Assessment of Exenatide Extended‐Release for Maintenance of Diabetic Remission in Cats by Chen Gilor, Linda M. Fleeman, Sean E. Hulsebosch, Stijn J. M. Niessen, Charlotte R. Bjørnvad, Jully Pires, Katarina Hazuchova, Jocelyn Mott, Allison L. O'Kell, Ruth Gostelow, Adam J. Rudinsky, Audrey K. Cook

“…The glucagon‐like peptide‐1 receptor agonist, exenatide extended‐release (exenatide‐ER), preserves β cell function in people with type 2 diabetes mellitus (DM). …”
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Effect of adding fenofibrate versus curcumin to glimepiride in patients with type 2 diabetes: a randomized controlled trial by Eman M. Nada, Nashwa M. El-Gharbawy, Haidy Abbas, Rehab H. Werida

“…Exclusion criteria were as follows: other types of diabetes, pregnancy, abnormal liver or kidney function tests, using other anti-diabetes medications, and non-adherence to medications. …”
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Egg exosome miR-145-5p decreases mitochondrial ROS to protect chicken embryo hepatocytes against apoptosis through targeting MAPK10 by Fengdong Zhang, Yongchang Han, Fan Li, Boya Guo, Jian Chen, Wenchuan Zhou, Pan Xiao, Hui Ma, Yongyan Jin, Jia Feng, Yuna Min

“…Abstract Background Higher embryonic mortality, especially in aged breeding hens, is associated with insufficient hepatic functionality in maintaining redox homeostasis. Our previous study demonstrated that egg exosome-derived miRNAs may play a key role in modulating embryonic oxidation-reduction process, whereas the exact function and mechanism were still poorly understood. …”
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LcIMT1, a litchi inositol methyl transferase gene, is responsible for d-bornesitol biosynthesis and confers drought tolerance by Liang-Liang Huang, Xin-Ying Li, Fang-Fang Liu, Xu-Ming Huang, Ren-Fang Zeng, Farhat Abbas, Hui-Cong Wang

“…Nonetheless, the biological function of l-quebrachitol is somewhat restricted. …”
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Advocating for the recognition of underlying immunosuppression in critical illness by Ignacio Martin-Loeches, Sascha David, Frédéric Pène, Louis Kreitmann, Lene Russel, Kathryn Puxty, João Santos Silva, Ana Vagos Mata, Ben Creagh-Brown, Pedro Castro, Jorge Salluh, Loreto Vidaur-Tello, Saad Nseir, Elie Azoulay

“…Summary: Immunosuppression, characterised by impaired immune function, significantly influences infection risk and ICU admissions in critically ill patients. …”
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Effects of West Nile virus on behavioral and cognitive performance, cortical Aβ pathology, viral loads, and immune measures of middle-aged NL-G-F/E3 and NL-G-F/E4 mice by Abigail O’Niel, Christopher J. Parkins, Alexandra Pederson, Elizabeth Saltonstall, Emily Bunnell, Ria Aggarwal, Phoebe Sandholm, Kat Kessler, Henry F. Harrison, Jessica L. Smith, Alec J. Hirsch, Jacob Raber, Jacob Raber, Jacob Raber, Jacob Raber

“…IntroductionWest Nile Virus (WNV) can cause severe and long-lasting neurological disease and results in some neuropathology and neuroinflammation seen in Alzheimer’s disease (AD). Exposure to WNV might impact AD-relevant behavioral and cognitive performance and neuropathology via AD-susceptibility genes (i.e., E4) and by inducing neuroinflammation (i.e., increases in TCR-α, IFN-γ, TNF-α, and CXCL- 10). …”
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Evaluation of pituitary and thyroid hormones in patients with subarachnoid hemorrhage due to ruptured intracranial aneurysm by Paola Mangieri, Kunio Suzuki, Moema Ferreira, Lucília Domingues, Luiz Augusto Casulari

