Targeted therapy for advanced forms of systemic mastocytosis in real clinical practice by D. I. Shikhbabaeva, O. Yu. Vinogradova, A. L. Neverova, M. M. Pankrashkina, M. V. Chernikov, E. O. Detkina, Yu. N. Kobzev, S. G. Malakho, V. V. Ptushkin

“…Advanced variants of systemic mastocytosis (aggressive systemic mastocytosis, systemic mastocytosis associated with hematological neoplasm, and mast cell leukemia) are characterized by infiltration of organs by mast cells, which leads to organs dysfunction. Such patients require a more active approach and the use of cytoreductive therapy. …”
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Ovarian Reserve: A Critical Indicator of Female Reproductive Health by Julia Ufnal, Anna Wolff, Maria Morawska, Dominika Lewandowska, Dominika Rosińska-Lewandoska, Marcelina Szewczyk, Klaudia Kożuchowska, Dawid Pilarz, Kinga Jarosz, Szymon Gruszka

“…Factors such as obesity, thyroid dysfunction and endometriosis significantly impact ovarian reserve. …”
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The aspirin resistance and platelets` receptors expression in chronic heart failure patients with type 2 diabetes mellitus by M. Yu. Kolesnyk, V. V. Syvolap

“…The presence of DM in CHF patients can dramatically increase platelet dysfunction. The problem is much complicated by high level of aspirin resistance in diabetic patients. …”
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AAV8 gene therapy for mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) in a patient's liver maintained ex situ for 9 days by Teresa Brevini, Lisa Swift, Helen Reynolds, John Ong, Richard Stopforth, Yogeshkumar Malam, Harry Spiers, AnnaPaterson, Adam Duckworth, Arthur Kaser, Vassillis Kosmoliaptsis, Ramon Marti, Jelle van den Ameele, Gwilym Webb, Christopher Watson, Andrew Butler, Fotios Sampaziotis

“…Introduction: Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is a rare genetic disorder caused by mutations in TYMP.1 This results in nucleoside accumulation, mitochondrial damage and progressive gastrointestinal and neurological dysfunction leading to cachexia and death before 40 years. …”
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The Functional State of the Myocardium in Patients with Ischemic Heart Disease, Diabetes Mellitus Type 2 and Cardiac Insufficiency by Horb Yu., Strona V., Komir I.

“…The earliest sign of myocardial damage in type 2 diabetes is the appearance of diastolic dysfunction of the left ventricle with subsequent dilatation of its cavity and the development of progressive heart failure and heart rhythm disorders. …”
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An Engineered Hierarchical Hydrogel with Immune Responsiveness and Targeted Mitochondrial Transfer to Augmented Bone Regeneration by Wenjin Cai, Shihua Mao, Ying Wang, Bicong Gao, Jiaying Zhao, Yongzheng Li, Yani Chen, Dong Zhang, Jintao Yang, Guoli Yang

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Hepatoprotective Therapy Efficacy in Obstructive Hepatobiliary Diseases: A Prospective Randomized Study by Mykhailo Maksymenko, Olexii Kulivets, Roman Havryliuk, Walery Zukow

“…Despite significant advances in interventional and surgical approaches, liver dysfunction associated with these disorders continues to substantially impact patient morbidity and mortality. …”
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Integrated Single-Cell and Spatial Transcriptomic Analysis Identifies ISR-Related Genes Driving Immune Regulation in Parkinson’s Disease by Jiang H, Zhang X, Feng S, Feng W

“…The integrated stress response (ISR), a conserved mechanism activated by cellular stress, has been linked to several neurological diseases, but its role in PD and the key ISR-related genes involved are still poorly understood.Materials and Methods: We used publicly available transcriptomic data from GEO, including single-cell RNA sequencing and spatial transcriptomics, to identify ISR-related genes involved in PD progression. …”
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The Role of qSOFA, Derived Neutrophil-to-Lymphocyte Ratio, MEWS, and PIRO Scores in Predicting the Severity of Odontogenic Infections in Young and Adult Patients by Serban Talpos Niculescu, Robert Avramut, Tareq Hajaj, Raluca Maracineanu, Antonis Perdiou, Roxana Talpos Niculescu, Marius Pricop, Horatiu Urechescu, Florin Urtila, Roxana Radu, Nicoleta Nikolajevic Stoican, Malina Popa

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ПСИХОТРОПНАЯ И АНТИОКСИДАНТНАЯ ТЕРАПИЯ В РЕАБИЛИТАЦИИ КАРДИОХИРУРГИЧЕСКИХ БОЛЬНЫХ by О. Ш. Ойноткинова, А. А. Спасский, А. П. Баранов, Е. А. Поддубская, Б. Л. Шкловский, Н. Ю. Лексина

