Kidney microbiota dysbiosis contributes to the development of hypertension by Xin-Yu Liu, Jing Li, Yamei Zhang, Luyun Fan, Yanli Xia, Yongyang Wu, Junru Chen, Xinyu Zhao, Qiannan Gao, Bing Xu, Chunlai Nie, Zhengyu Li, Aiping Tong, Wenjie Wang, Jun Cai

“…We hypothesized that gut microbes might translocate to the kidney to trigger hypertension. …”
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Soluble programmed cell death ligand-1 as a predictive biomarker for severity and poor prognosis in pulmonary tuberculosis by Xiaojue Wang, Weibing Lin, Huimin Li, Sibo Long, Jun Yan, Yiheng Shi, Hongtao Zhang, Xinting Yang, Ling Yi, Guirong Wang

“…Pleural effusion sPD-L1 levels might potentially function as an adjunctive marker for differentiating TPE from MPE.…”
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Insights on the User Experience and Feasibility of an Electromyography-Driven Exergame Combined With Blood Flow Restriction for Strength Training in Hospitalized Older Adults: Mixe... by Ruben Debeuf, Reinhard Claeys, Margo Berlanger, Myrthe Bunt, Aziz Debain, Daan De Vlieger, Matthias Eggermont, Mahyar Firouzi, Stefania Guida, Katarína Kostková, Siddhartha Lieten, Lubos Omelina, Silvia Zaccardi, Bart Jansen, Eva Swinnen, David Beckwée

“… Abstract BackgroundHospitalized older adults often spend prolonged periods of time bedridden, leading to decreased muscle strength and function. To tackle this, rehabilitation aims to keep patients active and train affected muscles. …”
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Association between fumarate hydratase variant subtypes and the risk of HLRCC-associated renal cell carcinoma: systematic review and meta-analysis by Han Wang, Shamsnur Rehim, Hongjing Wang

“…These stratifications were intended to assess whether clinical or methodological features might modulate the observed associations and to provide context for future hypothesis-driven research. …”
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Metabolic reprogramming by Acly inhibition using SB-204990 alters glucoregulation and modulates molecular mechanisms associated with aging by Alejandro Sola-García, María Ángeles Cáliz-Molina, Isabel Espadas, Michael Petr, Concepción Panadero-Morón, Daniel González-Morán, María Eugenia Martín-Vázquez, Álvaro Jesús Narbona-Pérez, Livia López-Noriega, Guillermo Martínez-Corrales, Raúl López-Fernández-Sobrino, Alejandro Castillo-Peña, Lina M. Carmona-Marin, Enrique Martínez-Force, Oscar Yanes, Maria Vinaixa, Daniel López-López, José Carlos Reyes, Joaquín Dopazo, Franz Martín, Benoit R. Gauthier, Morten Scheibye-Knudsen, Vivian Capilla-González, Alejandro Martín-Montalvo

“…Our findings indicate a mechanism for regulating molecular pathways of aging that prevents the development of metabolic abnormalities associated with unhealthy dieting. This strategy might be explored for devising therapeutic approaches to prevent metabolic diseases.…”
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Transcatheter edge‐to‐edge repair of atrial secondary mitral regurgitation positively influences atrial remodelling by Aniela Petrescu, Martin Geyer, Julian Andres Gelves Meza, Omar Hahad, Tobias Ruf, Valeria Maria deLuca, Lukas Hobohm, Theresa Gößler, Felix Kreidel, Philipp Lurz, Ralph Stephan vonBardeleben

“…Evidence of the effect of transcatheter edge‐to‐edge repair (TEER) on left atrial (LA) anatomy and function, especially reverse remodelling (LARR), is still sparse. …”
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Fufang Zhenzhu Tiaozhi capsule attenuates renal damage by restoring Th17/Treg balance in diabetic db/db mice by Yiqi YANG, Haibo TAN, Xiaoyu ZHANG, Minyi HUANG, Weijian BEI, Jiao GUO

“…Conclusion: FTZ exerted protective effects on the kidney in diabetic db/db mice, whose mechanism might be related to regulating the Th17/Treg balance and inhibiting NF-κB signaling pathway.…”
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A custom-made mouthguard reduces head acceleration during soccer heading and prevents acute electrophysiological and cognitive changes in amateur male playersResearch in context by Claire Pitteu, Philippine Lepère, Philippe Poisson, Etienne Guillaud, Emilie Doat, Bertrand Glize, Patrick Dehail, Hélène Cassoudesalle

“…Summary: Background: Repetitive head impacts related to soccer heading might lead to long-term risk of neurodegenerative diseases. …”
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Soil organic carbon mineralization is controlled by the application dose of exogenous organic matter by O. Mendoza, S. De Neve, H. Deroo, H. Li, A. Françoys, A. Françoys, S. Sleutel

“…The observed stimulation of soil macroporosity at higher EOM doses in the silt loam soil might have contributed to sustaining the aerobic conditions required for SOC mineralization. …”
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Multimodal imaging biomarkers of subretinal hyperreflective material accumulation in central serous chorioretinopathy by Jiaxin Pu, Guiqin He, Xiongze Zhang, Miaoling Li, Xinlei Hao, Xuenan Zhuang, Yongyue Su, Feng Wen

