Integrative genomic analysis identifies DPP4 inhibition as a modulator of FGF17 and PDGFRA downregulation and PI3K/Akt pathway suppression leading to apoptosis by Kiran Kumar Chitluri, Emerson Isaac Arnold

“…Further, in vitro assays were performed to investigate and validate the molecular role of DPP4 through pharmacological inhibition using Linagliptin, a selective DPP4 inhibitor. …”
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TOX, through a glass, darkly by Patrick G. Hogan, Patrick G. Hogan, Patrick G. Hogan, Bruno Villalobos Reveles, Leo Josue Arteaga Vazquez

“…We discuss some mechanisms that other HMG-box transcription factors employ to perform their cellular functions, as examples of the range of mechanisms TOX might employ in furthering T cell exhaustion. …”
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ESCO2 inhibition induces cell cycle arrest and apoptosis in breast cancer via the P53-CDK1 axis and the BAX/Bcl2/caspase signaling cascade by Pingchuan Li, Lineng Wei, Meng Li, Xiaoqiang Liu, Huawei Yang

“…ESCO2 expression was further investigated in breast cancer cell lines. Functional assays, including overexpression and knockdown of ESCO2 in MDA-MB-231 and MDA-MB-468 cells, were performed to assess its effects on the cell cycle and apoptosis. …”
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Exploring the level of metabolic reprogramming and the role of prognostic factor SF3A3 in hepatocellular carcinoma through integrated single-cell landscape analysis. by Wanshuo Wei, Yuan Gan, Xindan Zhang, Yumo Chen, Zengfeng Huang, Shuhan Wang, Xiaomei Xie, Yongle Li, Pengtao Qin, Lihe Jiang

“…Analysis of copy number variations (CNVs) was performed on tumor-derived epithelial cells, with the epithelial cells in Cluster 3 subgroup showing the highest CNV levels. …”
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Small GTPase ARL4C Associated with Various Cancers Affects Microtubule Nucleation by Evgeniia Ulas, Ilya Brodsky, Anton Burakov

“…Although ARL4C can bind alpha-tubulin and affect intracellular transport, the role of ARL4C in the functioning of the tubulin cytoskeleton remained unclear. …”
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Subtype cluster analysis unveiled the correlation between m6A- and cuproptosis-related lncRNAs and the prognosis, immune microenvironment, and treatment sensitivity of esophageal c... by Ming Zhang, Yani Su, Pengfei Wen, Xiaolong Shao, Peng Yang, Peng An, Wensen Jing, Lin Liu, Zhi Yang, Mingyi Yang

“…Drug sensitivity analysis was performed to identify potential therapeutic agents for EC. …”
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Elite Alleles of EPE1 Identified via Genome-wide Association Studies Increase Panicle Elongation Length in Rice by Hao Sun, Qiqi Yao, Mei Hai, Tianhu Li, Jinghan Sun, Zhengbo Liu, Yang Ang, Yingying Zhao, Yanan Zhang, Xianping Cheng, Tao Huang, Yinping Chang, Mingyu Du, Erbao Liu

“…Mining genes controlling PEL in rice (Oryza sativa L.) has great practical significance in breeding cytoplasmic male sterility (CMS) lines with increased PEL and simplified, high-efficiency seed production. …”
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Preliminary study of the mechanism of isolinderalactone inhibiting the malignant behavior of bladder cancer by Qun Wang, Wenkai Xu, Lu Ying, Hongjin Shi, Yuxin Sun, Wei Feng, Haole Xu, Jun Xie, Hairong Wei, Zhao Yang, Haifeng Wang

“…Isolinderalactone (ILL), extracted from the dried tubers of Linderae aggregate, has multiple functions, such as antioxidation, antitumor, and anti-infection effects. …”
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Immunomodulatory and anticancer effects of moringa polyherbal infusions: potentials for preventive and therapeutic use by Wamidh H. Talib, Wamidh H. Talib, Hadeel Shaher Al Junaidi, Heba K. Alshaeri, Moudi M. Alasmari, Moudi M. Alasmari, Rawan W. Hadi, Ahmad Riyad Alsayed, Douglas Law

“…The “miracle tree,” Moringa oleifera (Moringa), possesses remarkable nutritional and medicinal properties.AimThis study assesses the anti-tumor and immunomodulatory characteristics of M. oleifera aqueous leaf extract and its combinations with green tea, saffron, lavender, and turmeric.MethodsThe MTT assay evaluated the anti-proliferative effectiveness of uncombined M. oleifera and its combinations against three breast cancer cell lines. Quantitative LC-MS/MS spectrometry was performed on the most potent extracts. …”
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Development of a Novel KCNN4-Related ceRNA Network and Prognostic Model for Renal Clear Cell Carcinoma by Hengtao Bu, Qiang Song, Jiexiu Zhang, Yuang Wei, Bianjiang Liu

