Percutaneous unilateral biportal endoscopic discectomy for symptomatic lumbar disc herniation in geriatric patients by Rongqing Qin, Rongqing Qin, Anhong Guan, Anhong Guan, Min Zhu, Pin Zhou, Bing Zhou, Bing Zhou, Ruihua Zhou, Ruihua Zhou, Zaiyong Guan, Zaiyong Guan

“…Only three cases were found to be complicated by low extremity numbness, all of which were recovered via conservative treatment in 3 weeks. …”
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A Closer Look at Periocular Necrotizing Fasciitis: A Systematic Review of Literature by David Oliver-Gutierrez, Elena Ros-Sanchez, Gloria Segura-Duch, Tirso Alonso, Miguel Ángel Arcediano, Alejandra Herranz-Cabarcos, Jessica Matas, Roberto Castro Seco, R. L. P. van der Veen, Anna Boixadera, José García-Arumí, Joan Oliveres

“…Bias on individual studies is low as they represent case reports or case series, and publication bias is partially addressed including all the large case series even if no individual data could be retrieved. …”
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Computational analysis of reproducibility and image quality of 2011 and 2017 models of Heidelberg Spectralis SD-OCT machines by Kyoung A Viola Lee, Corey Tesdahl, Keith Zimmerman, Kimberly Jun, Sabrina Khalil, Alexander Shahin, Abdullah Abou-Samra, Ramesh Ayyala, Radouil Tzekov

“…Heatmap analysis indicated greater inter-patient variability in the nasal retinal regions, while intra-patient variability was consistently low (<1%) across both devices. PCA and MDS plots affirmed the reproducibility of measurements. …”
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Development and validation of a clinical-friendly model for predicting 180-day mortality in the older with community-acquired pneumonia by Bingxuan Weng, Lixue Huang, Wenshu Jiao, Yuanqi Wang, Mengyuan Wang, Xuefeng Zhong, Xunliang Tong, Jin Jin, Yanming Li

“…Internal validation was performed using both bootstrap resampling and 10-fold cross-validation. The model was visualized by a nomogram and a questionnaire. The optimal cutoff value of the nomogram was determined based on the maximum Youden index for the 180-day mortality prediction, dividing patients into high- and low-risk groups. …”
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A Multidisciplinary Approach for the Assessment of the Last Surviving ‘Marrone di Chiusa Pesio’ Chestnut Trees in the Piemonte Region (Italy) by Giovanna Neirotti, Alessandro Tomatis, Federica Germanà, Alessia Imparato, Andrea Valisena, Maria Gabriella Mellano, Paola Ruffa, Dario Donno, Daniela Torello Marinoni, Gabriele Loris Beccaro, Giovanni Gamba

“…This study highlighted the value of a local chestnut cultivar, presenting the low conservation status of the few remaining specimens. …”
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Deep Learning–Driven Glaucoma Medication Bottle Recognition: A Multilingual Clinical Validation Study in Patients with Impaired Vision by Aidin C. Spina, BS, Christopher D. Yang, BS, Ayush Jain, BS, Christine Ha, BS, Lauren E. Chen, MD, Philina Yee, MD, Ken Y. Lin, MD, PhD

“…Patients with poor vision were selected on the basis of visual acuity (VA) of 20/70 or worse in 1 eye as per the California Department of Motor Vehicles' driver's license screening standard. …”
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Coupling antitoxins and blue/white screening with parAB/resolvase mutation as a strategy for Salmonella spp. plasmid curing by Dereje D. Gudeta, Shaohua Zhao, Nesreen Aljahdali, Steven L. Foley

“…Expression of bgaB from target plasmids can greatly facilitate visual detection of plasmid cured colonies avoiding time-consuming screening procedures. …”
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Safety and effectiveness of multimodal opioid-free anaesthesia for pain and recovery after laparoscopic surgery: a systematic review and meta-analysis by Jiang Liu, Li Jing, Lin Cheng, Sifan Qin, Xinyan Geng, Shirong Fang

“…I² coefficients were used to assess high, medium and low heterogeneity. RoB was used to assess the risk of bias of the included studies. …”
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LianChuang ZhiXue Liquid Enema Modulates the Macrophage Polarization of Ulcerative Colitis via Inhibiting the Jagged-1/Notch1 Signaling Pathway by Zhang Y, Liu J, Zhang D, Qian H