“…It is well known that the central nervous system (CNS) influences the pituitary hormone secretions and that diseases of CNS are frequently associated with an altered endocrine function. The aim of this study has been the evaluation of the serum concentrations of the pituitary and thyroid hormones in a series of patients with subarachnoid hemorrhage due to a ruptured cerebral aneurysm. …”
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Long-term forecast of monthly reference evapotranspiration of the period 2018-2027 using SARIMA and GRNN models (case study: Rasht synoptic station) by Pouya Aghelpoor, Vahid Varshavian, Mehraneh Khodamoradpoor

“…The target-input matrices were divided into calibration (75%) and validation (25%) sections. Autocorrelation Function (ACF) indicated a seasonal trend in the ET0 monthly series, with a return period of 12. …”
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MicroRNA-146a Serves as a Biomarker for Adverse Prognosis of ST-Segment Elevation Myocardial Infarction by Shengjue Xiao, Tongneng Xue, Qinyuan Pan, Yue Hu, Qi Wu, Qiaozhi Liu, Xiaotong Wang, Ailin Liu, Jie Liu, Hong Zhu, Yufei Zhou, Defeng Pan

“…MicroRNA-146a can serve as a biomarker for adverse prognosis of STEMI and might function in its pathogenesis by targeting S100A12, which may exert its role via an inflammatory response. …”
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Comparative transcriptomics reveal stage-dependent parasitic adaptations in the myxozoan Sphaerospora molnari by Monika M. Wiśniewska, Jiří Kyslík, Gema Alama-Bermejo, Alena Lövy, Martin Kolísko, Astrid S. Holzer, Anush Kosakyan

“…We performed stage-specific transcriptomic profiling to identify differentially expressed key functional gene groups that relate to these functions and provide a fundamental understanding of the mechanisms S. molnari uses to optimize its parasitic lifestyle. …”
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Fatal disseminated mucormycosis due to Cunninghamella bertholletiae infection after ABO-incompatible living donor liver transplantation: a case report by Atsuyoshi Mita, Shohei Hirano, Takeshi Uehara, Kai Uehara, Yasunari Ohno, Koji Kubota, Yuichi Masuda, Tsuyoshi Notake, Kazuki Yoshizawa, Akira Shimizu, Yuji Soejima

“…Although liver graft function improved, mass-like infiltrates appeared in the lungs following intubation for > 1 week due to impaired consciousness. …”
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Dilatation of the main pulmonary artery in patients with isolated pulmonary stenosis: Arteriopathy or hemodynamic consequence? by Pietro Paolo Tamborrino, Michela Miglianti, Dario Freitas, Camelia Demetrescu, Christopher Rush, Claudia Montanaro, Alessandra Frigiola

“…The aim of our study was to detect the incidence of mPA dilatation and aneurysm in patients with isolated PV stenosis and the association with PV function. Methods: In this single-center retrospective observational study, all patients with a diagnosis of isolated PV stenosis referred to our center were enrolled. …”
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Excretory/secretory products from Hymenolepis nana adult worms alleviate ulcerative colitis in mice via tuft/IL-13 signaling pathway by Rong Mou, Xuanyin Cui, Hongyan Wang, Zhenfen Zhang, Yi Cheng, Wenlan Wu, Jinfu Li, Ke Zhang

“…The protective mechanism of ESPs might be related to the activation of the tuft/IL-13 signaling pathway, regulating intestinal barrier function and promoting the regeneration of intestinal stem cells. …”
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Ventricular volume adjustment of brain regions depicts brain changes associated with HIV infection and aging better than intracranial volume adjustment by Benedictor Alexander Nguchu, Benedictor Alexander Nguchu, Jing Zhao, Jiajun Fan, Yifei Han, Yu Lu, Han Jin, Yanming Wang, Hongjun Li, Peter Shaw

