Aggregation potency and proinflammatory effects of SARS-CoV-2 proteins by Monica Costa, Da-Wei Wang, Kai-Dong Zhao, Lin Yuan, Anita Krisko, Jia-Yi Li, Tiago Outeiro, Wen Li

“…We found that the ER stress was induced and that the autophagy-lysosome pathway was inhibited upon viral protein expression. Boosting autophagy function attenuated protein aggregation, suggesting that modulation of autophagy might be a valid strategy for inhibiting cytotoxic effects of SARS-CoV- 2 proteins. …”
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Handgrip weakness and overall life satisfaction decline: derivation of cutoff values and analysis of sex differences in older Chinese adults by Liangyu Yin, Lan Zhong

“…Low HGS is positively associated with LSS decline among men in a linear-like manner, but not among women. These findings might facilitate the development of strategies to promote healthy aging.…”
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Roman Domination of Cartesian Bundles of Cycles over Cycles by Simon Brezovnik, Janez Žerovnik

“…A Roman dominating function <i>f</i> of a graph <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>G</mi><mo>=</mo><mo>(</mo><mi>V</mi><mo>,</mo><mi>E</mi><mo>)</mo></mrow></semantics></math></inline-formula> assigns labels from the set <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mo>{</mo><mn>0</mn><mo>,</mo><mn>1</mn><mo>,</mo><mn>2</mn><mo>}</mo></mrow></semantics></math></inline-formula> to vertices such that every vertex labeled 0 has a neighbor labeled 2. …”
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The CECARI Study: Everolimus (Certican®) Initiation and Calcineurin Inhibitor Withdrawal in Maintenance Heart Transplant Recipients with Renal Insufficiency: A Multicenter, Randomi... by Jan Van Keer, David Derthoo, Olivier Van Caenegem, Michel De Pauw, Eric Nellessen, Nathalie Duerinckx, Walter Droogne, Gábor Vörös, Bart Meyns, Ann Belmans, Stefan Janssens, Johan Van Cleemput, Johan Vanhaecke

“…The poor adherence to the everolimus therapy might have masked a potential benefit of CNI withdrawal on renal function.…”
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Second ‘pop-off’ of fetal giant urinoma: case report and review by Xiaoying Qi, Houqing Pang, Ling Wang, Yifei Tan, Hong Luo

“…It was speculated that the urinoma might experience a secondary rupture. Ascites drainage was performed and the urinoma disappeared. …”
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SGK1 Mediates Hypoxic Pulmonary Hypertension through Promoting Macrophage Infiltration and Activation by Xin Xi, Jing Zhang, Jian Wang, Yuqin Chen, Wenmei Zhang, Xiaoping Zhang, Jie Du, Guangfa Zhu

“…The effects of SGK1 on macrophage function and cytokine expression were assessed by comparing WT and SGK1-/- macrophages in vitro. …”
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The association of BMI and subclinical myocardial dysfunction in breast cancer patients after single or dual anti-HER2 targeted therapy by Feng Zhang, Siyuan Wang, Chao Yu, Wenying Jin, Dan He, Xiaoxiao Hu, Shu Wang, Tiangang Zhu

“…Abstract Background Anti-HER2 targeted therapy has significantly reduced the recurrence and death of HER2-overexpressing breast cancer patients, but might lead to cardiotoxicity. Some patients with normal myocardial function may suffer from subclinical myocardial dysfunction after anti-HER2 targeted therapy. …”
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Musical auditory feedback BCI: clinical pilot study of the Encephalophone by Thomas A. Deuel, Thomas A. Deuel, James Wenlock, Alana McGovern, James Rosenthal, Juan Pampin

“…Innovative technologies such as brain-computer interfaces (BCIs) have been developed recently that might benefit certain types of patients.MethodsHere, we tested a previously described auditory BCI, the Encephalophone, which may offer new options to improve quality of life and function. …”
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Expression of LTR and LINE1 transposable elements defines atypical teratoid/rhabdoid tumor subtypes by Martin V. Hamann, Shweta Godbole, Maisha Adiba, Sabrina M. Leddy, Jelena Navolić, Ghazaleh Tabatabai, Daniel J. Merk, Ulrike C. Lange, Julia E. Neumann

“…The sole recurrent biallelic loss-of-function mutation in SMARCB1 in ATRTs, a core component of the SWI/SNF chromatin remodeling complex, raises the question of how TE transcription contributes to ATRT development. …”
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Dihydromyricetin ameliorates lipopolysaccharide‒induced hepatic injury in chickens by activating the Nrf2/Keap1 pathway and regulating mitochondrial dynamics by Liang Yuan, Xinru Jiang, Yani Ren, Bingke Ma, Zhenghua Ji, Shibo Wang, Beili Hao, Changwen Li, Rui Li, Fangping Liu

“…Network pharmacology results showed that the effect of DHM on hepatic injury might be related to oxidative stress and mitochondrial function. …”
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Age- and Post-Based Complex Analyses of Heart Rate Variability in Young Male Handball Players for Potential Prevention of Overload-induced Injuries by Zita Petrovszki, Olivér Czimbalmos, Vera Gal, Gabor Korosi, Edit Nagy, Rita Mikulan, Gyongyi Horvath

