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2441
A Comparative Study on the Wettability of Two Coal Samples during Deep Burial Metamorphism
Published 2020-01-01“…The zeta potential and DLVO theory analyses of superficial particles and deep coal particles indicate that deep burial metamorphism process might be favorable for bubble-particle collision and attachment, while might be unfavorable for the wetting process oppositely. …”
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2442
Circular at the very beginning: on the initial genomes in the RNA world
Published 2024-12-01“…It is likely that an RNA world existed in early life, when RNA played both the roles of the genome and functional molecules, thereby undergoing Darwinian evolution. …”
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2443
The potential role of biomarkers CD28 and PF4 in the pathogenesis of idiopathic pulmonary fibrosis and their impact on the prognosis: an immune microenvironment analysis
Published 2025-06-01“…Conclusion The results of this study suggested that the biomarkers CD28 and PF4 might play a potential role in the pathogenesis of IPF and might have an impact on the prognosis of the disease. …”
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2444
Genome-wide landscape of genetic diversity, runs of homozygosity, and runs of heterozygosity in five Alpine and Mediterranean goat breeds
Published 2025-03-01“…The high levels of ROH identified in some breeds might indicate high levels of inbreeding and a lack in genetic variation, which might negatively impact the animal population. …”
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2445
Dextromethorphan Dampens Neonatal Astrocyte Activation and Endoplasmic Reticulum Stress Induced by Prenatal Exposure to Buprenorphine
Published 2021-01-01“…Our findings suggest that prenatal exposure to buprenorphine might instigate long-lasting effects on hippocampal and astrocytic functions. …”
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2446
The Increment of Choroidal Thickness in Euthyroid Graves’ Ophthalmopathy: Is It an Early Sign of Venous Congestion?
Published 2018-01-01“…Impaired ocular blood flow may disrupt the retinal microstructure and functions. In this study, we aimed to investigate the macular and choroidal thickness changes in GO compared with healthy subjects. …”
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2447
Astrocytes at the Hub of the Stress Response: Potential Modulation of Neurogenesis by miRNAs in Astrocyte-Derived Exosomes
Published 2017-01-01“…Repetitive stress negatively affects several brain functions and neuronal networks. Moreover, adult neurogenesis is consistently impaired in chronic stress models and in associated human diseases such as unipolar depression and bipolar disorder, while it is restored by effective antidepressant treatments. …”
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2448
Dietary composition and overlap between cattle and endangered mountain gazelle (Gazella gazella)
Published 2025-06-01“…However, competition between livestock and endangered, native ungulates in these areas might impair their functioning as refugia. We used fecal DNA metabarcoding to study the diets of native mountain gazelles (Gazella gazella) and domestic cattle (Bos taurus), in two nature reserves with distinct vegetation types (shrubland vs grassland), and during different seasons. …”
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2449
Single Nucleotide Polymorphisms in MicroRNA Binding Sites: Implications in Colorectal Cancer
Published 2014-01-01“…Further we performed expression analysis to shed light on the potential tissues that might be affected by mutation, enrichment analysis to find the metabolic functions of the gene, and network analysis to highlight the important interactions of cancer causing genes with other genes to provide insight that complex network will be disturbed upon mutation. …”
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2450
Can dextromethorphan-bupropion reduce mental pain in depressed individuals? A hypothesis-generating overview perspective
Published 2025-03-01“…It negatively impacts social interactions and significantly limits daily functioning, ultimately reducing life satisfaction. …”
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2451
Genome-wide DNA methylation regulation analysis provides novel insights on post-radiation breast cancer
Published 2025-02-01“…Enrichment analysis revealed that these radiation-associated genes involved diverse biological functions and pathways in BC. Combining epigenetic data, we identified radiation-associated genes whose transcriptional changes might be associated with aberrant methylation. …”
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2452
Interferon Regulator Factor 8 (IRF8) Limits Ocular Pathology during HSV-1 Infection by Restraining the Activation and Expansion of CD8+ T Cells.
Published 2016-01-01“…Although IRF8 expression is induced in activated T cells, the functional relevance of IRF8 in T cell-mediated immunity is not well understood. …”
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2453
Evaluation of Study and Patient Characteristics of Clinical Studies in Primary Progressive Multiple Sclerosis: A Systematic Review.
Published 2015-01-01“…<h4>Conclusion</h4>Optimal PPMS study methods involve appropriate patient selection, especially regarding the PPMS phenotype and progression rate. Functional composite endpoints might be more sensitive than single endpoints in capturing progression.…”
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2454
Association of genetic variants in Wnt signaling pathway with tuberculosis in Chinese Han population.
Published 2014-01-01“…Further epidemiological and functional studies in larger populations are warranted to verify our results.…”
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2455
Overexpression of the microtubule-binding protein CLIP-170 induces a +TIP network superstructure consistent with a biomolecular condensate.
Published 2021-01-01“…Moreover, bioinformatic studies demonstrate that the presence of intrinsically disordered regions is conserved in key +TIPs, implying that these regions are functionally significant. Together, these results indicate that the CLIP-170 induced patches in cells are phase-separated liquid condensates and raise the possibility that the endogenous +TIP network might form a liquid droplet at MT ends or other +TIP locations.…”
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2456
Claudin-1 is a p63 target gene with a crucial role in epithelial development.
Published 2008-07-01“…The epidermis of the skin is a self-renewing, stratified epithelium that functions as the interface between the human body and the outer environment, and acts as a barrier to water loss. …”
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2457
Kompetencje późnorzymskiego vicarius Thraciae w VI-VII wieku
Published 2010-12-01“…As one example shows, before 582 there was also a vicarius Thraciae who was most probably a military commander, others might have performed functions of heads of the army in emergency, when in the last decades of the 6th and 7th centuries Balkan provinces were threatened by the attacks of Avars and Slavs. …”
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2458
Diaryl Disulfides as Novel Stabilizers of Tumor Suppressor Pdcd4.
Published 2016-01-01“…Finally, computational modelling indicated that the flexibility of the disulfide linker might be necessary to exert the biological functions of the compounds, as the inactive compound appeared to be energetically more restricted.…”
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2459
Role of the Mucin-2 and Kaiso genes in the social behavior of mice
Published 2015-12-01“…These results suggest that intestinal homeostasis might have a strong impact on the nervous system of the animals. …”
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2460
Innovative applications of biochar in nuclear remediation and catalysis
Published 2025-05-01“…Abstract Emphasizing its potential for environmental sustainability, this review investigated how biochar—a carbon-rich material obtained from biomass pyrolysis—might be used into nuclear science and technology. …”
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