Our Experiences and Learnings in Diagnosing MODY from Non-Institutional-Based Diabetes Care Clinics by Arunkumar R. Pande, Santosh Chaubey, Dinesh Kumar, Kumar P. Chandra, Thenral Geetha, Akshita Sharma

“…Introduction: Maturity-onset diabetes of the young (MODY) is a rare group of disorders characterised by impaired functions or development of pancreatic islets and monogenic diabetes at a young age. …”
Get full text

A Successful Nodular Basal Cell Carcinoma Defect Closure On The Mid-Cheek Using Modified Mini Cheek Advancement Flap by Widjaya MRH, Koswara T

“…Wide local excision might be an effective treatment option for BCC and is usually followed by a surgical defect reconstruction procedure. …”
Get full text

Neurophysiological underpinnings of balance control and cognitive-motor interaction in early Parkinson’s disease by Manca Peskar, Paolo Manganotti, Uros Marusic, Klaus Gramann

“…Participants with PD exhibited reduced postural sway compared to controls, and postural sway was lower in DT as opposed to ST. Reduced sway in PD might be attributed to postural rigidity and tonic muscle activation, while in the DT, it might reflect resource conflicts. …”
Get full text

Astrocyte Hypertrophy Contributes to Aberrant Neurogenesis after Traumatic Brain Injury by Clark Robinson, Christopher Apgar, Lee A. Shapiro

“…Astrocytes are important in maintaining the integrity of neuronal functioning, and it is possible that astrocyte hypertrophy after TBIs might contribute to pathogenesis. …”
Get full text

Comparative genome analysis of two peanut Ralstonia solanacearum strains with significant difference in pathogenicity reveals 16S rRNA dimethyltransferase RsmA involved in inducing... by Xiaodan Tan, Huiquan Tang, Dong Yang, Jinling Huang, Yushuang Wu, Junyi Yu, Jiajun Chen, Qiang Wang, Ruixue Yang, Xiaorong Wan, Yong Yang

“…In this study, comparative genomics analysis was performed to reveal the difference of the genomes between ZKRS126 and ZKRS146, as well as the function of the strain specific gene rsmA in triggering immunity. …”
Get full text

The Small GTPase Ran Increases Sensitivity of Ovarian Cancer Cells to Oncolytic Vesicular Stomatitis Virus by Karen Geoffroy, Mélissa Viens, Emma Mary Kalin, Zied Boudhraa, Dominic Guy Roy, Jian Hui Wu, Diane Provencher, Anne-Marie Mes-Masson, Marie-Claude Bourgeois-Daigneault

“…The small guanosine triphosphatase (GTPase) Ras-related nuclear protein (Ran) has been reported to be highly expressed in high-grade serous ovarian cancers (HGSOCs) and associated with poor outcomes. Blocking Ran function or preventing its expression were shown to be promising treatment strategies, however, there are currently no small molecule inhibitors available to specifically inhibit Ran function. …”
Get full text

Pathogenicity of psychrotolerant strains of Antarctic Pseudogmynoascus fungi reveals potential opportunistic profiles by Eldon Carlos Queres Gomes, Vívian Nicolau Gonçalves, Marliete Carvalho da Costa, Gustavo José Cota de Freitas, Daniel Assis Santos, Susana Johann, Jefferson Bruno Soares Oliveira, Tatiane Alves da Paixão, Peter Convey, Luiz Henrique Rosa

“…Survival of BALB/c mice was affected, with oscillations between weight gain and loss, and impacts on sensory function, reflexes and autonomic function. Histopathological data from the organs of infected mice showed evidence of inflammatory processes, with numerous neutrophils, a small number of macrophages, fluid accumulation inside the lungs and intense hyperemia. …”
Get full text

Fine particulate matter (PM2.5) induces microRNA-192–5p causing glomerular damage by Melina Yarbakht, George Sarau, Yanyi Xu, Xinyi Fang, Zeynab Mirzaei, René Krüger, Yalan Xiao, Arslan Usman, Christoph Daniel, Mario Schiffer, Silke Christiansen, Janina Müller-Deile

“…Therefore, air pollution might be involved in developing MGN through inflammatory pathways and the induction of microRNA-192–5p, which targets gene expression important for glomerular cell function.…”
Get full text

Theoretical Study of Pentacoordinated Lanthanide Single-Ion Magnets via Ab Initio Electronic Structure Calculation by Yu-Xi Wang, Yu-Fei Wang, Bing Yin

Get full text

Removal of 2-chlorophenol from aqueous system by adsorption over maize husk by Md. M.H. Mondol, Md. I. Khalil, Md. N. Amin

