Cryo-EM structures of Nipah virus polymerases and high-throughput RdRp assay development enable anti-NiV drug discovery by Zhenhang Chen, Jeanne Quirit Dudley, Colin Deniston, Cosmo Z. Buffalo, Debjani Patra, Dongdong Cao, Julia Hunt, Ahmed Rohaim, Debapriya Sengupta, Lan Wen, Tiffany Tsang, Lili Xie, Michael DiDonato, Glen Spraggon, Matthew C. Clifton, Nadine Jarrousse, Judith Straimer, Bo Liang

“…We identify two conserved loops in the polyribonucleotidyltransferase (PRNTase) domain of L and the binding between RdRp-PRNTase and CD domains. …”
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Senataxin prevents replicative stress induced by the Myc oncogene by Silvia Sberna, Marco Filipuzzi, Nicola Bianchi, Ottavio Croci, Federica Fardella, Chiara Soriani, Sara Rohban, Sara Carnevali, Alessandra Alberta Albertini, Nicola Crosetto, Simona Rodighiero, Arianna Chiesa, Laura Curti, Stefano Campaner

“…Pharmacological dissection of the upstream kinases regulating the DDR uncovered a protective role of the ATR pathway, that once inhibited, boosted SETX driven-DDR. While SETX loss did not lead to a genome-wide increase of R-loops, mechanistic analyses revealed enhanced R-loops localized at DDR-foci and newly replicated genomic loci, compatible with a selective role of SETX in resolving RNA-DNA hybrids to alleviate Myc-induced RS. …”
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Simulation Study on the Static Characteristics of ‘Five-tier Outer Eave Column-head Dougong Bracket’ from the Main Hall of Nanchan Temple in Tang Dynasty by Chang Chen, Yuanhe Li, Dongnan Han, Hongfa Kang, Yongzheng Li

“…The vertical response followed a tri-linear stiffness degradation model, while horizontal behavior aligned with multi-linear restoring force models. …”
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Optimization of Remote Backup Protection Coordination Logic Based on Dynamic Identification of Faulty Components in Transmission Grids by LIN Xiangning, JI Jihao, DING Yifan, LI Zhengtian, WENG Hanli

“…This study addresses the dynamic adaptability of backup protection in power grids with renewable energy， overcoming the bottlenecks of looped network deadlocks and rigid setting values. …”
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Forward genetic approach identifies a phylogenetically conserved serine residue critical for the catalytic activity of UBIQUITIN-SPECIFIC PROTEASE 12 in Arabidopsis by Anita Hajdu, Dóra Vivien Nyári, Éva Ádám, Yeon Jeong Kim, David E. Somers, Dániel Silhavy, Ferenc Nagy, László Kozma-Bognár

“…Abstract Circadian clocks rely on transcriptional/translational feedback loops involving clock genes and their corresponding proteins. …”
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Long‐Term, High‐Resolution Permafrost Monitoring Reveals Coupled Energy Balance and Hydrogeologic Controls on Talik Dynamics Near Umiujaq (Nunavik, Québec, Canada) by Philippe Fortier, Nathan L. Young, Jean‐Michel Lemieux, Michelle A. Walvoord, Richard Fortier

“…The first, found at the top of the mound feature, is characterized by very low moisture contents (<0.05 m3/m3), while the second, found at the side of the mound feature, shows higher annual moisture contents that strongly influence the dynamics of heat and groundwater flow. …”
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Integrating Systems Thinking and Behavioural Science by John A. Parkinson, Ashley Gould, Nicky Knowles, Jonathan West, Andrew M. Goodman

“…Behavioural science provides insights into individual decision-making, while systems approaches offer ways of understanding, and working with, the dynamic interactions and feedback loops within complex systems. …”
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Exploring the molecular mechanisms of huperzine a in the treatment of rosacea through network pharmacology, machine learning, and molecular dynamics simulations by Xin Luo, Suhan Yang, Lian Zhong, Peng Zhang

“…IntroductionRosacea is a common chronic inflammatory skin disorder and dysregulation of neuroimmune functions and neurovascular loops play critical roles in the development of rosacea. …”
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Repair of Peroneus Brevis Tear with Autologous Gracilis: A Case Report by Gautam Kumar, Dennis P Jose, Rajesh Simon, Surekh Ravi, Deepu J Punnoose

“…The proximal end of donor graft was secured to the proximal end of remaining PBT using pulverate weaving technique, while the distal end graft was looped through the drill hole in 5th metatarsal base and sutured to itself. …”
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Canonical Discriminant Mapping of Origins in Andalusian Black Cattle: Inbreeding and Coancestry Decomposition via Mendelian Sampling Variances and Nodal Ancestor Contributions by Luis Favian Cartuche Macas, María Esperanza Camacho Vallejo, Antonio González Ariza, José Manuel León Jurado, Juan Vicente Delgado Bermejo, Carmen Marín Navas, Francisco Javier Navas González

