Modern strategy of metastatic colorectal cancer treatment (literature review) by O. I. Kit, Yu. A. Gevorkyan, N. V. Soldatkina, V. E. Kolesnikov, O. K. Bondarenko, A. V. Dashkov

“…In this regard, the study of modern directions of treatment of metastatic CRC is of particular interest.In this study, both literature data and obtained treatment results of patients with metastatic colorectal cancer have been analyzed (PubMed, Scopus, eLibrary databases were used) at the National Medical Research Centre for Oncology.Currently, many factors should be taken into account when planning therapy for patients with metastatic CRC: the characteristics of the tumor itself (biology and localization of the tumor, tumor burden, RAS, BRAF mutational status), the patient (age, performance status, functional state of organs and systems, comorbidity, patient attitude, expectations and preferences) and the treatment itself (toxicity, flexibility of the treatment program, socio-economic factors, quality of life). …”
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Therapeutic Potential of Rho Kinase Inhibitors in Corneal Disease: A Systematic Review of Preclinical and Clinical Studies by Laura Andreea Ghenciu, Diana Andrei, Claudia Borza, Roxana Iacob, Emil Robert Stoicescu, Sorin Lucian Bolintineanu, Daniela Iacob, Ovidiu Alin Haţegan

“…Preclinical models (rabbit, porcine, human explants) uniformly showed ROCKis (Y-27632, Ripasudil, Netarsudil, H-1152) accelerate corneal endothelial cell proliferation, migration, and restoration of a hexagonal monolayer with improved barrier and pump function over days to weeks. In 17 clinical investigations, topical Ripasudil or Netarsudil and cultured cell injections achieved significant corneal thinning, endothelial cell density and central corneal thickness changes, and visual acuity improvements (≥2 lines) with minimal adverse events. …”
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Quantitative proteomic analysis unveils a critical role of VARS1 in hepatocellular carcinoma aggressiveness through the modulation of MAGI1 expression by Natalia Hermán-Sánchez, Mercedes del Rio-Moreno, Rubén Ciria, Marina E. Sánchez-Frias, Maite G. Fernández-Barrena, Iker Uriarte, Eduardo Chicano-Galvez, Ignacio Ortea, Ángela Peralbo-Molina, Javier Briceño, Matías A. Avila, Manuel Rodríguez-Perálvarez, Raúl M. Luque, Juan L. López-Cánovas, Manuel D. Gahete

“…However, its proteomic characterization is incomplete. We performed non-targeted quantitative proteomics of HCC samples and explored its clinical, functional, and molecular consequences. …”
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Genealogy of the Arab tribes living in Syria during the Caliphate of Imam Ali (AS)Typology of the Arab Tribes Living in the Levant during the Caliphate of Imam Ali (AS) Typology... by Akram sadat Hoseini, Yahya Mirhoseini

“…This categorization could aid in analyzing the nuanced performance of the Levantine population and reconciling the scattered and conflicting historical accounts. …”
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Regulatory mechanism of ABCB1 transcriptional repression by HDAC5 in rat hepatocytes under hypoxic environment by Ziqin Wei, Ziqin Wei, Hongfang Mu, Fangfang Qiu, Fangfang Qiu, Minghui Zhao, Minghui Zhao, Xiaojing Zhang, Wenbin Li, Hai Jia, Rong Wang, Rong Wang

“…Rhodamine 123 accumulation assay was performed to examine the effect of HDAC inhibitors on ABCB1 functional activity. …”
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Integrated transcriptomic and proteomic analysis identified key folate biosynthesis gene in waxy maize by Yanyan Jiao, Yaxing Shi, Hui Dong, Yujing Pan, Hui Liu, Zhiyong Li, Xiaqing Wang, Chunhui Li, Tianyi Wang, Shuai Wang, Ronghuan Wang, Baishan Lu, Wei Song, Jiuran Zhao

“…In this study, transcriptome and proteome analyses of three waxy maize inbred lines with high, medium, and low folate contents were performed to identify key genes controlling folate biosynthesis. …”
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CYP75B4-Mediated Tricin and Lignin Accumulation Improve Salt Tolerance in Rice by Nan Ruan, Hai Xu, Kaixuan Chen, Fuhao Tian, Deyuan Gao, Zihan Wang, Xiao Yang, Xia Yan, Ye Wang, Meihan Wang, Zhengjun Dang, Xuelin Yin, Yijun Tang, Quan Xu, Fengcheng Li, Wenfu Chen

