Relationships between intensity, duration, cumulative dose, and timing of smoking with age at menopause: A pooled analysis of individual data from 17 observational studies. by Dongshan Zhu, Hsin-Fang Chung, Nirmala Pandeya, Annette J Dobson, Janet E Cade, Darren C Greenwood, Sybil L Crawford, Nancy E Avis, Ellen B Gold, Ellen S Mitchell, Nancy F Woods, Debra Anderson, Daniel E Brown, Lynnette L Sievert, Eric J Brunner, Diana Kuh, Rebecca Hardy, Kunihiko Hayashi, Jung Su Lee, Hideki Mizunuma, Graham G Giles, Fiona Bruinsma, Therese Tillin, Mette Kildevæld Simonsen, Mette Kildevæld Simonsen, Hans-Olov Adami, Elisabete Weiderpass, Marianne Canonico, Marie-Laure Ancelin, Panayotes Demakakos, Gita D Mishra

“…If the toxic impact of cigarette smoking on ovarian function is irreversible, we hypothesized that even former smokers might experience earlier menopause, and variations in intensity, duration, cumulative dose, and age at start/quit of smoking might have varying impacts on the risk of experiencing earlier menopause.…”
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Pulsed Low-Intensity Focused Ultrasound (LIFU) Activation of Ovarian Follicles by Yan Xiao, Lixia Yang, Yicong Wang, Yu Wang, Yuning Chen, Wenhan Lu, Zhenle Pei, Ruonan Zhang, Yao Ye, Xiaowei Ji, Suying Liu, Xi Dong, Yonghua Xu, Yi Feng

“…<italic>Objective:</italic> A biological system&#x0027;s internal morphological structure or function can be changed as a result of the mechanical effect of focused ultrasound. …”
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Decision-Making Impairments in Patients with Parkinson’s Disease by Matthias Brand, Kirsten Labudda, Elke Kalbe, Rüdiger Hilker, David Emmans, Gerd Fuchs, Josef Kessler, Hans J. Markowitsch

“…Thus, strategic components besides feedback processing might influence decision-making in this task. We found that PD patients were impaired in the Game of Dice task performance and that the frequency of disadvantageous choices correlated with both executive functions and feedback processing. …”
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Role of IL-17 and Th17 Cells in Liver Diseases by Linda Hammerich, Felix Heymann, Frank Tacke

“…Indeed, initial studies in humans revealed activated Th17 cells and Th17-related cytokines in various liver diseases. However, functional experiments in mouse models are not fully conclusive at present, and the pathogenic contribution of Th17 cells to liver inflammation might vary upon the disease etiology, for example, between infectious and autoimmune disorders. …”
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Intrauterine Adhesions following Conservative Treatment of Uterine Fibroids by Pietro Gambadauro, Johannes Gudmundsson, Rafael Torrejón

“…In order to achieve a successful conservative treatment of fibroids, functional integrity of the uterus is as important as tumor removal or symptoms relief. …”
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Can Top Down Participatory Budgeting Work? The Case of Polish Community Fund by Dawid Sześciło, Bartosz Wilk

“…The purpose of this article is to determine when top down approach to PB might be welcomed, taking into account the characteristics of PB schemes all around the world that they emerged as local initiatives, instigated either by civil society groups or local governments. …”
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Inflation Targeting and Economic Growth in the Middle East and North Africa (MENA): empirical modeling using ARDL approach by Brahim Bouyacoub

“…The results show that Inflation Targeting can have several functions. It is a monetary policy framework based on an appropriate institutional architecture. …”
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The new perspective on understanding the mechanisms of cardiovascular diseases development by Ulyana Khovantseva, Diana Kiseleva, Vadim Cherednichenko, Deyyara Chakal, Denis Breshenkov, Yuliya Markina, Rustam Ziganshin, Eduard Charchyan, Alexander Markin

“…However, scientists have suggested that the main causes of the development of CVD might be functional disorders and phenotypic modulation of smooth muscle cells (SMCs) that make up the vascular wall. …”
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HISTORICAL-COMPARATIVE ANALYSIS OF THE BUREAUCRACY AT THE MAIN STAGES OF DEVELOPMENT OF PUBLIC AUTHORITY by I. V. Levakin

“…The task of searching for ways of debureaucratization of public authority (restrictions of negative manifestations, areas of work and functions of bureaucracy) might be accomplished with a historical and comparative methodology. …”
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Impacts of mitochondrial dysfunction on axonal microtubule bundles as a potential mechanism of neurodegeneration by Scott Murray-Cors, Milli Owens, Yu-Ting Liew, Maureece Day, William Cairns, Andreas Prokop

“…However, apart from ATP production, mitochondria have many other functions the aberration of which may impact neurons in very different ways. …”
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COMPARISON OF INOTROPIC AND ANTIARRHYTHMIC ACTIVITY OF FLAVONOIDS — QUERCETIN, RUTIN AND (+)-CATECHIN by Sh. S. Khushmatov, R. R. Makhmudov, S. M. Mavlyanov

“…Also the action of the flavonoids might be related to the production of functional activity modulation of Na+ and Са2+-channels in cardiomyocytes.…”
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Ferroptosis in diabetic cardiomyopathy: from its mechanisms to therapeutic strategies by Meimei Tian, Xinli Huang, Min Li, Pingping Lou, Huijie Ma, Huijie Ma, Xinli Jiang, Yaru Zhou, Yan Liu

