Olympic combat sports and mental health in children and adolescents with disability: a systematic review of controlled trials by Youngjun Lee, Flavia Guidotti, Flavia Guidotti, Laura Capranica, Caterina Pesce, Valentin Benzing, Janet Hauck, Simone Ciaccioni, Simone Ciaccioni

“…Olympic combat sports (OCS) such as judo, taekwondo, and others might encourage social engagement, self-control, and resilience. …”
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Subpopulations of natural killer-T-like cells before and after surgical treatment of laryngeal cancer by Janusz Klatka, Ewelina Grywalska, Anna Hymos, Ewelina Krasowska, Michał Mielnik, Dorota Siwicka-Gieroba, Justyna Markowicz, Piotr Trojanowski, Witold Olszański, Jacek Roliński

“…Different research projects suggest that the role of T lymphocytes might be significant in tumour development. iNKT cells are a new subpopulation of T cells and show cytotoxic activity against tumours. iNKT cells participate in modulating the function of other cells which have anti-tumour properties and secrete cytokines, which have pro-inflammatory and anti-inflammatory effects. …”
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Hypomethylation of GCNT2 isoform A correlates with transcriptional expression and is associated with poor survival in acute myeloid leukemia by De-hong Wu, De-hong Wu, Hong-chun Qiu, Jing Xu, Jiang Lin, Jun Qian

“…BackgroundThe function of GCNT2 has been documented to act as an oncogenic driver or tumor suppressor in different types of tumor, but the role of GCNT2 and the epigenetic regulation mechanism in AML, however, has not yet been clarified. …”
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A novel mesothelioma molecular classification based on malignant cell differentiation by Jun Liu, Yifan Liu, Yuwei Lu, Wei Zhang, Jiale Yan, Bingnan Lu, Yuntao Yao, Shuyuan Xian, Donghao Lyu, Jiaying Shi, Yuanan Li, Xinru Wu, Chenguang Bai, Jie Zhang, Yuan Zhang

“…We also constructed regulatory networks to detect the function of important tumor cell differential genes (TCDGs) in the MESO. …”
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Treatment success and mortality among people with multi-drug resistant and rifampicin resistant-tuberculosis on bedaquiline-based regimen at three referral hospitals in Uganda: A r... by Lodiong Jackson Dumo Lodiong, Jonathan Izudi, Boniface Amanee Elias Lumori

“…The weaknesses are the smaller sample size, we analyzed data spanning a relatively shorter period, and alcohol use was measured by self-reporting, this might have underestimated its association with treatment success.…”
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Feasibility of teleyoga for people with post COVID-19 condition– a mixed method design by Marie Lundberg, Leonie Klompstra, Lotti Orwelius, Mirjam Schimanke, Cecilia Olsson, Anna Strömberg

“…Conclusion Adherence to the online yoga sessions was quite low and might be improved with shorter yoga sessions. Online yoga was safe, but some participants experienced an increase in symptoms. …”
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Midline-1 inhibited high glucose-induced epithelial-mesenchymal transition, fibrosis and inflammation through WNT/β-catenin signaling in benign prostatic hyperplasia by Xun Fu, Xun Fu, Hao Zhang, Jiang Liu, Yan Li, Zhen Wang, Shu Yang, Daoquan Liu, Yongying Zhou, Ping Chen, Michael E. DiSanto, Hongjun Li, Xinhua Zhang

“…On a cellular level, HG treatment inhibited the expression of MID1, thus stimulating cellular proliferation and triggering EMT, fibrosis and inflammation of two prostatic cells via enhanced WNT/β-catenin signaling.ConclusionsIn general, our novel data demonstrate targeting MID1 might be a promising area of medical treatment for patients with both BPH and diabetes.…”
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Hypothyroidism and hypopituitarism as immune-related adverse events due to lenvatinib plus pembrolizumab therapy in the immediate postoperative period after laparoscopic hepatectom... by Kimimasa Sasaki, Shin Kobayashi, Masashi Kudo, Motokazu Sugimoto, Shinichiro Takahashi, Yoshiaki Nakamura, Akihito Kawazoe, Kohei Shitara, Takahiro Kinoshita, Naoto Gotohda

“…Regarding surgery after ICI therapy, it is important to recognize that irAEs might occur in the postoperative period.…”
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Abnormal Expression of BTLA and CTLA-4 Immune Checkpoint Molecules in Chronic Lymphocytic Leukemia Patients by L. Karabon, A. Partyka, L. Ciszak, E. Pawlak-Adamska, A. Tomkiewicz, A. Bojarska-Junak, J. Roliński, D. Wołowiec, T. Wrobel, I. Frydecka, A. Kosmaczewska

“…Our results indicate that CLL development is associated with the affected expression of BTLA and CTLA-4 checkpoint receptors in PB and its impaired expression might be associated with lowering of the threshold for B cell activation and proliferation, while upregulated CTLA-4 expression in CLL peripheral BTLA+ T cells may contribute to suppressed T cell effector functions. …”
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Genetic and therapeutic heterogeneity shape the baseline and longitudinal immune ecosystem of ovarian clear cell carcinoma by Min Yu, Fei Xu, Xiaohua Wu, Jiajia Li, Xiaojun Chen, Lihua Chen, Jiaxin Chen, Mengdong Ni, Siyu Xia, Jiana Li, Chaohua Liu

