A comparison between virus- versus patients-centred therapeutic attempts to reduce COVID-19 mortality by Serge Camelo, Mathilde Latil, Sam Agus, Waly Dioh, Stanislas Veillet, René Lafont, Pierre J. Dilda

“…We also discuss the therapeutic options that might further reduce death rates associated with the disease in the future. …”
Get full text

The protective effect of carnosic acid on dextran sulfate sodium-induced colitis based on metabolomics and gut microbiota analysis by Changhui Du, Zhenjie Li, Jing Zhang, Ni Yin, Lirong Tang, Jie Li, Jingyin Sun, Xiaoqing Yu, Wei Chen, Hang Xiao, Xian Wu, Xuexiang Chen

“…Changes in gut microbiota and the correlated metabolites might partially explain CA’s anti-inflammatory effects against colitis. …”
Get full text

Effect of Butein, a Plant Polyphenol, on Apoptosis and Necroptosis of Prostate Cancer Cells in 2D and 3D Cultures by Yeji Lee, Changyeol Lee, Sang-Han Lee, Yoon-Jin Lee

“…Molecular mechanisms by which butein could affect cell viability, ROS levels, mitochondrial function, apoptosis, and necrosis in prostate cancer cells were investigated using 2D monolayer and 3D sphere culture systems. …”
Get full text

Academic Philosophy as a Way of Life by Eli Kramer, Marta Faustino, Hélder Telo

“…Preview: Over the past few decades, the idea of philosophy as a way of life (PWL) has gained undeniable prominence in contemporary debates about the nature and function of philosophy. Pierre Hadot forged the notion to denote the specific way in which ancient philosophers conceived of and practiced philosophy, stressing its performative character and its potential for self-transformation on the basis of what he called “spiritual exercises.” …”
Get full text

Minimization of proteome reallocation explains metabolic transition in hierarchical utilization of carbon sources by Zhihao Liu, Minghao Chen, Jingmin Hu, Yonghong Wang, Yu Chen

“…We hypothesized that in response to rapid environmental changes, cells might minimize reallocation of the proteome and accordingly adjust metabolism. …”
Get full text

Differences in Clinical Characteristics of Patients with Chronic Obstructive Pulmonary Disease (COPD) in Osijek and Zadar and Possible Association with Global DNA Methylation as an... by Eugenia Basioli Kasap, Ljubica Glavaš Obrovac, Marijana Jukić, Ivica Mihaljević, Ana Posavi, Sanda Škrinjarić Cincar

“…We hypothesized that COPD patients from two different Croatian regions might have clinical characteristics, quality of life, and global DNA methylation, which could be used as a possible epigenetic marker. …”
Get full text

The health care needs of multidimensional frail elderly patients with multimorbidity in primary health-care settings: a qualitative study by Linlin Zhao, Bingjie Chang, Qinghua Hu, Xiaolei Chen, Juan Du, Shuang Shao

“…In contrast, it is when increased psychological and social frailty has an impact on physical functioning that might drive patients to develop psychological and social demands. …”
Get full text

A systematic review and meta-analysis of unilateral versus bilateral pedicle screw fixation in transforaminal lumbar interbody fusion. by Xu-Qi Hu, Xin-Lei Wu, Cong Xu, Xu-Hao Zheng, Yong-Long Jin, Li-Jun Wu, Xiang-Yang Wang, Hua-Zi Xu, Nai-Feng Tian

“…Despite these findings, our meta-analysis was based on studies with small sample size and different study characteristics that might lead to the inconsistent results such as various functional outcomes among the included studies. …”
Get full text

Clinical events and patient-reported outcome measures in peritoneal dialysis by Aruni Malaweera, Louis L. Huang, Lawrence P. McMahon

“…Hypothesis We hypothesise that the POS-S renal score does not correlate with traditional markers of dialysis adequacy but that it might be associated with future outcomes including mortality, technique survival and hospitalisations. …”
Get full text

Genome-wide analysis of DnaJA proteins in Nicotiana tabacum reveals NtDnaJA3 responses to drought stress by Qiao Wang, Lijun Meng, Zechao Qu, Huan Su, Jiemeng Tao, Peng Lu, Chenfeng Hua, Jinbang Wang, Jianfeng Zhang, Peijian Cao, Jingjing Jin

“…Abstract Background DnaJA proteins, a prominent subfamily of the DnaJ family, function as molecular chaperones that respond to various external stresses. …”
Get full text

