Acral lentiginous melanoma with subsequent spontaneous vitiligo vulgaris: a case report and literature review by Ronak Saeed Ahmed, Rozhgar Rashid Ali, Dilan S. Hiwa, Abdullah K. Ghafour, Shvan Omar Siddiq, Saywan K. Asaad, Ari M. Abdullah, Rawa M. Ali, Zuhair D. Hammood, Rebaz M. Ali, Fahmi H. Kakamad

“…There is a suggestion that normal melanocytes might function as neutral observers and become targets of immune responses directed against melanoma cells, leading to melanoma-associated vitiligo. …”
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Refining the link between obesity and heart failure: insights from GLP-1 receptor agonist trials and studies adopting direct adiposity measures by Nicola Riccardo Pugliese, Francesco Paneni, Domenico Tricò, Alessandra Violet Bacca, Nicolò De Biase, Hermann Dalpiaz, Alessandro Mengozzi, Agostino Virdis, Lorenzo Ghiadoni, Stefano Taddei, Reinhold Kreutz, Konstantinos Tsioufis, Stefano Masi

“…Additionally, it highlights epidemiological and molecular data supporting EAT as a novel adiposity measure that might allow refining patient selection for pharmacological weight-loss treatments. …”
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What change in body mass index is associated with improvement in percentage body fat in childhood obesity? A meta-regression by Rachel Perry, Julian PH Shield, Laura Birch, Linda P Hunt, Rhys Matson, Amanda Chong, Rhona Beynon

“…Meta-regression demonstrated that reduction of at least 0.6 in mean BMI-SDS ensured a mean reduction of percentage body fat mass, in the sense that the associated 95% prediction interval for change in mean percentage body fat was wholly negative.Conclusions Interventions demonstrating reductions of 0.6 BMI-SDS might be termed successful in reducing adiposity, a key purpose of weight management interventions.Trial registration number CRD42016025317.…”
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Clinical presentation and outcome of coronavirus disease 2019 infection in chronic obstructive pulmonary disease patients by Reham M. El Morshedy, Maha M.S.A. El-Kholy, Madonna Y.R. Kelada, Abdelroauf M.S. Abdelroauf, Marwan N.E. Mohamed

“…Background It was observed that coronavirus disease 2019 (COVID-19) respiratory complications might be deleterious in patients with prior chronic respiratory diseases. …”
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Action Mechanism of β-Glucan from Ganoderma sinense Produced in Wuping on Gut Microbiota and Metabolism in Mice with Acute Alcoholic Liver Injury by LIN Biaosheng, WANG Jinping, WANG Wuchang, CHEN Tong, Lin Weiming, SHEN Shaoxin

“…Therefore, the protective mechanism of G. sinense polysaccharides against AALI in mice might be related to the regulation of amino acid metabolism, lipid and lipid-like molecule metabolism, and propionic acid metabolism by improving the composition of the gut microbiota.…”
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The anti-inflammatory cytokine IL-37 improves the NK cell-mediated anti-tumor response by Nadine Landolina, Francesca Romana Mariotti, Andrea Pelosi, Valentina D’Oria, Tiziano Ingegnere, Claudia Alicata, Paola Vacca, Lorenzo Moretta, Enrico Maggi

“…IL-37 is a member of the IL-1 superfamily exerting anti-inflammatory functions in a number of diseases. Extracellular IL-37 triggers the inhibitory receptor IL-1R8 that is known to regulate different NK cell pathways and functional activities including their anti-tumor effect. …”
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Identification of circRNA Expression Profiles in BMSCs from Glucocorticoid-Induced Osteoporosis Model by Zhipeng Chen, Wei Lin, Shengli Zhao, Xiaoyi Mo, Zhenxing Wen, Wing Hoi Cheung, Dan Fu, Bailing Chen

“…The present study is aimed at systematically characterizing the circRNA expression profiles in GIOP and predict the potential functions of the associated regulatory networks. Methods. …”
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Perinatal Inflammation Results in Sex-Dependent Cardiac Dysfunction by Leeann R. Pavlek, Kathryn M. Heyob, Nitya R. Jacob, Saichidroopi Korada, Zahra Khuhro, Aiman Q. Khan, Terri A. Shaffer, Sara Conroy, Markus Velten, Lynette K. Rogers

“…Correlative changes were observed in left ventricular function with a more severe phenotype in the males indicating sex-based differences in cardiac adaptation. …”
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Exploring the mechanistic link between the oxytocinergic system and mindfulness training in adults with heightened stress: study protocol for a double-blind, randomized, placebo-co... by E. van Weert, HJ. De Vuyst, K. Van der Gucht, E. Debbaut, J. Steyaert, K. Alaerts

“…Discussion These findings could provide valuable insights into how combining oxytocin and mindfulness-based interventions might enhance stress regulation, particularly in populations with impaired oxytocinergic function. …”
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Efficacy of the maxillary anterior segmental distraction osteogenesis in patients with cleft lip and palate by Panjun Pu, Shanying Bao, Jianbo Gao, Yuhua Jiao, Feiyu Wang, Huaxiang Zhao, Yuxia Hou, Yalin Zhan

