An Insight on Gut Flora, Colorectal Cancer Mechanism, and Treatment Strategies by Rajendra Kumar, Ashmeen Kaur, Divyanshu Rajput

“…The microbiota in the stomach functions like an actual organ. To maintain gut homeostasis, the digestive tract’s symbiotic relationships with the local microorganisms are crucial. …”
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MONTELUKAST IN THE TREATMENT OF BRONCHIAL ASTHMA IN CHILDREN by I.V. Vasilevsky, E.N. Skep'yan

“…Among all the children, the researchers examined atopy markers and functions of the respiaratory functions in dynamics. …”
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ALT Donor Area Compartment Syndrome: A Rare and Devastating Complication by Gloria Alsina, Teresa Nunez-Villaveirán, Daniel Camporro, Clara Martin

“…Intense pain is an alarm sign but might be absent in patients with epidural infusion pumps. …”
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Two splicing variants of amino acid transporter-like 4 (OsATL4) negatively regulate rice tillering and yield by mediating the transport of amino acids by Chuanbo Wang, Weiting Huang, Rui Miao, Bowen Wu, Wenhao Wu, Chongchong He, Chang Zheng, Quanzhi Zhao, Zhongming Fang

“…Altered expression of OsATL4 might affect the expression of genes in nitrogen, auxin, and cytokinin pathways. …”
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Nucleotide binding as an allosteric regulatory mechanism for Akkermansia muciniphila β-N-acetylhexosaminidase Am2136 by Chang-Cheng Li, Huan Yi, Yan-Mei Wang, Xin-Yue Tang, Yi-Bo Zhu, Ying-Jie Song, Ning-Lin Zhao, Qin Huang, Xing-Yu Mou, Gui-Hua Luo, Tong-Gen Liu, Gang-Long Yang, Yu-Jiao Zeng, Li-Jie Wang, Hong Tang, Gang Fan, Rui Bao

“…Structural and enzyme activity assay experiments allowed us to probe the essential function of the inter-domain interactions in β23-β33. …”
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Enhanced B7-H4 expression in gliomas with low PD-L1 expression identifies super-cold tumors by Yan Zhang, Di Chen, Qiqi Lu, Yu Yao, Gaopeng Li, Chunxia Ji, Ying Qi, Chao Tang, Ji Xiong, Jian Hu, Fatma Betul Aksoy Yasar, Dave S B Hoon, Liangfu Zhou

“…The distinct B7-H4 pathways modulating T-cell function and immune evasion in glioma patients deserved to be further explored in the future during immunotherapy.…”
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Validation of Takotsubo Syndrome Scoring System by Dana Deeb, Ranel Loutati, Louay Taha, Mohammad Karmi, Akiva Brin, Ofir Rabi, Nir Levi, Noam Fink, Pierre Sabouret, Mohammed Manassra, Abed Qadan, Motaz Amro, Benyamin Khalev, Michael Glikson, Elad Asher

“…<b>Conclusions</b>: The 10-point TS scoring system is an easy, reliable, and useful diagnostic tool that might help in distinguishing patients with TS and ACS.…”
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Bioactive peptides from salmon aquaculture processing by-product affect growth performance, plasma biochemistry, gut health, and stress resistance of gilthead seabream (Sparus aura... by Elisa Benini, Eliana Musmeci, Serena Busti, Elena Biagi, Sara Ciulli, Enrico Volpe, Francesca Errani, Åge Oterhals, Odd Helge Romarheim, Tone Aspevik, Francesco Dondi, Giulio Zanaroli, Pier Paolo Gatta, Alessio Bonaldo, Luca Parma

“…Overall, while BP inclusion offers a sustainable alternative protein source, incorporating more than 5 % in the diet might compromise fish health under challenging environmental conditions.…”
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Primary osteosarcoma of the breast during lactation: a case report and literature review by Huifang Zhuo, Huifang Zhuo, Yubei Duan, Shuangshuang Dong, Shuangshuang Dong, Jun Zhang, Jun Zhang, Zijing Wang, Zijing Wang, Lian Meng, Lian Meng, Chenyan Wang, Man Li, Xiaotian Yang, Ning Wang, Ning Wang, Jianming Hu

