VIEshunt: towards a ventricular intelligent and electromechanical shunt for hydrocephalus therapy by Fabian Flürenbrock, Leonie Korn, Dominik Schulte, Anthony Podgoršak, Joris Chomarat, Janina Hug, Tiago Hungerland, Caroline Holzer, David Iselin, Luca Krebs, Rosina Weiss, Markus F. Oertel, Lennart Stieglitz, Miriam Weisskopf, Mirko Meboldt, Melanie N. Zeilinger, Marianne Schmid Daners

“…The VIEshunt prototype was tested in vitro using a hardware-in-the-loop (HiL) test bench that runs real-time patient simulations involving changes in intracranial and intra-abdominal pressure, as well as changes in posture ranging between supine and upright position. …”
Get full text

Butyrate alleviates food allergy by improving intestinal barrier integrity through suppressing oxidative stress‐mediated Notch signaling by Jialu Shi, Wenjun Mao, Yuqing Song, Yuxin Wang, Lili Zhang, Yan Xu, Huiwen Gu, Siyu Yao, Yuanhang Yao, Zhifeng Liu, Vijaya Raghavan, Jin Wang

“…However, butyrate counteracted this loop by restoring microbiota structure and suppressing reactive oxygen species (ROS)/Notch cascades. …”
Get full text

Intrapleural dual blockade of IL-6 and PD-L1 reprograms CAF dynamics and the tumor microenvironment in lung cancer-associated malignant pleural effusion by Qinpei Cheng, Xueying Zuo, Zimu Wang, Wanjun Lu, Yuxin Jiang, Jiaxin Liu, Xinying Li, Qiuli Xu, Suhua Zhu, Xin Liu, Yong Song, Ping Zhan, Tangfeng Lv

“…IL-6 was found to drive a positive feedback loop with iCAFs, promoting an immunosuppressive environment. …”
Get full text

Spatial, temporal, and meteorological impact of the 26 February 2023 dust storm: increase in particulate matter concentrations across New Mexico and West Texas by M. C. Robinson, K. Schueth, K. Ardon-Dryer

Get full text

Genetic Divergence and Isolation of the Green Sea Turtle (Chelonia mydas) in the Red Sea by K. Scott, S. He, R. S. Hardenstine, L. K. Tanabe, H. Barrios‐Garrido, M. P. Jensen, L. Afiq‐Rosli, N. E. Wildermann, C. M. Duarte, J. E. M. Cochran, M. L. Berumen

“…We analysed 710 bp of the mtDNA d‐loop from five Red Sea rookeries. Five haplotypes, grouped into two highly divergent haplogroups, were identified. …”
Get full text

Development of a qPCR and a Lamp Assay for Verticillium longisporum Detection and a Triplex qPCR Assay for Simultaneous Detection of V. longisporum, Leptosphaeria biglobosa, and L.... by Heting Fu, Yalong Yang, Junye Jiang, Greg C. Daniels, Blake Hill, Shiming Xue, Kher Zahr, L. Stellar, Michael W. Harding, David Feindel, Carol Bvindi, W. G. Dilantha Fernando, Lipu Wang, Jie Feng

“…In this study, a quantitative PCR (qPCR) and a loop-mediated isothermal amplification (LAMP) assay were developed for the detection of V. longisporum from canola stem samples. …”
Get full text

Genome-wide identification of five fern bHLH families and functional analysis of bHLHs in lignin biosynthesis in Alsophila spinulosa by Xiong Huang, Jiangtao Fan, Cai Liu, Peiyun Wang, Hongfei Li, Gang Wang, Xiaohong Chen

“…Abstract Background The basic helix-loop-helix (bHLH) transcription factors are involved in the biosynthesis of various secondary metabolites. …”
Get full text

