Genome-wide association study for charcoal rot resistance in soybean harvested in Kazakhstan by A. Zatybekov, S. Abugalieva, S. Didorenko, A. Rsaliyev, A. Maulenbay, C. Fang, Y. Turuspekov

“…The phenotypic evaluation was performed under natural conditions during the 2021–2022 period. …”
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Enhancing Creativity and Validation in Explanatory Deep Learning-Based Symbolic Music Generation: A Hybrid Approach With LSTM and Genetic Algorithms by Ahmad Zainul Fanani, Arry Maulana Syarif, Ika Novita Dewi, Abdul Karim

“…The model successfully generates new bars and lines with notation sequences not found in the original dataset, indicating creative variation. …”
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Tumor-derived exosomal miR-1247-3p promotes angiogenesis in bladder cancer by targeting FOXO1 by Zonglai Liu, Dan Du, Shizhong Zhang

“…Exosomes isolation from the culture medium of normal or bladder cancer cell lines was performed using a differential centrifugation method. miR-1247-3p expression in exosomes and cells was detected by quantitative real-time PCR (qRT-PCR). …”
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The Diverse Activities and Mechanisms of the Acylphloroglucinol Antibiotic Rhodomyrtone: Antibacterial Activity and Beyond by Rupa Rani, Gabriela Marinho Righetto, Ann-Britt Schäfer, Michaela Wenzel

“…Its antibacterial properties have been extensively studied. <b>Methods:</b> We performed a comprehensive literature review on rhodomyrtone and summarized the current knowledge about this promising acylphloroglucinol antibiotic and its diverse functions in this review. …”
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High-temperature terahertz quantum-cascade lasers: design optimization and experimental results by D. V. Ushakov, A. A. Afonenko, I. A. Glinskiy, R. A. Khabibullin

“…The THz QCL operating frequency band contains absorption lines for a number of substances that are suitable for biomedical and environmental applications. …”
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The Aporia of Reality/Imagination: Uncertainty in Selected Iranian Monodramas and Surrealist Dramas by Mohammad Bagher Ghahramani, Rahmat Amini, Sahar Meshginghalam

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LncRNA H19 acts as a ceRNA to promote glioblastoma malignancy by sponging miR-19b-3p and upregulating SERPINE1 by Wonyi Jang, Mijung Im, Goeun Yoon, Jungwook Roh, Wanyeon Kim

“…Our results offer new insights into the regulatory interplay among H19, miR-19b-3p, and SERPINE1 in GBM cell lines, a relationship that has not been clearly defined in previous research. …”
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Some aspects of morphogenesis of diabetic encephalopathy by V. A. Tumanskiy, Yu. N. Avramenko

“…As a result, energetic deficit and lactic acidosis are developing that in its turn leads to their structural and functional abnormalities [9]. It is determined that the important role in the development of chronicle abnormalities of cerebral blood flow under diabetes mellitus is performed by endothelial dysfunction, violation of autoregulation of cerebral blood flow, raising of viscosity and aggregative properties of blood [9]. …”
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Machine learning-enhanced discovery of tsRNA-mRNA regulatory networks: identifying novel diagnostic biomarkers and therapeutic targets in breast cancer by Zhongling Ma, Rui Wang, Ming Yuan, Bo Wang, Li Li, Tianfu Zhao, Xinhan Zhao

“…Comprehensive multi-omics analyses including survival, immune infiltration, drug sensitivity, and pathway enrichment were performed for identified targets. Functional validation was conducted in breast cancer cell lines.ResultsWe identified 297 differentially expressed tsRNAs and developed a four-tsRNA signature (tRF-21-FSXMSL73E, tRF-20-XSXMSL73, tRF-23-FSXMSL730H, tRF-23-YJE76INB0J) achieving AUC of 0.98 in discovery and 0.82 in validation cohorts. tRF-21-FSXMSL73E showed strong correlation with FAM155B expression. …”
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FCGBP promotes ovarian cancer progression via activation of IL-6/JAK-STAT signaling pathway by Zhiqin Fu, Kelie Chen, Fang Zheng, Wangang Gong, Ding Chao, Chao Lu

“…FCGBP expression was validated in ovarian cancer tissues using quantitative PCR, western blotting, and immunohistochemistry. Functional assays, including proliferation, migration, invasion, and colony formation, were conducted in SKOV3 and ES-2 ovarian cancer cell lines with FCGBP knockdown. …”
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The oncogenic lncRNA MIR503HG suppresses cellular senescence counteracting supraphysiological androgen treatment in prostate cancer by Julia Kallenbach, Mahdi Rasa, Mehdi Heidari Horestani, Golnaz Atri Roozbahani, Katrin Schindler, Aria Baniahmad

“…Functional assays reveal that MIR503HG promotes PCa cell proliferation and inhibits SAL-mediated cellular senescence, partly through miR-424-5p. …”
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Integrative analysis of T cell-associated markers in Ewing sarcoma reveals prognostic signatures and immune dynamics by Umair Ali Khan Saddozai, Umair Ali Khan Saddozai, Chenxu Liu, Chenxu Liu, Fei Yan, Zhendong Lu, Muhammad Babar Khawar, Muhammad Babar Khawar, Muhammad Usman Akbar, Saadullah Khattak, Haibo Sun, Haibo Sun, Ping Yang

