Amine-Terminated Silver Nanoparticles Exhibit Potential for Selective Targeting of Triple-Negative Breast Cancer by Jayshree H. Ahire, Qi Wang, Yuewei Tao, Yimin Chao, Yongping Bao

“…Our findings reveal that the amine-capped AgNPs exhibit significant selective toxicity against TNBC cell lines MCF7 and MDA-MB-231 at a concentration of 40 µg/mL without affecting normal breast cell lines MCF10A. …”
Get full text

Allelic expression mapping across cellular lineages to establish impact of non‐coding SNPs by Veronique Adoue, Alicia Schiavi, Nicholas Light, Jonas Carlsson Almlöf, Per Lundmark, Bing Ge, Tony Kwan, Maxime Caron, Lars Rönnblom, Chuan Wang, Shu‐Huang Chen, Alison H Goodall, Francois Cambien, Panos Deloukas, Willem H Ouwehand, Ann‐Christine Syvänen, Tomi Pastinen

“…By perturbing NFκB action in lymphoblasts, we identified 489 cis‐regulated transcripts with altered AE after NFκB perturbation. Altogether, we perform a comprehensive analysis of cis‐variation in four cell populations and provide new tools for the identification of functional variants associated to complex diseases.…”
Get full text

High transfection efficiency and cell viability of immune cells with nanomaterials-based transfection reagent by Song Wang, Dan Tian

“…This method should be applicable for many cell lines and can be used to decipher gene functions of lymphocytes.…”
Get full text

Tankyrase inhibitors suppress hepatocellular carcinoma cell growth via modulating the Hippo cascade. by Jiaoyuan Jia, Yu Qiao, Maria G Pilo, Antonio Cigliano, Xianqiong Liu, Zixuan Shao, Diego F Calvisi, Xin Chen

“…Previous data indicate that Tankyrase inhibitors exert anti-growth functions in many cancer cell lines due to their ability to inactivate the YAP protooncogene. …”
Get full text

The effect of PDLIM7 on cell proliferation, migration, and drug sensitivity in clear cell renal cell carcinoma by Chong Shen, Jian Zhuo, Jianying Wang

“…PDLIM7 is a protein containing PDZ and LIM structural domains, which performs varied functions through interactions with different proteins. …”
Get full text

Calculation of Technological Consumption (Loss) of Electricity in Modern 0.38–10 kV Electrical Distribution Networks by M. I. Fursanov, A. A. Zalotoy, V. V. Makarevich

“…. New conditions of functioning of electric power industry, tougher of requirements to technological condition of the industry predetermined transition to restructuring of electric networks on the basis of innovative structure of SMART GRID. …”
Get full text

Identification and Validation of Immune Implication of R-Spondin 1 and an R-Spondin 1-Related Prognostic Signature in Esophagus Cancer by Yuansheng Lin, Xinqi Lou, Shengjun Li, Wei Cai, Tuanjie Che

Get full text

HDAC5, an early osimertinib-responsive gene, is a novel therapeutic target for the drug resistance in EGFR-mutant lung adenocarcinoma cells by Hanbing Lyu, Akihiko Ishimura, Ryusuke Suzuki, Khurelsukh Buyanbat, Gerelsuren Batbayar, Makiko Meguro-Horike, Shin-ichi Horike, Seiji Yano, Takeshi Suzuki

Get full text

Digitalization Development as Factor Causing Changes in Taxation Administration by V. I. Bratcev, A. M. Grishanova

“…Managing changes in the field of digital economy requires designing and adopting regulatory decisions, which could eliminate barriers and create favorable conditions for the development of this field and cut risks connected with broad application of new technologies. In order to perform their principle functions, including those providing a high level of cash receipts to the budget system of the Russian Federation in conditions of economy digitalization tax bodies today shall develop their own digital platform, around which the ecosystem for taxpayers will be formed. …”
Get full text

The mechanisms of HER2 targeted ADCs are dependent on Rab GTPases by Astrid Medhus, Kay Oliver Schink, Ane Sager Longva, Olav Engebraaten, Kristian Berg, Anette Weyergang

“…Functional studies, including knockdown (KD), overexpression, and microscopy, were performed to evaluate the impact of Rab GTPases on ADC cytotoxicity. …”
Get full text

Single-cell analysis of mature hepatocytes reveals an IRF1-driven restriction of HDV infection by Frauke Lange, Jonathan Garn, Matthias Bruhn, Thomas Pietschmann, Arnaud Carpentier

