Upregulation of stomatin is associated with poor prognosis and promotes tumor progression of orbital diffuse large B-cell lymphoma by Wen Chen, Wen Chen, Jingyi Chi, Jingyi Chi, Weichen Song, Xiuyun Li, Jinlei Ma, Xinyu Liu, Lihua Xiao, Wenwen Zhu

“…The functional role of stomatin was examined through siRNA-mediated knockdown in DLBCL cell lines, followed by validation using quantitative RT-PCR and Western blot. …”
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PDK1 promotes epithelial ovarian cancer progression by upregulating BGN by Zhang Lei, Yan Lina, Fu Xin, Tao Ziqi, Liu Shuna, Li Rong, Wang Ting, Mao Yepeng, Shang Wenwen, Gong Mi, Jia Xuemei, Wang Fang

“…RNA sequencing analyses are performed to explore the differentially expressed genes in PDK1-silenced EOC cells. …”
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Comprehensive analysis and experiments identified ANXA1 as an unfavorable prognosticator in glioma by Yu Fan, Yanwen Chen, Xingda Run, Huaide Qiu, Qianxing Hu, Xudong Zhao, ZhongYuan Bao, Zengli Miao

“…The cancer-promoting mechanisms of ANXA1 in glioma and its correlation with the functional status of glioma patients warrant further investigation.…”
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Exploring fatty acids from royal jelly as a source of histone deacetylase inhibitors: from the hive to applications in human well-being and health by Fernanda Aparecida dos Santos France, Debora Kazumi Maeda, Ana Beatriz Rodrigues, Mai Ono, Franciele Lopes Nogueira Marchetti, Marcos Martins Marchetti, Allana Cristina Faustino Martins, Roberto da Silva Gomes, Cláudia Aparecida Rainho

“…Biochemical assays and gene expression analyses (Reverse Transcriptase – quantitative Polymerase Chain Reaction) were performed to evaluate the functional effects of the major RJ fatty acids, 10-HDA and 10-HDAA (10-hydroxy-decanoic acid), in two human cancer cell lines (HCT116 and MDA-MB-231). …”
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The LncRNA lnc-POTEM-4:14 promotes HCC progression by interacting with FOXK1 by Bo Peng, Zhipeng Quan, Lixing Liang, Mingjiang Liu, Kai Hu, Shilian Chen, Qiuli Xie, Jing Qin, Jingzhao Chen, Lijuan Liao, Songqing He, Zeyuan Li

“…We established lnc-POTEM-4:14 knockdown and overexpression cell lines to analyse the role of lnc-POTEM-4:14 in liver cancer through functional experiments such as qPCR and WB. …”
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Endoplasmic reticulum-localized circular RNA FAM13B restrains nasopharyngeal carcinoma lymphatic metastasis through downregulating XBP1 by Guo-Dong Jia, Si-Yi Xie, Xiao-Yun Li, Liang-Ji Li, Jing Jin, Li-Ting Liu, Xue-Song Sun, Sai-Lan Liu, Qiu-Yan Chen, Lin-Quan Tang, Li Yuan, Hai-Qiang Mai

“…Functional experiments, including cell invasion, migration, and metastasis assays, were performed in vitro and in vivo. …”
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Persistence of activated anti‐mesothelin hYP218 chimeric antigen receptor T cells in the tumour is associated with efficacy in gastric and colorectal carcinomas by Sameer Mir, Abhilash Venugopalan, Jingli Zhang, Nishanth Ulhas Nair, Manjistha Sengupta, Manakamana Khanal, Chaido Stathopoulou, Qun Jiang, Raffit Hassan

“…Mesothelin expression in gastric and colorectal cancer cell‐lines (n = 5) was analysed using flow cytometry. …”
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Relationship between Interleukin-6 gene polymorphism and hippocampal volume in antipsychotic-naïve schizophrenia: evidence for differential susceptibility? by Sunil Vasu Kalmady, Ganesan Venkatasubramanian, Venkataram Shivakumar, S Gautham, Aditi Subramaniam, Dania Alphonse Jose, Arindam Maitra, Vasanthapuram Ravi, Bangalore N Gangadhar

“…<h4>Background</h4>Various lines of evidence including epidemiological, genetic and foetal pathogenetic models suggest a compelling role for Interleukin-6 (IL-6) in the pathogenesis of schizophrenia. …”
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Empirical Analysis of Vulnerabilities in Blockchain-based Smart Contracts by Dr. Kashif Mehboob Khan, Ansha Zahid

“…The Ethereum network’s computing capabilities and functionalities are founded on the basis of SC. A smart contract is a self-executing agreement between buyer and seller with the terms of the settlement between them, written directly as lines of code, existing across a distributed decentralized blockchain network. …”
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Exosomal miR-452-5p Induce M2 Macrophage Polarization to Accelerate Hepatocellular Carcinoma Progression by Targeting TIMP3 by Hu Zongqiang, Chen Jiapeng, Zhao Yingpeng, Yan Chuntao, Wang Yiting, Zhu Jiashun, Li Li

“…Next, HCC cell lines were transfected with the mimics or the inhibitor of miR-452-5p. …”
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Identification of hub genes within the CCL18 signaling pathway in hepatocellular carcinoma through bioinformatics analysis by Jinlei Mao, Yuhang Tao, Keke Wang, Hanru Sun, Manqi Zhang, Liang Jin, Yi Pan