A novel missense variant of HS6ST2 gene in Paganini-Miozzo syndrome with a rare neurodevelopmental and Endocrine phenotypes by Meiling Zhang, Xiao Chang, Xiaoyun Du, Xiaoyun Du, Zhen Chen, Xinyue Zhang, Fucheng Cai

“…Comparison with previously reported cases revealed that different mutations might lead to different alternations in the function of HS6ST2 protein, resulting in distinct clinical phenotypes.…”
Get full text

Chronic active Epstein–Barr Virus infection in a teenage girl with suspect autoimmune Hepatitis by Wen-Yu Tseng, Shiu-Feng Huang, Chao-Yi Wu, Shih-Hsiang Chen, Chien-Chang Chen

“…An evaluation for impaired liver function showed positivity for EBV IgM, IgG, and early antigen (EBEA) antibodies. …”
Get full text

Heart abnormality classification using ECG and PCG recordings with novel PJM-DJRNN by Nadikatla Chandrasekhar, Sujatha Canavoy Narahari, Sreedhar Kollem, Samineni Peddakrishna, Archana Penchala, Babji Prasad Chapa

“…Then, the important features are selected using Poisson Distribution Function - Snow Leopard Optimization (PDF-SLO), and the PJM-DJRNN is used to classify the types of disease. …”
Get full text

Genome-Wide Ultrabithorax Binding Analysis Reveals Highly Targeted Genomic Loci at Developmental Regulators and a Potential Connection to Polycomb-Mediated Regulation. by Daria Shlyueva, Antonio C A Meireles-Filho, Michaela Pagani, Alexander Stark

“…The Drosophila melanogaster Hox factor Ultrabithorax (Ubx) directs the development of thoracic and abdominal segments and appendages, and loss of Ubx function can lead for example to the transformation of third thoracic segment appendages (e.g. halters) into second thoracic segment appendages (e.g. wings), resulting in a characteristic four-wing phenotype. …”
Get full text

Diagnosis and management of a giant retroperitoneal hematoma compressing the femoral nerve, following an ultrasound-guided lumbar sympathetic block: a case report by Yan Bai, Xinqiao Zhou, Lingqing Zeng, Xiaokai Zhou, Zhuqing Rao, Cunming Liu, Yinbing Pan, Xiaodi Sun

“…We considered that the femoral nerve might be compressed by a hematoma or abscess. An emergency percutaneous drainage was performed, resulting in partial symptom relief. …”
Get full text

Transcriptional profiles reveal physiological mechanisms for compensation during a simulated marine heatwave in Yellowtail Kingfish (Seriola lalandi) by Sharon E. Hook, Ryan J. Farr, Jenny Su, Alistair J. Hobday, Catherine Wingate, Lindsey Woolley, Luke Pilmer

“…In the muscle, numerous transcripts with mitochondrial function had altered abundance. There was a profound change to the regulation of transcription, as well as numerous transcripts with differential exon usage, suggesting that this may be a mechanism for conferring physiological resilience to heat stress. …”
Get full text

Heat shock protein 90 is a chaperone regulator of HIV-1 latency. by Somaya Noorsaeed, Nawal AlBurtamani, Ahmed Rokan, Ariberto Fassati

“…Hence to perturb latency, multiple pathways need to be simultaneously targeted without affecting CD4+ T cell function. Hsp90 has been shown to regulate HIV-1 latency, although knowledge on the pathways is limited. …”
Get full text

Different Long-Term Nutritional Regimens of <i>Drosophila melanogaster</i> Shape Its Microbiota and Associated Metabolic Activity in a Sex-Specific Manner by Repac Jelena, Trajković Jelena, Rakić Marija, Lunić Tanja, Savić Tatjana, Božić Bojan, Božić Nedeljković Biljana, Sofija Pavković-Lučić

“…Bacterial families of lower abundance also emerged as differentially present among the studied fly groups. Additionally, functional prediction provided initial clues into how nutrient availability might modulate the metabolic traits of adult fly microbiota in a sex-specific manner to meet host metabolic needs. …”
Get full text

BMSC-derived exosomes promote osteoporosis alleviation via M2 macrophage polarization by Yanbin Zhang, Jing Bai, Bin Xiao, Chunyan Li

“…This study aimed to clarify the regulatory function and molecular mechanism of BMSCs-derived exosomes in osteogenic differentiation and their potential therapeutic effects on osteoporosis. …”
Get full text

Augmentation cystoplasty in children with stages III and IV chronic kidney disease secondary to neurogenic bladder by Sanjay Sinha, Mehul Shah

“…Ureteric re-implantation might not be necessary.…”
Get full text