The 3′ region of the ZPA regulatory sequence (ZRS) is required for activity and contains a critical E-box by Kathryn F. Ball, Kathryn F. Ball, Stephen Manu, Abbie K. Underhill, Jeanyoung Kim, Jessica C. Britton, Sarah R. Rudd, Madison M. Malone, Japhet Amoah, Allen Cooper, Charmaine Pira, Kerby C. Oberg

“…Reinstating each of the Hoxd13 sites restored focal activity, while restoring the 5′ and central E-boxes had little effect. …”
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COFLEX: a novel set point optimiser and feedforward–feedback control scheme for large, flexible wind turbines by G. Lazzerini, J. Deleuran Grunnet, T. Gybel Hovgaard, F. Caponetti, V. Datta Madireddi, D. De Tavernier, S. P. Mulders

“…Furthermore, the generator power shows an increase of up to 5 % in the partial-load region compared to the reference scheme while maintaining blade deflection at a similar level.…”
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Hot and cold exposure triggers distinct transcriptional and behavioral responses in laboratory-inbred pond snails by Veronica Rivi, Anuradha Batabyal, Cristina Benatti, Fabio Tascedda, Johanna Maria Catharina Blom, Ken Lukowiak

“…These data suggest, albeit at the transcriptional level, the existence of a negative feedback loop necessary for sustaining cellular functions when metabolic demands might shift towards conserving energy during prolonged cold exposure. …”
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Transcriptome remodeling drives acclimation to iron availability in the marine N2-fixing cyanobacterium Trichodesmium erythraeum IMS101 by Xin Zhong, Ran Duan, Shengwei Hou, Meng Chen, Xiaoming Tan, Wolfgang R. Hess, Tuo Shi

“…ABSTRACT While enhanced phytoplankton growth as a result of iron (Fe) fertilization has been extensively characterized, our understanding of the underlying mechanisms remains incomplete. …”
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Exploring the possibilities and limitations of customized large language model to support and improve cervical cancer screening by Viola Angyal, Ádám Bertalan, Péter Domján, Elek Dinya

“…Females valued guidance on screening schedules and early detection, while males highlighted the usefulness of information regarding HPV vaccination and its role in preventing HPV-related cancers. …”
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Expanding surgical training access: A phacoemulsification course via Orbis Cybersight by Fatma Shakarchi, Ayorinde Cooley, Curtis R Martin, Traeson Brandenburg, Nicolas Zaunbrecher, Christopher L Shelby, Stephen A LoBue, Wyche T Coleman, III

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Ultrasonic Transmit Beam Steering Using Slitted Transducer Design by Yinuo Enoch Zhao, Zheng Jie Tan, Wei-Bin Ewe, Wai Siang Yeoh, Rahul Singaram Senthilkumar, Viet Phuong Bui, Daniel Ssu-Han Chen, Xing Haw Marvin Tan

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The impact of high-salt diet and diuretics on the development of the aestival phenomenon in patients with chronic heart failure by Dmitrii O. Dragunov, Dmitrii O. Dragunov, Anna V. Sokolova, Anna V. Sokolova, Vadim M. Mitrokhin, Grigory P. Arutyunov

“…BackgroundChronic heart failure (CHF) often requires the use of high-dose loop diuretics to achieve decongestion. However, such therapy may lead to adverse effects, including deterioration of renal function and electrolyte imbalance. …”
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Breaking the psoriasis pathological signaling cycle: A novel nanomedicine strategy targeting metabolism and oxidative stress by Fugen Wu, Xing Xia, Yuqi Han, Zihao Huang, Yitianhe Xu, Zihao Tao, Yunzhi Wang, Dingchao Shen, Shengnan Song, Wanling Zhu, Ruijie Chen, Xianbao Shi, Xinyu Jiang, Longfa Kou

“…The abnormal metabolism and increased oxidative stress in psoriasis lesions have been identified as key drivers in the pathogenesis of psoriasis, forming a positive feedback loop within psoriatic skin. Therefore, targeting this feedback loop through modulation of local metabolism and alleviation of oxidative stress could be a rational and promising therapeutic strategy for addressing psoriasis. …”
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Generating Mechanism of Online Public Opinion Heat in Public Emergencies from the Perspective of Information Ecology: Fuzzy Set Qualitative Comparative Analysis Based on 50 Cases by YOU Ge, LI Jielin, ZHANG Fangshun

“…The intrinsic linkage between public emergencies and online discourse amplifies the dissemination of public emotions, attitudes, and perspectives across online platforms, creating a feedback loop that influences event dynamics. Investigating the generation mechanism of public opinion on hot topics in such contexts provides critical theoretical foundations for mitigating cyber discourse risks, while enhancing the accuracy and efficiency of governmental mangement over online public opinion. …”
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Enhancing seabed sediment classification with multibeam echo-sounding and self-training: a case study from the East Sea of South Korea by Changhoon Lee, Sujung Park, Daeung Yoon, Bo-Yeon Yi, Moonsoo Lim

