Patients´ experiences of an exercise intervention in primary care following robot-assisted radical cystectomy due to bladder cancer: a qualitative study by Patrik Karlsson, Malin Nygren-Bonnier, Simon Torikka, Andrea Porserud, Lars Henningsohn, Christina B. Olsson, Elisabeth Rydwik, Maria Hagströmer

“…The available literature on exercise interventions following radical cystectomy in patients with bladder cancer is scarce but suggests that physical activity and exercise might improve physical function and health-related quality of life, thus calling for further investigation. …”
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Correlative 99m Tc-labeled tropane derivative single photon emission computer tomography and clinical assessment in the staging of parkinson disease by Ajit Shinto, Joppy Antony, Koramadai Kamaleshwaran, Krishnan Vijayan, Arul Selvan, Aruna Korde, Mythili Kameshwaran, Grace Samuel

“…No remarkable adverse reactions were found in either healthy volunteers or PD patients during or after imaging. 99m Tc-TRODAT-1 is accurate and widely available for the assessment of DAT activity, which might shed light on the integrity of the presynaptic nigrostriatal function. …”
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A microfluidics platform for simultaneous evaluation of sensitivity and side effects of anti-cancer drugs using a three-dimensional culture method by Yuki Kobayashi, Honoka Hashizume, Sotaro Takiguchi, Jiajue Ji, Ryuji Kawano, Keiichiro Koiwai, Haru Yamamoto, Mohamed Elbadawy, Tsutomu Omatsu, Amira Abugomaa, Masahiro Kaneda, Tatsuya Usui, Kazuaki Sasaki

“…These techniques have recently been used to reproduce the structure and function of organs in vitro and are expected to be promising alternatives for animal experiments in the future. …”
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Role of Iron in Children With Immunoglobulin A Nephropathy and Macrohematuria-Induced Acute Kidney Injury by Shingo Ishimori, Tomoko Horinouchi, Tomohiko Yamamura, Junya Fujimura, Naohiro Kamiyoshi, Hiroshi Kaito, Yuriko Tanaka, Hiroyoshi Matsukura, Wataru Shimabukuro, Yuko Shima, Azusa Kawaguchi, Yoshinori Araki, Koichi Nakanishi, Shigeo Hara, Kandai Nozu

“…CD163-positive cells might scavenge hemoglobin in patients with MH-AKI IgAN, but not their roles as macrophages. …”
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Classification of ROI-based fMRI data in short-term memory tasks using discriminant analysis and neural networks by Magdalena Fafrowicz, Marcin Tutajewski, Igor Sieradzki, Jeremi K. Ochab, Jeremi K. Ochab, Anna Ceglarek-Sroka, Koryna Lewandowska, Tadeusz Marek, Barbara Sikora-Wachowicz, Igor T. Podolak, Paweł Oświęcimka, Paweł Oświęcimka, Paweł Oświęcimka

“…In recent years, machine learning methods have been widely used to detect connections between regions of interest (ROIs) involved in cognitive functions, as measured by the fMRI technique. However, it's essential to match the type of learning method to the problem type, and extracting the information about the most important ROI connections might be challenging. …”
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Sitagliptin Prevents Inflammation and Apoptotic Cell Death in the Kidney of Type 2 Diabetic Animals by Catarina Marques, Cristina Mega, Andreia Gonçalves, Paulo Rodrigues-Santos, Edite Teixeira-Lemos, Frederico Teixeira, Carlos Fontes-Ribeiro, Flávio Reis, Rosa Fernandes

“…In conclusion, sitagliptin might have a major role in preventing diabetic nephropathy evolution due to anti-inflammatory and antiapoptotic properties.…”
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The m6A writer KIAA1429 regulates photoaging progression via MFAP4-dependent collagen synthesis by Yuanyuan Liu, Jian Li, Chenhui Wang, Jiangbo Li, Kai Luo, Kang Tao, Yuan Tian, Xiang Song, Zhifang Zhai, Yuandong Tao, Jia You, Lihua Wu, Wenqian Li, Yuanyuan Jiao, Rongya Yang, Mingwang Zhang

“…Nevertheless, the precise function of m6A methylation in photoaging remains unknown. …”
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Case report: Clinical and genetic characteristics of heterozygous CaSR variants in three Chinese females with familial hypocalciuric hypercalcemia type 1: a report of three cases by Ruxuan Zhang, Ruxuan Zhang, Tingting Hu, Shuai Wang, Yiping Cheng, Dandan Luo, Dongmei Zheng, Xinli Zhou, Xinli Zhou, Xinli Zhou

“…The analysis of the conservation of homologous species and the prediction of protein structure for all variant sites demonstrated that due to the heterozygous variants in CaSR, relatively conserved amino acids were altered, affecting the interaction forces between adjacent amino acids, resulting in changes in the protein structure, which might affect the function of the protein.ConclusionIn conclusion, we report three cases of FHH1 with different heterozygous variant sites in the CaSR gene. …”
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Efficacy and safety of DL‐3‐N‐butylphthalide in the treatment of ischemic poststroke aphasia: A randomized clinical trial by Jing Tian, Peng Yang, Jianing Yang, Rui Wang, Biyi Zhou, Kun Zhang, Yanying Zhao, Binbin Wang, Lijuan Liu, Ruomeng Chen, Haoran Wu, Ruihan Miao, Li Guo, Xiaoyun Liu

“…Interpretation NBP treatment might promote the recovery of WAB‐AQ in patients with ischemic PSA by increasing levels of monoamine neurotransmitters.…”
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Orai–vascular endothelial-cadherin signaling complex regulates high-glucose exposure-induced increased permeability of mouse aortic endothelial cells by Wei He, Juan Du, Suwen Bai, Yuan Wei, Wenxuan Hou, YanHeng Yao, Junwei Zhu, Yinan Du, Bing Shen, Haoshu Fang