“…Zonula occludens-1 (Zo-1) Immunohistochemistry (IHC) and Hematoxylin-Eosin (HE) staining were performed to visualize the colon injury. ELISA was used to detect cytokines content in serum. …”
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Assessing the latest advances in bone marrow stem cell therapy for Avascular Necrosis hip: A comprehensive systematic review, meta-analysis, and meta-regression of randomized contr... by Robin Novriansyah, Tanti Ajoe Kesoema, Kevin Christian Tjandra, I Nyoman Sebastian Sudiasa, Shakira Amirah, Imke Maria Del Rosario Puling, Prudence Lucianus, Revina Maharani, Danendra Rakha Putra Respati, Laksmana Adi Krista Nugraha, Ismail Hadisoebroto Dilogo

“…Risk of bias assessment using RoB 2.0 tool revealed 70% of the RCTs were rated as having a low risk of bias, while 30% were judged to have some concerns. …”
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Short-term pre-meal whey protein microgel supplementation reduces postprandial glycemia and appetite in adults with overweight: An open-label randomised controlled trial by Ian J. Neeland, Kostas Tsintzas, Bo Ahrén, Robert J. Chilton, Ambra Giorgetti, Alric Mondragon, Rachel Ambiaux, Eugenia Migliavacca, David Philippe, Olivier Aprikian, Odd Erik Johansen

“…We assessed the effects of twice daily consumption of a low-dose non-gelling novel WP formulation (WP microgel [WPM]) on PPG, self-reported appetite, and ad-libitum food consumption. …”
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Systems analysis and improvement to optimize opioid use disorder care quality and continuity for patients exiting jail (SAIA-MOUD) by Sarah Gimbel, Anirban Basu, Emily Callen, Abraham D. Flaxman, Omeid Heidari, Julia E. Hood, Anna Kellogg, Eli Kern, Judith I. Tsui, Ericka Turley, Kenneth Sherr

“…Discussion SAIA packages user-friendly systems engineering tools to guide decision-making by front-line care providers to identify low-cost, contextually appropriate health care improvement strategies. …”
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Prognostic value of tumor-infiltrating T-lymphocytes density in the therapeutic response to initial platinum-based chemotherapy in patients with non-small cell lung cancer by Novaković-Lacković Lora, Latinović-Tadić Ljilja, Stanetić Mirko, Lacković Marko

“…During statistical data processing, low infiltration density combined score 0 and score 1 groups, and high infiltration density combined score 2 and score 3 groups. …”
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Comparison of extracorporeal shockwave therapy, ultrasound therapy, and corticosteroid injections for treatment of lateral epicondylitis: an umbrella review of meta-analyses by Pengcheng Zhu, Peiyuan Tang, Jingyue Su, Yixin Yang, Shengwu Yang, Chunwu Zhang, Wenfeng Xiao, Yang Zhou, Yusheng Li, Zhenhan Deng

“…ESWT can effectively reduce the pain assessed by the visual analogue scale (VAS) compared with placebo (MD = −0.68; 95% CI −1.06, −0.3; P = 0.0004; I 2 = 75%). …”
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Clinical Characteristics, Risk Factors, and Predictors of Nonobese Fatty Liver Disease: A Cross-Sectional Study by Zhang X, Wang S, Xu S, Min R, Ling Y, Sun S, Gong R

“…Fatty liver disease was diagnosed based on at least two of the following criteria: diffuse echo patterns relative to the liver, spleen, and kidney; ultrasonic beam attenuation; and poor intrahepatic visual details. The associations between non-obese fatty liver and gender, age, total bilirubin(TBIL), direct bilirubin(DBIL), alanine aminotransferase(ALT), aspartate aminotransferase(AST), glutamine transferase(GGT), alkaline phosphatase(ALP), triglycerides(TG), total cholesterol(TC), high-density lipoprotein cholesterol(HDLC), low-density lipoprotein cholesterol(LDLC), urea nitrogen(BUN), creatinine(Cr), uric acid(UA), Central nervous system sensitivity PTFQI, TSHI, TT4RI, TFQI, Peripheral sensitivity, free thyroxine(FT4), thyroid-stimulating hormone(TSH), triiodothyronine(FT3), fasting blood glucose(FBG), systolic blood pressure(SBP), diastolic blood pressure(DBP), body mass index(BMI) were analyzed via binary logistic regression. …”
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Feeding behavior of Holstein and Jersey cows fed diets based on either alfalfa silage or corn silage at 2 forage fiber levels by O.I. Santana, M.E. Uddin, M.A. Wattiaux

“…Dietary treatments were 2 FNDF levels (19% FNDF [low FNDF; LF] or 24% FNDF [high FNDF; HF]) and 2 FNDF sources (70:30 or 30:70 ratio of AS:CS). …”
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Pooled prevalence and multilevel determinants of stillbirths in sub-Saharan African countries: implications for achieving sustainable development goal by Bewuketu Terefe, Mahlet Moges Jembere, Nega Nigussie Abrha, Dejen Kahsay Asgedom, Solomon Keflie Assefa, Nega Tezera Assimamaw