“…Notably, the cyp75b4 and CYP75B4-OE lines showed decreased and improved, respectively, salt tolerance performances in terms of survival rate, ROS accumulation, and Na+/ K+ homeostasis. …”
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CAR-macrophages targets CD26 to eliminate chronic myeloid leukemia stem cells by Jiang Guoyun, Qin Yuefeng, Huang Zhenglan, Yuan Zuowei, Zhou Hongyan, Yuan Ying, Feng Wenli

“…Chimeric antigen receptor macrophages (CAR-M) not only perform phagocytosis on target cells but also function as antigen-presenting cells, thereby activating the anti-tumor immune response.CD26 (dipeptidyl peptidase 4, DPP IV) is abundantly expressed in CML-LSCs and functions as a tumor-specific antigen (TSA) in CAR-M treatment. …”
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Genome-Wide Identification and Expression Analysis of Auxin-Responsive <i>GH3</i> Gene Family in Pepper (<i>Capsicum annuum</i> L.) by Qiao-Lu Zang, Meng Wang, Lu Liu, Xiao-Mei Zheng, Yan Cheng

“…Notably, after overexpressing <i>CaGH3-7</i> in tomato, RNA-seq was performed on wild-type and transgenic lines, and the differentially expressed genes were mainly enriched in response to external stimuli. …”
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Metabolic Effects of the Cancer Metastasis Modulator MEMO1 by Marziyeh Ghanbarian, Natalia Dolgova, Frederick S. Vizeacoumar, Franco J. Vizeacoumar, Deborah Michel, Anas El-Aneed, Oleg Y. Dmitriev

“…Our previous genome-wide analysis of <i>MEMO1</i> genetic interactions across multiple cancer cell lines revealed that gene sets involved in mitochondrial respiration and the TCA cycle are enriched among the gain-of-function interaction partners of <i>MEMO1</i>. …”
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ATP6V0A4 as a novel prognostic biomarker and potential therapeutic target in oral squamous cell carcinoma by Xiaopu Gao, Jiamin Zhou, Yu Qiao, Chuyin Lin, Guanxiong Zhang, Qiuyu Wu, Zhikang Su, Qianji Zhang, Songkai Huang

“…For experimental validation, RT-qPCR was performed to measure ATP6V0A4 expression in OSCC cell lines, and plasmid transfection technology was used to establish overexpression models, followed by systematic evaluation of its regulatory effects on tumor cell proliferation, migration, and invasion. …”
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Decidual natural killer cells and trophoblast cells: cellular, humoral and molecular mechanisms of interaction by P. V. Grebenkina, V. A. Mikhailova, A. A. Oshkolova, S. O. Vershinina, M. S. Dukhinova, D. O. Bazhenov, S. A. Selkov, D. I. Sokolov

“…Summarizing the data presented in the literature, one may emphasize that there is an extensive mutual influence of NK cells and trophoblast cells in decidual lining of uterus during pregnancy, thus leading to a changes in phenotype and functions of these cells. …”
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Genome-Wide Analysis of Caffeoyl-CoA-O-methyltransferase (CCoAOMT) Family Genes and the Roles of <i>GhCCoAOMT7</i> in Lignin Synthesis in Cotton by Lina Ma, Jin Wang, Kaikai Qiao, Yuewei Quan, Shuli Fan, Liqiang Wu

“…In this research, we observed 50 <i>CCoAOMT</i> genes from four cotton species, including two diploids (<i>Gossypium arboretum</i>, 9, and <i>Gossypium raimondii, 8</i>) and two tetraploids (<i>Gossypium hirsutum</i>, 16, and <i>Gossypium barbadense, 17</i>), performed bioinformatic analysis, and focused on the involvement and functions of <i>GhCCoAOMT7</i> in lignin synthesis of <i>Gossypium hirsutum</i>. …”
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HMGB1 Mediates Microglia-Astrocyte/Neuron Crosstalk and Pyroptosis by the TLR4/NF-κB Pathway in Multiple Sclerosis by Yang Feng, Liang Wang, Zhuofeng Mao, Weiping Wang

