Structural elucidation of mulberry leaf oligosaccharide and its selective promotion of gut microbiota to alleviate type 2 diabetes mellitus by Tenggen Hu, Yuanshan Yu, Jijun Wu, Yujuan Xu, Gengsheng Xiao, Kejing An, Erna Li, Sentai Liao, Yuxiao Zou

“…These results demonstrated that MLO 2-1 might alleviate T2DM by selectively accelerating the proliferation of L. murinus.…”
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Time to replace the oral glucose tolerance test for cystic fibrosis related diabetes first-step screening? Establishing glycemic tools relevant to cystic fibrosis by Mathew P. Estey, Shelby Sissons, Heather Sharpe, Michelle Doll-Shankaruk, Dan Beriault, Julie Gilmour, Kathleen Lee, Winnie Leung, Michael D. Parkins, Bradley S. Quon, Elizabeth Tullis, Jie Zheng, Grace Y. Lam

“…Oral glucose tolerance test (OGTT) is the current gold standard test to screen for CFRD, which is associated with reduced lung function and body mass index (BMI). However, this is a cumbersome test with poor adherence, and emerging evidence suggests that HbA1c or serum fructosamine might be viable alternative screening tools.Research Design and Methods A multi-center study across four Canadian adult CF centers was conducted to determine the ability of HbA1c and serum fructosamine levels to predict screening OGTT results. …”
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Transcriptomic Profiling Reveals Altered Expression of Genes Involved in Metabolic and Immune Processes in NDV-Infected Chicken Embryos by Malarmathi Muthusamy, Kannaki T. Ramasamy, Sunday Olusola Peters, Srinivasan Palani, Vasudevan Gowthaman, Murali Nagarajan, Sivakumar Karuppusamy, Vasanthakumar Thangavelu, Thiruvenkadan Aranganoor Kannan

“…Gene Ontology and KEGG pathways’ analyses revealed significant alterations in gene expression related to immune function, metabolism, cell cycle, nucleic acid processes, and mitochondrial activity due to NDV infection. …”
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Performance of the digital trail making test in older adults with white matter lesions by Xinjun Shan, Le Tian, Hongyi Zhao, Hongyi Zhao, Xiuli Zhao, Fangyuan Wei

“…Multiple neuropsychological assessments were carried out to assess cognitive function. The Purdue Pegboard Test (PPT) was used to display the unimanual dexterity (dominant hand task) and fine motor control (assembly task). …”
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Faecal microbiota transplantation protects against radiation‐induced toxicity by Ming Cui, Huiwen Xiao, Yuan Li, Lixin Zhou, Shuyi Zhao, Dan Luo, Qisheng Zheng, Jiali Dong, Yu Zhao, Xin Zhang, Junling Zhang, Lu Lu, Haichao Wang, Saijun Fan

“…Faecal microbiota transplantation (FMT) increased the survival rate of irradiated animals, elevated peripheral white blood cell counts and improved gastrointestinal tract function and intestinal epithelial integrity in irradiated male and female mice. …”
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Comprehensive exploration of unexplained dyspnoea in subjects with normal ejection fraction and low natriuretic peptides by Emmanuelle Berthelot, Tarek Laouar, Antoine Beurnier, Nataliya Hrynchynshyn, Jean Christophe Eicher, Jean‐Michel Tartière, Patrick Jourdain, Olivier Lairez, Barnabas Gellen

“…Abstract Background Unexplained exertional dyspnoea without significant elevation of natriuretic peptides is common. One of the causes might be early heart failure with preserved ejection fraction (HFpEF). …”
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Toxoplasma gondii virulence in mice is determined by the pseudokinase ROP5B and countered by an IRG-GBP protein interplay by Shishir Singh, Shishir Singh, Shishir Singh, Mateo Murillo-León, Mateo Murillo-León, Mateo Murillo-León, Mateo Murillo-León, Mateo Murillo-León, Aura María Bastidas Quintero, Aura María Bastidas Quintero, Florence Melbert, Florence Melbert, Klaus Pfeffer, Daniel Degrandi, Tobias Steinfeldt, Tobias Steinfeldt

“…The same parasite effectors that inhibit IRG protein accumulation and function reduce the vacuolar amount of Guanylate Binding Proteins (GBP proteins). …”
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Sensitive character, melancholic type, and extras on personality and mental disorders by Maurício Viotti Daker

“… A traditional view in psychiatry concerns the intimate relationship between personality disorders and primary mental disorders in a spectral model. Psychic functions with common roots might play a role in personality and psychosis or other disorders, probably not only in terms of deficits but also balance or proportions among them. …”
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Climate change distress and impairment in Germany by Lars König, Lars König, Priska Breves, Gesa Alena Linnemann, Tim Hamer, Ralf Suhr, Ralf Suhr

“…Such a distinction is crucial because not all negative affective states are pathological, and they might even motivate pro-environmental behavior. Functional impairments, like not being able to work or maintaining social relationships, however, might require immediate treatment. …”
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Aging and Synaptic Plasticity: A Review by Jorge A. Bergado, William Almaguer

“…A gradual loss of memory functions is one of the earliest and most widespread consequences of brain aging. …”
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Benefits of aldosterone receptor antagonism in chronic kidney disease: the BARACK-D RCT by F D Richard Hobbs, Richard McManus, Clare Taylor, Nicholas Jones, Joy Rahman, Jane Wolstenholme, Louise Jones, Jennifer Hirst, Sam Mort, Ly-Mee Yu

