The analysis of risk factors for diabetic kidney disease progression: a single-centre and cross-sectional experiment in Shanghai by Shan Huang, Juan Du, Nan Zhao, Wen Liu, Fan Hu, Xiaoxu Ge, Xiaohong Jiang, Wenfang Peng, Lisha Shen, Lili Xia

“…More potential clinical indexes such as thyroid function and inflammatory indicators might be considered as early warning factors for DKD in T2DM. …”
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Immune-related diagnostic indicators and targeted therapies for COPD combined with NASH were identified and verified via WGCNA and LASSO by Jianwei Hong, Zikai Xu, Fangrui Xu, Haifeng Wu, Jinxia Liu, Lishuai Qu

“…The immune infiltration indicated that these two core genes might be involved in the immunomodulatory process of NASH by regulating the function or recruitment of specific immune cell types. …”
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Associations of serum uric acid to eGFR ratio with diabetic retinopathy in individuals with type 2 diabetes by Chenyu Nie, Qiaofeng Ma, Chunyao Liu, Li Chen, Chuan Wang, Xinguo Hou

“…Since uric acid is primarily excreted by the kidneys, the ratio of SUA to eGFR (SUA/eGFR) serves as a renal function-corrected indicator of SUA levels. We tested whether SUA/eGFR might be involved in the pathogenesis and progression of DR. …”
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Development and Validation of a Machine Learning Model for Predicting Long-Term Depression Risk in ACS Patients After PCI: A Retrospective Cohort Study by Lv H, Sun F, Zhang Y, Zhou X

“…Our goal was to predict who might develop depression in the year after their procedure. …”
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Control of anterior GRadient 2 (AGR2) dimerization links endoplasmic reticulum proteostasis to inflammation by Marion Maurel, Joanna Obacz, Tony Avril, Yong‐Ping Ding, Olga Papadodima, Xavier Treton, Fanny Daniel, Eleftherios Pilalis, Johanna Hörberg, Wenyang Hou, Marie‐Claude Beauchamp, Julien Tourneur‐Marsille, Dominique Cazals‐Hatem, Lucia Sommerova, Afshin Samali, Jan Tavernier, Roman Hrstka, Aurélien Dupont, Delphine Fessart, Frédéric Delom, Martin E Fernandez‐Zapico, Gregor Jansen, Leif A Eriksson, David Y Thomas, Loydie Jerome‐Majewska, Ted Hupp, Aristotelis Chatziioannou, Eric Chevet, Eric Ogier‐Denis

“…Although these biological effects are well established, the underlying molecular mechanisms of AGR2 function toward inflammation remain poorly defined. …”
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MONOCYTE SUBSETS IN HEALTHY ADULTS AND SEPSIS PATIENTS by A. A. Kalashnikova, T. M. Voroshilova, L. V. Chinenova, N. I. Davydova, N. M. Kalinina

“…These monocyte subtypes have different phenotypes and functions. The ratio of appropriate subpopulations varies with development of the antibacterial response. …”
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Novel skin defense peptides and microbiota contribute to disease resilience of the Ngäbe-Buglé leopard frog by Douglas C. Woodhams, Douglas C. Woodhams, Aura Muñiz-Torres, Andreas Hertz, Patrick Kearns, Nina McDonnell, Laura Reinert, Louise A. Rollins-Smith, Louise A. Rollins-Smith, Brandon LaBumbard, Jamie Voyles, Corinne L. Richards-Zawacki, Daniel Callahan, J. Michael Conlon

“…When compared to nine co-occurring amphibians, the Ngäbe-Buglé leopard frog had similar skin bacterial richness and anti-Bd function, but the skin microbiome structure differed significantly among species. …”
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Investigating the eye in Down syndrome as a window to Alzheimer’s disease: the REVEAL protocol – a clinical cross-sectional study by Henrik Zetterberg, Tunde Peto, Imre Lengyel, Kathryn Saunders, Sarah Atkinson, André Strydom, Julie-Anne Little, Elaine Murray, Jamie Mitchell, Aoife Mary Louise Hunter, Lajos Csincsik

“…Introduction There is a need for early, non-invasive and inexpensive biomarkers for Alzheimer’s disease (AD), which could serve as a proxy measure in prevention and intervention trials that might eventually be suitable for mass screening. …”
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Cloning and expression of a C3H-type zinc finger protein gene BoCCCH2 from Brassica oleracea var. italica by JIANG Ming, LIU Qing’e, ZHANG Yanru, ZHU Qi, GONG Xiu, YU Keke, ZHOU Xiuqian

“…Cloning and expression analysis of BoCCCH2 provide evidence for further studies on gene function.…”
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MdUGT88F4 involved in the synthesis of isosalipurposide positively regulates the salt stress response of apple plants by Ying Ye, Yanrong Hu, Yuan Liu, Cheng Yu, Kun Zhou, Fengwang Ma, Xiaoqing Gong

“…In order to verify whether it had biological function in apple plants, we generated transgenic apple plants overexpressed MdUGT88F4 and treated them with salt stress. …”
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Targeting miR‐223 in neutrophils enhances the clearance of Staphylococcus aureus in infected wounds by Maiko de Kerckhove, Katsuya Tanaka, Takahiro Umehara, Momoko Okamoto, Sotaro Kanematsu, Hiroko Hayashi, Hiroki Yano, Soushi Nishiura, Shiho Tooyama, Yutaka Matsubayashi, Toshimitsu Komatsu, Seongjoon Park, Yuka Okada, Rina Takahashi, Yayoi Kawano, Takehisa Hanawa, Keisuke Iwasaki, Tadashige Nozaki, Hidetaka Torigoe, Kazuya Ikematsu, Yutaka Suzuki, Katsumi Tanaka, Paul Martin, Isao Shimokawa, Ryoichi Mori

