Agreement of glomerular filtration rate estimation equations for chemotherapy dosing in cancer patients at a tertiary referral hospital in Sub-Saharan Africa. by Wubshet Jote Tolossa, Tigist Workneh Leulseged, Abdu Adem, Feyissa Challa, Tirumebet Mezgebu, Ruth S Aytehgeza, Nebiat Adane Mera, Kalsidagn Girma Asfaw, Momina M Ahmed, Kebede H Begna

“…This suggests that current GFR estimation practices in cancer patients might be inaccurate, potentially leading to improper chemotherapy dosing and poorer patient outcomes.…”
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Mechanistic insights into the cardiovascular effects of acute heat exposure: A multi-omics analysis based on a randomized crossover trial by Xinlei Zhu, Xihao Du, Yixiang Zhu, Lu Zhou, Cong Liu, Yue Niu, Qingli Zhang, Yixuan Jiang, Haidong Kan, Renjie Chen

“…Multi-omics analyses indicated heat-induced perturbations in pathways were mostly related to systemic inflammation, oxidative stress, coagulation, and lipid metabolism disorder. Acute heat exposure might impair cardiovascular function and promote multiple adverse biological processes, especially those related to atherosclerosis progression and increase of plaque instability.…”
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Efficacy and safety of dual antiplatelet therapy in the elderly for stroke prevention: a subgroup analysis of the CHANCE-2 trial by Liping Liu, Yongjun Wang, Yilong Wang, Zixiao Li, Xingquan Zhao, Jing Jing, Philip M Bath, Hao Li, Xia Meng, Anxin Wang, Yong Jiang, Xinmiao Zhang, Jianhua Li, Jinxi Lin, S Claiborne Johnston, Xinsheng Han, Qin Xu, Weifeng Chen, Xuewei Xie, Xuhai Gong

“…Ticagrelor-aspirin group was associated with lower risks of stroke recurrence within 90 days in younger patients (HR 0.68, 95% CI 0.51 to 0.91, p=0.008), which was no differences in old-old patients.Conclusion Elderly patients aged over 80 in CHANCE-2 trial had higher risks of composite vascular events, disabling stroke, severe or moderate bleeding and mortality within 90 days. Genotype-guided DAPT might not be as effective in old-old patients as in younger ones.Trial registration number NCT04078737.…”
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A systematic review of robot-assisted partial nephrectomy outcomes for advanced indications: Large tumors (cT2-T3), solitary kidney, completely endophytic, hilar, recurrent, and mu... by Savio Domenico Pandolfo, Clara Cerrato, Zhenjie Wu, Antonio Franco, Francesco Del Giudice, Alessandro Sciarra, Paolo Verze, Giuseppe Lucarelli, Ciro Imbimbo, Sisto Perdonà, Edward E. Cherullo, Francesco Porpiglia, Ithaar H. Derweesh, Riccardo Autorino

“…Certainly, a higher likelihood of complication might be expected when facing extremely challenging cases. …”
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Effect of lower-body ischemia duration in aortic arch surgery under mild-to-moderate hypothermic circulatory arrestCentral MessagePerspective by Giacomo Murana, MD, Chiara Nocera, MD, Luca Zanella, MD, Luca Di Marco, MD, Silvia Snaidero, MD, Sabrina Castagnini, MD, Carlo Mariani, MD, Davide Pacini, MD, PhD

“…Objectives: Aortic arch surgery is performed at increasingly higher circulatory arrest temperatures. This might affect visceral protection. We analyzed the effect of visceral ischemic time in arch surgery under mild-to-moderate hypothermia. …”
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Virulence perspective genomic research unlocks the secrets of Rhizoctonia solani associated with banded sheath blight in Barnyard Millet (Echinochloa frumentacea) by T. S. S. K. Patro, K. B. Palanna, B. Jeevan, Pallavi Tatineni, T. Tharana Poonacha, Farooq Khan, G. V. Ramesh, Anusha M. Nayak, Boda Praveen, M. Divya, N. Anuradha, Y. Sandhya Rani, T. E. Nagaraja, R. Madhusudhana, C. Tara Satyavathi, S. Koti Prasanna

“…The Gene Ontology (GO) annotation of RAP2 proteins revealed that “phosphorylation”, “membrane”, and “ATP binding” have the highest gene enrichment in the “biological process”, “cellular component” and “molecular function” domains, respectively. The genome comprises a majority of secretory proteins in the pectin lyase fold/virulence factor superfamily, which break down plant cell wall polymers to extract saccharides. …”
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Isolation of mitogen-activated protein kinase SlMAPK12 gene and characterization of its expression pattern in Solanum lycopersicum by KONG Fu-ling, WANG Jie, CHENG Lin, GUAN Xiao-yan, HE Yan-jun, LU Gang

