Critical role of Oas1g and STAT1 pathways in neuroinflammation: insights for Alzheimer’s disease therapeutics by Zhixin Xie, Linxi Li, Weizhong Hou, Zhongxi Fan, Lifan Zeng, Limin He, Yunxiang Ji, Jingbai Zhang, Fangran Wang, Zhou Xing, Yezhong Wang, Yongyi Ye

“…Interferon responses and Interferon-stimulated genes (ISGs) significantly function in neuroinflammatory and neurodegenerative diseases involving AD. …”
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Novel potential biomarkers for predicting childhood caries via metagenomic analysis by Hui Zhang, Hui Zhang, Xiao Zheng, Xiao Zheng, Xiao Zheng, Yongmao Huang, Yongmao Huang, Yuanqiang Zou, Tao Zhang, Maria Alice Repo, Maria Alice Repo, Meixiang Yin, Yang You, Zhuye Jie, Wen-an Xu, Wen-an Xu

“…Numerous unclassified microorganisms, such as Campylobacter SGB19347 and Catonella SGB4501, are intimately linked to dental caries and display intricate interaction networks, suggesting the potential formation of a distinct ecological network. In functional assessment, we identified a possible link between pectin and caries, suggesting that microorganisms that produce pectinase enzymes might play a role in the advancement of severe dental caries. …”
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ANTP-SmacN7 enhances radiosensitivity in TPC-1 cells through XIAP-mediated activation of apoptotic protein by Chen Wang, Li Zhang, Kaixue Wen, Qiang Liu, Zhilin Li, Peixia Yu, Shuxin Wen, Yuhao Zhang

“…It interacts closely with CASP family members involved in apoptosis, which might critically inform therapeutic strategies for radioresistant THCA. …”
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Longitudinal characterization of the muscle metabolome in dairy cows during the transition from lactation cessation to lactation resumption by H. Sadri, M.H. Ghaffari, H. Sauerwein, S. Schuchardt, J. Martín-Tereso, John Doelman, J.B. Daniel

“…The metabolites produced by the l-Arg pathway might contribute to regulating skeletal muscle mass and function in periparturient dairy cows. …”
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Clinical significance of plasma-free amino acids and tryptophan metabolites in patients with non-small cell lung cancer receiving PD-1 inhibitor: a pilot cohort study for developin... by Akihiko Kawahara, Tetsuro Sasada, Koichi Azuma, Hidenobu Ishii, Norikazu Matsuo, Takaaki Tokito, Tomoaki Hoshino, Yohei Miyagi, Huihui Xiang, Tomoyuki Tagami, Rika Kasajima, Yumiko Kato, Sachise Karakawa, Shinya Kikuchi, Akira Imaizumi, Kenta Murotani

“…Background Amino acid metabolism is essential for tumor cell proliferation and regulation of immune cell function. However, the clinical significance of free amino acids (plasma-free amino acids (PFAAs)) and tryptophan-related metabolites in plasma has not been fully understood in patients with non-small cell lung cancer (NSCLC) who receive immune checkpoint inhibitors.Methods We conducted a single cohort observational study. …”
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Step-by-step: Intra-arterial renal hypothermia during robot-assisted partial nephrectomy by Joris Vangeneugden, Pieter De Backer, Camille Berquin, Saar Vermijs, Peter Dekuyper, Alexandre Mottrie, Charlotte Debbaut, Thierry Quackels, Charles Van Praet, Karel Decaestecker

“…Objective: Renal hypothermia, which can be achieved through several techniques, might allow for longer clamping times in complex robot-assisted partial nephrectomy (RAPN). …”
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Urinary exosomal lnc-TAF12–2:1 promotes bladder cancer progression through the miR-7847–3p/ASB12 regulatory axis by Song Chen, Jie Cheng, Shuangtai Liu, Danni Shan, Ting Wang, Xinghuan Wang

“…In this study, we identified exosomal lnc-TAF12–2:1 as a novel biomarker in BCa diagnosis and aimed to investigate the underlying biological function. Dual luciferase reporter assay, RNA immunoprecipitation (RIP), RNA pulldown assays, and xenograft mouse model were used to verify the competitive endogenous RNA mechanism of lnc-TAF12–2:1. …”
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Correlation of intestinal bacteria, fungi and dietary nutrient intake in NAFLD patients with spleen deficiency syndrome by Guiru Lin, Wanyi Ou, Jianmei Yang, Dongliang Chen, Yuanfei Wang, Aiping Wu, Lilian Gao, Wan Qu, Chenli Lin, Chenli Lin, Yinji Liang, Yinji Liang

“…The independent and interactive effects of intestinal bacteria and fungi might have collectively influenced the immune function and inflammation levels in NAFLD patients with SDS. …”
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Optimizing a Bayesian Method for Estimating the Hurst Exponent in Behavioral Sciences by Madhur Mangalam, Taylor J. Wilson, Joel H. Sommerfeld, Aaron D. Likens

“…To address this issue, we have provided data on the estimation accuracy of the Hurst exponent <i>H</i> for synthetic time series as a function of a priori known values of <i>H</i>, the time series length, and the simulated sample size from the posterior distribution <i>n</i>—a critical step in the Bayesian estimation method. …”
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Oxidative Stress and Semen Quality Among Night- and Day-Shift Workers: A Cross-Sectional Study by Luca Boeri, Federica Passarelli, Ludovico Maria Basadonna, Edoardo Sorba, Giorgio Graps, Fabio Ciamarra, Damiano Dagnino, Valentina Parolin, Marco Nizzardo, Gianpaolo Lucignani, Emanuele Montanari

