization, ammonium homeostasis, signalling transduction, in the underlying disease mechanism. …”
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Complex Loci in human and mouse genomes. by Pär G Engström, Harukazu Suzuki, Noriko Ninomiya, Altuna Akalin, Luca Sessa, Giovanni Lavorgna, Alessandro Brozzi, Lucilla Luzi, Sin Lam Tan, Liang Yang, Galih Kunarso, Edwin Lian-Chong Ng, Serge Batalov, Claes Wahlestedt, Chikatoshi Kai, Jun Kawai, Piero Carninci, Yoshihide Hayashizaki, Christine Wells, Vladimir B Bajic, Valerio Orlando, James F Reid, Boris Lenhard, Leonard Lipovich

“…A sampling approach indicated that over 40% of all TUs might actually be in cis-antisense pairs, and that only a minority of these arrangements are likely to be conserved between human and mouse. …”
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Implications of Environmental Variations on <i>Saccharina japonica</i> Cultivation in Xiangshan Bay, China by Yikang Bao, Peng Xu

“…Furthermore, the environmental factors were evaluated using suitability functions of kelp growth, aiming to provide references for promoting kelp cultivation in South China. …”
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Farmers’ decision-making dynamics in bio-based fertilizer adoption: an agent-based model by Erika De Keyser, Siavash Farahbakhsh, Erik Mathijs, Liesbet Vranken

“…Several researchers have investigated farmer preferences regarding bio-based fertilizers, but how bio-based fertilizer adoption might evolve with changing social and economic contexts remains uncertain. …”
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Host-derived apolipoproteins play comparable roles with viral secretory proteins Erns and NS1 in the infectious particle formation of Flaviviridae. by Takasuke Fukuhara, Tomokazu Tamura, Chikako Ono, Mai Shiokawa, Hiroyuki Mori, Kentaro Uemura, Satomi Yamamoto, Takeshi Kurihara, Toru Okamoto, Ryosuke Suzuki, Kentaro Yoshii, Takeshi Kurosu, Manabu Igarashi, Hiroshi Aoki, Yoshihiro Sakoda, Yoshiharu Matsuura

“…Here we show that host-derived apolipoproteins play functional roles similar to those of virally encoded Erns and NS1 in the formation of infectious particles. …”
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Managers' Ability and Debt Structure: Evidence from Iran's Financial Reporting Environment by Aqil al hasoon, Seyed Abbas Hashemi, Narges Hamidian

“…Moreover, the preferential use of short-term debt may function as a positive market signal, conveying managers' confidence in the firm's near-term financial prospects. …”
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Analysis of transcriptome and chromatin accessibility changes during the differentiation of human embryonic stem cells into neural progenitor cells by LI Linying, CAI Xiaodong, TONG Ran, YANG Chen, WANG Zhiming, HE Xiaoyu, MA Ziyue, ZHANG Feng, LI Lingjie, ZHOU Junmei

“…RNA-seq analysis revealed that compared to the hESC stage, there were 5 597 genes upregulated and 3 654 genes downregulated at the NPC stage. Gene function enrichment analysis showed that the upregulated genes at the NPC stage were enriched in the functions related to neural development. …”
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The mechanistic study of codonopsis pilosula on laryngeal squamous cell carcinoma based on network pharmacology and experimental validation by Huina Guo, Huina Guo, Yichen Lou, Yichen Lou, Yichen Lou, Xiaofang Hou, Xiaofang Hou, Xiaofang Hou, Xiaoya Guan, Xiaoya Guan, Yujia Guo, Yujia Guo, Qi Han, Qi Han, Xuting Xue, Xuting Xue, Ying Wang, Ying Wang, Long He, Long He, Zhongxun Li, Zhongxun Li, Chunming Zhang, Chunming Zhang, Chunming Zhang

