Synthesis, characterization, molecular docking and pharmacological evaluation of isoxazole derivatives as potent anti-inflammatory agents by Sonu, Kamal YT, Girendra Kumar Gautam, Arun Kumar Mishra, Baby Rabiya Parveen, Arvind Kumar, Mhaveer Singh, Harpreet Singh

“…Results: The results indicated that three compounds (5b, 5c, and 5d) demonstrated significant in vivo anti-inflammatory potential (% edema inhibition 75.68, 74.48, & 71.86 in 2 h and 76.71, 75.56, & 72.32 in 3 h) with modest effectiveness (0.83, 0.81 & 0.71), low toxicity, and minimal adverse effects. The molecular docking analyses further elucidated the interaction with the active site COX-2 enzyme (PDB ID: 4COX) using Autodock Vina. …”
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H‐Shaped Anatomical Titanium Plate: Biomechanical Validation and Clinical Application in the Treatment of Complex Posterior Wall/Column Acetabular Fractures by Qiaoli Zhang, Liang Jin, Xiaorui Hao, Weijie Zheng, Fei Zhou, Shuxin Zhang, Tianfeng Li, Xiaohui Xiong, Yihan He, Xiaojie Chen, Jiexin Huang

“…The incidence of various complications was low, with no cases of implant failure observed. …”
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Effect of Floating Needle Perfusion Therapy combined with Joint Mobilization on Shoulder Pain of Hemiplegia after Stroke by Xin WANG, Hu LI, Xiuyan LU

“…The control group only received routine rehabilitation training, including normal limb position, prevention of secondary injury, active or auxiliary functional exercise, low-frequency electrical stimulation, and daily living ability simulation training of upper limb, etc., 25 minutes a time, once a day, five days per week, continuous treatment for four weeks. …”
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Assessment of public literacy in TB prevention and control in the National 13th Five-Year plan for Tuberculosis Prevention and Control (2016–2020) in China by Shuaihu Ni, Gang Chen, Jia Wang, Yuhong Li, Hui Zhang, Yan Qu, Yanlin Zhao, Xiaofeng Luo

“…TB public education materials and health-related information should use more audio-visual types.…”
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Effect of ketorolac tromethamine on pain management in patients with condyloma acuminata treated with 5-aminolevulinic acid photodynamic therapy by Xiaomeng Chen, Chang Liu, Shuanglin Cao, Xin Wang

“…Background: Photodynamic therapy is widely used to treat condyloma acuminatum, which has the advantages of proven efficacy, low recurrence rates, and local minimally or non-invasive. …”
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Thoracic CT Angiographies in Children Using Automated Power Injection with Bolus Tracking Versus Manual Contrast Injection: Analysis of Contrast Enhancement, Image Quality and Radi... by Jochen Pfeifer, Deborah Driulini, Katrin Altmeyer, Gudrun Wagenpfeil, Martin Poryo, Christian Giebels, Arno Bücker, Alexander Massmann, Hashim Abdul-Khaliq, Peter Fries

“…<b>Conclusions:</b> Automated contrast agent applications with power injectors and bolus tracking ensure better image quality in pediatric CTA, even when low volumes and flow rates need to be applied. There is a slight increase in radiation associated with bolus tracking. …”
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Effect of Extracorporeal Shock Wave Therapy Combined with Kinesio Taping on Plantar Fasciitis by Mingliang JIN, Hua YUAN, Xu HU, Xu JIN, Hongru YUAN, Jiajin FAN

“…The control group received routine rehabilitation treatment, including low-power He-Ne laser, ultrasonic therapy, exercise therapy (triceps of the leg, plantar fascia relaxation). …”
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Staged lateral⁃posterior lumbar interbody fusion for degenerative spinal deformity by LIU Zhen‐lei, WANG Kai, LI Kang, ZHANG Lei, JIAN Feng‐zeng, WU Hao

“…Pain severity was assessed by Visual Analog Scales (VAS), and disability was evaluated by Oswestry Disability Index (ODI). …”
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The Bottleneck in the Scalar Dissipation Rate Spectra: Dependence on the Schmidt Number by Paolo Orlandi

“…The bottleneck is dismantled, and at very low <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>S</mi><mi>c</mi></mrow></semantics></math></inline-formula> values, the spectrum tends towards Batchelor’s theoretical prediction, diminishing proportionally to <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msup><mi>k</mi><mrow><mo>−</mo><mn>17</mn><mo>/</mo><mn>3</mn></mrow></msup></semantics></math></inline-formula>. …”
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Socioeconomic inequalities in patient-reported outcome measures among total hip and knee arthroplasty patients: a comprehensive analysis of instruments and domains by Joshua M. Bonsel, Max Reijman, Erin M. Macri, Jan A. N. Verhaar, Liza N. van Steenbergen, Gouke J. Bonsel

“…Abstract Background Prior to total hip and knee arthroplasty (THA/TKA), patients with low socioeconomic status (SES) report worse Patient-Reported Outcome Measures (PROMs), persisting postoperatively. …”
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CYP2C9 Polymorphism Study in Patients with Acute Back Pain and its Impact on the Effectiveness of Treatment with the Non-Steroidal Anti-Inflammatory Drugs by Maslova I., Mykhailovska N., Slobodin T.

