Hybrid Integration of a Beam-Steering Leaky-Wave Antenna and Power Amplifier MMIC Using UPD Printing in 220 to 325 GHz Range by Georg Gramlich, Elizabeth Bekker, Luca Valenziano, Joel Dittmer, Martin Roemhild, Holger Baur, Fabian Thome, Axel Tessmann, Michael Kuri, Tom Neerfeld, Andreas Stohr, Sebastian Randel, Christian Koos, Norbert Fruehauf, Thomas Zwick, Akanksha Bhutani

“…A separate UPD-printed CPW test assembly is manufactured on a single polymer substrate, and custom through-reflect-line calibration standards are printed on the same substrate to experimentally validate the insertion loss of a UPD-printed CPW in the 220 GHz to 325 GHz range. …”
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Anoikis in hepatocellular carcinoma: genetic alterations and immune microenvironment insights from single-cell and computational analysis by Bing Zhou, Jialing Zhang, Mingfeng Guo

“…Key findings were validated using qPCR on clinical samples, and functional assays using shRNA-mediated knockdown of KPNA2 were conducted in Hep-3B cell lines to assess changes in proliferation and migration. …”
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Comprehensive bioinformatics analysis of EXOSC family genes in head and neck squamous cell carcinoma by Xuezhong Zhang, Mengmeng Zhao, Tingting Chu, Jiasha Wei, Qingmei Jia

“…Experimental validation was performed by qRT-PCR in HNSC and normal cell lines. …”
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Exploring the therapeutic potential and in vitro validation of baicalin for the treatment of triple-negative breast cancer by Yuan Ma, Ying Pan, Qiancheng Zhao, Chongheng Zhang, Haitao He, Lihua Pan, Jianling Jia, Aiping Shi, Yiming Yang, Wenfeng Zhang

“…Three compound target prediction platforms, Swiss Target Prediction, SEA and Pharmmapper, were used to predict baicalin-related targets, and mapped with the triple-negative breast cancer-related targets retrieved from GeneCards and OMMI databases to obtain the potential targets of baicalin for the treatment of triple-negative breast cancer; the STRING database and the STRING database and Cytoscape software were used to construct the protein interaction network and screen the core targets; GO and KEGG enrichment analyses were performed on the core targets; the binding of baicalin to the key targets of triple-negative breast cancer was verified by molecular docking and molecular dynamics simulation; and the expression of the relevant proteins was verified.ResultsBaicalin showed more obvious antiproliferative effects on triple-negative breast cancer cell lines at certain concentrations, and had less effect on the proliferation of normal breast cells. …”
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An electroactive microfluidic platform integrated with AM-pDEP focusing and side-counter design for selective cell sorting and single-cell quantification by Zuyuan Tian, Mohamed Shaheen, Tianxiang Jiang, Shaoxi Wang, Xihua Wang, Jie Chen

“…The focusing module is combined with our side-counter design to detect cells. The performance of our device and its embedded modules has been verified with mixed breast cancer and blood model cell lines, where high consistency between optical and electrical detection has been demonstrated. …”
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Establishment and characterization of liver‐specific Apoa4‐Cre and Cyp2c11‐Cre rat models in juvenile and adult stages by Wei Dong, Xiang Gao, Feifei Guan, Jirong Pan, Wei Chen, Li Zhang, Lianfeng Zhang

“…The blood biochemical analysis of several liver enzymes and liver lipid profile was performed to evaluate the liver function of Cre rats. …”
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The AusAB non-ribosomal peptide synthetase of Staphylococcus aureus preferentially generates phevalin in host-mimicking media by Adriana Moldovan, Markus Krischke, Claudia Huber, Clara Hans, Martin J. Müller, Wolfgang Eisenreich, Thomas Rudel, Martin J. Fraunholz

“…In addition, owing to its minimal canonical NRPS structure and autonomous function (i.e., most NRPS pathways require the assembly of several NRPS proteins), AusA represents an excellent model system for studying such molecular assembly lines. …”
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High expression of LIMD2 predicts a poor prognosis and promotes migration of colon cancer cells by Jianjun Wang, Fengjuan Cai, Guodong Liu, Jingtao Zhang, Dongdong Li, Yujie Cai, Yu Wang, Wanjun Xu, Xiaoyan Wang, Xiaomin Li