“…Conclusion: The presence of SHRM was associated with choroidal and RPE alterations, suggesting that changes in hydrostatic pressure and RPE function might be involved in SHRM formation in CSC.…”
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Toxic Effects of 3,3′-Iminodipropionitrile on Vestibular System in Adult C57BL/6J Mice In Vivo by Shan Zeng, Wenli Ni, Hui Jiang, Dan You, Jinghan Wang, Xiaoling Lu, Liman Liu, Huiqian Yu, Jingfang Wu, Fangyi Chen, Huawei Li, Yunfeng Wang, Yan Chen, Wenyan Li

“…The utricle is one of the five sensory organs in the mammalian vestibular system, and while the utricle has a limited ability to repair itself, this is not sufficient for the recovery of vestibular function after hair cell (HC) loss induced by ototoxic drugs. …”
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CXCL13 suppresses liver regeneration through the negative regulation of HGF signaling by Qun Zhao, Jingyi Wu, Mengyuan Feng, Anjie Zhang, Liwei Fu, Jinglin Chen, Lian Li, Fangzhou Li, Tingting Li, Shu Jin, Shengbao Li, Xianjun Yu

“…Overall, our findings revealed a novel function of CXCL13 in negatively regulating liver regeneration. …”
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L’enterrement d’une triade divine féminine à Lugdunum : étude du dépôt de la place d’Albon à Lyon (Métropole de Lyon) by Lucas Guillaud, Emmanuel Bernot, Aline Colombier-Gougouzian, Amaury Gilles, Nicolas Garnier

“…Based on the evidence collected, it seems that the items examined might have been part of a small cult space located within the warehouse. …”
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Construction and validation of acetylation-related gene signatures for immune landscape analysis and prognostication risk prediction in luminal breast cancer by Mengdi Zhu, Jinna Lin, Haohan Liu, Jingru Wang, Nianqiu Liu, Yudong Li, Hongna Lai, Qianfeng Shi

“…Our results also suggested that KAT2B and TAF1L might serve as potential therapeutic targets in luminal breast cancer.…”
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Depletion of myeloid-derived suppressor cells sensitizes murine multiple myeloma to PD-1 checkpoint inhibitors by Qiang Wang, Qing Yi, Wei Xiong, Rui Duan, Jianfei Qian, Liuling Xiao, Miao Xian, Pan Su, Chuanchao Zhang, Yabo Li, Ling Zhong, Chengyun Zheng

“…T cell proliferation and function were detected using flow cytometry. Peptide-Fc fusion proteins were used to deplete myeloid-derived suppressor cells (MDSCs). …”
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Endoplasmic reticulum adenylate transporter activity affects amino acid metabolism under photorespiratory conditions by Jieni Li, Yuxin Song, Xin Luan, Yajun Gou, Tao Xie, Yu Hong, Na Liu, Yao Su, Xueli Fu, Tianxiu Zhong, Shu Chen, Yuexiong Zhang, Gang Qin, Xiang-Qian Zhang

“…This supports the hypothesis that the lack of ER-ANT1-induced limitation of ATP usage might inhibit GDC activity by modulating the NADH/NAD+ ratio. …”
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INVESTIGATION OF THE GENETIC ALTERATIONS IN CDKN2A/B AND IL7R IN T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA by RMB Lemos, ES Costa, T Ferraz, MT Schramm, MM Lins, MCN Fagundes, ALT Maciel, M Emerenciano

“…The activation of IL7R, either due to the presence of gain-of-function mutations (̃10% of cases) or its upregulation, is a recurrent event in T-ALL associated with disease relapse. …”
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Identification of CD38high Monocyte as a Candidate Diagnostic Biomarker and Therapeutic Target for Sepsis by Ning Hua, Limin Kong, Li Fan, Yanan Bai, Yujun Zhou, Yanfang Zhang, Qingwei Zhao, Xiaoyang Lu, Hongyu Yang, Hangyang Li, Peili Ding, Yuyu Nan, Qinghua Ji, Ping Yang, Lu Li, Yijing Xin, Lijuan Zhao, Wei Yang, Wenqiao Yu, Saiping Jiang

“…These findings demonstrate that CD38high monocytes might serve as a candidate diagnostic biomarker and therapeutic target for sepsis.…”
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Trajectories of sleep disturbance and self-management of chronic conditions during COVID-19 among middle-aged and older adults by Minjee Kim, Lauren Rogers, Stephanie Batio, Julia Y. Benavente, Morgan Bonham, Pauline Zheng, Rebecca M. Lovett, Stacy C. Bailey, Mary J. Kwasny, Daniela P. Ladner, Sherry HY. Chou, Jeffrey A. Linder, Sandra Weintraub, Yuan Luo, Phyllis C. Zee, Michael S. Wolf

“…Public health and health system strategies might consider monitoring sleep quality in adults with chronic conditions to optimize health outcomes.…”
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Platelet spleen tyrosine kinase is a key regulator of anti-PF4 antibody–induced immunothrombosis by Jan Zlamal, Vera M. Ripoll, Christine S.M. Lee, Filip Toma, Karina Althaus, Flavianna Rigoni, Andreas Witzemann, Shane Whittaker, David Capraro, Günalp Uzun, Tamam Bakchoul, Vivien M. Chen

“…Most importantly, the specific inhibition of SYK in platelets but not in neutrophils prevented VITT antibody–induced multicellular thrombus formation, without perturbing the platelet function. Our findings indicate that the specific targeting of platelet SYK might be a promising therapeutic approach to prevent thrombotic complications in patients with antibody-mediated immunothrombosis.…”
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