“…One in five patients with acute low back pain has genotypes with the CYP2C9 (Arg144Cys) and CYP2C9 (IIe369Leu) mutant alleles, which means there is an increased risk of side effects of non-steroidal anti-inflammatory drug treatment. …”
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Ultrasound-Guided Inactivation of Trigger Points Combined with Muscle Fascia Stripping by Liquid Knife in Treatment of Postherpetic Neuralgia Complicated with Abdominal Myofascial... by Xiang-Hong Lu, Xiao-Lan Chang, Si-Lan Liu, Jing-Ya Xu, Xiao-Jun Gou

“…Patients with 2 < VAS (visual analogue scale) score < 6 were subjects of the study. …”
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Assessment of relationship between chickpea genotypes from ICARDA with a western Iranian landrace (Bivanij) by farhad Nazarian Firouzabadi, Mahin Rahimi, Ahmad Ismaili

“…Although in most cases a low level of polymorphism with RAPD markers have been reported, this study showed a considerable amount of polymorphism. …”
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Synthesis and preliminary biological evaluation of a novel PET tracer for α-synuclein PET imaging by WANG Ce, PAN Donghui, TAN Siyi, WANG Lizhen, WANG Xinyu, YAN Junjie, CHEN Chongyang, XU Yuping, ZOU Lianghua

“…Furthermore, a biodistribution study in normal mice reveals that 18F-YM can be quickly cleaned from the brain of normal mice, indicating that the non-specific binding of 18F-YM in the brain is low, which allowed for obtaining good contrast images.ConclusionThis preclinical study demonstrates that the benzothiazole analog, 18F-YM, owns preferable imaging prosperities, hence be a new candidate for α-synuclein PET imaging.…”
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The efficacy and safety of ketorolac for postoperative pain management in lumbar spine surgery: a meta-analysis of randomized controlled trials by Jianbin Guan, Ningning Feng, Kaitan Yang, Haimiti Abudouaini, Peng Liu

“…In the 12–24-h period, Ketorolac continued to show significant pain reduction (MD =  − 0.48; 95% CI: − 0.68 to − 0.28; P < 0.0001), but this reduction was also below the MCID. Heterogeneity was low in the 12–24-h period (I2 = 13%), indicating consistent results across studies. …”
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Genicular Nerve Ultrasound-Guided Cryoanalgesia for the Treatment of Chronic Knee Joint Pain: An Observational Retrospective Study by Giuliano Lo Bianco, Francesco Paolo D’angelo, Guillherme Ferreira Dos Santos, Agnes Stogicza, Matteo Luigi Giuseppe Leoni, Andrea M. Trescot, Robert Jason Yong, Christopher L. Robinson

“…Cryoanalgesia of the genicular nerves (GNCryo) is one such intervention that disrupts sensory input by applying extremely low temperatures to the target nerves, potentially leading to sustained pain relief without the need for neurodestructive heat lesions. …”
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The state of the biogeometric profile of the posture of young athletes specializing in hand-to-hand combat as a prerequisite for the development of corrective and preventive measur... by Vitalii Kashuba, Аndrii Radchenko, Yuri Radchenko, Ilia Vako, Vitaly Usychenko

“…Based on the results of screening the biogeometric profile of posture of an experimental contingent of young athletes specializing in hand-to-hand combat, a general tendency was traced to a decrease in the average values of the number of points at high and medium levels of the state of the biogeometric profile of posture of martial arts athletes with normal posture, and at low and medium levels - the state of the biogeometric profile of the posture of athletes with a stooped back, flat back, round back and scoliotic posture. …”
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Roxadustat attenuates brain injury in mice with heat stroke by regulating mitochondrial fission and fusion by 10.16016/j.2097-0927.202405009, HUANG Xueyan, SHEN Tingting

“…Methods A total of 140 male C57BL/6J mice (6~8 weeks old, weighing 18~22 g) were subjected, and 40 of them were randomly divided into HS group, and low-, medium- and high-dose roxadustat groups (LD, MD and HD groups, 5, 10 and 20 mg/kg), with 10 mice in each group. …”
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Use of a multidimensional RAPID3 questionnaire to assess the achievement of remission and minimal disease activity in patients with early psoriatic arthritis treated according to T... by E. Yu. Loginova, T. V. Korotaeva, A. D. Koltakova

“…Joint pain measurement, patient (PGA) and physician (PhGA) global assessment on visual analog scale (VAS) was performed, the serum level of C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were evaluated. …”
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High levels of serum uric acid are associated with microvascular complications in patients with long-term diabetes by Hanying Wang, Liping Gu, Yuhang Ma, Xindan Xing, Yuan Qu, Xin Shi, Xinyi Liu, Hancong Wan, Qian Zhu, Yingchen Shen, Chong Chen, Li Su, Yufan Wang, Kun Liu

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