A compact electromagnetic syringe stirrer and temperature controller for the reliable dispensing of living cells and microparticles by Maryamsadat Ghoreishi, Giovanna Peruzzi, Lucia Iafrate, Gianluca Cidonio, Noemi D’Abbondanza, Giancarlo Ruocco, Marco Leonetti, Riccardo Reale

“…SEC prevents sedimentation through the cyclic movement of a magnet actuated by an electromagnetic field, while maintaining a stable temperature (within ± 0.5 °C from a set-point) with a feedback loop. …”
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HETEROPLASMY-ASSOCIATED MITOCHONDRIAL DNA VARIANTS IN HUMAN BLOOD AND SKELETAL MUSCLE SAMPLES by Çağrı Güleç, Asuman Gedikbaşı, Gökçen Şahin, Güven Toksoy, Altuğ Duramaz, Zehra Oya Uyguner

“…Variants with heteroplasmy ratios both ranging from 5% to 95% and out of this range were used for statistical analysis.Result: A total of 194 heteroplasmic variants were identified, of which 13 displayed lower heteroplasmy ratios in both blood and skeletal muscle samples from females, while the mitochondrial control region (D-Loop) exhibited higher ratios.Conclusion: The study findings confirm the correlation between the m.10398A>G variant and mitochondrial heteroplasmy levels, consistent with prior research. …”
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Chaperone-mediated autophagy directs a dual mechanism to balance premature senescence and senolysis to prevent intervertebral disc degeneration by Zhangrong Cheng, Haiyang Gao, Pengzhi Shi, Anran Zhang, Xianglong Chen, Yuhang Chen, Weikang Gan, Kangcheng Zhao, Shuai Li, Cao Yang, Yukun Zhang

“…Abstract Intervertebral disc degeneration (IDD) is a progressive and dynamic process in which the senescence-associated secretory phenotype (SASP) of nucleus pulposus cells (NPC) plays a significant role. While impaired chaperone-mediated autophagy (CMA) has been associated with inflammation and cellular senescence, its specific involvement in the self-perpetuating feedback loop of NPC senescence remains poorly understood. …”
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Enhanced Sliding Mode Control for Dual MPPT Systems Integrated with Three-Level T-Type PV Inverters by Farzaneh Bagheri, Jakson Bonaldo, Naki Guler, Marco Rivera, Patrick Wheeler, Rogerio Lima

“…Real-time results obtained using the OPAL-RT Hardware-in-the-Loop platform validated the performance of the proposed control strategy under realistic test scenarios. …”
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Novel insight into the impact of black soldier fly larvae meal and protease on cecal microbiome, SCFAs, and excreta composition in laying hens by Jing Lu, Renée Maxine Petri, Janice Leigh MacIsaac, Stephanie Anne Collins

“…Abstract Background Insect farming represents a sustainable loop that recycles organic wastes back to the food chain while requiring minimal inputs such as land and water. …”
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Constructing an Ecological Spatial Network Optimization Framework from the Pattern–Process–Function Perspective: A Case Study in Wuhan by An Tong, Yan Zhou, Tao Chen, Zihan Qu

“…The results reveal a distinct “increase-then-decrease” trend in EN structural attributes: from 2000 to 2020, source areas declined from 39 (900 km²) to 37 (725 km²), while corridor numbers fluctuated before stabilizing at 89. …”
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Integrated Perspective on Functional Organic Electrochemical Transistors and Biosensors in Implantable Drug Delivery Systems by Xiao-Le Han, Tao Zhou, Jian-Ming Xu, Shu-Feng Zhang, Ye-Zhou Hu, Yi Liu

“…Looking ahead, the seamless integration of OECT-based biosensors with IDDSs holds the potential to create more precise and efficient closed-loop therapeutic platforms, accelerating progress in the fields of personalized and precision medicine.…”
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Structural and functional insights into the nuclear role of Parkinson’s disease-associated α-synuclein as a histone chaperone by Sneha Jos, Archanalakshmi Kambaru, Thazhe Kootteri Prasad, Shylaja Parthasarathi, Neelagandan Kamariah, Sangeeta Nath, Balasundaram Padmanabhan, Sivaraman Padavattan

“…Nonetheless, the αSyn C-terminal end in both modes overlap but runs in opposite orientations, specifically interacting with the H2a-L2 and H2b-L1 loop regions of the dimer and cap the H2a-R78 residue. …”
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Cryptochrome magnetoreception: Time course of photoactivation from non-equilibrium coarse-grained molecular dynamics by Jessica L. Ramsay, Fabian Schuhmann, Ilia A. Solov’yov, Daniel R. Kattnig

“…The C-terminal (CT) region responded on a timescale of 4.7 µs, followed by the EEE-motif, while the phosphate binding loop (PBL) showed slower dynamics (9 µs). …”
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ERF114/115/109 are essential for jasmonate-repressed non-canonical JAZ8 activity in JA signaling by Jiaxuan Sui, Qianlan Yin, Yiying Chen, Min Sun, Xianzheng Yuan, Zhaojun Ding, Xiangpei Kong

