MiR-7 inhibits progression of glioblastoma by impairing autophagy resolution, energy metabolism and ECM remodeling by Marta Torrecilla-Parra, Virginia Pardo-Marqués, Antonio C. Fuentes-Fayos, Miguel E. G-García, Mario Fernández-de Frutos, José L. López-Aceituno, Cristina Puigdueta, Carmen Zamora, Ana Pérez-García, Juan F. Aranda, Rebeca Busto, Manuel D. Gahete, Raúl M. Luque, Cristina M. Ramírez

“…In this context, microRNAs are known to regulate autophagy and associated cellular functions, which point them as promising therapeutic candidates. …”
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PLK1 Mediates the Proliferation and Contraction of Airway Smooth Muscle Cells and Has a Role in T2-High Asthma with Neutrophilic Inflammation Model by Pan Y, Xue Y, Fei X, Zhao L, Han L, Su H, Lin Y, Zhou Y, Zhang Y, Xie G, Kong D, Bao W, Zhang M

“…In vivo, PLK1 inhibition reduced airway inflammation (particularly neutrophilic infiltration), airway remodeling (airway smooth muscle proliferation and collagen deposition), and airway hyperresponsiveness and resistance, improving lung function (of both large and small airways), with superior therapeutic effects to those of dexamethasone. …”
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Structure-destabilizing mutations unleash an intrinsic perforation activity of antiapoptotic Bcl-2 in the mitochondrial membrane enabling apoptotic cell death by Ping Gao, Zhi Zhang, Rui Wang, Li Huang, Hao Wu, Zhenzhen Qiao, Xiaohui Wang, Haijing Jin, Jun Peng, Lei Liu, Quan Chen, Jialing Lin

“…Bcl-2 and Bax share a similar structural fold in solution, yet function oppositely in the mitochondrial outer membrane (MOM) during apoptosis. …”
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Curcumin alleviates LPS-induced WI-38 cell inflammation injury by regulating PTGS2 expression by Hongli Xiao, Wangsheng Ma, Lin Zha, Yanmin Xiao, Hui Li

“…The therapeutic effects of CUR on infantile pneumonia might relate to anti-viral and anti-inflammatory effects predicted by GO and KEGG enrichment analysis. …”
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Development and evaluation of customized software to automatically align macula and optic disc centered scanning laser ophthalmoscope fundus images by M. Elena Martinez-Perez, Franziska G. Rauscher, Pingping Zhao, Tobias Elze

“…The methods are highly promising for applications under real-world clinical conditions and might help to facilitate disease detection and monitoring over time.…”
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Ectopic Mediastinal Thyroid: A Crossroad Between a Multi-Layered Endocrine Perspective and a Contemporary Approach in Thoracic Surgery by Claudiu Nistor, Mihai-Lucian Ciobica, Oana-Claudia Sima, Anca-Pati Cucu, Florina Vasilescu, Lucian-George Eftimie, Dana Terzea, Mihai Costachescu, Adrian Ciuche, Mara Carsote

“…No post-operatory complications were registered, the thyroid function remained normal, and the mentioned symptoms were remitted. …”
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Mechanical injuries of the eye: Incidence, structure and possibilities for prevention by Jovanović Miloš, Stefanović Ivan

“…By further analysis, it might be concluded that many injuries could have been prevented, avoiding long medical treatment and accompanying costs, and what is most important - permanent invalidity caused by reduced visual function or blindness of the injured eye is avoidable.…”
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<i>FoxO1</i> Mediated by H3K27me3 Inhibits Porcine Follicular Development by Regulating the Transcription of <i>CYP1A1</i> by Zhi Zhou, Yuanyuan Lv, Liying Li, Xiaolong Yuan, Xiaofeng Zhou, Jiaqi Li

“…It is well known that the function of granulosa cells (GCs) is closely related to follicular development, and <i>FoxO1</i> and histone methylation have been implicated in follicular development. …”
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Differences in the Clinical and Hematological Characteristics of COVID-19 Patients with and without Type 2 Diabetes by Yujing Sun, Ruxing Zhao, Zhao Hu, Weili Wang, Shouyu Wang, Ling Gao, Jianchun Fei, Xiangdong Jian, Yu Li, Huizhen Zheng, Xinguo Hou, Li Chen

“…T2D patients required more recovery time from pneumonia, as shown by follow-up CT findings, which might contribute to the prolonged hospitalization. …”
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Integrating an exercise program into opioid agonist therapy: a pilot study on feasibility, fitness improvements, and participation challenges by Einar Furulund, Siv-Elin Leirvåg Carlsen, Silvia Eiken Alpers, Jørn Henrik Vold, Karl Trygve Druckrey-Fiskaaen, Tesfaye Madebo, Sindre M. Dyrstad, Torgeir Gilje Lid, Lars Thore Fadnes

“…However, increased psychological distress and fatigue might indicate the need for additional support. The low attendance rate highlights engagement challenges, emphasizing the need for tailored strategies to enhance participation. …”
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Clinical manifestations of dual-gene variants involving ABCA4 in retinal dystrophies by Lasse Wolfram, David A. Merle, Laura Kühlewein, Milda Reith, Melanie Kempf, Krunoslav Stingl, Tobias Haack, Pascale Mazzola, Karin Poths, Nicole Weisschuh, Bernd Wissinger, Susanne Kohl, Katarina Stingl

