A citrullinated histone H3 monoclonal antibody for immune modulation in sepsis by Wenlu Ouyang, Yuchen Chen, Tao Tan, Yujing Song, Tao Dong, Xin Yu, Kyung Eun Lee, Xinyu Zhou, Zoe Tetz, Sophia Go, Xindi Zeng, Liujiazi Shao, Chao Quan, Ting Zhao, Yuzi Tian, Katsuo Kurabayashi, Hua Jin, Jichun Ma, Jingdong Qin, Brandon Williams, Qingtian Li, Gui-dong Zhu, Hasan B. Alam, Kathleen A. Stringer, Yongqing Li, Jianjie Ma

“…In murine models, hCitH3-mAb reduces cytokine production, mortality and acute lung injury (ALI) caused by LPS and Pseudomonas aeruginosa while enhancing bacteria phagocytosis in the lungs, spleen, and liver. …”
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An atypical basement membrane forms a midline barrier during left-right asymmetric gut development in the chicken embryo by Cora Demler, John C Lawlor, Ronit Yelin, Dhana Llivichuzcha-Loja, Lihi Shaulov, David Kim, Megan Stewart, Frank K Lee, Natalia Shylo, Paul A Trainor, Thomas M Schultheiss, Natasza A Kurpios

“…Correct intestinal morphogenesis depends on the early embryonic process of gut rotation, an evolutionarily conserved program in which a straight gut tube elongates and forms into its first loops. However, the gut tube requires guidance to loop in a reproducible manner. …”
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Tuberculosis Diagnosis: Current, Ongoing, and Future Approaches by Guilherme Bartolomeu-Gonçalves, Joyce Marinho de Souza, Bruna Terci Fernandes, Laís Fernanda Almeida Spoladori, Guilherme Ferreira Correia, Isabela Madeira de Castro, Paulo Henrique Guilherme Borges, Gislaine Silva-Rodrigues, Eliandro Reis Tavares, Lucy Megumi Yamauchi, Marsileni Pelisson, Marcia Regina Eches Perugini, Sueli Fumie Yamada-Ogatta

“…Integrating these techniques, such as polymerase chain reaction (PCR) and loop-mediated isothermal amplification (LAMP), has significantly improved the sensitivity and specificity of <i>M. tuberculosis</i> identification. …”
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Drivers of soil organic carbon stocks and stability along elevation gradients by Nicolas Bonfanti, Philippe Choler, Norine Khedim, Jean-Christophe Clément, Pierre Barré, Romain Goury, François Baudin, Lauric Cécillon, Amélie Saillard, Wilfried Thuiller, Jerome Poulenard

“…These results suggest that at high-elevations, harsh climatic conditions favor stabilization of SOC, while less developed soils limit organo-mineral interactions. …”
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Review on biphasic blood drying method for rapid pathogen detection in bloodstream infections by Jongwon Lim, Katherine Koprowski, Matthew Wester, Enrique Valera, Rashid Bashir

“…The biphasic blood drying method, in combination with isothermal amplification methods such as loop-mediated isothermal amplification (LAMP) or recombinase polymerase amplification (RPA), has recently been shown to improve the sensitivity of detection of bacterial, viral, and fungal pathogens from ∼1 mL of whole blood, while minimizing DNA loss and avoiding the use of extraction/purification/concentration kits. …”
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The Role of HPV Genotyping, Cytology, and Methylation in the Triage of High-Risk HPV-Positive Patients by Anastasia Mortaki, Athanasios Douligeris, Maria-Anastasia Daskalaki, Eleni-Sivylla Bikouvaraki, Eirini Louizou, George Daskalakis, Alexandros Rodolakis, Themos Grigoriadis, Kalliopi I Pappa

“…DNA methylation (QIAsure^®) and cervical cytology were performed prior to cervical large loop excision of the transformation zone (LLETZ). …”
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Noncanonical Poly(A) Polymerase TENT4 Drives Expression of Subgenomic Hepatitis A Virus RNAs in Infected Cells by You Li, Ankit Gupta, Brian N. Papas, David Aponte-Diaz, Jayden M. Harris, Ichiro Misumi, Jason K. Whitmire, Craig E. Cameron, Marcos Morgan, Stanley M. Lemon