“…Night-shift work, through circadian disruption, may exacerbate oxidative imbalance and impair reproductive function. This study investigates the impact of night-shift work on oxidative stress and semen quality and evaluates the potential benefits of antioxidant supplementation in this context. …”
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Effects of dietary Bacillus coagulans on the productive performance, egg quality, serum parameters, and intestinal morphology of laying hens during the late laying period by Xiaoming Wang, Huafeng Jian, Wenyan Zhao, Jiankui Li, Xiaoting Zou, Xinyang Dong

“…The aim of this study was to investigate the effects of Bacillus coagulans (B. coagulans) on the productive performance, egg quality, blood biochemistry, antioxidant capacity, reproductive hormones, immune function, and intestinal morphology of laying hens (86 weeks old) during the late laying period. …”
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eIF5A downregulated by mechanical overloading delays chondrocyte senescence and osteoarthritis by regulating the CREBBP-mediated Notch pathway by Jialuo Huang, Jianrong Zheng, Jianbin Yin, Rengui Lin, Junfeng Wu, Hao-Ran Xu, Jinjian Zhu, Haiyan Zhang, Guiqing Wang, Daozhang Cai

“…Conclusion: Our findings identified a crucial functional mechanism for the onset of OA, and suggest that intra-articular eIF5A injections might be a useful therapeutic strategy for OA treatment. …”
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Adjusting the timing of inseminations to the time lag on luteolysis alerts results in higher conception in dairy cattle by D. Meuwissen, M.J. Gote, R. Meyermans, S. Janssens, I. Adriaens, B. Aernouts

“…Ignoring this variation might decrease the accuracy of the optimal insemination window and, therefore, decreases the likelihood of conception. …”
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Any closer to successful therapy of multiple myeloma? CAR-T cell is a good reason for optimism by Faroogh Marofi, Safa Tahmasebi, Heshu Sulaiman Rahman, Denis Kaigorodov, Alexander Markov, Alexei Valerievich Yumashev, Navid Shomali, Max Stanley Chartrand, Yashwant Pathak, Rebar N. Mohammed, Mostafa Jarahian, Roza Motavalli, Farhad Motavalli Khiavi

“…However, several factors might be considered during CAR-T cell therapy for better response and reduced side effects. …”
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Vitamin K Epoxide Reductase Complex (VKORC1) Electrochemical Genosensors: Towards the Identification of <i>1639 G>A</i> Genetic Polymorphism by Tiago Barbosa, Stephanie L. Morais, Renato Carvalho, Júlia M. C. S. Magalhães, Valentina F. Domingues, Cristina Delerue-Matos, Hygor Ferreira-Fernandes, Giovanny R. Pinto, Marlene Santos, Maria Fátima Barroso

“…However, warfarin has a limited therapeutic index and might cause bleeding and other clinical problems. …”
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Low expression of CCKBR in the acinar cells is associated with insufficient starch hydrolysis in ruminants by Yan Cheng, Tianxi Zhang, Chao Yang, Kefyalew Gebeyew, Chengyu Ye, Xinxin Zhou, Tianqi Zhang, Ganyi Feng, Rui Li, Zhixiong He, Oren Parnas, Zhiliang Tan

“…Here we show more robust pancreatic exocrine function in adult goats (AG) than in neonatal goats (NG) by combining scRNA-seq and proteomic analysis. …”
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INFLAMMATORY MEDIATORS ROLE IN ATHEROSCLEROTIC LESION DEVELOPMENT IN THE LARGE ARTERIES IN PATIENTS WITH SYSTEMIC SCLERODERMIA by A. L. Maslyansky, E. P. Kolesova, A. V. Kozlenok, E. Yu. Vasilieva, I. N. Penin, O. P. Rotar, N. M. Lazareva, S. V. Lapin, K. A. Sysoev, V. N. Solntsev, A. N. Bazhenov, A. O. Konradi

“…This can point on the specific interrelation of pathogenetic mechanisms of arterial wall involvement in SSD, and might require repeated assessment of IMT in SSD, using larger patients selection and additional investigation methods.…”
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Aberrances of Cortex Excitability and Connectivity Underlying Motor Deficit in Acute Stroke by Juan Du, Jianping Hu, Jingze Hu, Qiang Xu, Qirui Zhang, Ling Liu, Minmin Ma, Gelin Xu, Yong Zhang, Xinfeng Liu, Guangming Lu, Zhiqiang Zhang, Fang Yang

“…This study was aimed at evaluating the motor cortical excitability and connectivity underlying the neural mechanism of motor deficit in acute stroke by the combination of functional magnetic resonance imaging (fMRI) and electrophysiological measures. …”
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Is intensive management associated with low soil carbon in Irish farms? Implications for developing indicators of farm soil health and nature value by S. Hodge, A. Lee, S. Ruas, R. Rotchés-Ribalta, K.A. Ahmed, S. Maher, M. Larkin, J. Stout, J. Moran, M. Gormally, D. Ó hUallacháin, B. White

“…Ecologically functioning soils are increasingly viewed as a key component of sustainable agriculture, a means of sequestering carbon and a major contributor to farmland biodiversity. …”
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The orchestrated feature of Cornus kousa fruit and gut microbiota against obesity via integrated pharmacology by Ki‐Kwang Oh, Sang‐Jun Yoon, Sang Youn Lee, Satya Priya Sharma, Sung‐Min Won, Jin‐Ju Jeong, Dong Joon Kim, Ki‐Tae Suk

“…Abstract Cornus kousa fruit (CKF) has been utilized as anti‐obesity supplementation in East Asia, including Korea, and gut microbiota (GM) might have synergistic effects on obesity (OB) via its interplay. …”
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