“…The proposed systemic analyses explored age- and post-based differences in autonomic function suggesting that individual alterations from the mean values in different subgroups might indicate changes in performance.…”
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The Role of Centella asiatica and Its Main Bioactive Compound, Asiatic Acid in Cardiac Remodeling: A Systematic Review of Animal Studies by Muhamad Rizqy Fadhillah, Wawaimuli Arozal, Heri Wibowo, Arleni Bustami, Suci Widya Primadhani, Nurul Gusti Khatimah, Rizky Clarinta Putri, Clara Riski Amanda, Nur Azizah

“…Cardiac remodeling is a phenotype of heart failure characterized by a molecular, cellular, and interstitial change in the heart, which manifests in the change of size and function of the heart after specific insults with multiple mechanisms. …”
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Remifentanil Protects against Lipopolysaccharide-Induced Inflammation through PARP-1/NF-κB Signaling Pathway by Jian-ning Zhang, Yang Ma, Xi-yan Wei, Ke-yin Liu, Hao Wang, Hui Han, Yi Cui, Ming-xiang Zhang, Wei-dong Qin

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Ras-PI3K pathway promotes osteosarcoma progression via regulating VRK1-mediated H2A phosphorylation at threonine 120 by Xianlun Xu, Hao Yu

“…H2AT120ph participated in the oncogenic functions of Ras-PI3K pathway on osteosarcoma by modulating the transcription of Ras-PI3K-targeted genes. …”
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Ultra-High-Performance Liquid Chromatography–Tandem Mass Spectrometry and Network Pharmacology Reveal the Mechanisms of <i>Rhodiola crenulata</i> in Improving Non-Alcoholic Fatty L... by Xin Zeng, Jianwei Wang, Qinyi Xu, Chengdan Deng, Xi Yi, Shang Wang, Ling Yao, Wei Xiang

“…<i>Rhodiola crenulata</i> (RC) is a traditional herb and functional food that has demonstrated beneficial effects in improving physical function, enhancing work capacity, alleviating fatigue, and preventing altitude sickness. …”
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Pilot Randomised Controlled Trial of a Web-Based Intervention to Promote Healthy Eating, Physical Activity and Meaningful Social Connections Compared with Usual Care Control in Peo... by Jose Lara, Nicola O'Brien, Alan Godfrey, Ben Heaven, Elizabeth H Evans, Scott Lloyd, Suzanne Moffatt, Paula J Moynihan, Thomas D Meyer, Lynn Rochester, Falko F Sniehotta, Martin White, John C Mathers

“…<h4>Background</h4>Lifestyle interventions delivered during the retirement transition might promote healthier ageing. We report a pilot randomised controlled trial (RCT) of a web-based platform (Living, Eating, Activity and Planning through retirement; LEAP) promoting healthy eating (based on a Mediterranean diet (MD)), physical activity (PA) and meaningful social roles.…”
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Human umbilical cord mesenchymal stem cells ameliorate liver fibrosis by inhibiting hepatocyte ferroptosis and macrophage polarization via the miR-455-3p/PLAU axis by Yong Zhang, Jin Dou, Shipeng Dai, Yuchen Xie, Hongyu Wang, Zhongda Chen, Haiwen Zhuang, Sanrong Xu

“…Methods Bioinformatics showed the miR-455-3p/PLAU axis might regulate ferroptosis in liver fibrosis and affect the immune microenvironment. hUC-MSCs were transplanted into CCL4 induced liver-fibrotic male C57BL/6 mice. …”
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Effect of electroacupuncture on vascular remodeling in rats with cerebral ischemia by regulating irisin based on VEGF/Akt/eNOS signaling pathway by Lu Cao, Wenchao Ding, Yashuo Feng, Chong Guan, Li Liu, Hongyu Xie, Kewei Yu, Dongyan Xu, Lijuan Zhao, Xuan Sha, Xiaoman Deng, Santian Wu, Yangrui Wang, Yi Wu, Tingting Zhang, Nianhong Wang

“…EA facilitated vascular remodeling after cerebral ischemia, and this might be associated with the activation of the irisin-mediated VEGF/Akt/eNOS signaling pathway.…”
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Regulation of neutrophil senescence by microRNAs. by Jon R Ward, Paul R Heath, James W Catto, Moira K B Whyte, Marta Milo, Stephen A Renshaw

“…Neutrophils translate mRNA to make new proteins that are important in maintaining functional longevity. We therefore hypothesised that neutrophil functions and lifespan might be regulated by microRNAs expressed within human neutrophils. …”
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Insights on Natural Membrane Characterization for the Rational Design of Biomimetic Drug Delivery Systems by Daniela Donghia, Sara Baldassari, Giuliana Drava, Giorgia Ailuno, Gabriele Caviglioli

“…They are composed of a complex lipid bilayer embedded with proteins, allowing them to perform multiple functions like maintaining the cell structure, regulating which substances enter or leave the cell, and intercellular communication. …”
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