“…Summary: Jasmonate (JA), a key plant hormone, regulates various aspects of plant development and stress responses, primarily through the degradation of canonical jasmonate-ZIM domain (JAZ) proteins by the SCFCOI1 complex. While JAZ8, a non-canonical JAZ protein lacking the degron signal, has been shown to repress JA responses, the mechanism by which JA inhibits JAZ8 activity remains unclear. …”
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Dynamic mechanisms and targeted interventions in cerebral ischemia–reperfusion injury: pathological cascade from ischemia to reperfusion and promising therapeutic strategies by Xufeng Meng, Zhi Zheng, Li Yang, Chen Yang, Xiaoli Li, Xiaoli Li, Yunfei Hao, Yunfei Hao

“…Hypoxia-induced mitochondrial energy failure and TLR4/NF-κB-mediated inflammation predominate in the ischemic phase, while reperfusion triggers a reactive oxygen species (ROS) burst, amplifying oxidative stress (OS). …”
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Exploring the influence of circular economy on big data analytics and supply chain resilience nexus: A structural equation modeling approach by Samia Islam, Sanjida Hassan, Sourav Hossain, Tazim Ahmed, Chitra Lekha Karmaker, A.B.M. Mainul Bari

“…Again, to reduce dependency on finite resources, minimize waste, and create adaptive, closed-loop systems, the role of circular economy has also been analyzed widely. …”
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Influence of solubilizer PEG-40 hydrogenated castor oil on carbopol gels’ structural-mechanical properties by Ye. V. Gladukh, І. М. Grubnik, Н. Р. Kukhtenko

“…Addition of PEG-40 GMM to the carbopol gel increases the yield strength by 53 % (to 188.22 Pa at 5 % PEG-40 GKM injection), reduces the value of the yield strength of the base to 337.0–374.0 Pa s and, accordingly, increases the structure breakdown from 1.56 Up to 2.39 Pa s with an increase in the shear rate to 350 s-1, increases the hysteresis loop to 22525.9 Pa/s while reducing the stability of the system by more than 2 times and increases the value of mechanical stability to 1.16–1.37, that at the end can affect the deterioration of the restoration of the structure after deformation. …”
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Moving Plasma Structures and Possible Driving Mechanisms of Solar Microflares Observed with High-resolution Coronal Imaging by Qingmei Wang, Yi Bi, Hongfei Liang, JiaYan Yang, Liufan Gong

“…These tiny ejections propagate roughly perpendicular to the flaring loops. They often originate as dot-like structures with a length scale of approximately 10 ^3 km. …”
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Research on Integrated Fast Reactor Economic Analysis Method by LIU Lin, LUO Mei, FU Qi

“…At present, the economic analysis of nuclear power in China focuses on pressurized water reactors, while the economic analysis of fast reactors is mainly methodological analysis, and there are few case studies. …”
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Synthesis of a parametrically invariant servo drive using the model parameters recovery method by N. A. Malev

“…The parameters are identified by a searchless gradient algorithm while minimizing the discrepancy between the object of study and its inverse model, as well as restoring the coefficients of differential equations using integration and the corresponding computational procedures. …”
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The first fossil representative of the dragonfly family Synthemistidae by Andre Nel, Valerie Ngo Muller, Romain Garrouste, Mathieu Boderau

“…It shows the main synapomorphies of the family, viz. hind wing with 3–5 costal braces (complete antenodal crossveins) alternating with non-aligned antenodals; presence of crossveins in median area and between CuP and PsA; absence of postsubnodal crossveins below first postnodal crossveins; in hind wing, a very large and elongate anal loop without a well-defined mid-rib; and CuAa without posterior branches. …”
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Genetic characterization of foot-and-mouth disease virus in cattle in Northern Egypt by Sarah G. Yousef, Hend M. El Damaty, Hussein A. Elsheikh, Yousry A. El-Shazly, Eman Metwally, Samar Atwa

“…Serotype A accounted for 72.3% of cases, while 27.7% were serotype O. Sequence analysis identified FMDV serotype A (African topotype, genotype IV) and serotype O (East Africa-3 topotype) as the outbreak-causing strains. …”
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The Role of RNA Polymerase II Contiguity and Long-Range Interactions in the Regulation of Gene Expression in Human Pluripotent Stem Cells by Livia Eiselleova, Viktor Lukjanov, Simon Farkas, David Svoboda, Karel Stepka, Irena Koutna

“…Diverse approaches have demonstrated that transcription takes place at discrete sites known as transcription factories, wherein RNA polymerase II (RNAP II) is attached to the factory and immobilized while transcribing DNA. It has been proposed that transcription factories promote chromatin loop formation, creating long-range interactions in which relatively distant genes can be transcribed simultaneously. …”
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Young carers’ perspectives on navigating the healthcare system and co-designing support for their caring roles: a mixed-methods qualitative study by Jill I Cameron, Shoshana Hahn-Goldberg, Karen Okrainec, Marianne Saragosa, Yona Lunsky, Isabelle Caven, Susan Bookey-Bassett, Kristine Newman

“…Phase 1 resulted in three overarching themes: (1) navigating the YC role within the healthcare system; (2) being kept out of the loop; and (3) normalising the transition into caregiving. …”
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