“…This study focused on investigating the prognostic value, functional impact, and molecular mechanisms of LIMD2 in colon cancer. …”
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Magnetic Fields in Massive Star-forming Regions (MagMaR). V. The Magnetic Field at the Onset of High-mass Star Formation by Patricio Sanhueza, Junhao Liu, Kaho Morii, Josep Miquel Girart, Qizhou Zhang, Ian W. Stephens, James M. Jackson, Paulo C. Cortés, Patrick M. Koch, Claudia J. Cyganowski, Piyali Saha, Henrik Beuther, Suinan Zhang, Maria T. Beltrán, Yu Cheng, Fernando A. Olguin, Xing Lu, Spandan Choudhury, Kate Pattle, Manuel Fernández-López, Jihye Hwang, Ji-hyun Kang, Janik Karoly, Adam Ginsburg, A.-Ran Lyo, Kotomi Taniguchi, Wenyu Jiao, Chakali Eswaraiah, Qiu-yi Luo, Jia-Wei Wang, Benoît Commerçon, Shanghuo Li, Fengwei Xu, Huei-Ru Vivien Chen, Luis A. Zapata, Eun Jung Chung, Fumitaka Nakamura, Sandhyarani Panigrahy, Takeshi Sakai

“…Using the Davis–Chandrasekhar–Fermi method with an angle dispersion function analysis, we estimate in this core a magnetic field strength of 6.2 mG and a mass-to-magnetic-flux ratio of 18. …”
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Consequences of Surface Composition and Aggregation Conditions of Ag Nanoparticles on Surface-Enhanced Raman Scattering (SERS) of Pesticides by Marcelo José dos Santos Oliveira, Gilia Cristine Marques Ruiz, Rafael Jesus Gonçalves Rubira, Santiago Sanchez-Cortes, Carlos José Leopoldo Constantino, Leonardo Negri Furini

“…Additionally, to obtain the SERS signal of MBC with AgCT, besides the presence of chlorinated salts, other adjustments were necessary, such as changing both the pH of the medium (from pH 5.8 to pH 8, for which MBC is in its neutral form) and the laser lines (from 785 to 514.5 nm). These findings demonstrated that although the pesticide molecules belong to the same chemical functional group, their detection was strongly influenced by the surface of the silver nanoparticles and the salts added. …”
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A novel polypeptide encoded by circSPIRE1 promotes prostate cancer proliferation and migration by restraining the ubiquitin-dependent degradation of LRP5 by Jintao Hu, Juanyi Shi, Junjie Wang, Yunfei Xiao, Degeng Kong, Mingchao Gao, Tianlong Luo, Shizhong Xu, Zhihan Yuan, Xinyi Ma, Xueseng Dong, Jingang Huang, Cheng Liu, Kewei Xu

“…Expression levels of circSPIRE1 and rtSPIRE1 were analyzed via qPCR, FISH, and immunohistochemistry. Gain- and loss-of-function assays were performed to evaluate their effects on cell proliferation and migration. …”
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SLC1A5 is a key regulator of glutamine metabolism and a prognostic marker for aggressive luminal breast cancer by Lutfi H. Alfarsi, Rokaya El Ansari, Busra Erkan, Ali Fakroun, Madeleine L. Craze, Mohammed A. Aleskandarany, Kiu Wai Cheng, Ian O. Ellis, Emad A. Rakha, Andrew R. Green

“…Further research is needed to explore SLC1A5 function in luminal BC and its association with Gln metabolism pathways.…”
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Dysfunction of ATP7B Splicing Variant Caused by Enhanced Interaction With COMMD1 in Wilson DiseaseSummary by Donghu Zhou, Huaduan Zi, Xiaoxi Yang, Xiaojin Li, Yanmeng Li, Anjian Xu, Bei Zhang, Wei Zhang, Xiaojuan Ou, Jidong Jia, Jian Huang, Hong You

“…The ATP7B knockout HuH-7 cell line and Atp7b-/- mice were created, and the functional consequence of the mutant ATP7B were evaluated in vitro and in vivo. …”
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Exploring program-cell death patterns to predict prognosis and sensitivity of cervical cancer immunotherapy via multi-omics analysis and clinical samples by Chunhong Pang, Xianfeng Long, Yongjin Luo, Ying Luo