“…Diabetic cardiomyopathy (DCM) is defined as structural and functional cardiac abnormalities in diabetes, and cardiomyocyte death is the terminal event of DCM. …”
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Abnormal α-synuclein binds to synaptotagmin 13, impairing extracellular vesicle release in synucleinopathies by Yasuo Miki, Shuji Shimoyama, Makoto T. Tanaka, Hanae Kushibiki, Asa Nakahara, Xiaopeng Wen, Masanori Hijioka, Tomoya Kon, Megha Murthy, Tomonori Furukawa, Conceição Bettencourt, Fumiaki Mori, Hiroki Mizukami, Shirushi Takahashi, Mari Tada, Yoshihisa Kitamura, Akiyoshi Kakita, Thomas T. Warner, Koichi Wakabayashi

“…Our findings provide insights into therapeutic strategies for alleviating dysregulations of vesicular transport and synaptic function in patients with synucleinopathies.…”
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PIEZO1 variant implications for biological understanding and human health by Chew W. Cheng, Sophie L. Earle, Oleksandr V. Povstyan, Chloe Randall, Katie A. Smith, Marjolaine Debant, Fraser L. Macrae, Daniel G. Beech, Anna McGrane, Fiona Bartoli, Eulashini Chuntharpursat-Bon, Richard M. Cubbon, Kathryn J. Griffin, Marc A. Bailey, Antreas C. Kalli, Lara C. Morley, Klaus K. Witte, David J. Beech

“…When these channels are activated by force, cell membrane permeability to calcium ions and other ions increases rapidly, coupling force to cell function through ionic control. In humans and other species, PIEZO1 is both widely expressed and functional across major systems that include the cardiovascular, haematological and musculoskeletal systems, thereby serving diverse needs. …”
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Analysis of brain dynamics changes in patients with cerebral small vessel disease-related cognitive impairment based on electroencephalogram microstates by Xin Jin, Yanru Zhou, Diwen Zhang, Xiu Chen, Jianghai Ruan, Dengfu Fang

“…Over time, cognitive decline related to CSVD might evolve into dementia. This study aims to explore the changes in brain functional networks of CSVD patients with cognitive impairment through microstate analysis of resting-state electroencephalogram, and to investigate the association between these changes and cognitive dysfunction. …”
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Comparative midterm results of surgical mitral valve replacement and transcatheter mitral valve replacement with the Tendyne SystemCentral MessagePerspective by Andrea Colli, MD, PhD, Cristina Di Franco, MD, Federico Giorgi, MD, Giosuè Falcetta, MD, Danilo Ruggiero, MD, Michele Celiento, MD, Giacomo Ravenni, MD, Riccardo Morganti, Stat Sci, Laura Besola, MD

“…However, TMVR resulted in a lower postoperative complication rate and faster recovery. Therefore, TMVR might be a possible alternative to surgery for selected high-risk patients.…”
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Free Triiodothyronine Concentrations Are Inversely Associated with Microalbuminuria by Yulin Zhou, Lei Ye, Tiange Wang, Jie Hong, Yufang Bi, Jie Zhang, Baihui Xu, Jichao Sun, Xiaolin Huang, Min Xu

“…Thyroid function and microalbuminuria are both associated with vascular disease and endothelial damage. …”
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The extracellular matrix protein type I collagen and fibronectin are regulated by β-arrestin-1/endothelin axis in human ovarian fibroblasts by Ilenia Masi, Flavia Ottavi, Valentina Caprara, Danila Del Rio, Martina Kunkl, Francesca Spadaro, Valerio Licursi, Loretta Tuosto, Anna Bagnato, Laura Rosano’

“…Targeting ET-1 signaling with ETAR/ETBR antagonists might interfere with the ability of CAFs to produce key ECM proteins in this tumor.…”
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Interleukin Family-Based Signature Relates to Cancer-Associated Fibroblasts Spatial Distribution and Immune Therapy Response in Pancreatic Carcinoma by Cheng Y, Xiao S, Li X, Wang B, Lei Y, Sun P, Ma L, Zhu Y

“…IL high-risk group also exhibited increased apCAF/tumor cell and apCAF/Tregs engagement, resulting in suppressed immune responses, crippled T-cell function and B-cell function, and elevated levels of biomarkers associated with poor immune response.Conclusion: This study constructed the first IL expression pattern related to CAFs infiltration, immunotherapy response, and prognosis in PC patients. …”
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Checkpoint immunotherapy is associated with preferential activation of tumor antigen–specific CD4+ T cells in MDS by Elizabeth A. Griffiths, Pragya Srivastava, Eduardo Cortes Gomez, Junko Matsuzaki, Kunle Odunsi, Laura W. Dillon, Devdeep Mukherjee, Christopher S. Hourigan, Jacqueline Peng, Shovik Bandyopadhyay, Kai Tan, Kristopher M. Attwood, Joseph B. Kuechle, Prashant K. Singh, Jianmin Wang, Michael J. Nemeth

“…Approaches to augment the number and function of cDC1 populations in myeloid disease might overcome this defect and enhance the efficacy of immunotherapy for patients with MDS. …”
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