“…Introduction Diabetes-associated endothelial barrier function impairment might be linked to disturbances in Ca2+ homeostasis. …”
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Amantadine modulates novel macrophage phenotypes to enhance neural repair following spinal cord injury by Shijie Yang, Beibei Yu, Qing Zhang, Yongfeng Zhang, Longhui Fu, Bisheng Zhou, Haining Wu, Jianzhong Li, Shouping Gong

“…This modulation promotes neural regeneration and enhances functional recovery following SCI. Conclusions Amantadine modulates macrophage phenotypes following SCI, reduces early inflammatory responses, and enhances neural function recovery. …”
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Nanotoxicological Assessment of Green-Synthesized Silver Nanoparticles from Brazilian Cerrado Plant in a Murine Model by Cínthia Caetano Bonatto, Ivy Garcez Reis, Dalila Juliana Silva Ribeiro, Raquel das Neves Almeida, Rafael Corrêa, Livia Pimentel Sant’Ana Dourado, Gabriel Pasquarelli-do-Nascimento, Kelly Grace Magalhães, Luciano Paulino Silva

“…Biochemical analyses of liver and kidney function markers also revealed no significant differences across the treatment groups. …”
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Postbiotics Regulate Intestinal Microbiota and Reduce Amyloid β-Protein Deposition in the Brain, Thereby Ameliorating Cognitive Impairment in Rats with Alzheimer’s Disease by XIAO Ling, TANG Linlin, SONG Xiaoyan, ZHANG Yihua, HAN Xuemei, LÜ Houjiao, LIANG Wu, WANG Yanping, GENG Weitao, JIA Longgang

“…This study aimed to investigate the impact of three postbiotics at different doses on cognitive function in a rat model of Alzheimer’s disease (AD) induced by D-galactose combined with AlCl3. …”
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Relationships of triglyceride-glucose-related indices with colorectal cancer incidence and mortality in an American population: a dose-response meta-analysis and cohort study by Lan Luo, Zhu Liu, Quan Gan, Jing Feng, Lingyun Wang, Weiwei Ouyang

“…Abstract Background The degree to which the triglyceride-glucose (TyG) index might interact with colorectal cancer (CRC) incidence and mortality is undefined. …”
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miR-21 and Pellino-1 Expression Profiling in Autoimmune Premature Ovarian Insufficiency by Xinran Li, Jiaxin Xie, Qingru Wang, Huihua Cai, Chuhai Xie, Xiafei Fu

“…Positive correlation between miR-21 and Peli1 was observed in autoimmune POI patients, suggesting that miR-21 and Peli1 might be associated with the pathogenesis of autoimmune POI.…”
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Two Novel Single-Chain Variable Fragments, EB211 and EB279, Exert Antibacterial Activity Against Acinetobacter baumannii by Destabilizing the Outer Membrane by Eilnaz Basardeh1, Farzaneh Nazari1, Abolfazl Fateh1, Seyed Davar Siadat1, Akbar Oghalaie2, Masoumeh Azizi3, Fatemeh Rahimi-Jamnani1*

“…Their unique ability to function independently of the host immune system makes scFvs a highly promising option for effective treatment. …”
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Crohn’s disease therapeutic dietary intervention (CD-TDI): study protocol for a randomised controlled trial by Subrata Ghosh, Levinus A Dieleman, Christopher Ma, Ian Lewis, Herman W Barkema, Humberto Jijon, Kathy D McCoy, Georgios V Gkoutos, Maitreyi Raman, Lorian M Taylor, Jeff K Vallance, Derek M McKay, David M Mutch, Deanna Gibson, Marcus Rauch

“…Introduction Dietary patterns that might induce remission in patients with active Crohn’s disease (CD) are of interest to patients, but studies are limited in the published literature. …”
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Gut microbiota constituents may affect hypertrophic scarring risk through interaction with specific immune cells in a two-step, two-sample Mendelian randomization study by Jiaqi Lou, Ziyi Xiang, Xiaoyu Zhu, Jiliang Li, Guoying Jin, Shengyong Cui, Neng Huang, Pei Xu, Sida Xu, Youfen Fan, Xin Le

“…The principal aim of this study is to elucidate the causal relationship among gut microbiota (GM), immune cell function, and hypertrophic scarring in a European demographic. …”
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Palmitoleic acid on top of HFD ameliorates insulin resistance independent of diacylglycerols and alters gut microbiota in C57BL/6J mice by Qijian Liang, Yan Zheng, Fanli Meng, Xiaofan Jiang, Qingcai Zhen, Zhongting Lu, Shixiu Zhang, Lei Du, Hao Wu, Xin Guo

“…Therefore, in HFD-fed mice, palmitoleic acid reduced insulin resistance by an independent-manner of DAGs. It might be associated with the beneficial effects of palmitoleic acid on altering the gut microbiota composition, improving of intestinal barrier function, and downregulating the inflammation in colon, liver, and adipose tissue.…”
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IL‐17 is associated with disease severity and targetable inflammatory processes in heart failure by Lukas Baumhove, Bart J. vanEssen, Martin M. Dokter, Sietske N. Zijlstra, Frederik E. Deiman, Jon D. Laman, Chim C. Lang, Gwenny M.P.J. Verstappen, Dirk J. vanVeldhuisen, Peter van derMeer, Nils Bomer, Adriaan A. Voors

“…In animal HF models, interleukin‐17A (IL‐17) has been linked to deterioration of cardiac function and fibrosis, whereas knock‐out of IL‐17 showed beneficial cardiac effects. …”
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