Suppression of multiple mouse models of refractory malignancies by reprogramming IL-18 ligand-receptor interaction by Zhen Fan, Ying Liu, Xueying Lin, Jifu Zhang, Jiehong Chen, Shiming Yi, Cheng Hu, Xincheng Liu, Cui Guo, Cuiying Xu, Xiaoyu Chen, Xuyan Tian, Xuanming Liang, Yang Liu, Linyi Hu, Shanyu Huang, Li Guo, Wenbo Zhu, Jun Hu, Guangmei Yan, Yuan Lin, Jing Cai, Jiankai Liang

“…Therefore, we engineer armed oncolytic alphavirus M1 expressing wild-type IL-18 (wtIL-18) or a mutant variant (mutIL-18) that evades IL-18 binding protein (IL-18BP) while maintaining IL-18 receptor (IL-18R) binding. …”
Get full text

Adaptive Integral Sliding Mode Control for Flexible Joint Space Manipulators by QIAO Bing, HUANG Shuai-ming, HUANG Zu-yan

“…In addition, an adaptive law for switching gain is proposed for the slow and fast subsystems in the FJSM, which eliminates the requirement of knowing the upper limit of the external perturbation. The closed-loop stability of the whole FJSM system is verified by Lyapunov's theorem. …”
Get full text

The Impact of Digital Technology–Based Exercise Combined With Dietary Intervention on Body Composition in College Students With Obesity: Prospective Study by Chengyuan Hu, Zixin Lv, Jieping Zhu, Chunyuan Lai, Dongjuan Guo, Maolin Chen, Xiaoyan Cheng, Mingxin Rao, Xinyou Zhou, Liqiang Su

“…Between-group comparisons were made using a 1-way ANOVA, while within-group comparisons used a repeated-measures ANOVA. …”
Get full text

Oxidative stress and Kras mutation in Mist1+ cells act in a double-hit manner to drive gastric tumorigenesis by Fan Chen, Yi Han, Jingwu Yue, Hui Zhang, Luyang Tian, Zhifa Cao, Mengwen Zhu, Wenjia Wang, Yan Meng, Liwei An, Feng Li, Huanhu Zhang, Wenqi Bai, Yanfeng Xi, Zaisheng Ye, Shi Jiao, Zhaocai Zhou

“…Persistent ROS induce R-loop accumulation and activate YAP signaling in Mist1+ cells for proliferation and tumorigenesis. …”
Get full text

Ultra-high dose rate radiotherapy overcomes radioresistance in head and neck squamous cell carcinoma by Hong-Shuai Li, Ruo Tang, Hua-Shan Shi, Zi-Jian Qin, Xiao-Yang Zhang, Yun-Fei Sun, Zhi-Gong Wei, Chao-Fan Ma, Liu Yang, Ye Chen, Zhe-Ran Liu, Li-Li Zhu, Wen Yang, Li Yang, Ai-Ning Xu, Zhuo Zhang, Shu-Qing Liao, Jin-Shui Shi, Jian-Jun Deng, Xiao-Zhong He, Xing-Chen Peng

“…In vitro experiments indicated that UHDR-RT suppressed radioresistant cell proliferation and invasion, while promoting apoptosis and exacerbating DNA damage. …”
Get full text

Multi-observatory Study of Young Stellar Energetic Flares (MORYSEF): No Evidence for Abnormally Strong Stellar Magnetic Fields after Powerful X-Ray Flares by Konstantin V. Getman, Oleg Kochukhov, Joe P. Ninan, Eric D. Feigelson, Vladimir S. Airapetian, Abygail R. Waggoner, L. Ilsedore Cleeves, Jan Forbrich, Sergio A. Dzib, Charles J. Law, Christian Rab, Daniel M. Krolikowski

“…Our results also indicate a preference for dipolar magnetic loops in PMS flares, consistent with Zeeman–Doppler imaging of fully convective stars. …”
Get full text

Hypoxic cancer-associated fibroblast exosomal circSTAT3 drives triple negative breast cancer stemness via miR-671-5p/NOTCH1 signaling by Lu Yang, Siyuan Zhao, Xu Liu, Yuchen Zhang, Shaorong Zhao, Xuan Fang, Jin Zhang