“…So more detailed biochemical and functional characterization is likely to be carried out to understand the function of tomato MAPKs.The cDNA sequence of novel SlMAPK12 (GenBank No. …”
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Personalised, GIS-based counselling to promote habitual walking in mobility-limited and chronically ill older adults: protocol of the MOBITEC-Routes randomised controlled trial by Timo Hinrichs, René Schilling, Alexandros Sofios, Denis Infanger, Luisa Prechtl, Nora Stauffer, Viviane Eichenberger, Eleftheria Giannouli, Taina Rantanen, Erja Portegijs, Corina Schuster-Amft, Anna Mai, Arno Schmidt-Trucksäss, Christina Röcke, Robert Weibel

“…A personalised walking intervention – emphasizing personal preferences and local facilitators by employing Geographic information System (GIS)-based methods for communication and goal setting – might help to overcome problems of low long-term adherence to walking interventions. …”
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GWAS combined with transcriptomics revealed key regulatory genes for inflorescence traits and fruit set rate in Litchi (Litchi chinensis Sonn.) by Fachao Shi, Kan Huang, Yonghua Jiang, Hailun Liu, Yingjie Wen, Qian Yan

“…Transcriptome results revealed that differentially expressed genes between two typical inflorescence litchi varieties were mainly enriched in molecular function categories such as catalytic activity and transferase activity, affecting metabolic pathways and secondary metabolite synthesis. …”
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Network pharmacology and experimental validation to elucidate the mechanism of the treatment of polycystic ovary syndrome with insulin resistance by Resina Draconis by Jing Wang, Yehao Luo, Yueting Liu, Xiusong Tang, Jianhui Gu, Zheng Huang, Ting Lv, Jun Luo, Gang Fang

“…In addition, RD increased the levels of PI3K, p-PI3K, Akt, p-Akt and GLUT4, and decreased the levels of FOXO3a and P27 in the ovarian tissues of PCOS-IR rats, suggesting that RD may improve the symptoms of PCOS-IR in rats through the PI3K/Akt signalling pathway. Conclusion RD might improve insulin resistance and ovarian function in PCOS-IR by upregulating PI3K, p-PI3K, Akt, p-Akt and GLUT4 expression and downregulating FOXO3a and P27, thereby activating the PI3K/Akt signaling pathway. …”
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Tubular CD44 plays a key role in aggravating AKI through NF-κB p65-mediated mitochondrial dysfunction by Jiewu Huang, Ping Meng, Ye Liang, Xiaolong Li, Shan Zhou, Jiemei Li, Xiaoxu Wang, Jinhua Miao, Weiwei Shen, Lili Zhou

“…Several reports showed a cluster of differentiation-44 (CD44), a cell-surface glycoprotein, might be involved in AKI. However, its role in AKI has not been clearly clarified. …”
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Effectiveness of remdesivir for hospitalized COVID-19 patients depending on the severity of respiratory status: a multicenter retrospective study in Japan by Hidero Yoshimoto, Kazuma Yamakawa, Yoshihiro Tanaka, Itsuki Osawa, Takashi Tagami, Akira Endo, Ryo Yamamoto, Mineji Hayakawa, Takayuki Ogura, Atsushi Hirayama, Hideo Yasunaga, Akira Takasu, Sang-Woong Lee, J-RECOVER study group

“…Subgroups analyses were conducted to identify patient groups that might benefit from remdesivir treatment. Methods This retrospective observational study (the J-RECOVER) enrolled patients with COVID-19 from 64 institutions in Japan between January 1 and September 30, 2020. …”
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Improved mental health outcomes and normalised spontaneous EEG activity in veterans reporting a history of traumatic brain injuries following participation in a psilocybin retreat by Grace Blest-Hopley, Giuseppe Pasculli, Giuseppe Pasculli, Simon G. D. Ruffell, WaiFung Tsang, Olateju Emmanuel, Kathryn M. Pate, Hannes Kettner, Hannes Kettner, Leor Roseman, David Erritzoe, Robin Carhart-Harris, Robin Carhart-Harris