“…We visualised viral genomic and antigenomic sequences abundance and innate immune response at the single-cell level. Further functional characterisation was performed in HLCs and hepatoma cell lines. …”
Get full text

Implication of CCNG1 in radiosensitivity via the Wnt/β-catenin pathway in esophageal squamous cells by Yuxiang Zhang, Zhiman Zhu, Naihan Ren, Dongni Wang, Xue Zeng, Na Zhang

“…Radioresistant ESCC cell lines were generated to explore the functional role of CCNG1. …”
Get full text

Lipid-mediated hydrophobic gating in the BK potassium channel by Lucia Coronel, Giovanni Di Muccio, Brad S. Rothberg, Alberto Giacomello, Vincenzo Carnevale

“…Abstract Structures of the large-conductance, calcium-activated potassium (BK) channel in the Ca2+ −bound and Ca2+ −free states have suggested that K+ conduction is not gated via a steric closure of the pore-lining helices of the channel, in contrast to the gating mechanism of other 6TM channels. …”
Get full text

Effect of long-stranded non-coding RNA-BANCR on the progression of thyroid papillary carcinoma and its mechanism by Jiayi Yu, Kai Hong, Lingli Yao, Dongbo Shi, Jiabo Zhang

“…Methods Sixteen PTC patients were stratified into four groups (PTC, HT, HT-LNM, and PTC-LNM) based on cervical lymph node metastasis and concurrent Hashimoto's thyroiditis (HT) to explore BANCR expression and its relationship with immune-related factors and tumor microenvironment (TME). Functional assays, including Transwell invasion, colony formation, and CCK8 were performed to evaluate the biological effects of BANCR in PTC cell lines. …”
Get full text

Efficient, cell-type-specific production of flavonols by multiplexed CRISPR activation of a suite of metabolic enzymes by Anaxi Houbaert, Valérie Denervaud Tendon, Lukas Hoermayer, Nicholas Morffy, Lucia C. Strader, Niko Geldner

“…Here, we present a CRISPR activation system that efficiently drives expression in a cell-type-specific manner in stable lines, which requires assessing expression on a cellular basis using fluorescent reporter lines. …”
Get full text

The Pillars of Societal Bioharmonism a Conceptualist Contribution to the Evolution of the Contemporary Society by Romulus Gruia, Liviu Gaceu, Oana Bianca Oprea

“…This paper analyzes the definition and role of societal bioharmonism, then the methodological argumentation based on specific notions, principles, and laws, and finally, describes the application lines of the pillars of bioharmonism, using as a case study the provision of food for the human population. …”
Get full text

Adenosine Receptor 3 in Liver Cancer: Expression Variability, Epigenetic Modulation, and Enhanced Histone Deacetylase Inhibitor Effects by Louise Kaldjob-Heinrich, Sandro Nuciforo, Steffen Lemke, Aaron Stahl, Stefan Czemmel, Sepideh Babaei, Lauriane Blukacz, Marie-Anne Meier, Yizheng Zhang, Christian M. Schürch, Irene Gonzalez-Menendez, Pascal Woelffing, Nisar P. Malek, Veit Scheble, Sven Nahnsen, Manfred Claassen, Markus Templin, Hans Bösmüller, Markus H. Heim, Daniel Dauch, Michael Bitzer

Get full text

Pulmonary surfactant system by Zafer Durgun, Ercan Keskin

“…Pulmonary surfactant, a phospholipid-protein complex that lines the alveoli and small airways of the lungs, is secreted by type ll alveolar epithelial cells. …”
Get full text

THE ROLE OF PAYMENT AGENTS IN THE PROCESS OF SHAPING THE NATIONAL PAYMENT SYSTEM by Irina V. Vashchekina

“…The author puts forward concrete steps aimed at shaping a united system of payment agents' interaction, identifies 4 strategic lines of their development depending on functions performed by bank agents.…”
Get full text

Cytosolic delivery of monobodies using the bacterial type III secretion system inhibits oncogenic BCR: ABL1 signaling by Chiara Lebon, Sebastian Grossmann, Greg Mann, Florian Lindner, Akiko Koide, Shohei Koide, Andreas Diepold, Oliver Hantschel

“…Phospho flow cytometry and apoptosis assays were performed to assess the functional effects of monobody translocation into BCR:ABL1-expressing leukemia cells. …”
Get full text