“…Real-time quantitative PCR (qRT-PCR) and immunohistochemistry were used to verify the expression of the model genes. Finally, functional analysis of low- and high-risk groups based on the median risk score was performed, including immune infiltration, genomic mutations, tumor mutational burden (TMB), and drug sensitivity. …”
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DHCR24 overexpression is involved in lipid metabolic reprogramming to drive cervical cancer malignant progression and is associated with immune microenvironment by Lin Cheng, Yuance Xu, Zhuo Li, Danting Sun, Yan Xu, Junqi He, Yulong Chen, Qin Yao

“…A prognostic nomogram incorporating tumor stage and DHCR24 expression levels was developed to predict clinical outcomes in patients. Functional studies using SiHa cell lines were conducted to elucidate the oncogenic properties of DHCR24. …”
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Antioxidant, bioactive, and nutritional potential of soybeans with brown and yellow seed coats by Victor Delino Barasuol Scarton, Ivan Ricardo Carvalho, Christiane de Fátima Colet, Jaqueline Piesanti Sangiovo, Willyan Júnior Adorian Bandeira, Murilo Vieira Loro, Ellen Cristina Perin, Solange Teresinha Carpes, Patricia Brugnerotto

“…Given the growing interest in biofortification to enhance the nutritional value of crops, this study aimed to assess the agronomic performance, nutritional, functional and physicochemical composition of soybean lines with both brown and yellow seed coats, with a particular focus on their biofortification potential. …”
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Machine learning-driven multi-omics analysis identifies a prognostic gene signature associated with programmed cell death and metabolism in hepatocellular carcinoma by Xiang Li, Donghao Yin, Jiahao Geng, Yanyu Xu, Zijing Xu, Xuemeng Yang, Quanwei Li, Zimeng Shang, Zhiyun Yang, Zhong Xu, Jiabo Wang, Enxiang Zhang, Xinhua Song

“…Lastly, the expression of the model genes was evaluated in HCC mouse models and cell lines, and the biological function of a representative gene was further investigated through in vitro assays. …”
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Transcriptional regulation of KCNA2 coding Kv1.2 by EWS::FLI1: involvement in controlling the YAP/Hippo signalling pathway and cell proliferation by Maryne Dupuy, Anaïs Postec, Mathilde Mullard, Aurélie Chantôme, Philippe Hulin, Régis Brion, Maxime Gueguinou, Laura Regnier, Marie Potier-Cartereau, Bénédicte Brounais-Le Royer, Marc Baud’huin, Steven Georges, François Lamoureux, Benjamin Ory, Françoise Rédini, Christophe Vandier, Franck Verrecchia

“…Results This research identified KCNA2 (encoding for a functional Kv1.2 channel) as highly expressed in ES biopsies and cell lines. …”
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Aldo-keto reductase family 1 member B10 prevents esophageal squamous cell carcinoma from reactive carbonyl species-induced cell death and promotes its progression by Shau-Hsuan Li, Wan-Ting Huang, Yen-Hao Chen, Hung-I Lu, Chien-Ming Lo, Hsin-Ting Tsai, Chang-Han Chen

“…Bioinformatics analysis using gene ontology (GO) was performed to categorize these genes. To validate the findings, immunohistochemical staining in specimens from 169 surgically resected ESCC patients was performed and then correlated with treatment outcomes. …”
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Reversal of ABCG2-mediated drug resistance by tinodasertib (ETC-206) by Haigan Yang, Haigan Yang, Zheshen Li, Zhuoxun Wu, Xiang Chen, Letao Bo, Harsh Patel, Bohan Zhang, Wenjun Xiong, Wei Wang, Zhe-Sheng Chen

“…This study investigates whether tinodasertib can reverse ABCG2-dependent MDR in both two-dimensional (monolayer) cancer cell cultures and three-dimensional multicellular tumor spheroids.Materials and MethodsABCG2-overexpressing cancer cell lines and their nonresistant parental counterparts were cultured as monolayers and as multicellular spheroids. …”
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