Autologous Peripheral Blood-Derived Orthobiologics for the Management of Elbow Disorders: A Review of Current Clinical Evidence by Ashim Gupta, Filippo Migliorini, Tommaso Bardazzi, Nicola Maffulli

“…Conclusions The current peer-reviewed published studies demonstrated that administering APBOs, including PL and ACS, might be safe and effective in reducing pain and improving function in patients with elbow disorders. …”
Get full text

EMOTIVE SPEECH ACTS IN CROSS-CULTURAL COMMUNICATION: A COMPREHENSIVE ANALYSIS AND EXPERIMENTAL STUDY by Kenul E. Abdurehmanova

“…Our data reveals that language learners develop what might be termed an “emotional interlanguage” — a dynamic system of emotional expression that incorporates elements from both their native emotional repertoire and the target language’s cultural norms. …”
Get full text

Identification of potential pathogenic genes associated with the comorbidity of rheumatoid arthritis and renal fibrosis using bioinformatics and machine learning by Jiao Qiu, Yalin Xu, Luyuan Tong, Xingchun Yang, Xiao Wu

“…Gene set enrichment analysis (GSEA) clarified the potential biological pathways through which BIRC3 and PSMB9 might function in RF. The constructed miRNA-TF-mRNA regulatory network provided a comprehensive overview of the post-transcriptional and transcriptional regulatory mechanisms. …”
Get full text

GINS1 facilitates the development of lung adenocarcinoma via Wnt/β-catenin activation by Luyuan Ma, Rongyang Li, Pengyong Li, Wenhao Yu, Zhanpeng Tang, Libo Si, Hui Tian

“…GINS1 has a significant regulatory function in DNA replication. It is overexpressed in various malignant tumors, but the specific molecular mechanisms of GINS1 in LUAD pathogenesis are not fully elucidated. …”
Get full text

Association between gut microbiota in HIV-infected patients and immune reconstitution following antiretroviral therapy (ART) by Yuru Shi, Miaomiao Hu, Jing Wu, Ting Liu, Yingjie Qi, Ang Li

“…Based on the observed immune function reconstruction, we further categorized the ART(+) group into a responder group (n = 30) and a non-responder group (n = 20). …”
Get full text

Exaggerated IL-15 and Altered Expression of foxp3+ Cell-Derived Cytokines Contribute to Enhanced Colitis in Nlrp3−/− Mice by Simon A. Hirota, Aito Ueno, Sarah E. Tulk, Helen M. Becker, L. Patrick Schenck, Mireille S. Potentier, Yan Li, Subrata Ghosh, Daniel A. Muruve, Justin A. MacDonald, Paul L. Beck

“…In the current study, we sought to determine how the loss of NLRP3 might be altering the function of regulatory T cells, a major source of IL-10. …”
Get full text

PPAR-α Agonist Fenofibrate Upregulates Tetrahydrobiopterin Level through Increasing the Expression of Guanosine 5′-Triphosphate Cyclohydrolase-I in Human Umbilical Vein Endothelial... by Jinbo Liu, Changlin Lu, Fuwang Li, Haining Wang, Liyun He, Yanting Hao, Alex F. Chen, Huijie An, Xian Wang, Tianpei Hong, Guang Wang

“…These results suggested that fenofibrate might help protect endothelial function and against atherosclerosis by increasing level of BH4 and decreasing production of ROS through upregulating the level of intracellular GTPCH-I.…”
Get full text

Metabolic Syndrome Alters the Cargo of Mitochondria-Related microRNAs in Swine Mesenchymal Stem Cell-Derived Extracellular Vesicles, Impairing Their Capacity to Repair the Stenotic... by Rahele A. Farahani, Xiang-Yang Zhu, Hui Tang, Kyra L. Jordan, Amir Lerman, Lilach O. Lerman, Alfonso Eirin

“…However, only MetS-EVs failed to improve renal mitochondrial density, structure, and function or attenuate oxidative stress, tubular injury, and fibrosis. …”
Get full text

The Gut Microbiome of the Asiatic Toad (Bufo gargarizans) Reflects Environmental Changes and Human Activities by Xuena Kang, Meiying Shao, Jiyang Jiang, Lewei He, Yunwei Lu, Jiarong Song, Jue Xu, Zhenxin Fan

“…There were significant differences in the composition and function of the gut microbiome among the samples from the three different habitats. …”
Get full text

Sensory innervation in the prostate and a role for calcitonin gene-related peptide in prostatic epithelial proliferation by Hanyu Xia, Hanyu Xia, Travis J. Jerde, Travis J. Jerde, Jill C. Fehrenbacher, Jill C. Fehrenbacher, Jill C. Fehrenbacher, Jill C. Fehrenbacher

“…In addition to the dense innervation of the prostate, we found that Calca haploinsufficiency, the genotype control for our intersectional ablation model, results in a diminished level of Ki67 staining in the stromal compartment of the dorsal lobe and a diminishing Ki67 trend in other lobes.DiscussionThese findings suggest that sensory neurons might have developmental or homeostatic effects within the prostate. …”
Get full text