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A meta-analysis of epigenome-wide association studies of ultra-processed food consumption with DNA methylation in European children by Joana Llauradó-Pont, Nikos Stratakis, Giovanni Fiorito, Evangelos Handakas, Alexander Neumann, Henrique Barros, Anne Lise Brantsæter, Kiara Chang, Leda Chatzi, Janine F. Felix, Regina Grazuleviciene, Vincent W. V. Jaddoe, Marianna Karachaliou, Marion Lecorguillé, Carla Lopes, Christopher Millett, Rosemary R. C. McEachan, Eleni Papadopoulou, Remy Slama, Eszter P. Vamos, Paolo Vineis, Martine Vrijheid, John Wright, Trudy Voortman, Mariona Bustamante, Oliver Robinson, Camille Lassale

“…These CpGs have been previously associated with health outcomes such as carcinomas, and the related genes are mainly involved in pathways related to thyroid hormones and liver function. Conclusion We only found suggestive changes in methylation at 7 CpGs associated with UPF intake in a large EWAS among children: although this shows a potential impact of UPF intake on DNAm, this might not be a key mechanism underlying the health effects of UPFs in children. …”
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Dietary Se-enrich Cardamine violifolia supplementation decreases lipid deposition and improves antioxidant status in the liver of aging laying hens by Mengke Yan, Xin Cong, Hui Wang, Kun Qin, Yuhui Tang, Xiao Xu, Dan Wang, Shuiyuan Cheng, Yulan Liu, Huiling Zhu

“…Selenium (Se)-enriched Cardamine violifolia (SEC) is known for its excellent antioxidant function. The objective of this study was to evaluate the effects of SEC on antioxidant capacity and lipid metabolism in the liver of aged laying hens. …”
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A first-in-human, prospective pilot trial of umbilical cord-derived mesenchymal stem cell eye drops therapy for patients with refractory non-Sjögren's and Sjögren's syndrome dry ey... by Di Zhang, Taige Chen, Qi Liang, Xuebing Feng, Jiaxuan Jiang, Zeying Chen, Yun Tang, Yiran Chu, Bin Wang, Kai Hu

“…Secondary assessments focused on the evaluation of lipid layer, meibomian gland function, and bulbar conjunctival redness. Safety was monitored by recording adverse events (AEs) throughout the study. …”
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Early high nutrition enhances grass-fed beef productivity through epigenetically regulated muscle metabolism, altered early adipogenesis, and rumen fermentation dynamics by D. Nishino, S. Khounsaknalath, K. Saito, A. Saito, T. Abe, E. Kobayashi, F. Ebara, S. Maak, E. Albrecht, M.W. Pfaffl, R. Saneshima, S. Shimamoto, D. Ijiri, S. Koike, S. Yasuo, T. Gotoh

“…These findings suggest that the increase in LM IMF might be the result of early adipocyte hyperplasia, greater nutrient supply through rumen programming of high propionate production, and epigenetic regulation of metabolism, involving decreased muscle mitochondrial function inducing a shift towards myofibres that consume less lipids.…”
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TLR4 interaction with PIEZO1 facilitates the 5-HT-mediated intestinal motility dysfunction in offspring mice induced by LPS exposure during pregnancy by Ruifang Luo, Yuan Miao, Riqiang Hu, Fang Lin, Junyan Yan, Ting Yang, Lu Xiao, Zhujun Sun, Yuting Wang, Jie Chen

“…Several factors during pregnancy, such as changes in serotonin (5-HT) levels, can affect intestinal function in offspring mice. The role of 5-HT in regulating intestinal motility after lipopolysaccharide (LPS) exposure during pregnancy is unclear. …”
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Mechanistic study on the mitigation of cadmium accumulation in Ligusticum sinense cv. Chuanxiong through plant growth-promoting rhizobacteria Arthrobacter sp. CX-2 by Shu-qi Niu, Ting Li, Lin Liu, Xiu-wen Bao, Xing-mao Yang, Hao-ran Song, Yang Li, Jing Bai, Li-ying He, Qing-he Wang, Si-jing Liu, Jin-lin Guo

