Prognostic Role of SETDB2 in Clear Cell Renal Cell Carcinoma: Linking Immune Infiltration, Cuproptosis, and Tumor Suppression by Lu SH, Lui K, Qian Y, Zhou WY, Mu YY, Zhang W

“…In the end, the core target and the active molecule were both given the green light for a molecular docking investigation. Functional assays and Western blotting performed with ccRCC cell lines were employed for the validation of the findings from these predictive analyses.Results: SETDB2 downregulation was observed in ccRCC, and lower levels were found to linked with poor patient outcomes. …”
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An in vitro pharmacogenomic approach reveals subtype-specific therapeutic vulnerabilities in atypical teratoid/rhabdoid tumors (AT/RT) by David Pauck, Daniel Picard, Mara Maue, Kübra Taban, Viktoria Marquardt, Lena Blümel, Jasmin Bartl, Nan Qin, Nadezhda Kubon, Dominik Schöndorf, Frauke-Dorothee Meyer, Johanna Theruvath, Siddhartha Mitra, Martin Hasselblatt, Michael C. Frühwald, Guido Reifenberger, Marc Remke

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MLN0905 effectively kills gemcitabine-resistant pancreatic cancer cells by targeting PLK1 by Min Lin, YongSha Pan, Shanshan Han, Lifei Zhu, Peng Ye, Ming Ye, Zejun Fang

“…Meanwhile, several detects for alanine aminotransferase (ALT), aspartate aminotransferase (AST), glucose (GLU) and creatinine (Cr) were also performed to further confirm the safety of MLN0905 in liver and kidney functions. …”
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Network analyses identify liver‐specific targets for treating liver diseases by Sunjae Lee, Cheng Zhang, Zhengtao Liu, Martina Klevstig, Bani Mukhopadhyay, Mattias Bergentall, Resat Cinar, Marcus Ståhlman, Natasha Sikanic, Joshua K Park, Sumit Deshmukh, Azadeh M Harzandi, Tim Kuijpers, Morten Grøtli, Simon J Elsässer, Brian D Piening, Michael Snyder, Ulf Smith, Jens Nielsen, Fredrik Bäckhed, George Kunos, Mathias Uhlen, Jan Boren, Adil Mardinoglu

“…Experiments in human cancer cell lines, mouse liver samples, and primary human hepatocytes validated our predictions by demonstrating functional relationships between these liver genes, and showing that their inhibition decreases cell growth and liver fat content. …”
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Mitochondrial fission regulator 2 promotes cell proliferation, migration and invasion in hepatocellular carcinoma through regulating PI3K/AKT signaling pathway by Qiang Sun, Kaikun Liu, Fangjie Zheng, Xinwei Chen

“…Validation of MTFR2 expression levels in clinical samples and HCC cell lines was performed through qRT-PCR and western blot. …”
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Modern methods of eliminating conjunctival defects by I. A. Filatova, S. A. Shemetov, O. V. Sokolova

“…Performing important physiological functions, the conjunctiva is a structure necessary for maintaining the normal anatomy and physiology of the eye. …”
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Protein kinase R regulates pancreatic ductal adenocarcinoma progression by modulating the cell cycle via GADD45A by Yuki Numata, Mitsuhito Koizumi, Takao Watanabe, Osamu Yoshida, Yoshio Tokumoto, Kaori Marui, Sho Ishikawa, Masahito Kokubu, Yusuke Okujima, Yoshiki Imamura, Teruki Miyake, Teru Kumagi, Yoichi Hiasa

“…Abstract Protein kinase R (PKR) functions both as a promoter and inhibitor in various cancers; however, its role in pancreatic ductal adenocarcinoma (PDAC) remains unclear. …”
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Frequency of irritable bowel syndrome in spondyloarthritis: a multicentric cross-sectional study and meta-analysis by Adeline Ruyssen-Witrand, Thomas Barnetche, Cécile Gaujoux-Viala, Sylvain Mathieu, Anne Tournadre, Marie-Elise Truchetet, Cédric Lukas, Jessika Bernard, Charlotte Amory, Jerome Despres, Maxime Vandersmissen, Justine Landrin, Pascale Vergne-Salle

“…Patients with IBS symptoms tended to have more difficult to manage disease characterised by higher activity, worse functional score and multiple lines of treatment in univariate analysis.…”
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METTL3/YTDHF1 Stabilizes MTCH2 mRNA to Regulate Ferroptosis in Glioma Cells by Hongjun Liu, Shasha Tan, Zhenyu Zhao, Xiaoping Tang, Zhou Li, Jian Qi

“…To assess the effects of MTCH2 knockdown and overexpression on glioma cell functions, we performed a series of functional assays, including cell viability, colony formation, and measurements of lipid reactive oxygen species (lipid ROS) and malondialdehyde (MDA) levels. …”
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Bioprinting of GelMA-Based Hydrogels to Aid in Creation of Biomimetic 3D Models for Glioblastoma by Kaitlyn Ann Rose Schroyer, Kylie Marie Schmitz, Gunjeeta Raheja, Bin Su, Justin D. Lathia, Liqun Ning

“…Biocompatibility testing was performed via live/dead and AlamarBlue analyses using GBM cells (both commercial cell lines and patient-derived cell lines) encapsulated in the constructs, along with immunohistochemistry staining to understand how ECM properties altered the functions of GBM cells. …”
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The Role of Fat Mass and Obesity-Associated (FTO) Gene in Non-Small Cell Lung Cancer Tumorigenicity and EGFR Tyrosine Kinase Inhibitor Resistance by Aayush Rastogi, Rong Qiu, Rachel Campoli, Usama Altayeh, Sarai Arriaga, Muhammad J. Khan, Subaranjana Saravanaguru Vasanthi, Robert Hillwig, Neelu Puri