“…VEGF inhibition remodeled OCCC stroma, restored T cell function and potentiated immunotherapy. CD36 and CD47 might be potential therapeutic targets for recurrent OCCC.…”
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Comparative Transcriptomic Analysis Between High- and Low-Growth-Rate Meat-Type Rabbits Reveals Key Pathways Associated with Muscle Development by Chao Yang, Lingxi Zhu, Li Tang, Xiangyu Zhang, Min Lei, Xiaohong Xie, Cuixia Zhang, Dingsheng Yuan, Congyan Li, Ming Zhang

“…Different expression of energy metabolism hub-genes might be the primary reason for interbreed muscle developmental disparities.…”
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Characterizing trajectories of diabetes-related health parameters before diabetes diagnosis in diabetes subtypes: analysis of a 20-year long prospective cohort study in Sweden by Tatjana P. Liedtke, Eike A. Strathmann, Emma Ahlqvist, Olof Asplund, Charlena S. Penz, Paula Stürmer, Cara Övermöhle, Anton Lager, Boel Brynedal, Hrafnhildur Gudjonsdottir, Wolfgang Lieb, Katharina S. Weber

“…Conclusions In a Swedish population, trajectories of diabetes-related health parameters differed up to 20 years before diagnosis between the T2D-related subtypes and controls. This might support early prediction of subtype-specific risks for long-term complications, allowing early initiation of personalized treatment strategies. …”
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Tissue-specific expression and correlation with promoter DNA methylation of the LBP gene in pigs by Yue CAO, Zhong-cheng GAO, Zheng-chang WU, Hai-fei WANG, Wen-bin BAO

“…It is speculated that the methylation of CpG2 and CpG3 sites might inhibit YY1 binding to the promoter sequences, thereby regulating the tissue-specific expression of LBP. …”
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FLT3LG modulates the infiltration of immune cells and enhances the efficacy of anti-PD-1 therapy in lung adenocarcinoma by Fengyu Zhao, Han Bai, Yiwei Liu, Shuoze Gao, Chengcheng Yang, Jie Wu, Hao Cheng, Jiao Ma, Yuanyuan Li, Hong Ren, Junke Fu, Shanzhi Gu, Xinhan Zhao, Sida Qin

“…FLT3LG is regarded as being associated with tumor diagnosis and immunotherapy in a variety of tumor types, but its function in LUAD is uncertain. Methods Bioinformatics analysis was conducted to evaluate the clinical value, functional enrichment, genetic correlation, and immune infiltration of FLT3LG in LUAD. …”
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Early Atherosclerosis and Acute Vascular Events in Ulcerative Colitis Patients – a Case Series by Ana Maria NEGREANU, Ana STEMATE, Teodora SPATARU, Lucian NEGREANU

“…Tailored treatment with better control of the ulcerative colitis and endoscopic healing might result in decrease risk of atherothrombotic events. …”
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Analysis of human factor H-related gene and protein expressed in rheumatoid arthritis synovium identifies a novel mechanism promoting dysregulated complement pathway activation by Nirmal K. Banda, Larry W. Moreland, Kevin D. Deane, Dmitri Simberg, Robert I. Scheinman, Rachel M. Frank, Jennifer A. Seifert, Accelerating Medicines Partnership (AMP) RA/SLE Network, Rachel Lau, Costantino Pitzalis, Myles J. Lewis, V. Michael Holers

“…In sum, due to the absence of FH but the presence of FHRs, the synovial lining might fail to be protected from complement-mediated attack, and FHR3 may play a particularly important pathogenic role.…”
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Folic Acid Mitigates Sertraline-Induced Liver Damage in Adult Female Albino Rats During Pregnancy and Postpartum: A Biochemical and Histological Study by Ayman A. Refai, Mohammad I. Jumaa, Einas M. Yousef, Ala M. Aljehani, Rana Ahmed Alduraywish, Mohamed R. Elkabary, Safaa M. Hanafy, Hanan S. Seleem, Eman S. El-Roghy

“…Folic acid, a recommended supplement currently used during the first trimester of pregnancy, has antioxidant and anti-inflammatory effects. Hence, folic acid might be a potential protective agent against sertraline-induced liver injury. …”
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Systematic Review of Screening and Surveillance Programs to Protect Workers from Nanomaterials. by Mary Gulumian, Jos Verbeek, Charlene Andraos, Natasha Sanabria, Pieter de Jager

“…In addition, differences in early effects on pulmonary function or neurobehavioral tests were not observed. …”
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SOX7: Autism associated gene identified by analysis of multi-Omics data. by Samantha Gonzales, Jane Zizhen Zhao, Na Young Choi, Prabha Acharya, Sehoon Jeong, Xuexia Wang, Moo-Yeal Lee

“…Thus, it is unclear which of these mutations might be functional and thus potentially causal variants. …”
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A 17.1 kb duplication downstream GATA6 is strongly associated with egg weight in chicken by Lei Wang, Shaobo Han, Weijian Fan, Yangming Pan, Bo Yuan, Guanyu Hou, ShiJun Li

“…Given the liver’s essential role in synthesizing yolk precursors, we hypothesized this signal region might influence EW through liver function. Although SNPs and indels within this signal region were ruled out as causal variants for EW, SV-gwas between DZH and WCH revealed a 17.1 kb duplication (dup, chr2:102,721,722–102,738,778 bp) approximately 66.6 kb downstream of GATA6. …”
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