“…These findings reveal a novel picornaviral subgenomic RNA species while highlighting mechanistic differences in the manner in which HAV and HBV exploit the host ZCCHC4-TENT4 complex for their replication.…”
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Valorization of Residual Silica from the Aqueous-Phase Silicate Conversion of Microsilica as Sustainable Reinforcing Fillers in Rubber Composites by Hai Wang, Gang Hu, Linwei Yan, Xia Hou, Junfeng Gao, Guoyun Zhao, Lei Wang, Ruilong Zhao, Yifan Zhang

“…A tailored HCl/H _2 SO _4 leaching process (liquid—solid ratio of 2:1) achieved 80% impurity removal while enabling resource recovery (80.95% Fe, 84.12% Al) via pH-controlled precipitation. …”
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Liquid–liquid–solid three-phase flow in horizontal wells: flow pattern modeling and dimensionless analysis by Hamed Nejati, Saeed Shad, Sasan Yousefirad, Aras Sheikhi

“…To visualize the flow regimes occurred under different conditions, a transparent flow loop system has been developed to facilitate the flow of two liquids (water and oil) alongside with solid particles. …”
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Patterns of inflammation and immune activation by coreceptor use in people living with HIV-1 by Francisco Xavier Guerra-Castillo, Francisco Xavier Guerra-Castillo, Sandra Pinto-Cardoso, Santiago Ávila-Ríos, Monserrat Chávez-Torres, Amy Peralta-Prado, Carolina González-Torres, Javier Gaytán-Cervantes, Brenda Requena-Benitez, Dafne Díaz-Rivera, Carmen Alaez-Verson, María Concepción Hernández-García, Vilma Carolina Bekker-Méndez

“…Logistic regression was used to evaluate associations between immune activation profiles and the presence of X4-tropic viruses.ResultsNinety-eight individuals had high-quality V3 loop sequences, 81.6% harbored only R5 variants (R5 group), while 18.4% had mixed R5/X4 populations (X4 group). …”
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Synergistic thermal and surface area properties of Al2O3–TiO2/water hybrid nanofluids by Yokanan Gustino Djentoe, Farrel Yoga Widiasto, Hilbran Tama Dida Effendi, Musabbikhah, Sri Hartati, Budi Santoso, Budi Kristiawan, Agung Tri Wijayanta

“…Morphology and structure characterization were performed using Transmission Electron Microscope (TEM) and Surface Area Analysis (SAA), while thermal properties were analyzed using a thermal properties analyzer. …”
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Skin-flap bridge ileostomy in radical resection of mid and low rectal cancer by Yang Yong, Zheng Fan, Huang Bin, Duan Pengfei, Li Longlong, Zheng Huichao, Zhang Mingran, Li Jun, Tong Weidong

“…Patients were divided into the treatment group (receiving skin-flap bridge ileostomy, n=45) and the control group (receiving loop ileostomy, n=42) depending on the type of ileostomy. …”
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Starting a synthetic biological intelligence lab from scratch by Md Sayed Tanveer, Dhruvik Patel, Hunter E. Schweiger, Kwaku Dad Abu-Bonsrah, Brad Watmuff, Azin Azadi, Sergey Pryshchep, Karthikeyan Narayanan, Christopher Puleo, Kannathal Natarajan, Mohammed A. Mostajo-Radji, Brett J. Kagan, Ge Wang

“…They can be trained in a feedback loop to perform tasks similar to deep artificial neural networks that are trained on big data. …”
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Revolutionising young adult diabetes care: a patient-centred transformation to improve access, engagement and outcomes in one of England's most deprived areas by Tala Balafshan, Heather Sullivan, Suzanne Keigan, Amanda Wilson, Ifeoluwa Oyedeji

“…Materials and methods: We implemented data-driven, multidisciplinary interventions to optimise care delivery and reduce healthcare burdens1,2: • Reducing DNA rates: pre-appointment outreach by healthcare assistants reduced DNA rates from 50% to 18.1%, while follow-up waiting times decreased from 5.5 months to 3 months, boosting engagement and clinic efficiency. • Improving access: a dedicated email service and urgent access clinic allowed patients to bypass traditional appointment barriers, ensuring timely advice and intervention. • Preventing emergency admissions: early identification and personalised management plans reduced recurrent diabetic ketoacidosis (DKA) admissions by 80%, improving patient safety. • Expanding diabetes technology: 87.8% of patients now use continuous glucose monitoring (CGM), with most insulin pump users transitioning to hybrid closed-loop systems, improving glycaemic control and autonomy. • Continuous quality improvement: annual audits of nine key care processes maintained high standards, achieving a median HbA1c of 63 mmol/mol, among the best nationally. …”
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Nuclear pore complex dysfunction drives TDP-43 pathology in ALS by O. Ramírez-Núñez, S. Rico-Ríos, P. Torres, V. Ayala, A. Fernàndez-Bernal, M. Ceron-Codorniu, P. Andrés-Benito, A. Vinyals, S. Maqsood, I. Ferrer, R. Pamplona, M. Portero-Otin

