AGL61/80 regulates BGAL9, which participates in early somatic embryogenesis and increases longan resistance to heat stress by Yan Chen, Xiangwei Ma, Wentao Ma, Luzhen Xu, Chunwang Lai, Xueying Zhang, Qing Guan, Zihao Zhang, Yukun Chen, Zhongxiong Lai, Yuling Lin

“…Dual-luciferase assays and transient transformation indicated that the transcription factor (TF) DlAGL61 and DlAGL80 might bind to the DlBGAL9 promoters to activate DlBGAL9 transcription. …”
Get full text

Renal Artery Blood Flow and Surface Parenchymal Perfusion During Renal Artery Endoshunting in a Porcine Model by Johan Millinger, Marcus Langenskiöld, Andreas Nygren, Klas Österberg, Joakim Nordanstig

“…This suggests that endoshunting to the kidney using an endoshunt system might be a promising strategy to preserve renal function when temporary interruption of native renal artery blood flow is needed during complex vascular surgical repairs involving the renal arteries.…”
Get full text

A fungal ubiquitin ligase and arrestin binding partner contribute to pathogenesis and survival during cellular stress by Lukas M. du Plooy, Calla L. Telzrow, Connie B. Nichols, Corinna Probst, Natalia Castro-Lopez, Floyd L. Wormley, J. Andrew Alspaugh

“…These proteins are fungal specific and might be targets for novel anti-infection therapy.…”
Get full text

Comprehensive analysis of the INDETERMINATE DOMAIN (IDD) gene family in Marchantia polymorpha brings new insight into evolutionary developmental biology by Congye Zhou, Ting Yang, Manlei Cai, Hongchang Cui, Fei Yu, Huawei Liu, Jing Fu

“…Cis-regulatory element prediction demonstrated that MpIDDs might be hormone and stress responsive. The expression levels of most MpIDDs display tissue specificities and could be changed by hormone treatment. …”
Get full text

Xuesaitong Protects Podocytes from Apoptosis in Diabetic Rats through Modulating PTEN-PDK1-Akt-mTOR Pathway by Rui Xue, Ruonan Zhai, Ling Xie, Zening Zheng, Guihua Jian, Teng Chen, Jun Su, Chongting Gao, Niansong Wang, Xifei Yang, Youhua Xu, Dingkun Gui

“…XST (5 mg/kg·d) or Losartan (10 mg/kg·d) was given to diabetic rats for 12 weeks. Albuminuria, renal function markers, and renal histopathology morphological changes were examined. …”
Get full text

Lacticaseibacillus paracasei sh2020 induced antitumor immunity and synergized with anti-programmed cell death 1 to reduce tumor burden in mice by Shi-Long Zhang, Bing Han, Yu-Qin Mao, Zheng-Yan Zhang, Zhan-Ming Li, Chao-Yue Kong, You Wu, Guo-Qiang Chen, Li-Shun Wang

“…Meanwhile, the modulation of gut microbiota caused by L. paracasei sh2020 enhanced its antitumor effect and gut barrier function. Overall, our study offered novel insights into the mechanism by which gut microbiota shaped the outcome of cancer immunotherapy and, more importantly, the novel strain L. paracasei sh2020 might serve as an easy and effective way to promote anti-PD-1 effect in clinical practice.…”
Get full text

A Rat Model of Hyperoxia-Induced White Matter Injury by Yue Song, Ting Zhang, Hua Wang

“…Aberrant differentiation and apoptosis of oligodendrocytes might be the reason for hyperoxia-induced WMI.…”
Get full text

Evaluating the Potential Use of Wearable Fitness Devices as a Measure of Outcomes in Orthopaedics by Jordan Henderson BS, Santiago Logan-Baca BS, Sara Kisiel BS, Fadi Muheidat PhD, David Jaffe MD

“…Surveys utilized were the Foot and Ankle Ability Measure Computerized Adaptive Testing (FAAM CAT), PROMIS physical function, mobility and pain interference scores, and Visual Analog Scale (VAS). …”
Get full text

Compound heterozygous variants in OTULIN are associated with fulminant atypical late‐onset ORAS by Julia Zinngrebe, Barbara Moepps, Thomas Monecke, Peter Gierschik, Ferdinand Schlichtig, Thomas F E Barth, Gudrun Strauß, Elena Boldrin, Carsten Posovszky, Ansgar Schulz, Ortraud Beringer, Eva Rieser, Eva‐Maria Jacobsen, Myriam Ricarda Lorenz, Klaus Schwarz, Ulrich Pannicke, Henning Walczak, Dierk Niessing, Catharina Schuetz, Pamela Fischer‐Posovszky, Klaus‐Michael Debatin

“…Patients with homozygous loss‐of‐function variants in the OTU‐deubiquitinase OTULIN suffer from neonatal‐onset OTULIN‐related autoinflammatory syndrome (ORAS) characterized by fever, panniculitis, diarrhea, and arthritis. …”
Get full text

CORELATION OF PARENTS' PROFILES OF CHILDREN WITH LATE CLEFT REPAIR IN SURABAYA CLEFT LIP AND PALATE CENTRE (JANUARY 2015–DECEMBER 2017) by Laras Puspita Ningrum, Iswinarno Doso Saputro, Lobredia Zarasade