“…Abstract Argonaute 2 bound mature microRNA (Ago2‐miRNA) complexes are key regulators of the wound inflammatory response and function in the translational processing of target mRNAs. …”
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Association between retinal layer thickness and postoperative delirium in older patients by Timothy T Houle, Xin Ma, Yuan Shen, Hailin Zheng, Meijuan Wang, Ariel Mueller, Edward R Marcantonio, Tianyi Tang, Zhongcong Xie, Zhongyong Shi, Yupeng Chen, Jingxiao Hu

“…Retinal layer thickness has been demonstrated to be associated with cognitive function in mild cognitive impairment and patients with Alzheimer’s disease. …”
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Baicalin Alleviates Piglet Immunosuppression Induced by <i>Glaesserella parasuis</i> via Promoting CD163/Tumor Necrosis Factor-like Weak Inducer of Apoptosis-Mediated Autophagy by Shulin Fu, Ronghui Luo, Jingyang Li, Yunjian Fu, Qiaoli Dong, Siyu Liu, Yamin Sun, Ling Guo, Jin Hu, Yinsheng Qiu

“…Baicalin possesses an anti-inflammatory function. Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) has been implicated in immunosuppression. …”
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VP3.15, a dual GSK-3β/PDE7 inhibitor, reduces glioblastoma tumor growth though changes in the tumor microenvironment in a PTEN wild-type context by Maria Castello-Pons, Maria A. Ramirez-Gonzalez, Patricia Iglesias-Hernández, Nermina Logo Lendo, Carlos Rodriguez-Martín, Laura Quiralte, Juan-Manuel Sepúlveda-Sánchez, Olaya de Dios, Carmen Gil, Ana Martínez, Pilar Sánchez-Gómez, Sergio Casas-Tinto

“…Our findings substantiate the pro-tumoral function of GSK-3β, which might depend on the PTEN genetic status. …”
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Biglycan as a mediator of proinflammatory response and target for MDS and sAML therapy by Christoforos K. Vaxevanis, Marcus Bauer, Karthikeyan Subbarayan, Michael Friedrich, Chiara Massa, Katharina Biehl, Haifa Kathrin Al-Ali, Claudia Wickenhauser, Barbara Seliger

“…Since the role of the proteoglycan biglycan (BGN) as an inflammatory mediator has not yet been investigated in both diseases and might play a role in disease progression, its expression and/or function was determined in cell lines and bone marrow biopsies (BMBs) of MDS and sAML patients and subpopulations of MDS stem cells by Western blot and immunohistochemistry. …”
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Alleviating Tumor Hypoxia and Immunosuppression via Sononeoperfusion: A New Ally for potentiating anti-PD-L1 blockade of solid Tumor by Guoliang Yang, Hui Li, Jiabei Yin, Lei Yao, Jun Yang, Jiawei Tang, You Wu, Meng Zhou, TingTing Luo, Yi Zhang, Jing Zhang, Xuezhi Yang, XiaoXiao Dong, Zheng Liu, Ningshan Li

“…Mechanically, the enhanced efficacy of combination therapy was mainly based on promoting the infiltration and function of CD8+ T cells within tumors. Together, sononeoperfusion could ameliorate hypoxia and immunosuppression in the TME, thereby potentiating anti-PD-L1 therapy for solid tumors. …”
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CD8+CD57+ T cells exhibit distinct features in human non-small cell lung cancer by Wei Sun, Rong Liu, Bing Huang, Peiliang Wang, Zhiwei Yuan, Jianjian Yang, Hui Xiong, Ni Zhang, Qi Huang, Xiangning Fu, Lequn Li

“…Boosting IL-15 activity might promote tumor-reactive CD8+ T-cell functional maturation while preserving their proliferative activity.…”
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On the possibility of yet a third kinetochore system in the protist phylum Euglenozoa by Corinna Benz, Maximilian W. D. Raas, Pragya Tripathi, Drahomíra Faktorová, Eelco C. Tromer, Bungo Akiyoshi, Julius Lukeš

“…Here, we employed deep homology detection protocols using profile-versus-profile Hidden Markov Model searches and AlphaFold-based structural comparisons to detect homologies that might have been previously missed. Interestingly, we still could not detect orthologs for most of the kinetoplastid or canonical kinetochore subunits with few exceptions including a putative centromere-specific histone H3 variant (cenH3/CENP-A), the spindle checkpoint protein Mad2, the chromosomal passenger complex members Aurora and INCENP, and broadly conserved proteins like CLK kinase and the meiotic synaptonemal complex proteins SYCP2/3 that also function at kinetoplastid kinetochores. …”
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Natural killer cell granule protein 7 contributes to CD8+ T cell-mediated platelet apoptosis in immune thrombocytopenia by Xiaolin Wang, Qiang Liu, Xiaojing Li, Wei Xing, Ping Chen, Qi Feng, Ming Hou, Qian Wang, Hai Zhou, Jun Peng

“…Natural killer cell granule protein 7 (NKG7) is essential for natural killer cell and CD8+ T cell cytotoxicity. The function of NKG7 in CD8+ T cells in ITP remains unclear. …”
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A Potential Antitumor Effect of Dendritic Cells Fused with Cancer Stem Cells in Hepatocellular Carcinoma by Ye-Bin Pang, Jian He, Bi-Yu Cui, Sheng Xu, Xi-Lei Li, Man-Ya Wu, Rong Liang, Yan Feng, Xing Guo, Xue-Hui Zhang, Xiao-Ling Luo

“…The influence of fusion cells on proliferation and immunological function transformation of lymphocytes was assessed by FCM and ELISA assay, respectively. …”
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