“…IntroductionPsilocybin, a serotonergic psychedelic, has shown therapeutic potential in treating mental health disorders by, amongst the many effects, promoting neuroplasticity and reorganising functional connectivity across cortical and subcortical networks involved in emotion and cognition. …”
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Exosomes Derived From Human Mesenchymal Stem Cells Mitigate Follicular Interstitial Cell Ferroptosis via the miR-26a-5p/PTEN/GPX4 Axis in Rats with Chemotherapy-Induced Premature O... by Chen J, Huo X, Qian M, Xue Q, He Y, Xu P, Wang Y, Tang X, Luo Q, Bao H, Xiong Y

“…Further bioinformatics analysis revealed that the inhibition of the PTEN/GPX4 pathway-mediated ferroptosis in TICs might be the main mechanism through which exosomes exert their regulatory/therapeutic effects. …”
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Contribution of the major HCHO metabolic pathways to HCHO-uptake by geranium leaves under liquid HCHO stress by Han Shuang, Xiao Suqin, Sun Zhen, Xuan Xiuxia, Li Kunzhi, Chen Limei

“…At the late stage (24-48 h) of HCHO treatment, two major metabolic pathways, the Cit produced pathway and ¹³C-labelled glucide ([U-¹³C] Gluc and [U-¹³C]Fruc) generation pathway, functioned simultaneously in geranium leaves. Some ¹³C-labelled glucide might also enter the glycolysis pathway or the tricarboxylate (TCA) cycle, which thereby allowed an enhancement in many organic acid peaks. …”
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Effect of L-Citrulline on Creatine Kinase MM (CK-MM) Isoenzymes in Mice: An In Vivo Study Focusing on Immunohistochemistry Analysis by Dhoni Akbar Ghozali, Annisa Aghnia Rahma, Shafira Nur Hanifa, Muhana Fawwazy Ilyas

“…These results were consistent with the role of CK-MM as a marker for muscle damage, and they indicated that L-citrulline might have a protective effect against muscle damage post-eccentric exercise. …”
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Diagnostic performance of procalcitonin for bacterial infection in severe alcoholic hepatitis compared with C-reactive protein by Min Kyu Kang, Yu Rim Lee, Soo Young Park, Kwang Il Seo, Sang Soo Lee, Byung Seok Kim, Jeong Eun Song, Jun Sik Yoon, Young Mi Hong, Ki Tae Yoon, Woo Jin Chung, Seung Ha Park, Eunju Kim, Kyung Ran Jun, Jung Gil Park, Yang-Hyun Baek, Nae-Yun Heo

“…Methods We prospectively enrolled patients with severe alcoholic hepatitis, defined as modified Maddrey’s Discriminant Function ≥ 32, from 10 medical centers. At admission, we performed an initial evaluation including physical examination, laboratory test, radiology, blood and urine culture, PCT, and C-reactive protein (CRP). …”
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The Impact of Radiation Dose on CT‐Based Body Composition Analysis: A Large‐Animal Study by Luca Salhöfer, Gregor Jost, Mathias Meetschen, Daniel vanLandeghem, Michael Forsting, Denise Bos, Christian Bojahr, Rene Hosch, Felix Nensa, Hubertus Pietsch, Johannes Haubold

“…Typically, the segmentation of muscle and fat compartments is performed with a thresholding‐based subsegmentation, which might be influenced by the image noise as a function of radiation dose. …”
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Role of <i>Thymus ciliatus</i> (Thyme) to Ameliorate the Acute Neurotoxicity Induced by Bisphenol A: <i>In Vivo</i> Supported with Virtual Study by Dallal Kourat, Djallal Eddine H. Adli, Mostapha Brahmi, Faisal K. Alkholifi, Faten F. Bin Dayel, Wafaa Arabi, Marie-Laure Fauconnier, Bakhta Bouzouira, Khaled Kahloula, Miloud Slimani, Sherouk Hussein Sweilam

“…<b>Conclusions</b>: Thymol might be a promising candidate for the treatment of neurodegenerative and neurological disorders such as depression, Parkinson’s disease, and Alzheimer’s disease while also preventing histological damage in the brain.…”
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RBIS regulates ribosome biogenesis to affect progression in lung adenocarcinoma by Hongyu Pan, Li Liao, Siwei Xu, Yujian Xu, Wenjun Chai, Xiaoli Liu, Jing Li, Yue Cao, Lei Sun, Qian Liu, Mingxia Yan

“…In this study, we investigated the function and underlying molecular mechanism of ribosome biogenesis factor (RBIS) in the progression of non-small cell lung cancer (NSCLC). …”
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