“…The presence of key compounds was verified by LC-MS, the MAPK3 expression was detected by qPCR in LSCC tissues, and the effects of MAPK3 knockdown on proliferation, migration, invasion, cell cycle, and apoptosis of LSCC cells were evaluated by cellular function assays.ResultsIn this study, 22 targets of Codonopsis pilosula that might regulate LSCC were screened based on network pharmacology. …”
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Modulation of rhizosphere microbiota by Bacillus subtilis R31 enhances long‐term suppression of banana Fusarium wilt by Ming‐Wei Shao, Hao‐Jun Chen, Ai‐Qin Huang, Li Zheng, Chun‐ji Li, Di Qin, Yun‐Hao Sun, Zheng Lin, Gang Fu, Yan‐Hong Chen, Yong‐Jian Li, Zhang‐Yong Dong, Ping Cheng, Heru Pramono, Guo‐Hui Yu, Zhi‐Min Xu, Shuang Miao, Kevin D. Hyde

“…R31 induced functional bacteria colonization in nascent banana root hair tissues, establishing new microbiome patterns that contributed to long‐term disease suppression. …”
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Persistent symptoms and clinical findings in adults with post-acute sequelae of COVID-19/post-COVID-19 syndrome in the second year after acute infection: A population-based, nested... by Raphael S Peter, Alexandra Nieters, Siri Göpel, Uta Merle, Jürgen M Steinacker, Peter Deibert, Birgit Friedmann-Bette, Andreas Nieß, Barbara Müller, Claudia Schilling, Gunnar Erz, Roland Giesen, Veronika Götz, Karsten Keller, Philipp Maier, Lynn Matits, Sylvia Parthé, Martin Rehm, Jana Schellenberg, Ulrike Schempf, Mengyu Zhu, Hans-Georg Kräusslich, Dietrich Rothenbacher, Winfried V Kern, EPILOC Phase 2 Study Group

“…A history of PEM was associated with more severe symptoms and more objective signs of disease and might help stratify cases for disease severity.…”
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從工具示能性與關係行動主體之觀點 探討偏鄉教育系統賦能策略之研究 Investigating the Construction of Empowerment Action Models in Remote Educational Systems Through the Lenses of Tool Affordance and Relational Age... by 陳佩英 Peiying Chen, 洪琴雯 Chin-Wen Hung

“…However, these existing disadvantages might be transformed by means of implementing the new National Curriculum Guidelines in 2019. …”
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Hydrogel-Based Nanocomposites and Mesenchymal Stem Cells: A Promising Synergistic Strategy for Neurodegenerative Disorders Therapy by Diego Albani, Antonio Gloria, Carmen Giordano, Serena Rodilossi, Teresa Russo, Ugo D’Amora, Marta Tunesi, Alberto Cigada, Luigi Ambrosio, Gianluigi Forloni

“…With regard to central nervous system (CNS) neurodegenerative disorders, the design of injectable nanocomposite hydrogels for in situ drug or cell release represents an interesting and minimally invasive solution that might play a key role in the development of successful treatments. …”
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Neutrophils, NETs and multiple sclerosis: a mini review by Moyuan Quan, Moyuan Quan, Moyuan Quan, Huining Zhang, Huining Zhang, Huining Zhang, Xiaohong Deng, Huijia Liu, Yanqiu Xu, Xiujuan Song, Xiujuan Song, Xiujuan Song

“…Neutrophils, often underestimated in MS, are gaining increased attention for their significant functions in MS patients and the experimental autoimmune encephalomyelitis (EAE) animal model. …”
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The landscape of human mutually exclusive splicing by Klas Hatje, Raza‐Ur Rahman, Ramon O Vidal, Dominic Simm, Björn Hammesfahr, Vikas Bansal, Ashish Rajput, Michel Edwar Mickael, Ting Sun, Stefan Bonn, Martin Kollmar

“…Abstract Mutually exclusive splicing of exons is a mechanism of functional gene and protein diversification with pivotal roles in organismal development and diseases such as Timothy syndrome, cardiomyopathy and cancer in humans. …”
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Fluorescence sensor array for highly sensitive pattern recognition of biothiols in food based on tricolor upconversion luminescence metal-organic frameworks by Mingyuan Yin, Dongfang Qiu, Meiqi Wang, Zedan Wang, Lirong Han, Linsen Li, Jie Tong, Hailiang Nie, Yun Wu, Xiaoqiang Qiao

“…Such fluorescence sensor array might provide a simple and efficient detection method for biothiols.…”
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