“…In Córdoba, contributions of nodal ancestors through inbreeding loops reached a maximum of 0.0447, while mean inbreeding (<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mover><mi mathvariant="normal">F</mi><mo>¯</mo></mover></mrow></semantics></math></inline-formula>) was 0.000949 and mean coancestry (<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mover><mi mathvariant="normal">C</mi><mo>¯</mo></mover></mrow></semantics></math></inline-formula>) was 0.000475, indicating moderate but geographically structured genetic drift. …”
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Striatal output regulates the postnatal maturation of cortical circuits by Michael Janeček, Tara Deemyad, Yi-Chun Shih, Vicente Valle, Andrew D’Agostino, Michael Matarazzo, Megan S. Perez, Kyle D. Ketchesin, Susana da Silva, Rui T. Peixoto

“…Summary: The dorsomedial prefrontal cortex (dmPFC) and basal ganglia (BG) are tightly interconnected through cortico-BG-thalamocortical (CBGT) loops that undergo extensive refinement during postnatal development. …”
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Ethical Considerations in Emotion Recognition Research by Darlene Barker, Mukesh Kumar Reddy Tippireddy, Ali Farhan, Bilal Ahmed

“…The development of real-time feedback loops for user awareness should be combined with clear disclosures about data use and participatory design practices. …”
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Topographic anatomy of the spleen in children and adolescents according to intravital imaging by A. S. Lozinskiy

“…A significant increase in the distance from the spleen to the liver, pancreas, aorta, inferior vena cava, and loops of the jejunum and ileum was determined from early childhood to adolescence; in individuals of the first and early childhood ages, the distance to the liver, pancreas, aorta, and inferior vena cava was the same, while in adolescents it was greater than in those examined in the second childhood. …”
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Investigation of structural, optical, magnetic, and electrochemical properties of La1 − xAgxFe0.5Mn0.5O3−δ perovskites by Abdullah Almohammedi, E. K. Abdel-Khalek, Yasser A. M. Ismail

“…Rietveld refinement of XRD data revealed the single phase rhombohedral (R3c) structure at x = 0.10, 0.15 while at x = 0.20 revealed the existence of the rhombohedral (R3c) and cubic structure of Ag (space group Fm3m). …”
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Evolution of the RNA alternative decay cis element into a high-affinity target for the immunomodulatory protein Roquin by Jan-Niklas Tants, Katharina Friedrich, Jasmina Neumann, Andreas Schlundt

“…RNA cis elements play pivotal roles in regulatory processes, e.g. in transcriptional and translational regulation. Two stem-looped cis elements, the constitutive and alternative decay elements (CDE and ADE, respectively) are shape-specifically recognized in mRNA 3’ untranslated regions (UTRs) by the immune-regulatory protein Roquin. …”
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The Influence of Implementing Process-Oriented Guided Inquiry Learning (POGIL) Model With Website Assistance To Improve Students' Logical Thinking by Alya Arthamevia Solehuddin, Munir, Rasim

“… This study designed and evaluated the impact of the Process-Oriented Guided Inquiry Learning (POGIL) model, supported by the XPOGIEDU website, on enhancing logical thinking skills in programming (branching, looping) among 37 students of 10th-grade vocational high school. …”
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Genetic deletion of calcium-independent phospholipase A2γ protects mice from diabetic nephropathy. by Andrey V Cybulsky, Joan Papillon, Julie Guillemette, José R Navarro-Betancourt, Hanan Elimam, I George Fantus

“…STZ induced progressive albuminuria in control mice (over 21 weeks), while albuminuria did not increase in iPLA2γ KO mice, remaining comparable to untreated groups. …”
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Understanding the layout of emergency scientific research during COVID-19 prevention and control: a comparative analysis of project solicitation and project approval by Jida Liu, Yuxin Wang, Yuwei Song, Qiaoqiao Li

“…Conclusions The effective deployment of ESR demands cross-regional coordination, real-time matching of needs and resources, and institutional feedback loops to ensure that research outputs are timely and actionable. …”
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A Comparative Study of Direct Power Control Strategies for STATCOM Using Three-Level and Five-Level Diode-Clamped Inverters by Diyaa Mustaf Mohammed, Raaed Faleh Hassan, Naseer M. Yasin, Mohammed Alruwaili, Moustafa Ahmed Ibrahim

“…DPC accomplishes several significant goals by avoiding the inner current control loops and doing away with coordinating transformations. …”
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The Effect of High-Temperature Annealing on the Magnetic and Structural Properties of (MnFePSi)-Based Glass-Coated Microwires by Mohamed Salaheldeen, Valentina Zhukova, Julian Gonzalez, Arcady Zhukov

“…XRD analysis reveals that increasing the annealing temperature leads to a notable increase in the Fe₂P phase content, reaching a maximum at 1123 K, while simultaneously reducing the presence of secondary phases observed in the as-prepared sample. …”
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