Prospects and challenges of targeted extracellular vesicles drug delivery for cancer treatment by Fatemeh Maher, Ali Samadi, Peyman Asadi, Isabella Jodoin

“…These EVs are abundant in human serum, yet it might be difficult to separate them from non-EV lipid particles and serum proteins. …”
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Integrating Literature-Based Knowledge Database and Expression Data to Explore Molecular Pathways Connecting PPARG and Myocardial Infarction by Rongyuan Cao, Yan Dong, Kamil Can Kural

“…Peroxisome proliferator-activated receptor γ (PPARG) might play a protective role in the development of myocardial infarction (MI) with limited mechanisms identified. …”
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Health-related quality of life assessment in Serbian schoolchildren hospitalized for malignant disease by Nedović Goran, Marinković Dragan, Rapaić Dragan, Berat Svetlana, Kozomara Ružica

“…Although long-term survival of childhood cancer patients is significantly improved, prolonged treatment and hospitalization might have negative impacts on child development. …”
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From Catalyst to Clarity by Ezra Chan

“…Some argue that without broad exclusivity for an entire disease, companies might not invest in orphan drug development at all. …”
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Disease suppression is driven by microbial community properties at fine taxonomic scales by Shan Shan, Isabelle George, Michael D. Millican, Linda L. Kinkel, Richard A. Lankau

“…Even though opposing components of microbial community structure might be related to the two functions, disease suppression did not cause a negative trade‐off in growth promotion. …”
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Testing of urodynamic dysfunctions in patients with multiple sclerosis by Babović Rade, Milićević Saša, Radovanović Saša, Jančić Jasna

“…Urodynamic testing could help to diagnose functional disorders of the lower urinary tract, which might not be otherwise possible by performing the standard invasive procedures or noninvasive scans, such us ultrasound, computed tomography or functional magnetic resonance imaging (fMRI). …”
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Chemical modification and antioxidant activity of Wendan peel polysaccharide by Bobo Lin, Gangliang Huang

“…At a concentration of 3.2 mg/mL, the scavenging rate of P-PP on DPPH free radicals could reach 72.50%, and the scavenging rate on superoxide anions was 69.38%.These results indicated that the antioxidant activity of modified polysaccharides was improved, which might be due to the introduction of new active functional groups through chemical modification, thereby altering the structure of polysaccharides.…”
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A case of glial fibrillary acidotic protein (GFAP) meningoencephalitis with rheumatoid arthritis by Mehri Salari, Masoud Etemadifar, Reyhaneh Soleymani, Aditya Ashok Murgai, Ronak Rashedi

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Kink Wave Phenomena in the Nonlinear Partial Differential Equation Representing the Transmission Line Model of Microtubules for Nanoionic Currents by Safyan Mukhtar, Weaam Alhejaili, Mohammad Alqudah, Ali M. Mahnashi, Rasool Shah, Samir A. El-Tantawy

“…The equation introduced here in this form is suitable for critical nanoscience concerns like cell signaling and might continue to explain some of the basic cognitive functions in neurons. …”
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CDCA7 enhances STAT3 transcriptional activity to regulate aerobic glycolysis and promote pancreatic cancer progression and gemcitabine resistance by Dijie Zheng, Yazhu Deng, Lu Deng, Zhiwei He, Xinghao Sun, Yanyu Gong, Binbin Shi, Deqin Lu, Chao Yu

“…However, its expression pattern and functional significance in PC require further research. …”
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X-point radiator control and its dynamics in ASDEX Upgrade and JET deuterium–tritium discharges by T.O.S.J. Bosman, M. Bernert, L. Ceelen, B. Sieglin, J.T.W. Koenders, T. Ravensbergen, O. Kudlác̈ek, P. Fox, D. Brida, H. Reimerdes, C. Lowry, M. Lennholm, L. Piron, H. Sun, P. Jacquet, K. Kirov, N. Vianello, C. Ashe, A. Parrott, D. Valcarcel, M. van Berkel, the ASDEX Upgrade Team, JET Contributors, the EUROfusion Tokamak Exploitation Team

“…We find that the sensitivity (relative gain) of the XPR varies as function the height of the radiator inside the confined region but that the relative phase is consistent for all operating points. …”
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Therapeutic effects of raw rhubarb on gastrointestinal complications in ischemic stroke: An integrated analysis of gut microbiota, metabolomics, and network pharmacology by Zhanhao Ye, Dongmin Cao, Wenxing Ao, Ting Li, Minghua Xian, Shumei Wang

“…Combining metabolomics, network pharmacology, and molecular docking analysis suggested that RR might regulate AA metabolism through the PI3K/mTOR signaling pathway to treat GITC in IS. …”
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Cloning and identification of human colipase-like 3 and its homologous cDNAs by LU Yan, XUE Yong-chang, YU Peng, WANG Ping-zhang