Infection with novel duck reovirus induces stress granule and methylation-mediated host translational shutoff in Muscovy ducklings by Tao Yun, Jionggang Hua, Liu Chen, Weicheng Ye, Zheng Ni, Yinchu Zhu, Cun Zhang

“…We discovered a new function for NDRV HN10 in translational shutoff by recruiting m6A-modified RNA into stress granules located in the Fabricius bursa of Muscovy ducklings.…”
Get full text

Deep brain stimulation of pallidal versus subthalamic for patients with Parkinson's disease: a meta-analysis of controlled clinical trials by XU F, MA W, HUANG Y, QIU Z, SUN L

“…After DBS, the pooled WMD of LED and BDI were −254.48 (95% CI =−341.66) and 2.29 (95% CI =0.83 to 3.75), respectively.Conclusion: These results indicate that during the off-medication state, the STN-DBS might be superior to GPi-DBS in improving the motor function and activities of daily living for PD patients; but during the on-medication state, the opposite result is observed. …”
Get full text

Fetuin-A Can Assess the Severity of Alcohol-Related Liver Disease by Musa Salmanoğlu, İrfan Küçük, Süleyman Baş

“…<i>Conclusions</i>: In ALD patients, decreased SFA levels, which exhibit disease severity, might be an auxiliary biomarker for the follow-up of AC patients.…”
Get full text

The Potential Mechanism of Curcumin in Treating Oral Squamous Cell Carcinoma Based on Integrated Bioinformatic Analysis by Wu Siyuan, Lv Xiaozhi, Wu Jialin, Haigang Wei, Shiwei Liu, Chen Zou, Jing Song, Li Xia, Ai Yilong

“…The enrichment analysis suggested that response to oxidative stress, epithelial cell proliferation, and AGE/RAGE pathway might involve in the effect of curcumin on OSCC. …”
Get full text

Drought-tolerant fungal microbes, Aspergillus oryzae and Aspergillus fumigatus, elevate physiohormonal and antioxidant responses of maize under drought stress by Kiran Niaz, Mamoona Rauf, Muhammad Arif, Muhammad Hamayun, Humaira Gul, Abeer Hashem, Elsayed Fathi Abd_Allah, Qiang-Sheng Wu

“…SAB and CBW modulated the expression of the ZmBSK1, ZmAPX, and ZmCAT1 genes in the maize shoot and root tissues under drought stress vs. control, signifying an essential regulatory function for SAB/CBW-induced drought stress tolerance via phytohormonal signaling pathway leading to the antioxidant upregulation.DiscussionThese findings imply that the exogenous administration of the SAB/CBW consortium might be a rather efficient strategy that contributes to optimizing the physio-hormonal attributes and antioxidant potential to alleviate the drought stress in maize.…”
Get full text

A case of complete atrioventricular septal defect in which extracorporeal membrane oxygenation could be removed after performing the bilateral Glenn procedure for severe cardiac dy... by Hiroki Ishii, Yu Matsumura, Yuji Hamamichi, Yuya Komori, Naoki Wada, Tadahiro Yoshikawa

“…After the bilateral Glenn procedure, the patient’s cardiac contractile function improved, and she could be taken off ECMO. …”
Get full text

KEAP1 promotes anti-tumor immunity by inhibiting PD-L1 expression in NSCLC by Jinghan Li, Daiwang Shi, Siyi Li, Xiang Shi, Yu Liu, Yi Zhang, Gebang Wang, Chenlei Zhang, Tian Xia, Hai-long Piao, Hong-Xu Liu

“…Our results also suggest that KEAP1 agonist might be a potential clinical drug to boost anti-tumor immunity and improve immunotherapies in NSCLC.…”
Get full text

Nutritional Status and Lung Cavity in Pulmonary Tuberculosis Patient by Christi Giovani Anggasta Hanafi, Fariz Nurwidya, Wiji Lestari, Heidy Agustin, Shaogi Syam

“…Conclusion: This study found that malnutrition was associated with lung cavities in PTB patients. These findings might indicate how malnutrition impaired the immune function in PTB patients.…”
Get full text

Determinants of left atrial reservoir strain and diagnostic potential for cardiac amyloidosis in pathological left ventricular hypertrophy by Katsuji Inoue, Yasuhisa Nakao, Makoto Saito, Masaki Kinoshita, Haruhiko Higashi, Osamu Yamaguchi

“…Abstract Background Left ventricular (LV) long-axis shortening at the cardiac base is a determinant of left atrial (LA) reservoir function. Cardiac amyloidosis (CA) is characteristic of amyloid deposition predominantly in the LV basal wall. …”
Get full text

Metabolic Markers Demonstrate the Heterogeneity of Walking Ability in Non-Disabled Community-Dwelling Older Adults by Shanshan Yao, Ziling Mao, Megan M. Marron, Eleanor M. Simonsick, Venkatesh L. Murthy, Ravi V. Shah, Anne B. Newman

“…<b>Conclusions</b>: Metabolites linked to the TCA cycle and energy metabolism, as well as inflammation and protein catabolism, were related to mobility function. Some metabolites might be particularly important for the early detection of older adults at risk of mobility decline. …”
Get full text