“…Stillbirth prevalence was visualized using a forest plot. A multilevel modeling analysis was used by considering individual-level factors and community level factors. …”
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Freeze-Dried Probiotic Fermented Camel Milk Enriched with Ajwa Date Pulp: Evaluation of Functional Properties, Probiotic Viability, and In Vitro Antidiabetic and Anticancer Activit... by Sally S. Sakr, Hassan Barakat

“…All FCM variants demonstrated low water activity (0.196–0.226), indicating good potential for shelf stability. …”
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Cerebral Venous Sinus Thrombosis in Systemic Lupus Erythematosus by Guntur Darmawan, Laniyati Hamijoyo, Amaylia Oehadian, Ria Bandiara, Lisda Amalia

“…Either digital subtraction angiography or anticoagulant was deferred due to low platelet. Further examination revealed positive for ANA, anti-SSA, and diagnosis of SLE was established. …”
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Effect of Lingnan Painless Apitherapy combined with McKenzie Therapy on Patients with Lumbar Disc Herniation by Hongbo WU, Xinghua CHEN, Ruike ZHANG, Qinglu LUO, Yongming CHENG

“…Objective:To observe the clinical efficacy of Lingnan painless apitherapy combined with McKenzie therapy on patients with lumbar disc herniation(LDH).Methods:A total of 80 patients with LDH who were treated in the department of rehabilitation medicine of the fifth affiliated hospital of Guangzhou medical university from February 2019 to June 2020 were randomly divided into the control group and the observation group according to the random number table method, with 40 cases in each group.The control group received magnetic thermal-vibration therapy and McKenzie therapy.The Japanese magnetic thermal-vibration therapy instrument(TM-3200)was used in the magnetic thermotherapy, the appropriate intensity(high, hot, warm and low temperature)was selected according to the patient's feeling and symptoms, 20 minutes each time, once a day, seven times a week, continuous treatment for two weeks.In addition, the patients with LDH received McKenzie therapy, which was assisted by the therapist or the patient actively completed the flowing training, such as prone position stretching, prone position stretching combined with compression, standing position lateral movement and so on.Each step rested for one minute, once every two days, continuous treatment for two weeks.The observation group received Lingnan painless apitherapy on the basis of treatment in the control group after half an hour's rest.Before treatment, the patients were given apitherapy tolerance test, performing apitherapy with one bee on each Zusanli acupoints on both sides.After apitherapy for 15 minutes, if there was no adverse reaction, the patients were given painless apitherapy with a quiet and comfortable environment, every other day.In this treatment, both sides of Huatuo Jiaji acupoints on the lumbar spinous processes were selected, and Huatuo Jiaji acupoints on both sides of the 5th lumbar spinous process were selected in the first treatment, one acupoint on the left and one on the right.After that, two acupoints were added each time, and each acupoint was treated by one bee.According to the order of Jiaji points on the 4th, 3rd, 2nd and 1st lumbar vertebrae, the number of bee needles increased to 10 bees.Before treatment and two weeks after treatment, visual analogue scales(VAS)was used to evaluate the pain degree, Oswestry disability index(ODI)was used to assess the lumbar spine dysfunction, and TCM syndrome score was used to evaluate the therapeutic effect, and the clinical efficacy was evaluated by <italic>the diagnosis and curative effect standards of TCM diseases</italic>.Results:Before treatment, there was no significant difference in the VAS score, ODI score and TCM syndrome score between the observation group and the control group(<italic>P</italic>&gt;0.05).Compared with treatment before, the VAS score, ODI score and TCM syndrome score after treatment for two weeks of the two groups were significantly reduced, with a statistically significant difference(<italic>P</italic>&lt;0.05).Compared with the control group, the VAS score and TCM syndrome score of the observation group were lower than those of the control group, with a statistically significant difference(<italic>P</italic>&lt;0.05), but there was no considerable difference in ODI score between the two groups(<italic>P</italic>&gt;0.05), and the clinical efficacy of the observation group(95%)was significantly higher than that of the control group(80%)(<italic>P</italic>&lt;0.05).Conclusion:Lingnan painless apitherapy combined with McKenzie therapy can significantly improve the pain degree and lumbar spine dysfunction of patients with LDH, which have a good effect and it is worthy of clinical promotion.However, it's necessary to develop large-sample randomized controlled trials and follow-up, to provide more reliable basis for clinical treatment of LDH.…”
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