“…Future work These findings might not be applicable to different mineralocorticoid receptor antagonists. …”
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Developing approaches to treating arterial hypertension in regard to possible pathways of angiotensin II synthesis by N. M. Chikhladze, N. V. Lebedeva, L. A. Belova, G. N. Litonova, E. B. Yarovaya, I. E. Chazova

“…To study antihypertensive effects of AT1-receptor blocker eprosartan and ACE inhibitor enalapril, in regard to leading pathway of angiotensin II (AT II) synthesis among arterial hypertension (AH) patients with various functional status of renin-angiotensin-aldosterone system (RAAS). …”
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Effects of Bariatric Surgery-Related Weight Loss on the Characteristics, Metabolism, and Immunomodulation of Adipose Stromal/Stem Cells in a Follow-Up Study by Amna Adnan, Miia Juntunen, Tuula Tyrväinen, Minna Kelloniemi, Laura Kummola, Reija Autio, Mimmi Patrikoski, Susanna Miettinen

“…However, it was inadequate to fully restore the immunosuppressive functions of ASCs in cocultures with macrophages. Therefore, not only donor BMI but also weight loss history, among other donor characteristics, might be considered for optimal ASC-based therapy.…”
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NDRG1 enhances the sensitivity to Cetuximab by promoting Stat1 ubiquitylation in colorectal cancer by Guang Yang, Chengsheng Ding, Xiao Yang, Jiang Jiang, Shiyuan He, Yanfei Shao, Enkui Zhang, Xiaodong Fan, Xueliang Zhou, Ling Huang, Cindy Xinyu Zhang, Jing Sun, Yu Wang, Lu Zang, Minhua Zheng, Junjun Ma

“…Methods: Through mass spectrometry analysis of our previously constructed CTX-resistant RKO and HCT116 cells, we found that the signal transducer and activator of transcription-1 (Stat1) might be a potential target of NDRG1. By knocking out NDRG1 or/and Stat1 genes, we then applied the loss-of-function experiments to explore the regulatory relationship between NDRG1 and Stat1 and their roles in the cell cycle, epithelial-mesenchymal transition (EMT), and the sensitivity to CTX in these two colorectal cancer (CRC) cells. …”
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Unraveling the source of corrosive microorganisms from fracturing water to flowback water in shale gas field: evidence from gene sequencing and corrosion tests by Yanran Wang, Shaomu Wen, Shibo Zhang, Yongfan Tang, Xi Yuan, Fang Guan, Fang Guan, Jizhou Duan

“…However, the complex corrosive microorganisms, that might induce MIC in underground pipelines, might be introduced by the fracturing water during the production period, or they may also exist in the native corrosive microbial community underground. …”
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Uricase-Expressing Engineered Macrophages Alleviate Murine Hyperuricemia by Yu-Zhong Feng, Hao Cheng, Guo-Qing Xiong, Jia-Zhen Cui, Zhi-Li Chen, Yuan-Yuan Lu, Zhi-Xin Meng, Chen Zhu, Hao-Long Dong, Xiang-Hua Xiong, Gang Liu, Qing-Yang Wang, Hui-Peng Chen

“…In this study, we constructed engineered macrophages that stably expressed uricase, which might serve as a promising alternative to the direct injection of uricases. …”
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Searching for protein partners of short-chain 3-hydroxyacyl-CoA dehydrogenase (SCHAD) reveals keratin 8 as a novel candidate for interaction in pancreatic β-cells by Kelly Velasco, Janniche Torsvik, Johanna L. St-Louis, Sarah Baghestani, Jonas S. G. Silvander, Rohit N. Kulkarni, Diana M. Toivola, Anders Molven

“…Conclusions We propose that the SCHAD protein interacts with K8 in a way that might be relevant for proper functioning of the pancreatic β-cell. …”
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Gene Expression Analysis of (Paired) Primary and Relapsed Wilms Tumor Samples to Unravel the Underlying Factors Driving Tumor Recurrence by Alissa Groenendijk, Jarno Drost, Annelies M. C. Mavinkurve‐Groothuis, Martine vanGrotel, Geert O. Janssens, Annemieke S. Littooij, Alida F. W. van derSteeg, Marry M. van denHeuvel‐Eibrink, Lennart Kester, Ronald R. deKrijger

“…Differentiation of CSCs into mesenchymal cells might attenuate the risk of relapse. Our prediction model might aid in selecting patients with an increased risk of relapse at primary diagnosis when externally validated.…”
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Integrating Strategy of Network Pharmacology, Molecular Dynamics Simulation, and Experimental Verification to Investigate the Potential Mechanism of <i>Gastrodia elata</i> Against... by Peiyuan Sun, Ruohan Zhang, Xuanyou Li, Dengwang Yang, Shunfeng Ji, Lei Peng, Jun Sheng, Jing Wang

“…Among them, the main functional components might be 4-hydroxybenzyl methyl ether, 4-ethoxytolyl-4′-hydroxybenzyl ether, pseudolaric acid B, palmitic acid, and myricetin. …”
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An electrophysiological investigation of skeletal muscles in polymyositis by R. E. P. Sica, Olga P. Sanz, Nidia Aguilera, A. Colombi

“…It was found a reduction of the number of functioning motor units in some patients with chronic polymyositis and only in one of those affected by acute polymyositis. …”
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