Targeting senescent cells in translational medicine by Marta Paez‐Ribes, Estela González‐Gualda, Gary J Doherty, Daniel Muñoz‐Espín

“…Abstract Organismal ageing is a complex process driving progressive impairment of functionality and regenerative potential of tissues. …”
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Statistical and Clustering Analysis of Safety Profiles of FDA-Approved Protein Kinase Inhibitors by Ioana Lavinia Radulian, Georgiana Nitulescu, Anca Zanfirescu, George Mihai Nitulescu

“…Real-world evidence complements clinical trial data, capturing AEs that might not be fully identified pre-approval.…”
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Ion channel mutations and cancer by Xinyu Cao, Liang Yan, Liang Hong

“…Ion channels are pore-forming transmembrane proteins that regulate ion transport across cellular membranes, influencing various cellular functions. Recent studies have indicated the emerging roles of ion channel proteins in cancer. …”
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Pachydermodactyly Treated with Tranilast in a Young Girl by Chikahisa Higuchi, Tetsuya Tomita, Hideki Yoshikawa

“…On the other hand, tranilast might be an effective drug to pachydermodactyly.…”
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It’s a long way to the top (if you want to personalize immunotherapy) by Sarah Haebe, Oliver Weigert

“…Of note, the immunogenic neoepitopes were derived from mutant CREBBP and MEF2B, two genes that have previously been shown to be functionally and prognostically relevant in this disease.In this commentary we discuss the promises but also the challenges of how to translate these findings into clinical practice.…”
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Discovering the Influences of Complex Network Effects on Recovering Large Scale Multiagent Systems by Yang Xu, Pengfei Liu, Xiang Li, Wei Ren

“…For example, if the network was recovered from the broken links or disfunction nodes, the network topology might have been shifted. Therefore, their influences on the overall multiagent system performance are unknown. …”
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Regulation of Signal Transduction by Glutathione Transferases by Julie Pajaud, Sandeep Kumar, Claudine Rauch, Fabrice Morel, Caroline Aninat

“…Taken together, these observations strongly suggest that GST might play a crucial role during normal or cancer cells proliferation or apoptosis.…”
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The Neuroprotective Effect of the Association of Aquaporin-4/Glutamate Transporter-1 against Alzheimer’s Disease by Yu-Long Lan, Shuang Zou, Jian-Jiao Chen, Jie Zhao, Shao Li

“…Here, we review the interaction of AQP4 and GLT-1 in astrocytes, which might play a pivotal role in the regulation of distinct cellular responses that involve neuroprotection against AD. …”
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Bayesian network based probabilistic approach for uncertainty analysis of earthquake induced landslides by Tanmoy Das, Deepankar Choudhury

“…The results showed that due to the event of an earthquake, the slope might experience permanent displacement. Finally, based on the variation of permanent displacement, the likelihood of landslide occurrences was estimated. …”
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QT and QTa interval duration and dispersion during stress test in coronary heart disease and ventricular arrhythmia patients by N. V. Furman, S. S. Shmatova, P. Ya. Dovgalevsky

“…In total, 77 patients with Functional Class II-FV angina were examined (mean age 51,1+8,1 years). …”
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Feel connected to create: Self-reported psychedelic drug users exhibit higher sense of connectedness and better divergent thinking skills compared to non-users. by Christian Rominger, Carolina Subow

“…Psychedelic drugs can increase health, wellbeing, and even boost cognitive functions such as creativity. Beyond this, previous studies indicated that psychedelic drug intake can increase the sense of connectedness to the world, to others, and to the self. …”
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Active transportation policy and practice in the city of Oulu from 1998 to 2016—A mixed methods study by Mikko Kärmeniemi, Tiina Lankila, Emilia Rönkkö, Kari Nykänen, Heli Koivumaa-Honkanen, Raija Korpelainen

“…Decreased active transportation mode share might have been due to inadequately assessed functional mix outside the inner city, increased urban sprawl and building more capacity for cars. …”
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Development of RNA interference-based therapy for rare genetic diseases by Milya Urfa Ahmad, Syarifah Dewi

“… In December 2022, the Indonesian Ministry of Health projected that rare diseases might affect 8–10% of the population, equating to approximately 27 million people. …”
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Ocular movement anomalies in intracranial space-occupying lesions by Henrietta Olubusayo Osoba, Bolanle Balogun, Olufemi Emmanuel Idowu

“…Conclusion: oculomotor abnormalities in patients with ICSOLs are diverse, and early identification of these is a key factor in improving functional visual outcomes in ICSOLs.…”
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The Use of Vascular Endothelial Growth Factor Inhibitors in Patients with Proliferative Diabetic Retinopathy by V. Yu. Evgrafov, G. R. Kudasheva

“…Diabetic retinopathy (DR) have been taking a leading position among retinal disorders, causing a persistent and significant decrease in visual functions. The base of the disease is a retinal vascular microangiopathy, which induces a tissue ischemia and excessive production of vascular endothelial growth factors. …”
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Nurturing the Growing Generation’s Values in the Process of Socio-Cultural Transformation of Society by Asbi Khaleb

“…To overcome the problem the author recommends developing and implementing a special training program focused on the value component de- velopment, as the students might have difficulty getting by in the real world without it.…”
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Increasing evidence of the role of Helicobacter pylori SabA in the pathogenesis of gastroduodenal disease by Yoshio Yamaoka

“…Many of the genes encoding outer membrane proteins undergo phase variation such that not all strains will produce functional proteins, and SabA expression is frequently switched “on” or “off”, suggesting that SabA expression can rapidly respond to changing conditions in the stomach or in different regions of the stomach. …”
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Investigating Psychosocial Causes of the Tendency for Rhinoplasty in Qazvin City, Iran, in 2023: A Descriptive Analytical Study by Reza Emrani, Mona Akhoundi

“…This study aimed to evaluate different determinants of the patient’s psychosocial functioning that might affect the outcome of rhinoplasty surgery. …”
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Death by suicide long after electroconvulsive therapy. Is the sense of coherence test of Antonovsky a predictor of mortality from depression? by John Erik Berg

“…Tentatively, a low pathological score on the SOC test may indicate low sense of coherence in life that might increase the propensity for suicide. These preliminary results need replication in larger studies.…”
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Active transportation policy and practice in the city of Oulu from 1998 to 2016—A mixed methods study by Mikko Kärmeniemi, Tiina Lankila, Emilia Rönkkö, Kari Nykänen, Heli Koivumaa-Honkanen, Raija Korpelainen

“…Decreased active transportation mode share might have been due to inadequately assessed functional mix outside the inner city, increased urban sprawl and building more capacity for cars. …”
Get full text