“…In this study, we seek to explore the role of FTO in non-small cell lung cancer (NSCLC) tumorigenicity and its relationship with epidermal growth factor receptor (EGFR) tyrosine kinase resistance. <b>Methods</b>: We performed qPCR, immunoblotting, viability assays, migration assays, and ATP assays to investigate the functions of FTO in EGFR tyrosine kinase inhibitor (TKI) resistance, specifically to erlotinib, in three NSCLC cell lines harboring either wild-type or mutant EGFR. …”
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Decreased PD-L1 contributes to preeclampsia by suppressing GM-CSF via the JAK2/STAT5 signal pathway by Yingying Tian, Xu Peng, Xiuhua Yang

“…In the present investigation, 30 normal pregnant females and 30 PE patients were enrolled. Cellular functional experiments were performed in two trophoblast cell lines by transfection with lentiviral vectors for overexpression and down-regulation of PD-L1. …”
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Medial Femoral Condyle Flap for Nasal Support in Cocaine-Induced Midline Destruction by Pedro Alvedro-Ruiz, Belén Andresen-Lorca, Iván Heredia-Alcalde, Alessandro Thione, María Dolores Pérez-del-Caz, Alberto Pérez-García

“…Total nasal reconstruction was performed using a medial femoral condyle free flap (MFCFF) for internal lining and bone support in combination with a paramedian forehead flap for external coverage. …”
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ELECTROMAGNETIC FIELD APPLICATION IN FLUIDIZATION OF METALLIC PARTICLES by GABRIELA MUNTIANU, ILEANA-DENISA NISTOR, DIANA-CARMEN MIRILĂ, ANA-MARIA GEORGESCU, VASILICA-ALISA ARUȘ, NICOLETA PLATON, COSMIN JINESCU

“…Mapping and measurement of the coaxial electromagnetic field were performed in the axial and radial directions of the magnetic field lines to determine the magnetic induction and to verify the electrical resistance. …”
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Development of Technical Diagnostics for Lubrication in Gear Modules for Advanced Robotic Applications by Silvia Maláková, Ľubomír Ilečko, Tibor Krenicky, Marian Dzimko

“…The paper focuses on the experimental investigation of the impact of filtration and tribological parameters on the reliability, service life, and functional characteristics of gear mechanisms used in robotics. …”
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m6A-modified lncRNA GAS5 promotes M1-polarization of microglia in alcohol use disorder by Shuang Zhu, Peng Wang, Jian Hu

“…The effect of GAS5 on the functionality of SH-SY5Y cells was evaluated using CCK-8 and Transwell assays. …”
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The teams’ formation in sport aerobics on the basis of application of multidimensional analysis methods by Zh.L. Kozina, T.V. Shepelenko, Miroslawa Cieslicka, Katarzyna Prusik, Radoslaw Muszkieta, A.V. Osiptsov, V.M. Kostiukevych, T.A. Bazilyuk, I.N. Sobko, O.A. Ryepko, S.B. Polishchuk, A.S. Ilnickaya

“…The general recommendations about selection of programs’ story lines for athletes of each group are developed. Conclusions. …”
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Surgical Anatomy of the Gastrointestinal Tract and Its Vasculature in the Laboratory Rat by Katarína Vdoviaková, Eva Petrovová, Marcela Maloveská, Lenka Krešáková, Jana Teleky, Mario Zefanias Joao Elias, Darina Petrášová

“…On adult Wistar rats corrosion casts were prepared from the arterial system and Duracryl Dental and PUR SP were used as a casting medium and was performed macroscopic anatomical dissection of the stomach, liver, and intestine was performed. …”
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Specific gene expression signatures induced by the multiple oncogenic alterations that occur within the PTEN/PI3K/AKT pathway in lung cancer. by Carmela De Marco, Carmelo Laudanna, Nicola Rinaldo, Duarte Mendes Oliveira, Maria Ravo, Alessandro Weisz, Michele Ceccarelli, Elvira Caira, Antonia Rizzuto, Pietro Zoppoli, Donatella Malanga, Giuseppe Viglietto

“…Expectedly, the analysis of the DEGs common to all three alterations highlighted a group of BioFunctions that included Cell Proliferation of tumor cell lines (14 DEGs), Invasion of cells (10 DEGs) and Migration of tumour cell lines (10 DEGs), with a common core of 5 genes (ATF3, CDKN1A, GDF15, HBEGF and LCN2) that likely represent downstream effectors of the pro-oncogenic activities of PI3K/AKT signalling. …”
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Identification of lactylation-associated immune and metabolic regulators in bladder cancer via integrated bulk and single-cell transcriptomics by Yanjun Chen, Yu Sun, Xiaoyan Liu, Xiaoyan Liu

“…Comprehensive bioinformatics analyses were conducted to assess immune infiltration, tumor microenvironment characteristics, and the lactylation landscape at the single-cell level. Furthermore, we performed in vitro experiments to evaluate the biological functions of key lactylation-related genes in BLCA cells.ResultsSix lactylation-related hub genes were identified, among which FASN and RUNX2 were significantly upregulated in BLCA and associated with poor prognosis. …”
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