“…The  soft  palate  must function  properly before the  patient  starts learning  to  talk,  otherwise  speech disorders such as persistent rhinolalia aperta might arise. …”
Get full text

Impact of different treatment methods and timings on soil microbial communities with transgenic maize straw return by Yanbo Xie, Jun-Yan Xiang, Likun Long, Yue Ma, Zhenjuan Xing, Ling Wang, Chunyu Shao, Na Liu, Feiwu Li

“…Early straw treatment prompted a rapid microbial response to nutrient availability, with notable changes in diversity and function over time. Straw treatments notably altered soil microbial functions, especially in carbon cycling and nutrient metabolism. …”
Get full text

Optimization of Controlled-Release Microspheres Containing Vitexin and Isovitexin Through Experimental Design and Evaluation of Their Hypoglycemic Effects by Nhu Huynh Mai, Hoang-Han Do, Phi Hoang Yen Tran, Cong-Phi Nguyen, Van-Ha Nguyen, Ngoc Phuc Nguyen Nguyen, Kien-Duc Ngo, Duc-Tuan Nguyen, Minh-Quan Le

“…The potential mechanisms might involve increasing the size of Islets of Langerhans and improving pancreatic β-cell function and insulin resistance, as observed in alloxan-induced diabetic mice. …”
Get full text

Pulmonary artery augmentation and aortic valve repair using novel tissue-engineered graftsCentral MessagePerspective by Hisayuki Hongu, MD, PhD, Masaaki Yamagishi, MD, PhD, Keiichi Kanda, MD, PhD, Yoshinobu Maeda, MD, Tomoya Inoue, MD, PhD, Hiroki Nakatsuji, MD, PhD, Hitoshi Yaku, MD, PhD

“…The reconstructed aortic valve function was good in the patient who underwent AVP. …”
Get full text

Gucy1α1 specifically marks kidney, heart, lung and liver fibroblasts by Valeria Rudman-Melnick, Davy Vanhoutte, Kaitlynn Stowers, Michelle Sargent, Mike Adam, Qing Ma, Anne Karina T. Perl, Alexander G. Miethke, Ashley Burg, Tiffany Shi, David A. Hildeman, E. Steve S. Woodle, J. Matthew Kofron, Prasad Devarajan

“…Abstract Fibrosis is a common outcome of numerous pathologies, including chronic kidney disease (CKD), a progressive renal function deterioration. Current approaches to target activated fibroblasts, key effector contributors to fibrotic tissue remodeling, lack specificity. …”
Get full text

A hundred species, mostly new—first assessment of ribbon worm diversity and distribution in Oman by Svetlana Maslakova, Irina Cherneva, Ethan Kahn, Audrey Wong, Gustav Paulay

“…Estimates of source diversity suggest that future surveys might uncover an additional ∼200 species by including other locations and types of habitats, particularly soft bottoms, and the water column. …”
Get full text

Effects of a Mobile Storytelling App (Huiyou) on Social Participation Among People With Mild Cognitive Impairment: Pilot Randomized Controlled Trial by Di Zhu, Abdullah Al Mahmud, Wei Liu

“…ConclusionsThis study indicates that the Huiyou mobile storytelling app is feasible to enhance social participation and specific aspects of social functioning such as interpersonal adaptation for people with MCI. …”
Get full text

Ferroptosis Mediates Pulmonary Fibrosis: Implications for the Effect of Astragalus and Panax notoginseng Decoction by Jing Wen, Cui Wang, Li-yun Song, Yin-ying Wang, Peng-tao Liang, Wen-lin Pang, Wen Yin, Qiang Zhang, Wei-tian Zhao, Xue-ping Sun, Jin-yuan Yan, Zhong-shan Yang

“…The underlying mechanisms might involve Hif-1α and EGFR.…”
Get full text

Understanding Ganoderma lucidum (Curtis) P. Karst's multipronged potential in improving drug delivery methods and its application in the management of prostate cancer by Salik Abdullah, Vivek Bakshi, Shreya Mukherjee, Sayandip Paul, Haider Ali Mollick, Sk Maksuda, Biplab Debnath

“…Results: Conventional cancer treatments might result in significant adverse reactions, making compounds from natural origin a potentially favourable option for cancer therapy. …”
Get full text

Chromatin remodelling factor BAF155 protects hepatitis B virus X protein (HBx) from ubiquitin-independent proteasomal degradation by Huijing Chen, Yi Zhang, Shuangshuang Ye, Qiong Wu, Youfen Lin, Kaiqin Sheng, Wannan Chen, Xinjian Lin, Xu Lin

“…Consequently, overexpression of BAF155 enhanced the transcriptional transactivation function of HBx, activated protooncogene expression and inhibited hepatoma cell clonogenicity. …”
Get full text

Phosphatidylinositol promoted the proliferation and invasion of pituitary adenoma cells by regulating POU1F1 expression by Tongjiang Xu, Xiaodong Zhai, RuiWei Wang, Xiaoben Wu, ZhiZhen Zhou, MiaoMiao Shang, Chongcheng Wang, Tengfei Qi, Wei Yang

“…These results suggested that elevated serum PI might contribute to the proliferation and invasion of pituitary adenoma by regulating the expression of PITPNM1/AKT/ERK/POU1F1 axis.…”
Get full text