Mast cell tryptase-PAR2 axis promotes ovarian fibrosis through RNF152-mediated stabilization of Bcl-xL. by Xiang Zhang, Jun Zhang, Chaojun Wang

“…C57BL/6 female mice were intraperitoneally injected with 10 mg/kg cromolyn (n = 20 per group) or sterile saline (n = 20 per group) at two days before cisplatin treatment to assess the effect of cromolyn sodium on ovarian function and fibrosis. The ovaries of each mouse were collected for histological examination and collagen levels analysis. …”
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Multitracer Positron Emission Tomographic Imaging of Exogenous Gene Expression Mediated by a Universal Herpes Simplex Virus 1 Amplicon Vector by Christiane Kummer, Alexandra Winkeler, Claus Dittmar, Bernd Bauer, Maria Adele Rueger, Benedikt Rueckriem, Michael T. Heneka, Stefan Vollmar, Klaus Wienhard, Cornel Fraefel, Wolf-Dieter Heiss, Andreas H. Jacobs

“…To develop efficient and safe gene therapy approaches, the herpes simplex virus type 1 thymidine kinase gene (HSV-1- tk ) has been shown to function as a marker gene for the direct noninvasive in vivo localization of thymidine kinase (TK) expression by positron emission tomography (PET) using radiolabeled nucleoside analogues as specific TK substrates. …”
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Macrophage immune modulation: TGF-β1's influence on IL-1β dynamics in dengue virus infection by Javier Serrato Salas, Brenda Ramírez Agüero, José Luis Montiel Hernández, Judith González Christen

“…Conclusions: these findings suggest that DENV might regulate TGF-β1 function in macrophages. Negative regulation of the TGF-β1 pathway is potentially a mechanism by which DENV evades the immune response. …”
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Magnesium-related gene ITGAL: a key immunotherapy predictor and prognostic biomarker in pan-cancer by Fengjie Lin, Hanxuan Yang, Zongwei Huang, Ying Li, Qin Ding, Yunbin Ye, Yunbin Ye, Sufang Qiu

“…BackgroundIntegrin subunit alpha L (ITGAL) is crucial for activating CD8+ T cells through magnesium-mediated immune synapse formation and specific cytotoxicity. ITGAL might exert an important function in the growth and transformation of cancer.MethodsOur study comprehensively analyzed ITGAL expression across various cancers, validated by Immunochemistry (IHC) in the laboratory. …”
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The role of HMOX1-mediated ferroptosis in blue light-induced damage to retinal pigment epithelium by Chunyi Ji, Yiqi Wang, Yahan Ju, Siwei Liu, Xirui Chen, Jiajing Wang, Na Sun, Zhimin Tang, Ping Gu, Jing Ji

“…In mice, treatment with ZnPP effectively rescued RPE degeneration and visual function. These results highlighted that HMOX1-mediated ferroptosis might be a potential target for protection against blue light-induced damage to RPE cells.…”
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Astrocytes phenomics as new druggable targets in healthy aging and Alzheimer’s disease progression by Daniele Lana, Filippo Ugolini, Ludovica Iovino, Selene Attorre, Maria Grazia Giovannini

“…The morphological and functional heterogeneity of astrocytes in different brain regions may be related to their different housekeeping functions. …”
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Inflammation and cancer cell survival: TRAF2 as a key player by Adriana Albini, Luisa Di Paola, Giampiero Mei, Denisa Baci, Nicola Fusco, Giovanni Corso, Douglas Noonan

“…Targeting TRAF2 or TRAF2-dependent signaling pathways might represent a promising anti-cancer therapeutic strategy.…”
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Beyond individual barriers and facilitators: Digital interventions to address diabetes in urban Ghana by Ethan Gray, Ann Blandford, Samuel Amon, Publa Antwi, Vida Asah-Ayeh, Raphael Baffour Awuah, Leonard Baatiema, Sandra Boatemaa Kushitor, Hassan Haghparast-Bidgoli, Hannah Maria Jennings, Irene Akwo Kretchy, Daniel Strachan, Megan Vaughan, Edward Fottrell

“…Conclusion Our findings challenge the widespread assumption that digital interventions should be targeted at the individual; rather, digital tools might be used to empower community leaders in Ga Mashie with training and clinical guidance to function as healthcare agents, scaling-up the delivery of education and screening services to their broader community. …”
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PIK3R1, SPNB2, and CRYAB as Potential Biomarkers for Patients with Diabetes and Developing Acute Myocardial Infarction by Yue Zheng, Yuheng Lang, Zhenchang Qi, Wenqing Gao, Xiaomin Hu, Tong Li

“…We aimed to investigate the differentially expressed genes (DEGs) that might be potential targets for DM patients with AMI. …”
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Analgesic Efficacy of Bromelain and Bromelain Plus Turmeric for Pain Control After Orthodontic Separator Placement: A Triple‐Blind Randomized Clinical Trial by Shabnam Ajami, Seyyed Hadi Hosseini, Neda Babanouri, Zahra Hashemi