“…Metagenome analysis demonstrated that the structure, composition, and function of the rhizosphere microbial community significantly changed in the CX-2 group. …”
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The fibrin-derived peptide FX06 protects human pulmonary endothelial cells against the COVID-19-triggered cytokine storm by Zhiran Wang, Dmitrii Lebedev, Simeng Li, Sudharshan Rao, Kevin Wu, Lorcan Doyle, Kieran Wynne, Alfonso Blanco, Margaritha M. Mysior, Jeremy C. Simpson, Dimitri Scholz, Petra Wülfroth, Kai Zacharowski, Walter Kolch, Vadim Zhernovkov, Günther Eissner

“…FX06 reduced capillary-like structure formation of the severe cytokine cocktail treated-ECs, indicating FX06 down-regulated the pro-inflammatory angiogenic activity caused by the severe cytokine cocktail. Additionally, FX06 might assist in maintaining the normal barrier function of ECs by altering the surface expression of Syndecan-1 (SDC1/CD138). …”
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RNA‐Binding Protein Hnrnpa1 Triggers Daughter Cardiomyocyte Formation by Promoting Cardiomyocyte Dedifferentiation and Cell Cycle Activity in a Post‐Transcriptional Manner by Chuling Li, Yijin Chen, Qiqi Chen, Haoxiang Huang, Michael Hesse, Yilin Zhou, Ming Jin, Yu Liu, Yifei Ruan, Xiang He, Guoquan Wei, Hao Zheng, Senlin Huang, Guojun Chen, Wangjun Liao, Yulin Liao, Yanmei Chen, Jianping Bin

“…In conclusion, Hnrnpa1 triggered daughter CM formation by promoting CM DACCA in a post‐transcriptional manner, indicating that Hnrnpa1 might serve as a promising target in cardiac repair post‐MI.…”
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Defective Cystic Fibrosis Transmembrane Conductance Regulator Accelerates Skeletal Muscle Aging by Impairing Autophagy/Myogenesis by Ziyi Chen, Jiankun Xu, Peijie Hu, Wanting Du, Junjiang Chen, Xiaotian Zhang, Wei Zhou, Jiayang Gao, Yuantao Zhang, Bingyang Dai, Guangshuai Nie, Jun Hu, Liangbin Zhou, Shunxiang Xu, Hisao Chang Chan, Wing‐hoi Cheung, Ye Chun Ruan, Ling Qin

“…Enhancing CFTR might be a potential treatment strategy for age‐related skeletal muscle disorders.…”
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A simple score, CKM2S2-BAG, to predict cardiovascular risk with cardiovascular-kidney-metabolic health metrics by Zhao Yang, Pan Zhou, Fangfang Fan, Yiming Hao, Wenlang Zhao, Ziyu Wang, Xuan Deng, Qiuju Deng, Yongchen Hao, Na Yang, Lizhen Han, Pingping Jia, Yue Qi, Yan Zhang, Jing Liu

“…Using clinical routine data, the CKM2S2-BAG score accurately discriminates participants at cardiovascular low, intermediate, and high risk. Thus, it might help improve CVD prevention and management in clinical practice without any paper or electronic tools.…”
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Dynamic regulation of Rgs16 and its correlation with Neuregulin1 expression in acute and chronic nerve injury by Marina García-Bejarano, Marina García-Bejarano, Marina García-Bejarano, Riccardo Aucello, Riccardo Aucello, Federica Zen, Federica Zen, Marwa El Soury, Marwa El Soury, Francesca Cordero, Jesús M. de la Fuente, Isabelle Perroteau, Giulia Ronchi, Giulia Ronchi, Giovanna Gambarotta, Giovanna Gambarotta

“…Further investigations are needed to clarify RGS16 function, which could pave the way for novel therapeutic strategies to enhance nerve regeneration and alleviate neuropathic pain.…”
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