“…This article marked one of the most significant problems of cardiology and cardiac surgery patients — mental and brain dysfunction. It was shown that depression is an independent risk factor for coronary heart disease and is associated with severe postoperative course. …”
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Memory Profiles after Unilateral Paramedian Thalamic Stroke Infarction: A Comparative Study by Antonio Carota, Herbert Neufeld, Pasquale Calabrese

“…The findings of this single case study suggest the possibility that the profile and severity of the executive dysfunction are determinant for the memory deficits and depend on from the side of the lesion. …”
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THE SYSTEMIC ELEMENT OF INFLAMMATION IN ASTHMA COMORBID WITH HYPERTENSION DISEASE by T. N. Zaripova, I. I. Antipova, I. N. Smirnova

“…Evaluation of the severity of inflammation at systemic level and its relation with clinical picture, lipid parameters, lipid peroxidation and antioxidant system (LP-AS) in bronchial asthma (BA) patients with comorbid arterial hypertension (AH).Material and methods. Totally, 77 BA and AH patients included. …”
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Left cardiac chambers after implantation of mitral valve prostheses “MIX”, “MEDINGE-2”, “KemCor”, and “PeriCor” by N. V. Rogulina, I. N. Sizova, E. V. Gorbunova

“…The exclusion criteria were aortal valve prosthesis, prosthesis dysfunction, and age under 18 years. Results and conclusion. …”
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Insights on acupuncture as a complementary method for therapeutic management of intervertebral disc diseases in dogs by Liliana Carpinisan, Gabriel Radbea, Domnica Bajinaru, Alina Ghise, Adrian C. Stancu, Petronela Mihaela Rosu, Denisa Sorescu

“…Intervertebral disc disease (IVDD) is a broad term, involving the degeneration of intervertebral disc structures and subsequent herniation of disc material in the spinal canal, but also clinical neurological disease due to disc herniation. …”
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Angiotensin receptor-1 antagonist eprosartan in patients with mild to moderate arterial hypertension by A. V. Shabalin, E. N. Gulyaeva, A. S. Krikovtsov

“…To study clinical effectiveness of eprosartan mesylate in treating patients with Stage I-II arterial hypertension (AH). Material and methods. In total, 28 patients (20 males, 8 females) with Stage I-II AH, risk 2-3, aged 28-56 years (mean age 40.0±1.3), were examined. …”
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Comparative study of the fluorescence spectrum of plasma proteins and red blood cells of blood in aging and drug addiction by A. I. Rabadanova, D. M. Bamatmurzaeva, V. R. Abdullaev, T. Razhabkadieva

“…Aging is accompanied by intensification of oxidative degradation of proteins, including lipoproteins, proteolytic system dysfunction and accumulation of oxidized proteins. Similar changes are found in drug addiction. …”
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USE OF ROSUVASTATIN AS A GEROPROTECTOR IN PEOPLE ENGAGED IN NATURAL GAS PRODUCING by A. T. Abdrashitova, T. N. Panova, I. A. Belolapenko, M. V. Frenkel

“…Prolong contact with manufacturing factors of gas producing, in particular hydrogen sulfide, results in dysfunction of various organs and systems, including immune system, which is involved in regulation of the aging process activity. …”
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Efficacy and safety of prolonged-release hyaluronic acid derivative vaginal application in the postpartum period: a prospective randomised clinical trial by Claudio Gustavino, Paolo Sala, Nadia Cusini, Brunella Gravina, Cecilia Ronzini, Diletta Marcolin, Valerio Gaetano Vellone, Michele Paudice, Rossella Nappi, Sergio Costantini, Simone Ferrero, Fabio Barra

“…Introduction In puerperium, the hypoestrogenic state induced by delivery and subsequently sustained by lactation may lead to vaginal dryness, burning, and itching sensation, contributing to the onset of sexual dysfunction.Material and methods This was a prospective, randomized, controlled, open-label study (NCT04560283) for evaluating the effects of application of a prolonged-release hyaluronic acid derivative vaginal gel in restoring sexual function during the postpartum period. …”
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Preemptive Analgesia with Nonsteroidal Anti-Inflammatory Drugs in the Perioperative Period by M. S. Danilov, I. S. Simutis, D. S. Salygina, E. G. Polovtsev, A. A. Syrovatsky, V. A. Ratnikov, A. A. Bogatikov, A. E. Karelov

“…More rare occurrence of renal dysfunction in Group 1 patients is indicative of lower nephrotoxicity of ibuprofen.…”
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Lysosome-Mitochondrial Crosstalk in Cellular Stress and Disease by Szilvia Kiraly, Jack Stanley, Emily R. Eden

“…The perception of lysosomes and mitochondria as entirely separate and independent entities that degrade material and produce ATP, respectively, has been challenged in recent years as not only more complex roles for both organelles, but also an unanticipated level of interdependence are being uncovered. …”
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