“…The observed phenotypes enhance our understanding of how these genes contribute to human retinal function and dysfunction. Furthermore, these insights can impact clinical decision-making, as patients with dual-gene variant constellations might experience questionable benefit from potential future gene therapies. …”
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Electroacupuncture alleviates damage to myopic RGCs probably through lncRNA-XR_002789763.1-mediated mitophagy by Xuejun Wang, Qinghong Lin, Li Tian, Xiaoying Li, Teruko Fukuyama, Weijung Ten, Xiehe Kong, Yanting Yang, Xiaopeng Ma, Xingtao Zhou

“…Abstract Background Mitophagy is closely related to the regulation of retinal ganglion cell (RGC) structure and function. Our previous study suggested that long noncoding RNAs (lncRNAs) can cause damage to myopic RGCs. …”
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Viewing Global Changes in the Heliosheath with IMAP’s Energetic Neutral Atom Imagers by E. J. Zirnstein, J. Heerikhuisen, D. J. McComas, J. Bower, G. Clark, M. A. Dayeh, H. O. Funsten, M. Gkioulidou, D. G. Mitchell, D. B. Reisenfeld, N. A. Schwadron

“…We aim to answer the following: (i) What are the time delays as a function of energy and direction; (ii) at what energies can we observe changes the soonest; and (iii) what might the ENA source distributions affecting the time delays look like? …”
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A Comprehensive Safety Assessment of <i>Ralstonia eutropha</i> H16 for Food Applications: Integrating Genomic, Phenotypic, and Toxicological Analyzes by Xiaoyan You, Shuxia Song, Bing Li, Hui Wang, Le Zhang, Xiangyang Li, Junliang Chen, Zhiguang Zhu, Guoping Zhao

“…Subacute toxicity studies (28-day, 1 × 10⁸–1 × 10¹⁰ CFU/kg) revealed no significant effects on growth, hematology, or organ function. Minor alterations in serum biochemistry might be attributed to physiological adaptation. …”
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Differential transcriptome study on the damage of testicular tissues caused by chronic infection of T. gondii in mice by Haoxin Li, Hao Yuan, Zi-Peng Yang, Yining Song, Jun-Jie Wang, Qingyuan Wen, Yu-Xiang Zheng, Xiu-Xiang Zhang, Miao Yu, Zi-Guo Yuan

“…In male reproduction, the main function of the testis is to provide a stable place for spermatogenesis and immunological protection. …”
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Affective neural signatures do not distinguish women with emotion dysregulation from healthy controls: A mega-analysis across three task-based fMRI studies by M. Sicorello, J. Herzog, T.D. Wager, G. Ende, M. Müller-Engelmann, S.C. Herpertz, M. Bohus, C. Schmahl, C. Paret, I. Niedtfeld

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Robust Video List Decoding in Error-Prone Transmission Systems Using a Deep Learning Approach by Yujing Zhang, Stephane Coulombe, Francois-Xavier Coudoux, Alexis Guichemerre, Patrick Corlay

“…Three new components are defined and used in the Transformer-assisted image quality evaluation metric: neighborhood-based patch fidelity aggregation, discriminant color texture transformation and ranking-constrained penalty loss function. We have also created our own database of non-uniformly distorted images, similar to those that might result from transmission errors, in a High Efficiency Video Coding (HEVC) context. …”
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Stabilization Splint Therapy for Patients with Temporomandibular Disorders Improves Opening Movements and Jaw Limitation and Attenuates Pain by Influencing the Levels of IL-7, IL-8... by Renata Sikora, Kristina Duspara, Anita Matić, Ana Petrović, Kristina Kralik, Robert Smolić, Miroslav Sikora, Martina Čalušić Šarac, Kristina Bojanić, Martina Smolić

“…<i>Conclusions:</i> The results indicate that SS therapy might have a role in reducing inflammation and that the GCF could be a valuable medium for assessing molecular biomarkers.…”
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Dynamic changes in DNA methylation play a regulatory role in gene expression during the formation of callus from immature barley embryos by Xinguo Huang, Jing Zhan, Haonan Wei, Siying Lou, Hongwu Bian, Junhui Wang, Ning Han

“…Our previous research suggests that epigenetic regulatory factors might influence barley callus formation and regeneration capacity, though the exact mechanisms remain unclear. …”
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Towards Prepared mums (TOP-mums) for a healthy start, a lifestyle intervention for women with overweight and a child wish: study protocol for a randomised controlled trial in the N... by Luc J I Zimmermann, Régine P M Steegers-Theunissen, Yvon E G Timmermans, Kim D G van de Kant, Dorien Reijnders, Lina M P Kleijkers, Edward Dompeling, Boris W Kramer, Marc E A Spaanderman, Anita C E Vreugdenhil

“…A preconception lifestyle intervention might be more effective to reduce perinatal complications. …”
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