Stable minichromosome and functional neocentromere derived from rye 7R chromosome arm by Zongxiang Tang, Qian Liu, Zijin Pan, Chang Liu, Jieran Dong, Fangpu Han, Shulan Fu

“…We theorize that R-loops and transposable element might be involved in the positioning of CENH3 nucleosomes in a functional neocentromere.…”
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Association between cannabis use and brain structure and function: an observational and Mendelian randomisation study by Anya Topiwala, Klaus Ebmeier, Saba Ishrat, Daniel F Levey, Joel Gelernter

“…Mendelian randomisation analyses found no support for causal relationships underlying associations between cannabis use and brain structure or function.Conclusions Associations between lifetime cannabis use and brain structure and function in later life are probably not causal in nature and might represent residual confounding.Clinical implications Cannabis use is associated with differences in brain structure and function. …”
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Expression and replication studies to identify new candidate genes involved in normal hearing function. by Giorgia Girotto, Dragana Vuckovic, Annalisa Buniello, Beatriz Lorente-Cánovas, Morag Lewis, Paolo Gasparini, Karen P Steel

“…In the current study, we followed up these SNPs to investigate which of them might show a genuine association with auditory function using alternative approaches. …”
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The Effect of Detethering Surgery on the Bladder Function and Psychology of Children with Primary Tethered Cord Syndrome by Shuai Yang, Zhaokai Zhou, Xingchen Liu, Zhan Wang, Yanping Zhang, He Zhang, Lei Lv, Yibo Wen, Qingwei Wang, Wei Jia, Jinhua Hu, Jian Guo Wen

“…It was hypothesized that the DS might have a significant effect on bladder function and psychology. …”
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Effect of mastitis on the function of milk-derived exosomes: observations from mammary epithelial cells by YING Yitian, YANG Jing, YAN Bingxuan, SHAO Fengjin, TAN Xun

“…The present study was conducted to investigate the effect of mastitic milk-derived exosomes on the viability and innate immune function of bovine mammary epithelial cells (MECs), with the aim to understand the role of exosomes in the pathogenesis of mastitis. …”
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Type I collagen secreted in white matter lesions inhibits remyelination and functional recovery by Reiji Yamazaki, Morio Azuma, Yasuyuki Osanai, Tom Kouki, Takeshi Inagaki, Akiyoshi Kakita, Masaki Takao, Nobuhiko Ohno

“…These results suggest that type I collagen secreted by monocyte-derived macrophages inhibited white matter regeneration, and therefore, the modulation of type I collagen metabolism might be a novel therapeutic target for white matter injury.…”
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Meta Analysis of Therapeutic Effect of Jichuan Decoction Combined with Acupuncture and Moxibustion for Functional Constipation by Haibing QIN, Aiyuan ZOU, Lianhuan YANG, Zhaotian WU

“…The inverted funnel plot analysis of the included studies with the effective rate as the index showed that there was incomplete symmetry, suggesting that there might be publication bias in the research literature.Conclusion:Jichuan decoction combined with acupuncture and moxibustion can improve effectively the TCM symptoms of patients with functional constipation, and the effect is better than using other drugs only, including Jichuan decoction, Chinese medicine preparation of hemp kernel, Cisapride tablets. …”
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Comparative analysis of synteny and functional divergence of APX genes in Fragaria vesca and Fragaria×ananassa by Shixiong Lu, Juanbo Yang, Guangling Shi, Huiming Gou, Zonghuan Ma, Wenfang Li, Baihong Chen, Juan Mao

“…These amino acid fragments might be closely related to the function of the APX genes. …”
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Evaluation of physiological functions and production performance in laying hens in three different housing systems by Gaku Shoji, Ryota Tochinai, Shin-ichi Sekizawa, Masayoshi Kuwahara

“…On the other hand, these diurnal patterns were unclear in hens raised in AV, which implies that AV may suppress parasympathetic nervous activity of hens during the dark phase. Therefore, AV might diminish the rest quality of hens, and lower the biological functions and recover of hens. …”
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Delivery of A Chemically Modified Noncoding RNA Domain Improves Dystrophic Myotube Function by Zeinabou Niasse‐Sy, Bo Zhao, Ajda Lenardič, Huyen Thuc Tran Luong, Ori Bar‐Nur, Johan Auwerx, Martin Wohlwend

“…This study, therefore, highlights the potential of identifying functional domains in noncoding RNAs. Delivery, or targeting of RNA domains might constitute next‐generation RNA therapeutics.…”
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Altered Functional Integration in the Salience and Default Mode Networks in Euthymic Pediatric Bipolar Disorder by Weifang Cao, Haoran Chen, Qing Jiao, Dong Cui, Yongxin Guo, Weijia Gao, Jianfeng Qiu, Linyan Su, Guangming Lu