“…The adsorption process was found to be exothermic in nature, and the adsorption mechanism might be explained by hydrogen and electrostatic force of interaction between the functional group of MH and 2-CP, along with some contribution of Van der Waals force. …”
Get full text

ME/CFS in Adolescents — Study Review by Justyna Szrajda

“…Anxiety might co-occur with ME/CFS in adolescents. Supportive therapy for comorbidities could be considered, if needed. …”
Get full text

Identification and Validation of Autophagy-Related Genes in Primary Ovarian Insufficiency by Gene Expression Profile and Bioinformatic Analysis by Siji Lv, Jiani Sun, Jing Sun

“…Totally, 6 genes were selected as candidate hub genes which might correlate with the process of primary ovarian insufficiency. …”
Get full text

Human Adipose Tissue Metabolism in Obesity by Shuhao Lin, Michael D. Jensen

“…In this review, we discuss the structure of adipose tissue, how normal and abnormal adipose tissue metabolism contributes to metabolic diseases, and how inflammation might or might not play a role in adipose tissue insulin resistance.…”
Get full text

Approaching the pygmy dipole resonance in Sn isotopes with the Oslo method by Markova Maria, Larsen Ann-Cecilie, Bello Garrote Frank Leonel

“…The γ-ray strength functions (GSF) and nuclear level densities (NLD) below the neutron separation energy were extracted for 111−113,116−122,124Sn from particle-γ coincidence data with the Oslo method in a model consistent way. …”
Get full text

The upside of epilepsy: Theories of an evolutionary paradox by Alyssa Ailion, Christoph Helmstaedter, Annamaria Vezzani, Matthias J. Koepp

“…Endogenous analgesic, anti‐depressant, and inflammatory mechanisms able to repair compromised functions can offer advantages in unexpected crises. …”
Get full text

Host plants selection of Centranthera grandiflora Benth. and nontargeted metabolomics analysis of its parasitic and non-parasitic samples. by Song Jin, Yuchuan Li, Jun Ni, Haili Xie, Falin Lei, He Liu

“…(C. grandiflora for short) might be a root hemiparasitic plant. The experiments of mixed sowing of C. grandiflora and 9 companion plants that might be hosts were conducted, and the growth, biological yield and other indexes were observed. …”
Get full text

Augmenting neurocognitive remediation therapy to Preventive Cognitive Therapy for partially remitted depressed patients: protocol of a pragmatic multicentre randomised controlled t... by Huibert Burger, Claudi Bockting, Marlies Brouwer, Gert J Geurtsen, Amanda M Legemaat, Johanne G J van der Stappen, Maria Semkovska, Isidoor O Bergfeld, Nicoline Lous, Damiaan A J P Denys

“…Brief psychological interventions such as preventive cognitive therapy (PCT) can reduce depressive symptoms or relapse for patients in partial remission, although achieving full remission with treatment is still a clinical challenge. Treatment might be more effective if cognitive functioning of patients is targeted as well since cognitive problems are the most persisting symptom in partial remission and predict poor treatment response and worse functioning. …”
Get full text

Follicle-like and other novel structures found in ovaries of aged white rhinoceroses and their potential impact on oocyte recovery rate by R. Appeltant, R. Hermes, S. Holtze, T.B. Hildebrandt, S.A. Williams

“…It remains to be investigated whether FLS might be present on ovaries from other rhinoceros species and whether they might serve as a general indicator for oocyte recovery success in aged females.…”
Get full text

Comparative RNA-Seq analysis of differentially expressed genes in the sertoli cells of yak and cattle-yak by Xue-Mei Chen, Ming-Xiu Wang, Peng Zhang, Ke-Min Jing, Bing-Lin Yue, Zhi-Juan Wu, Zhi-Xin Chai, Xin-Rui Liu, Jin-Cheng Zhong, Xin Cai

“…Conclusions Compared with yak Sertoli cells, the expression of genes related to protein activation, cell function, and membranous organelle composition in cattle-yak Sertoli cells appeared to be abnormal. …”
Get full text

Differentially expressed microRNAs in pre-transplant lung biopsies target immune checkpoint proteins and can predict primary graft dysfunction in lung transplantation by Vitale Miceli, Pia Ferrigno, Claudio Centi, Claudia Carcione, Gioacchin Iannolo, Valentina Agnese, Giovanna Lo Iacono, Rosa Liotta, Pier Giulio Conaldi, Massimo Pinzani, Lavinia De Monte, Alessandro Bertani

“…Additionally, the use of compounds that can modulate the function of these molecules could be evaluated for the management of LTx patients.…”
Get full text