“…Additionally, western blot (WB) analysis was performed to further elucidate the mechanisms involved. …”
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Deuterium plasma-driven permeation in chemical vapor deposition tungsten-copper composite by Yiwen Sun, Xuechun Li, Caibin Liu, Yifan Li, Yuhao Li, Jonathan Mougenot, Long Cheng, Haodong Liu, Di Hu, Sijie Hao, Yue Yuan, Haishan Zhou, Hongbo Zhou, Guang-Hong Lu

“…Density functional theory calculations confirmed that the presence of Cu in W could reduce the HI solution energy in W. …”
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MicroRNA-665 and its potential role in drug response and survival outcomes in multiple myeloma: a preliminary study by Rui Bergantim, Rui Bergantim, Rui Bergantim, Rui Bergantim, Sara Peixoto da Silva, Sara Peixoto da Silva, Sara Peixoto da Silva, Vanessa Pinto, Vanessa Pinto, Joana M. Pereira, Joana M. Pereira, Diana Sousa, Diana Sousa, Diana Sousa, Fernanda Trigo, Rune Matthiesen, José E. Guimarães, José E. Guimarães, José E. Guimarães, José E. Guimarães, José E. Guimarães, M. Helena Vasconcelos, M. Helena Vasconcelos, M. Helena Vasconcelos

“…In silico analysis for target-prediction and gene ontology (GO) enrichment was performed to explore the potential biological and functional role of the identified miRNAs.ResultsNGS profiling revealed several miRNAs differently expressed between treatment-refractory and sensitive patients, as well as between PB and BM. …”
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Stochastic demethylation and redundant epigenetic suppressive mechanisms generate highly heterogeneous responses to pharmacological DNA methyltransferase inhibition by Mie K. Jakobsen, Sofie Traynor, Aaraby Y. Nielsen, Christina Dahl, Mette Staehr, Simon T. Jakobsen, Maria S. Madsen, Rasmus Siersbaek, Mikkel G. Terp, Josefine B. Jensen, Christina B. Pedersen, Anup Shrestha, Jonathan R. Brewer, Pascal H. G. Duijf, Odd L. Gammelgaard, Henrik J. Ditzel, Alexei F. Kirkin, Per Guldberg, Morten F. Gjerstorff

“…Methods In this study, we used cancer/testis antigen genes as a model for methylation-dependent gene expression to examine the activity of DNA methyltransferase inhibitors and their potential synergistic effect with histone deacetylase inhibitors at the single-cancer cell level. The analysis was performed on breast cancer patient-derived xenograft tumors and cell lines, employing a comprehensive set of techniques, including targeted single-cell mRNA sequencing. …”
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Development of a machine learning-derived dendritic cell signature for prognostic stratification in lung adenocarcinoma by Fang Zhou, Fang Zhou, Meng Wang, Meng Wang, Zheng Wang, Zheng Wang, Wei Li, Wei Li, Xike Lu, Xike Lu

“…Immune landscape, genomic instability, drug sensitivity, and immunotherapy response were further analyzed. The functional role of PLEK2, a DCRS hub gene, was validated in clinical samples and LUAD cell lines.ResultsWe identified six DC clusters with distinct developmental states and transcriptional programs. …”
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INKA, an integrative data analysis pipeline for phosphoproteomic inference of active kinases by Robin Beekhof, Carolien van Alphen, Alex A Henneman, Jaco C Knol, Thang V Pham, Frank Rolfs, Mariette Labots, Evan Henneberry, Tessa YS Le Large, Richard R de Haas, Sander R Piersma, Valentina Vurchio, Andrea Bertotti, Livio Trusolino, Henk MW Verheul, Connie R Jimenez

“…These analyses show superior performance of INKA over its components and substrate‐based single‐sample tool KARP, and underscore target potential of high‐ranking kinases, encouraging further exploration of INKA's functional and clinical value.…”
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Transparent, metal-free PEDOT:PSS neural interfaces for simultaneous recording of low-noise electrophysiology and artifact-free two-photon imaging by Hyun Woo Kim, Jiwon Kim, Jong Youl Kim, Kyubeen Kim, Ju Young Lee, Taemin Kim, Shinil Cho, Jong Bin An, Hyun Jae Kim, Lulu Sun, Sunghoon Lee, Kenjiro Fukuda, Takao Someya, Mingyu Sang, Young Uk Cho, Jong Eun Lee, Ki Jun Yu

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