Pelvic floor muscle training associated with the photobiomodulation therapy for women affected by the genitourinary syndrome of menopause: a study protocol by Lívia Oliveira Bezerra, Maria Letícia Araújo Silva de Carvalho, Edson Silva-Filho, Maria Clara Eugênia de Oliveira, Palloma Rodrigues de Andrade, Maria Thereza Albuquerque Barbosa Cabral Micussi

“…Also, the international consultation on incontinence questionnaire—short form, the female sexual function index, the Utian Quality of Life scale, the patient global impression of improvement, the modified Oxford scale, and the vaginal health index will be the secondary outcomes. …”
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Calpain 2 promotes Lenvatinib resistance and cancer stem cell traits via both proteolysis-dependent and independent approach in hepatocellular carcinoma by Xiaolu Ma, Kaixia Zhou, Tianqing Yan, Ling Hu, Suhong Xie, Hui Zheng, Ying Tong, Heng Zhang, Yanchun Wang, Zhiyun Gong, Cuncun Chen, Yanan Tian, Lin Guo, Renquan Lu

“…Reducing CAPN2 protein rather than inhibiting its activity might be a promising strategy to improve Lenvatinib treatment efficiency in HCC.…”
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Identification of non-charged 7.44 analogs interacting with the NHR2 domain of RUNX1-ETO with improved antiproliferative effect in RUNX-ETO positive cells by Mohanraj Gopalswamy, David Bickel, Niklas Dienstbier, Jia-Wey Tu, Melina Vogt, Stephan Schott-Verdugo, Sanil Bhatia, Manuel Etzkorn, Holger Gohlke

“…The non-protonated species are predicted to be highly membrane-permeable, along with other favorable pharmacokinetic and toxicological properties. These compounds might serve as lead structures for compounds inhibiting RUNX1/ETO oncogenic function in t(8;21) AML.…”
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Lysosome-mediated aggregation of galactose-deficient IgA1 with transferrin receptor 1 links to IgA nephropathy by Meijun Si, Jingpeng Fu, Mengting Fang, Yunfei Lu, Junxuan Huang, Haojie Li, Peiyi Wang, Maofu Liao, Jian Zhu, Peiyao Li, Wenzhao Zhong, Zhifei Guo, Wei Yang, Zhiming Ye, Hongli Hu, Xueqing Yu

“…Here, we show that transferrin receptor 1 (TfR1) mediates Gd-IgA1 uptake into mesangial cell lysosomes, where it forms non-digestible aggregates, disrupts lysosomal function, and triggers inflammatory responses. In renal biopsies from IgAN patients, IgA1 aggregates co-localize with TfR1 within lysosomes. …”
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Mapping the lung-brain axis: Causal relationships between brain network connectivity and respiratory disorders by Hua Guo, Xiaohan Zhao, Ke Han, Yanqing Wang

“…Background: The mechanistic relationship between respiratory disorders and brain function remains poorly understood, despite growing evidence of cognitive and neurological manifestations in respiratory diseases. …”
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DEPDC1B, CDCA2, APOBEC3B, and TYMS are potential hub genes and therapeutic targets for diagnosing dialysis patients with heart failure by Wenwu Tang, Wenwu Tang, Zhixin Wang, Xinzhu Yuan, Liping Chen, Haiyang Guo, Zhirui Qi, Ying Zhang, Xisheng Xie

“…We constructed a ceRNA regulatory network, and found that 4 hub genes (TYMS, CDCA2 and DEPDC1B) might be regulated by 4 miRNAs (hsa-miR-1297, hsa-miR-4465, hsa-miR-27a-3p, hsa-miR-129-5p) and 21 lncRNAs (such as HCP5, CAS5, MEG3, HCG18). 24 small molecule drugs were predicted based on TYMS through DrugBank website. …”
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Cooling redistributed endotoxin across different biofluids via modulating the ruminal microbiota and metabolome without altering quorum sensing signal levels in heat-stressed beef... by Zuo Wang, Qingyang Wu, Weijun Shen, Fachun Wan, Jianhua He, Lei Liu, Shaoxun Tang, Zhiliang Tan

“…The Tax4Fun2 prediction suggested that QS function was upregulated in MVWS compared to CON. The metabolomic analysis indicated that cooling altered the ruminal metabolism profile and downregulated the pathways of lysine degradation, phenylalanine, tyrosine and tryptophan biosynthesis, and ubiquinone and other terpenoid-quinone biosynthesis. …”
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Physiological traits underlying sodicity tolerance in Jamun (Syzygium cumini L. Skeels) cultivars by Anshuman Singh, Ashwani Kumar, Jai Prakash, Daya Shankar Mishra

“…Conclusions Membership function analysis revealed a reasonable resilience to sodicity stress only in cultivar J-37. …”
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Co-administration of coenzyme Q10 and curcumin mitigates cognitive deficits and exerts neuroprotective effects in aluminum chloride-induced Alzheimer's disease in aged mice by Nida Rasheed, Hafiza Khushbakht Hussain, Zohabia Rehman, Azka Sabir, Waseem Ashraf, Tanveer Ahmad, Faleh Alqahtani, Imran Imran

“…AchE is an enzyme involved in acetylcholine breakdown which negatively impacts acetylcholine levels and memory function. AlCl3 exposure elevated AchE levels in mice brains vs. treatment. …”
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Screening and Analysis of Proteins Interacting with TaPDK from Physiological Male Sterility Induced by CHA in Wheat by Long-yu ZHANG, Gai-sheng ZHANG, Xin-liang ZHAO, Shu-ling YANG