“…The analyses of LV-adjusted metrics also show that atrophic patterns observed in the hippocampus, thalamus and pallidum were strongly correlated with HAND(especially dysfunction in executive function) and clinical markers (i.e., CD4/CD8 ratio).ConclusionWe conclude that models that control for individual variability in intracranial and ventricular volumes have the potential to minimize discrepancies and variations in structural reports of HIV, improving the diagnostic power of identified patterns and fostering greater consistency across research studies. …”
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AQP1 Affects Necroptosis by Targeting RIPK1 in Endothelial Cells of Atherosclerosis by Wang P, Zheng L, Yang Y, Yue X, Liu J, Fan K, Zhou H, Dong H

“…Then we collected femoral atherosclerosis and normal aortic samples, further conducted single-cell sequencing and spatial transcriptomic methods to confirm the potential function and pathway of AQP1 in endothelial cells. …”
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Enhancement of D1 dopaminergic responses in aged LRRK2 G2019S knock-in mice by Daniela Mercatelli, Alberto Brugnoli, Anna Di Maio, Federica Albanese, Derya R. Shimshek, Alessandro Usiello, Michele Morari

“…We conclude that the LRRK2 G2019S mutation is associated with age-dependent enhancement of D1 dopaminergic responses, possibly due to elevated endogenous D1 transmission in striatum, that might be instrumental to sustain motor and cognitive function over ageing and help explain the slower and more benign course of G2019S-associated Parkinson's disease.…”
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Context-aware single-cell multiomics approach identifies cell-type-specific lung cancer susceptibility genes by Erping Long, Jinhu Yin, Ju Hye Shin, Yuyan Li, Bolun Li, Alexander Kane, Harsh Patel, Xinti Sun, Cong Wang, Thong Luong, Jun Xia, Younghun Han, Jinyoung Byun, Tongwu Zhang, Wei Zhao, Maria Teresa Landi, Nathaniel Rothman, Qing Lan, Yoon Soo Chang, Fulong Yu, Christopher I. Amos, Jianxin Shi, Jin Gu Lee, Eun Young Kim, Jiyeon Choi

“…However, underlying mechanisms and target genes are largely unknown, as most risk-associated variants might regulate gene expression in a context-specific manner. …”
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Societal uses of the main water bodies inhabited by malaria vectors and implications for larval source management by Najat F. Kahamba, Felista S. Tarimo, Khamisi Kifungo, Winifrida Mponzi, Siaba A. Kinunda, Alfred Simfukwe, Salum Mapua, Betwel Msugupakulya, Francesco Baldini, Heather M. Ferguson, Fredros O. Okumu, Marceline F. Finda

“…Although traditionally used in urban and dry areas, recent research suggests it might also be effective in rural settings in eastern and southern Africa, where Anopheles funestus thrives in permanent water bodies that sustain year-round transmission. …”
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Impaired peroxisomal beta-oxidation in microglia triggers oxidative stress and impacts neurons and oligodendrocytes by Ali Tawbeh, Catherine Gondcaille, Fatima-Ezzahra Saih, Quentin Raas, Damien Loichot, Yannick Hamon, Céline Keime, Alexandre Benani, Francesca Di Cara, Mustapha Cherkaoui-Malki, Pierre Andreoletti, Stéphane Savary

“…These findings demonstrate that peroxisomal impairments in microglia exacerbate inflammatory response and ROS/NO production, affecting the survival of neurons and oligodendrocytes, as well as neuronal morphology and function. This dysfunction might contribute to the early neurodegenerative events in X-ALD by triggering and sustaining neuroinflammatory cascades. …”
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Molecular Characterization and Nutritional Regulation of Two Fatty Acid Elongase (<i>elovl8</i>) Genes in Chinese Perch (<i>Siniperca chuatsi</i>) by Yu He, Zhengyong Wen, Luo Zhou, Wanhong Zeng, Panita Prathomya, Tilin Yi, Qiong Shi

“…Elovl8 is a newly identified member of the ELOVL protein family, and its evolutionary and functional characterizations are still rarely reported. …”
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