“…Finally, quantitative real-time polymerase chain reaction and western blot were conducted for KCNN4 expression detection in cell lines and clinical samples. Small interfering RNA was employed to knock down KCNN4, and corresponding functional experiments were conducted on ccRCC cells as well. …”
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Elevated THOC5 expression in liver cancer and its implications for tumor progression and therapeutic response by Jin-Shu Pang, Jin-Shu Pang, Yu Yang, Yu Yang, Li Liang, Yu-Jia Zhao, Jin-Dan Li, Li-Peng Li, Xue-Xin Wei, Rui-Zhi Gao, Rong Wen, Yun He, Hong Yang, Hong Yang, Hong Yang, Xiu-Mei Bai, Xiu-Mei Bai

“…Single-cell RNA sequencing, in-house RNA-seq, immunohistochemistry, and proteomic analysis were employed to further validate THOC5 expression and prognosis in LIHC. Functional assays, including wound-healing and Transwell migration, were performed following THOC5 knockdown in LIHC cell lines. …”
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Inhibition of SIRT3 by a specific inhibitor induces cellular senescence and growth arrest of ovarian granulosa cell tumor via p53 and NF-κB axis by Jingxin Ma, Sailing Lin, Chuimian Zeng, Wenhao Wu, Qi Zhang, Guli Zhu, Qi Zhang, Qiongfang Fang, Lijun Fan, Shunichi Takeda, Xiaoyu Li, Xiaoyu Li, Xiushen Li, Yu Zhou, Xueqing Wu

“…SIRT3, an NAD + -dependent deacetylase, is upregulated in GCTs and implicated in tumorigenesis, yet its functional role and underlying mechanisms remain poorly understood. …”
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Long-read RNA sequencing enables full-length chimeric transcript annotation of transposable elements in lung adenocarcinoma by Yang Li, Yahui Liu, Yingxin Xie, Yaxuan Wang, Jing Wang, Huan Wang, Lin Xia, Dan Xie

“…To assess the functional roles of a specific TCTs, cell migration and cell proliferation assays were performed. …”
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Comprehensive Analysis Reveals the Potential Diagnostic Value of Biomarkers Associated With Aging and Circadian Rhythm in Knee Osteoarthritis by Hao Li, Yuze Yang, Bo Li, Jiaju Yang, Pengyu Liu, Yuanpeng Gao, Min Zhang, Guangzhi Ning

“…Additionally, the findings and functional roles of the biomarkers were further validated through experiments on human cartilage tissue and cell models. …”
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An intraoral approach to minimize morbidity in a pediatric trauma case by Bima Baskara, Lucas Pedro Bernardo, Poerwati Soetji Rahajoe, Bramasto Purbo Sejati, Erdananda Haryosuwandito

“…A CT scan disclosed more than two fracture lines that involved the mandibular symphysis and a basal triangle fracture. …”
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Isoliensinine Induces Ferroptosis in Urothelial Carcinoma Cells via the PI3K/AKT/HIF-1α Axis: Molecular Evidence from Next-Generation Sequencing by Yun-Chen Li, Hsuan-En Huang, Chia-Ying Yu, Ya-Chuan Chang, Shu-Yu Lin, Shao-Chuan Wang, Wen-Wei Sung

“…RNA sequencing analysis, performed to explain the underlying mechanisms, revealed a significant regulation of cell functions, including apoptosis, the cell cycle, hypoxia-inducible factor 1 (HIF-1) signaling, tumor necrosis factor (TNF) signaling, and ferroptosis. …”
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Abstract 219: Determining the Proportion of Patients with Poor Premorbid mRS presenting with Large Volume Stroke by Madheea Siddiqi

“…Introduction Several lines of evidence demonstrate the effectiveness of endovascular treatment (EVT) for large volume stroke (LVS) as defined by Alberta Stroke Program Early CT Score (ASPECTS) of <6 in decreasing severe disability and death. …”
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Identification of anoikis-related molecular patterns and the novel risk model to predict prognosis, tumor microenvironment infiltration and immunotherapy response in bladder cancer by Luochen Zhu, Feng Xiao, Yi Hou, Shenjun Huang, Yanyan Xu, Xiaohong Guo, Xinwei Dong, Chunlu Xu, Xiaolei Zhang, Haijuan Gu

“…In addition, representative genes were evaluated using immunohistochemistry in clinical specimens, and in BLCA cell lines, functional experiments were performed to determine the biological behavior of hub gene PLOD1.ResultTwo definite anoikis subgroups were identified. …”
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Ionotropic Gelation Synthesis of Chitosan-Alginate Nanodisks for Delivery System and In Vitro Assessment of Prostate Cancer Cytotoxicity by David Patiño-Ruiz, Leandro Marrugo, Niradiz Reyes, María Acevedo-Morantes, Adriana Herrera

“…Finally, the cytotoxicity effect of the Cs-Al nanodisks was performed in human prostatic epithelial PWR-1E and Caucasian prostate adenocarcinoma PC-3 cell lines, in which the cell viability was above 80% indicating low inhibition and determining the Cs-Al NDs as a promising technology for controlled delivery systems.…”
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Genetic interaction between DNA repair factors PAXX, XLF, XRCC4 and DNA‐PKcs in human cells by Mengtan Xing, Valentyn Oksenych

“…Moreover, ATM possesses overlapping functions with DNA‐PKcs, XLF, and XRCC4, but not with PAXX in response to DSBs. …”
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