“…Conclusions Bromelain with or without turmeric might be a useful alternative to Ibuprofen for pain control following orthodontic separator placement.…”
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Early postnatal exposure to bicuculline modulates E/I balance and induces ASD-like behavioral phenotypes in mice by Dongpil Shin, Eunbi Cho, Kwanghoon Park, ChiHye Chung, Dong Hyun Kim, Se Jin Jeon, Chan Young Shin

“…Nevertheless, these results suggest that GABAergic signaling disruption during the neonatal period might contribute to ASD-related brain pathophysiological changes.…”
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Physiological and transcriptomic analysis of the effect of overexpression of the NTPIP2;4 gene on drought tolerance in tobacco by Xu Luo, Yuanshuai Shi, Jie Tan, Tao Long, Juntao Song, Yang Liu

“…This study demonstrates that overexpression of NtPIP2;4 gene can enhance the drought resistance of tobacco plants, which will provide a basis for the research on the function of tobacco NtPIP2;4 gene and the creation of new germplasm resources.…”
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Institutional governance and responsiveness to antimicrobial resistance: a qualitative study of Australian hospital executives by Alex Broom, Jennifer Broom, Katherine Kenny, Pamela Konecny, Jeffrey J. Post

“…Data were analysed using the framework approach.Setting Two metropolitan tertiary-referral hospitals in Australia.Participants Twenty hospital managers and executives from the organisational level of department head and above, spanning a range of professional backgrounds and in both clinical and non-clinical roles, and different professional streams were represented.Results Thematic analysis demonstrated three key domains which managers and executives describe, and which might function to delimit institutional responsiveness to present and future AMR solutions. …”
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Decreased expression of p53 is associated with down expression of zyxin in breast cancer by Rezvan Rostampour, Kiana Bahremand, Hossein Mohammadi, Seyed Askar Roghani, Ebrahim Shakiba, Mohammad Taghi Goodarzi, Soheila Asadi

“…Conclusion Based on our observation, ZYX might have a tumor suppressor role and is associated with p53.…”
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Interaction between glutathione S‐transferase M1‐null/present polymorphism and adjuvant chemotherapy influences the survival of breast cancer by Shuang Li, Guan‐Tian Lang, Ying‐Zhou Zhang, Ke‐Da Yu, Zhi‐Ming Shao, Qiang Zhang

“…It is suggested that the GSTM1‐present genotype might prevent progression in breast cancer patients. …”
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Cold atmospheric plasma control metabolic syndromes via targeting fat mass and obesity-associated protein by Xiaofeng Dai, Shuo Feng, Tian Li

“…We also emphasized the need of intensive investigations in exploring the feasibility of using CAP in treating obesity and associated metabolic syndromes that might function through targeting FTO.…”
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Regulation of L-Lactate in Glutamate Excitotoxicity Under Cerebral Ischemia: Pathophysiology and Preventive Strategy by Mao Zhang, Yanyan Wang, Zili Gong, Wen Jiang, Guodong Ge, Hong Guo

“…Therefore, regulation of L-lactate in glutamate signaling in the CNS might become a preventive target for cerebral ischemia.…”
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Lactobacillus plantarum AR495 improves stress-induced irritable bowel syndrome in rats by targeting gut microbiota and Mast cell-PAR2-TRPV1 signaling pathway by Hongyun Zhang, Guangqiang Wang, Zhiqiang Xiong, Zhuan Liao, Yangyan Qian, Xin Song, Li Sui, Lianzhong Ai, Yongjun Xia

“…In total, L. plantarum AR495 might reduce visceral sensitivity through the Mast cell-PAR2-TRPV1 signaling pathway by maintaining the homeostasis of the intestinal barrier.…”
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Microarray analysis of gene expression by skeletal muscle of three mouse models of Kennedy disease/spinal bulbar muscular atrophy. by Kaiguo Mo, Zak Razak, Pengcheng Rao, Zhigang Yu, Hiroaki Adachi, Masahisa Katsuno, Gen Sobue, Andrew P Lieberman, J Timothy Westwood, D Ashley Monks

“…Notably, patterns of gene expression typical of loss of AR function were observed in all three models, as were alterations in genes involved in cell adhesion, energy balance, muscle atrophy and myogenesis. …”
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Vitamin D and Osteoporosis in HIV/HCV Coinfected Patients: A Literature Review by Paola Di Carlo, Lucia Siracusa, Giovanni Mazzola, Piero Colletti, Maurizio Soresi, Lydia Giannitrapani, Valentina Li Vecchi, Giuseppe Montalto

“…We found that vitamin D deficiency might influence liver disease progression in HIV/HCV coinfected patients. …”
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