“…According to the latest release of H-InvDB (release 6.2), 34511 protein-encoding genes were annotated and most of them were function-unknown. There is still a long road ahead to identify the whole human genes and their functions. …”
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Differential modulation of SARS-CoV-2 infection by complement factor H and properdin by Uday Kishore, Uday Kishore, Praveen M. Varghese, Chandan Kumar, Susan Idicula-Thomas, Martin Mayora Neto, Anthony G. Tsolaki, Pretty Ponnachan, Pretty Ponnachan, Khaled Masmoudi, Basel Al-Ramadi, Basel Al-Ramadi, Manu Vatish, Taruna Madan, Taruna Madan, Nigel Temperton, Nazar Beirag, Nazar Beirag

“…FP could aid cell viral entry and binding and aggravate hyperinflammation that might contribute to the severity of the infection.…”
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Bioinformatics analysis of lncRNA and mRNA differentially expressed in patients with cervical cancer by Xiaohua An, Xiaohua An, Xiaoxue Huang, Qiujie Yu, Qiujie Yu, Yiyue Tang, Yan Wang, Yan Wang, Huasu Chen, Huasu Chen, Yafei Zhang, Yafei Zhang, Qianhao Huang, Qianhao Huang, Yudi Rao, Yudi Rao, Guomei Hu, He Zha

“…Further analysis indicated that the 20 antisense lncRNAs with the most remarkable differences might exert biological functions by influencing their corresponding mRNAs. …”
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Enhancing antitumor immunity through the combination of cholesterolized TLR7 agonist liposomes and radiotherapy: a role for IL‐1β and the inflammasome pathway by Xuejiao Han, Yuan Cheng, Dandan Wan, Aqu Alu, Ziqi Zhang, Zhenfei Bi, Manni Wang, Yan Tang, Weiqi Hong, Siyuan Chen, Li Chen, Yuquan Wei

“…In vitro, primary mouse bone marrow‐derived dendritic cells (BMDCs) were utilized to investigate changes in function and the activated pathways through RNA sequencing. …”
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Pearls on a String: Dark and Bright Galaxies on a Strikingly Straight and Narrow Filament by M. Arabsalmani, S. Roychowdhury, B. Schneider, V. Springel, E. Le Floc’h, F. Bournaud, A. Burkert, J.-C. Cuillandre, P.-A. Duc, E. Emsellem, D. Galárraga-Espinosa, E. Pian, F. Renaud, M. A. Zwaan

“…Their darkness together with their large H i 21 cm line widths indicates that they contain gas that might not yet be virialized. These clouds must be marking the peaks of the dark matter and H i distributions over large scales within the filament. …”
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A new insight on alleviating the inhibitory effect of aflatoxin B1 on muscle development in grass carp (Ctenopharyngodon idella): The effect of 4-Methylesculetin in vivo and in vit... by Xiangning He, Jiajia Zhang, Weidan Jiang, Pei Wu, Yang Liu, Hongmei Ren, Xiaowan Jin, Hequn Shi, Xiaoqiu Zhou, Lin Feng

“…The present results revealed that supplementation of AFB1 contaminated feed with 4-ME reduced the inhibition of growth and muscle development by alleviating AFB1-induced ECM degradation in grass carp, which might be related to the p38 MAPK/uPA/MMP/ECM pathway. …”
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APPROACH: Analysis of Proton versus Photon Radiotherapy in Oligodendroglioma and Assessment of Cognitive Health – study protocol paper for a phase III multicentre, open-label rando... by Charlotte Smith, Martin Klein, Stuart Currie, Sarah Brown, Alexandra Smith, Elizabeth Miles, Helen Bulbeck, Gillian A Whitfield, Susan Short, Matthew Lowe, Samantha Noutch, Naomi Fersht, Catherine Parbutt, Louise Murray, Florien W Boele, John Lilley, Finbar Slevin, Rovel Colaco, Eleanor Mae Hudson, James R Powell, Myfanwy Borland, Anna Bruce, Neil G Burnet, Yen Ching Chang, Daniel Egleston, Robert D Murray, Daniel J O’Hara, Matthew Norris

“…Patients may experience long-term treatment-related toxicities, with RT linked to impairments of neurocognitive function (NCF) and health-related quality of life (HRQoL). …”
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Modelling analysis of dietary behaviors and oral health status to assess the impact on the mental well-being of elderly individuals: a cross-sectional survey study by Chan Huang, Mingzhu Song, Xiao Wei, Xingyan Wang, Honglin Dai, Zhiqiong Gou, Feiyang Chenwu, Yanqiu Jiang, Jie Wan, Yurun Guo, Xiaoping Yu

“…Participants scoring above 0 were categorized into the anxiety-prone group. Cognitive function was assessed through seven items, with higher scores suggestive of a propensity toward dementia. …”
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