“…IntroductionAccurate classification of seabed sediments is essential for marine spatial planning, resource management, and scientific research. While direct sampling yields precise sediment information, it is costly and spatially limited. …”
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Biocompatible Heterogeneous Packaging and Laser-Assisted Fluid Interface Control for In Situ Sensor in Organ-on-a-Chip by Yu-Hsuan Lin, Shing-Fung Lau, Yen-Pei Lu, Kuo-Cheng Huang, Chien-Fang Ding, Yu-Hsiang Tang, Hsin-Yi Tsai

“…By integrating precise biological and fluid condition sensing with microfluidics and electronic components, long-term dynamic closed-loop culture systems can be achieved. This study aims to develop biocompatible heterogeneous packaging and laser surface modification techniques to enable the encapsulation of electronic components while minimizing their impact on fluid dynamics. …”
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A Multi-Machine and Multi-Modal Drift Detection (M2D2) Framework for Semiconductor Manufacturing by Chin-Yi Lin, Tzu-Liang (Bill) Tseng, Tsung-Han Tsai

“…An interpretability layer—using attention visualization or SHAP/LIME—delineates which sensors, logs, or batch identifiers precipitate each drift alert, accelerating root-cause analysis. An active learning loop dynamically refines threshold settings and model parameters in response to real-time feedback, reducing false positives while adapting to evolving production conditions. …”
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Synthesis and exploration of structural, optical, magnetic, and electrical properties of Ti-doped Mn–Ni–Zn ferrite by Md. Arman Hossain, Hasan Khaled Rouf, Murad Hossain, Mohammad Khurshed Alam, Mohammed Nazrul Islam Khan

“…In addition, the dielectric constant and dielectric loss tend to decrease with increasing frequency, while resistivity increases with higher Ti concentrations. …”
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Critical review of methodological tools and trends for assessing the performance of inclusive circular cities by Susana Toboso-Chavero, Filippos K. Zisopoulos, Martin de Jong, Daan Schraven

“…Publications focusing simultaneously either on social and environmental dimensions or economic and environmental dimensions accounted for 3 % and 17 % of studies, respectively, while 70 % adopted a single-dimensional approach. …”
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Low-Cost Universal Multi-Mode Digital Compensator Design for Flyback Converters With Full Digital Feedback by Yun Gwan Kim, Jae Bin Kim, Byeong Gi Jang, Jae Hyung Jang, Sang-Sun Yoo, Seok Kee Kim, Yeon Jae Jung, Young Gun Pu, Kang-Yoon Lee

“…This study presents a low-cost digital compensator design for a flyback converter featuring a full digital feedback loop. This design replaces the traditional analog compensation circuit with a digital compensator, where the external resistance and capacitor are removed. …”
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Effect of teriflunomide on cortex-basal ganglia-thalamus (CxBGTh) circuit glutamatergic dysregulation in the Theiler's Murine Encephalomyelitis Virus mouse model of multiple sclero... by Claire M Modica, Ferdinand Schweser, Michelle L Sudyn, Nicola Bertolino, Marilena Preda, Paul Polak, Danielle M Siebert, Jacqueline C Krawiecki, Michele Sveinsson, Jesper Hagemeier, Michael G Dwyer, Suyog Pol, Robert Zivadinov

“…<h4>Objectives</h4>To investigate the effect of an immunomodulatory therapy (teriflunomide, Aubagio®) on changes of the CxBGTh loop in the Theiler's Murine Encephalomyelitis Virus, (TMEV) mouse model of MS.…”
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MAST Kinases’ Function and Regulation: Insights from Structural Modeling and Disease Mutations by Michael C. Lemke, Nithin R. Avala, Michael T. Rader, Stefan R. Hargett, Daniel S. Lank, Brandon D. Seltzer, Thurl E. Harris

“…<i>D. discoideum</i> contains MAST kinase-like proteins that exhibit a characteristic insertion within the T-loop but do not conserve DUF or PDZ domains. While the DUF domain is conserved in plants, the PDZ domain is not. …”
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Thermal limit of helical-nut surfaced tubes for divertor cooling by Ji Hwan Lim, Seung-Hwan Yu

“…This phenomenon stems from the fact that elevated subcooling expedites vapor condensation within the channel, while an augmented flow rate enhances forced convective heat transfer dynamics. …”
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Defective i6A37 modification of mitochondrial and cytosolic tRNAs results from pathogenic mutations in TRIT1 and its substrate tRNA. by John W Yarham, Tek N Lamichhane, Angela Pyle, Sandy Mattijssen, Enrico Baruffini, Francesco Bruni, Claudia Donnini, Alex Vassilev, Langping He, Emma L Blakely, Helen Griffin, Mauro Santibanez-Koref, Laurence A Bindoff, Ileana Ferrero, Patrick F Chinnery, Robert McFarland, Richard J Maraia, Robert W Taylor

“…This gene encodes human tRNA isopentenyltransferase, which is responsible for i6A37 modification of the anticodon loops of a small subset of cytosolic and mitochondrial tRNAs. …”
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