“…Our findings indicated that disturbed functional integration in salience and default mode networks might shed light on the physiopathology associated with emotional and cognitive dysregulation in PBD.…”
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Community differences and potential function along the particle size spectrum of microbes in the twilight zone by Yue Zhang, Hongbin Liu, Hongmei Jing

“…Conclusion Our study reveals significant shifts in microbial community composition and function in the twilight zone, with clear differences among the three particle sizes. …”
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Effect and mechanism of PYCR1 on biological function of hepatocellular carcinoma cells under hypoxia by Jiayi Guo, Xinxin Jin, Junli Zhang, Yuming Zhang, Wenjuan Wu

“…Methods GO and KEGG enrichment analyses were used to predict the biological function and possible mechanism of PYCR1 in hypoxic microenvironments. …”
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The influence of subjective well-being on anxiety, depression and quality of life in patients with functional dyspepsia by Guizhen Yong, Xi Wang, Yan Xu, Guobin He

“…Anxiety and depression are increasingly recognized as contributing causes of functional dyspepsia (FD), yet the role of SWB in FD patients has been largely overlooked. …”
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Cognitive neuroscience approach to explore the impact of wind turbine noise on various mental functions by Agnieszka Rosciszewska, Maciej Buszkiewicz, Gabriela Dobrzynska-Kobylec, Anna Klichowska, Tomasz Przybyla, Blanka B. Nagy, Andrzej Wicher, Michal Klichowski

“…Furthermore, we utilized various psychological scales and found that even tendencies towards rumination or reduced capacity for reflection and ambiguity tolerance did not lead to maladaptive perceptions of wind turbine noise and, therefore, to a state that might indirectly influence mental functioning. Although these results cannot be generalized, they support the concept that the interlinkage between exposure to wind turbine noise and human cognitive functioning is not a cause-and-effect relationship. …”
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Rheumatoid Arthritis and miRNAs: A Critical Review through a Functional View by Maria Cristina Moran-Moguel, Stefania Petarra-del Rio, Evangelina E. Mayorquin-Galvan, Maria G. Zavala-Cerna

“…After a critical reading, we provide in this paper a functional view with respect to miRNA biogenesis, interaction with targets that are expressed in specific cells and tissues, during different stages of inflammatory responses associated with RA, and recognized specific areas where miRNAs might also have a pathogenic role but remain undescribed. …”
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Effect of Fenofibrate on Markers of Gut Barrier Function in Dogs With Naturally Occurring Diabetes Mellitus by Allison L. O'Kell, Jocelyn Mott, Lauren Porter, Chiquitha D. Crews, Yu‐An Wu, Rosemary Walzem, Joerg M. Steiner, Chen Gilor

“…In diabetic dogs, short‐term fenofibrate treatment appears to be safe, and the improvement in gut barrier function and lipid profiles might lead to long‐term benefits, such as reduction in pancreatitis risk and frequency of signs of gastrointestinal disease.…”
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Integrated transcriptomic and functional modeling reveals AKT and mTOR synergy in colorectal cancer by Marcin Duleba, Eliza Zimoląg, Joanna Szuszkiewicz, Marcin Serocki, Joanna Szklarczyk, Olga Dracz, Alexander Kurzejamski, Izabella Więckowska, Marcelina Chmiel, Barbara Lipert, Katarzyna Sarad, Joanna Krawczyk, Oleksii Bryzghalov, Agata Stachowicz-Wałaszek, Karolina Pyziak, Joanna Drozdowska, Krzysztof Baczyński, Konrad Wojtowicz, Maurycy Chronowski, Krzysztof Rataj, Magdalena Otrocka, Michał Mikula, Paula Feliksiak, Rafał Dziadziuszko, Tomasz Rzymski, Andrew Thomason, Krzysztof Brzózka, Andrzej Mazan

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A novel loss-of-function SYCP2 variant causes asthenoteratozoospermia in infertile males by Cong Liu, Cong Liu, Cong Liu, Yinfeng Zhang, Yinfeng Zhang, Yinfeng Zhang, Youming Zhao, Youming Zhao, Youming Zhao, Haining Luo, Haining Luo, Haining Luo

“…Mini-gene splicing assays confirmed that this splicing variant impacted alternative splicing and that the stop codon appeared early, which was very likely to result in the loss of function of the protein and lead to the occurrence of male infertility.Conclusion:Our results suggested that the c.2600+5G>C variation in SYCP2 might be the genetic etiology for male infertility in this pedigree. …”
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Auto-aggregation Properties of Probiotic Lactobacillus delbrueckii str. IAHAHI: From Genes to Function by Astghik PEPOYAN, Liana GRIGORYAN, Natalya HARUTYUNYAN, Susanna MIRZABEKYAN, Marine BALAYAN, Artak GALSTYAN, Vardan TSATURYAN, Anahit MANVELYAN

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