“…Hypoxic CAF exosomes increased cisplatin IC₅₀ in TNBC cells, while circSTAT3 depletion restored chemosensitivity. …”
Get full text

Diseño y sintonización de una ley de control borrosa proporcional retardada: enfoque frecuencial by R. Villafuerte, J.A. Ortega Melo

“…While the tuning of the BPR control law, has been addressed in the frequency approach using D-partition method. …”
Get full text

Interconnections between the food system and antimicrobial resistance: A systems-informed umbrella review from a One Health perspective by Chloe Clifford Astbury, Catherine Hu, Krishihan Sivapragasam, Arabi Rajan, Mandy Geise, Cécile Aenishaenslin, Arne Ruckert, Kathleen Chelsea Togño, Mary Wiktorowicz, Tarra L. Penney

“…Introduction: Human food systems are a major driver of antimicrobial resistance (AMR), with significant implications for human, animal, and ecosystem health. While recent research frames AMR as an emerging property of a complex system, this perspective has not been systematically applied to the existing evidence. …”
Get full text

Brassica napus BnaWIP2 transcription factor promotes seed germination under salinity stress by repressing ABA biosynthesis and signaling by Shuangcheng He, Saiqi Yang, Yuanchang Min, Ankang Ge, Junjin Liu, Zijin Liu, Yuan Guo, Mingxun Chen

“…Under NaCl treatment, knocking out all six BnaWIP2 paralogs in B. napus led to significantly reduced germination, while overexpression of BnaC06.WIP2 promoted germination. …”
Get full text

X-TIME: Accelerating Large Tree Ensembles Inference for Tabular Data With Analog CAMs by Giacomo Pedretti, John Moon, Pedro Bruel, Sergey Serebryakov, Ron M. Roth, Luca Buonanno, Archit Gajjar, Lei Zhao, Tobias Ziegler, Cong Xu, Martin Foltin, Paolo Faraboschi, Jim Ignowski, Catherine E. Graves

“…Structured, or tabular, data are the most common format in data science. While deep learning models have proven formidable in learning from unstructured data such as images or speech, they are less accurate than simpler approaches when learning from tabular data. …”
Get full text

Improved longevity and in vivo performance of neurotransmitter detection using 30 µm cone-shaped carbon fiber microelectrode by Haeun Kwon, Hyun-U Cho, Jeongeun Sim, Kyung-Jun Boo, Kyung-Jun Boo, Yumin Kang, Sangmun Hwang, Youngjong Kwak, Jaehyun Jang, Kyung Min Kim, Se Jin Jeon, Chan Young Shin, Kevin E. Bennet, Kevin E. Bennet, Yoonbae Oh, Yoonbae Oh, Hojin Shin, Hojin Shin, Kendall H. Lee, Kendall H. Lee, Dong Pyo Jang, Dong Pyo Jang

“…These results suggest that while increasing CFME diameter improves sensitivity, it also increases tissue damage in vivo. …”
Get full text

Crosstalk Between Autophagy and Oxidative Stress in Hematological Malignancies: Mechanisms, Implications, and Therapeutic Potential by Antonio José Cabrera-Serrano, José Manuel Sánchez-Maldonado, Carmen González-Olmedo, María Carretero-Fernández, Leticia Díaz-Beltrán, Juan Francisco Gutiérrez-Bautista, Francisco José García-Verdejo, Fernando Gálvez-Montosa, José Antonio López-López, Paloma García-Martín, Eva María Pérez, Pedro Sánchez-Rovira, Fernando Jesús Reyes-Zurita, Juan Sainz

“…We discuss how oxidative stress triggers autophagy, creating a feedback loop that promotes tumor survival, and how autophagic dysregulation leads to increased ROS accumulation, exacerbating tumorigenesis. …”
Get full text