“…Differentially expressed genes (DEGs) intersected with T cell markers identified a total of 174 T cell-associated genes. Functional enrichment analysis and molecular subtyping were performed to explore immune-related pathways. …”
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PYK2 promotes cell proliferation and epithelial-mesenchymal transition in endometriosis by phosphorylating Snail1 by Lu Liu, Lan Liu, Chenjing Yue, Shiyu Du, Jiayu Liu, Zhenhai Yu

“…Protein extracts from both ectopic tissues and cells were subjected to Western blot and co-immunoprecipitation (Co-IP) interaction validation. Functional assays (proliferation/migration/invasion) were performed using EESC and 11Z cell lines with triplicate biological replicates. …”
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Integration of single-cell transcriptomics and bulk transcriptomics to explore prognostic and immunotherapeutic characteristics of nucleotide metabolism in lung adenocarcinoma by Kai Zhang, Kai Zhang, Luyao Wang, Huili Chen, Lili Deng, Mengling Hu, Ziqiang Wang, Yiluo Xie, Chaoqun Lian, Xiaojing Wang, Xiaojing Wang, Jing Zhang

“…Finally, the key gene SNRPA was screened, and a series of in vitro experiments were performed on LUAD cell lines to explore the role of SNRPA in LUAD.ResultLUAD patients could be accurately categorized into subtypes based on the nucleotide metabolism-related prognostic risk score (NMBRS). …”
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SRSF1-mediated alternative splicing regulates bladder cancer progression and cisplatin sensitivity through HIF1A/BNIP3/mitophagy axis by Qikai Wu, Hao Yu, Huanyou Sun, Jiancheng Lv, Juntao Zhuang, Lingkai Cai, Lingjing Jiang, Yuhan Chen, Yiran Tao, Kexin Bai, Haiwei Yang, Xiao Yang, Qiang Lu

“…Methods The expression of SRSF1 in BCa tissues and cell lines was investigated using quantitative real-time PCR (RT-qPCR) and western blotting. …”
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Novel Potent and Selective Dopamine D4 Receptor Piperidine Antagonists as Potential Alternatives for the Treatment of Glioblastoma by Federica Matteucci, Pegi Pavletić, Alessandro Bonifazi, Rian Garland, Hideaki Yano, Consuelo Amantini, Laura Zeppa, Emanuela Sabato, Giulio Vistoli, Valerio Mammoli, Loredana Cappellacci, Fabio Del Bello, Gianfabio Giorgioni, Riccardo Petrelli, Alessia Piergentili, Wilma Quaglia, Alessandro Piergentili

“…<b>Methods</b>: All the new compounds <b>9–20</b> were evaluated for their radioligand binding affinity at D2-like receptor subtypes and the results were rationalized by docking studies and molecular dynamics (MD) simulations. The functional profiles of the most interesting derivatives were assessed at D4R Go and Gi protein and β-arrestin by BRET assay and their potential anticancer activity was determined in GBM cell lines. …”
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Drought-induced transposon expression reveals complex drought response mechanisms in Brassica napus by Manyi Chen, Dan Luo, Hanzhao Kong, Yan Lv, Chunsheng Li, Yongguo Zhao, Qian Huang, Guangyuan Lu, Guangyuan Lu

“…Functional annotation was performed for protein-coding TE transcripts located in intergenic regions to predict their involvement in biological processes. …”
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Targeting the <i>ZMYM2-ANXA9</i> Axis with <i>FLT3</i> Inhibitor G749 Overcomes Oxaliplatin Resistance in Colorectal Cancer by Dezheng Lin, Yucheng Xu, Huanmiao Zhan, Yufan Liang, Riyun Liu, Jun Liu, Dandong Luo, Xiaochuan Chen, Jiawei Cai, Yifeng Zou

“…The expression of <i>ANXA9</i> was evaluated in oxaliplatin acquired-resistant CRC cell lines via qPCR and Western blot. Functional studies, including RNA interference, colony formation, apoptosis assays, and drug sensitivity testing, were performed in vitro and in vivo to assess the role of <i>ANXA9</i>. …”
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DGKα Enhances Tumorigenic Activity in Bladder Cancer Patients With Chronic Kidney Disease by Kenshiro Takemoto, Kohei Kobatake, Tomoya Hatayama, Shinsaku Tasaka, Mai Okazaki, Yoshinori Nakano, Hiroyuki Shikuma, Kazuma Yukihiro, Kyosuke Iwane, Ryoken Yamanaka, Ryo Tasaka, Yuki Kohada, Miki Naito, Shunsuke Miyamoto, Yohei Sekino, Hiroyuki Kitano, Keisuke Goto, Akihiro Goriki, Keisuke Hieda, Nobuyuki Hinata

“…Second, we conducted a molecular functional analysis of DGKα in BC and investigated the contribution of DGKα to cell invasion, migration, and proliferation activity using human BC cell lines. …”
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Developmental regulators in promoting genetic transformation efficiency in maize and other plants by Yilin Jiang, Xun Wei, Meirui Zhu, Xiaoyan Zhang, Qingping Jiang, ZiXiao Wang, Yanyong Cao, Xueli An, Xiangyuan Wan

“…Genetic transformation technology has become an effective tool for performing functional genomics research and molecular breeding. …”
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