“…Collectively, these datas indicated that the majority of candidate proteins might be related to pollen abortion in PHYMS lines, which further suggested that TaPDK plays multiple roles in pollen development, besides participating in regulating pyruvate dehydrogenase complex activity.…”
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Role of the Emphysema Index Combined with the Chronic Obstructive Pulmonary Disease Assessment Test Score in the Evaluation of Chronic Obstructive Pulmonary Disease by Qi Ding, Xia Wei, Jie Li, Yan-Zhong Gao, Shu-Di Xu, Nan Yu, Jiu-Yun Mi, Bai-Bing Mi, You-Min Guo

“…The records of pulmonary function and quantitative computed tomography findings were retrospectively analyzed. …”
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Rare malignant primary spinal chondrosarcoma: A case report by Ahmad Fitrah, MD, Btari Magistra Pancaputri, MD, Andreas Klemens Wienanda, MD, Atta Kuntara, MD, Abdul Kadir Hadar, MD, Muhammad Naseh Sajadi Budi Irawan, MD, Ahmad Ramdan, MD, Anglita Yantisetiasti, MD

“…The most effective treatment has been en bloc resection, and high-dose adjuvant radiotherapy might improve local control and survival rates. Recommended follow-ups are for the purpose of monitoring recurrence. …”
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Anticancer evaluation of Myo-inositol through carbonic anhydrase IV inhibition activity: A spectroscopic, quantum computational, topological, drug-likeness and in-silico molecular... by K. Rajkumar, V. Gokulakrishnan, S. Anand, R. Durga, G. Senthilkumar, S. Sri Karthick, R. Kayalvizhi Kothai

“…Understanding the charge distribution, localized electrons and weak interaction sites was achieved through molecular electrostatic potential surface, electron localization function, local orbital locator and reduced density gradient analyses. …”
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Parental kynurenine 3-monooxygenase genotype in mice directs sex-specific behavioral outcomes in offspring by Snezana Milosavljevic, Maria V. Piroli, Emma J. Sandago, Gerardo G. Piroli, Holland H. Smith, Sarah Beggiato, Norma Frizzell, Ana Pocivavsek

“…Conclusions These findings suggest that Kmo deficiency impacts KP biochemistry, sleep behavior, and brain mitochondrial function. Even though WT-Kmo +/+ inherit identical genetic material as WT-Control, their development might be shaped by the parent’s physiology, behavior, or metabolic state influenced by their Kmo genotype, leading to phenotypic sex-specific differences in offspring.…”
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TREM2 affects DAM-like cell transformation in the acute phase of TBI in mice by regulating microglial glycolysis by Lin Wang, Diqing Ouyang, Lin Li, Yunchuan Cao, Yingwen Wang, Nina Gu, Zhaosi Zhang, Zhao Li, Shuang Tang, Hui Tang, Yuan Zhang, Xiaochuan Sun, Jin Yan

“…However, their presence and function in the acute phase of TBI remain unclear. …”
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Impact of Body Mass Index on the Outcomes of Cryoballoon Pulmonary Vein Isolation for Paroxysmal Atrial Fibrillation by Konstantinos A. Papathanasiou, Dimitrios A. Vrachatis, Charalampos Kossyvakis, Sotiria G. Giotaki, Gerasimos Deftereos, Maria Kousta, Ioannis Anagnostopoulos, Dimitrios Avramides, George Giannopoulos, Vaia Lambadiari, Gerasimos Siasos, Spyridon Deftereos

“…Of note, obese patients showed greater improvement in their symptoms post-CBA, defined as improvement by at least one EHRA class, compared to normal weight patients; this might be explained by improved diastolic function. …”
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RETRACTED: COL10A1-DDR2 axis promotes the progression of pancreatic cancer by regulating MEK/ERK signal transduction by Zhihui Wen, Zhihui Wen, Zhihui Wen, Jingbo Sun, Junjie Luo, Yun Fu, Yue Qiu, Yanyan Li, Yangwei Xu, Hongmei Wu, Qingling Zhang, Qingling Zhang

“…Our study suggested that COL10A1 might be a critical factor in promoting PDAC progression. …”
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Modifying the Refuse Chute Design to Prevent Infection Spread: Engineering Analysis and Optimization by Kursat Tanriver, Mustafa Ay

“…In addition to the health measures described, this study calls for future research on how evolving global health conditions might impact refuse chute design.…”
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CLINICAL MASKS OF AMYLOIDOSIS WITH THE HEART INVOLVEMENT: MODERN DIAGNOSTIC ISSUES by O. V. Blagova, A. V. Nedostup, V. P. Sedov, E. A. Kogan, S. P. Pasha, N. V. Gagarina, I. N. Alieva, A. V. Sedov, D. A. Tsaregorodtsev, V. A. Kulikova, N. E. Shepeleva, N. D. Sarkisova

“…Antibodies to the nuclei of cardiomyocytes (specific ANF) was found in a female patient with AL-type and DCMP, which made not to rule out myocarditis.Conclusion. Cardiac amyloidosis might present as any structural and functional variant of cardiomyopathy, including DCMP. …”
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Population dynamics and monitoring applied to decision-making by M. J. Conroy, D. C. Lee

“…On the other hand, failure to take action (and thus spend funds) sooner might lead to a higher probability of extinction. …”
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