“…Our study focuses on investigating the prognostic impact of CCL18 and its signaling pathway in HCC patients and biological functions in vitro.MethodsHCC-related RNA-seq data were obtained from TCGA, ICGC, and GEO. …”
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SPP1 as a Prognostic and Immunotherapeutic Biomarker in Gliomas and Other Cancer Types: A Pan-Cancer Study by Wang K, Wan J, Zheng R, Xiao Y, Lv F, Ge H, Yang G, Cheng Y

“…The correlation of SPP1 expression with overall survival (OS), progression-free survival (PFS), immune cell infiltration, and immune checkpoint markers was analyzed. Functional validation was performed via SPP1 knockdown in glioma cell lines to evaluate effects on proliferation, invasion, and immune interactions.Results: SPP1 was found to be overexpressed in 27 tumor types, with high expression correlating with poor OS, PFS, and increased immune cell infiltration, particularly with CD8+ T cells and macrophages. …”
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MiR-181a-driven downregulation of cholesterol biosynthesis through SREBP2 inhibition suppresses uveal melanoma metastasis by Rui Wang, Claudia Gilbert, Houda Tahiri, Chun Yang, Solange Landreville, Pierre Hardy

“…Functional assays, including migration, invasion, and cancer stem-like cell (CSC) formation, were performed. …”
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Design of Magnetic Concrete for Inductive Power Transfer System in Rail Applications by Karl Lin, Shen-En Chen, Tiefu Zhao, Nicole L. Braxtan, Xiuhu Sun, Lynn Harris

“…This technology eliminates the need for overhead power lines and third rails, offering financial and operational advantages over conventional electric propulsion systems. …”
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Quantum Dot‐Based Immunolabelling of Extracellular Vesicles and Detection Using Fluorescence‐Based Nanoparticle Tracking Analysis by Eunyong Ha, Yewon Han, Minseop Kim, Zayakhuu Gerelkhuu, Sook Jin Kwon, Tae Hyun Yoon

“…They can interact with target cells to perform various functions, offering potential for therapeutic applications like drug delivery and diagnosis. …”
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Identification and validation of up-regulated TNFAIP6 in osteoarthritis with type 2 diabetes mellitus by Siyi Liu, Haitao Chen, Xu Yang, Yinxian Wen, Liaobin Chen

“…Differential expression analysis and weighted gene co-expression network analysis (WGCNA) were performed to screen out hub genes between OA and T2DM, and functional enrichment was done. …”
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High-Resolution Numerical Simulation and Impact Analysis of a Severe Convective Weather Process on the Kunming-Vientiane Route by Mei CHEN, Xiaohang WEN, Aijuan BAI, Minhong SONG

“…During March 23 and March 26， 2020， an area along the international route from Kunming， Yunnan to Vientiane， Laos experienced severe weather conditions including hail， thunderstorm winds， and heavy precipitation.A severe convective weather process was simulated using the mesoscale numerical model WRFV4.2 （Weather Research and Forecasting Model） and FNL （Final Operational Global Analysis） data from the National Centers for Environmental Prediction （NCEP）.Hourly weather station data from the China Meteorological Administration was used to check the reliability of the simulation.Furthermore， a diagnostic analysis of various physical quantities output from the WRF model was performed to provide an aviation safety reference for the Kunming-Laos Vientiane route in Yunnan.The results show that： （1） the WRF model can better simulate temperature and precipitable water， but the simulated values of the near-surface wind field are large during the daytime.（2） The simulated output physical quantity field of the simulation can indicate the time and location of severe convective weather， which has certain spatial and temporal forecasting and warning functions and can be used to judge the impact of severe convective weather on flight and the degree of impact according to it.（3） The severe convection was mainly caused by the eastward movement of the Southern Branch Trough， with dry and cold air in the upper levels superimposed on the warm and moist air forming an unstable structure， triggered by the surface convergence lines.Convective available potential energy （CAPE） in the route area is large， and the water vapor conditions are abundant-the rising motion and sinking motion alternate below 9 km altitude， which can cause turbulence during flights.Additionally， the 0 ℃ layer is located at an altitude of about 3 km， which can cause ice to form on the airframe or encounter hail weather， causing a certain impact on flight safety.…”
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Clinicо-morphological diagnostics and surgical treatment of paraduodenal pancreatitis by V. H. Yareshko, V. O. Tumanskyi, Yu. O. Mikheiev, O. M. Kiosov, A. O. Steshenko, N. O. Yareshko, A. V. Kanaki

“…In all cases, in the fields of fibrosis and chronic inflammation, cysts of various sizes were found: ductal cysts lined with ductal epithelium, and acinar cysts without epithelial lining with thickened connective tissue walls (encapsulated foci of enzymatically self-destroyed pancreatic tissue). …”
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HIF-PH inhibitors induce pseudohypoxia in T cells and suppress the growth of microsatellite stable colorectal cancer by enhancing antitumor immune responses by Yuehua Chen, Toshiaki Ohara, Yusuke Hamada, Yuze Wang, Miao Tian, Kazuhiro Noma, Hiroshi Tazawa, Masayoshi Fujisawa, Teizo Yoshimura, Akihiro Matsukawa

“…In vitro, we assessed the effects of HIF-PH inhibitors on human and murine colon cancer cell lines (SW480, HT29, Colon26) and murine T cells. …”
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Hypoxia-related Y RNA fragments as a novel potential biomarker for distinguishing metastatic oral melanoma from non-metastatic oral melanoma in dogs by MD Nazmul Hasan, MD Mahfuzur Rahman, Al Asmaul Husna, Daiki Kato, Takayuki Nakagawa, Mohammad Arif, Naoki Miura

“…However, further investigation is required to elucidate the biological functions of Y RNA under hypoxic conditions.…”
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