“…Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive motor neuron degeneration and pathological aggregation of TDP-43. While protein misfolding and impaired autophagy are established features, accumulating evidence highlights the nuclear pore complex (NPC)as a vulnerable, redox-sensitive hub in ALS pathogenesis. …”
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3,4-Dihydroxyphenylacetaldehyde synthase evolved an ordered structure to deliver oxygen to pyridoxal 5’-phosphate for cuticle assembly in the mosquito Aedes aegypti by Jing Chen, Christopher J. Vavricka, Shuangshuang Wei, Yasumoto Nakazawa, Yuri Matsumoto, Huaqing Chen, Yu Tang, Jing Liang, Jiukai Chen, Yaneng Huang, Keiichi Noguchi, Tomohisa Hasunuma, Huai Guan, Jianyong Li, Chenghong Liao, Qian Han

“…In the DHPAAS crystal structure, stabilization of the flexible 320–350 region accompanies the positioning of the 350–360 loop relatively close to the catalytic Asn192 residue while the conserved active site residue Phe103 adopts an open conformation away from the active center; these distinct features participate in the formation of a specific hydrophobic tunnel which potentially facilitates delivery of oxygen to pyridoxal 5’-phosphate in the conversion of dopa to DHPAA.…”
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Metal–organic nanostructures based on sono/chemo-nanodynamic synergy of TixOy/Ru reaction units: for ultrasound-induced dynamic cancer therapy by Tao Jiang, Zixiang Tang, Shumiao Tian, Haitian Tang, Zhekun Jia, Fangjian Li, Chenyue Qiu, Lin Deng, Lang Ke, Pan He, Gang Liu, Chengchao Chu, Yongfu Xiong

“…In this study, we innovatively designed a multifunctional metal–organic nanosheet (TiZrRu-MON) by hydrothermal coordination of [Ru(bpy)₃]2⁺ photosensitizing units with TiZr-O clusters, while incorporating Fe3⁺ to construct a cascade catalytic system. …”
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Targeting LINC02320 prevents colorectal cancer growth via GRB7-dependent inhibition of MAPK signaling pathway by Lingwei Zhang, Hong Chen, Yangmei Yang, Liangbo Zhao, Huimin Xie, Peixian Li, Xinrui Lv, Luyun He, Nian Liu, Benyu Liu

“…Phosphorylated FOS directly promotes LINC02320 transcription, forming a positive feedback loop and amplifies this pro-cancer signal. Notably, LINC02320-targeted ASO therapy significantly blocked tumor growth in vivo. …”
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Implantable continuous-flow total artificial heart for newborns and small pediatric patients: First report of working modelCentral MessagePerspective by Jamshid H. Karimov, MD, PhD, Chihiro Miyagi, MD, PhD, Taiyo Kuroda, MD, Anthony R. Polakowski, BS, MEng, Christine R. Flick, BS, Barry D. Kuban, BS, Kiyotaka Fukamachi, MD, PhD, Tara Karamlou, MD, Munir Ahmad, MD, Hani Najm, MD

“…The pump flow range (0.5-1.5 L/min) was confirmed in a mock circulatory testing loop. Within the tested flow range, the I-CFTAH can support small patients that could benefit from the intended cardiac output. …”
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Activating transcription factor 3 is an antitumor gene synergizing with growth differentiation factor 15 to modulate cell growth in human bladder cancer by Syue-Ting Chen, Kang-Shuo Chang, Wei-Yin Lin, Shu-Yuan Hsu, Hsin-Ching Sung, Yu-Hsiang Lin, Tsui-Hsia Feng, Chen-Pang Hou, Horng-Heng Juang

“…ATF3 positively regulated GDF15 expression in bladder cancer cells through a feedback loop. Conclusions: Our results identify that ATF3 is a metformin-upregulated antitumor gene. …”
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