“…It typically results in significant maxillary dysplasia, causing severe oral function problems and substantially affecting the patient’s facial aesthetics. …”
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Risk factors and the level of laboratory biomarkers abnormalities amongst COVID-19 admitted patients with acute kidney injury: A retrospective cross-sectional study by Mahdi Zarei, Juan Carlos Cotrina-Aliaga, Samaneh Atbaeitabari, Mohammad Darvishi, Sepideh KarkonShayan, Reza Akhavan-Sigari

“…Introduction: Infection with SARS-CoV-2 might lead to severe acute kidney injury (AKI) with high morbidity and mortality. …”
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Granulosa cell-specific FOXJ2 overexpression induces premature ovarian insufficiency by triggering apoptosis via mitochondrial calcium overload by Yunxia Zhang, Qiqian Wu, Furong Bai, Yanqin Hu, Bufang Xu, Yujie Tang, Jingwen Wu

“…High fork head box J2 (FOXJ2) expression might negatively regulate ovarian function; however, the mechanism is unclear. …”
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Efficacy and Safety of Early Use of Naoxueshu Within 72 hours in the Treatment of Spontaneous Intracerebral Hemorrhage: A Real-World Retrospective Cohort Study by Wang X, Shang Z, Zhao J, Hou H, Li Y, Song J

“…While randomized controlled trials have demonstrated its ability to promote hematoma absorption and improve neurological function prognosis, the efficacy and safety of NXS early use (within 72 hours) remain unclear. …”
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Improving nutrition knowledge and nutrient intake through nutrition education for post-stroke survivors and their families by Farah Faza, Lily Arsanti Lestari, Ismail Setyopranoto, Susetyowati Susetyowati

“…., anthropometry, blood pressure, physical function, and dietary were measured in the 1st week, a series of nutrition education in the 2nd and 3rd week, post-test and endline assessment in the 4th week. …”
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Alterations in mitochondrial DNA content in canine heart failure by Chavalit Boonyapakorn, Julalak Meechai, Panida Sansuktaweesup, Pitchaporn Karaket, Worawan Woravuthvitaya, Suphakan Chirathanaphirom, Phongsakorn Chuammitri, Chanon Piamsiri, Wanpitak Pongkan

“…Changes in mtDNA copy number could indicate the extent of mtDNA damage, serving as a potential biomarker for mitochondrial function and a predictor of several cardiovascular disease risks in humans. …”
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Exercise training partly ameliorates cardiac dysfunction in mice during doxorubicin treatment of breast cancer by Tytti-Maria Uurasmaa, Pauline Bourdin, Wail Nammas, Shiva Latifi, Heidi Liljenbäck, Antti Saraste, Olli Eskola, Johan Rajander, Anne Roivainen, Helene Rundqvist, Anu Autio, Ilkka Heinonen, Katja Anttila

“…However, the ET effects on cardiac function and glucose metabolism in DOX-treated breast cancer models remain unclear. …”
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Distinct Epigenetic Effects of Tobacco Smoking in Whole Blood and among Leukocyte Subtypes. by Dan Su, Xuting Wang, Michelle R Campbell, Devin K Porter, Gary S Pittman, Brian D Bennett, Ma Wan, Neal A Englert, Christopher L Crowl, Ryan N Gimple, Kelly N Adamski, Zhiqing Huang, Susan K Murphy, Douglas A Bell

“…Tobacco smoke exposure dramatically alters DNA methylation in blood cells and may mediate smoking-associated complex diseases through effects on immune cell function. However, knowledge of smoking effects in specific leukocyte subtypes is limited. …”
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Single-cell and spatial transcriptomics analysis reveals that Pros1+ oligodendrocytes are involved in endogenous neuroprotection after brainstem stroke by Shaojun Li, Guanfeng Zeng, Chunmei Pang, Jie Li, Li Wu, Ming Luo, Zhihua Qiu, Yongjun Jiang

“…As the predominant cellular component of nerve tracts, oligodendrocytes might provide some neuroprotection against ischemic injury in the context of brainstem stroke, but the underlying mechanism remains unclear. …”
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Deep-learning-based extraction of circle of Willis topology with anatomical priors by Dieuwertje Alblas, Iris N. Vos, Micha M. Lipplaa, Christoph Brune, Irene C. van der Schaaf, Mireille R. E. Velthuis, Birgitta K. Velthuis, Hugo J. Kuijf, Ynte M. Ruigrok, Jelmer M. Wolterink

“…In an individual CoW, arteries might be absent (aplasia) or underdeveloped (hypoplasia, diameter < 1 mm). …”
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Dynamin-1 is a potential mediator in cancer-related cognitive impairment by Ding Quan Ng, Casey Hudson, Tracy Nguyen, Sukesh Kumar Gupta, Yong Qin Koh, Munjal M. Acharya, Alexandre Chan

“…Consistently observed in both human and animal studies, the downregulation of DNM1 is linked with the onset of CRCI. DNM1 might be a biomarker and therapeutic target for CRCI.…”
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