HGH1 Promotes Breast Cancer Progression Through the PI3K/AKT/NF-κB Signaling Pathway: Potential Role for Prognosis and Targeted Therapy by Hu W, Si D, Liu C, Tie D, Xu D, Li N

“…Enrichment analysis of HGH1-related signaling pathways and immune infiltration was performed. BC cell lines with overexpression and knockdown of HGH1 gene were constructed to tested the proliferation, migration, invasion ability and cell apoptosis. …”
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The neutrophil extracellular trap-related gene FPR1 (formyl peptide receptor 1) as a potential prognostic and therapeutic target in osteosarcoma by Shihao Li, Qiong Yuan, Yuanyuan Zhang, Haiyang Zhang

“…Next, survival analysis and multivariate cox regression analysis were performed to evaluate the prognostic value of FPR1 in OS patients. …”
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Efficiency of neutralization of electric charges on the surface of dielectric nonwoven fabric of two dual and triode electrode systems by B. Yahiaoui, A. Messaoudene, A. Melahi, A. Rahmani, B. Bendahmane, L. Dascalescu

“…The neutralization was performed during 4 s, using the dual or the triode systems powered by sinusoidal high voltage. …”
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SNX10 Is Involved in Ovarian Cancer Cell Metastasis by Repolarizing Tumor-Associated Macrophages Through mTOR1/Lysosomes Pathway by Ranran Chai, Kewei Zheng, Ting Xu, Hui Wang, Xiaobo Cheng, Chong Lu, Yu Kang

“…This enhanced the migration and invasion of ovarian cancer cell lines A2780 and A2780/CP70 while reducing cisplatin-induced apoptosis. …”
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Improving synergistic drug combination prediction with signature-based gene expression features in oncology by Mozhgan Mozaffarilegha, Sajjad Gharaghani

“…Machine learning (ML) and deep learning (DL) models have advanced drug synergy prediction by integrating diverse datasets and modeling the interactions between drugs and cell lines. Despite these advancements, most algorithms primarily rely on drug-specific features, such as chemical structures, with limited incorporation of functional drug information and cellular content features.Methods:We propose a novel approach that integrates Drug Resistance Signatures (DRS) as a biologically informed representation of drug information. …”
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The Application of Single-Cell Technologies for Vaccine Development Against Viral Infections by Hong Nhi Nguyen, Isabel O. Vanderzee, Fei Wen

“…Single-cell technologies have emerged as transformative tools for dissecting this immune heterogeneity, providing comprehensive and granular insights into cellular phenotypes, functional states, and dynamic host–pathogen interactions. …”
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Transcriptional control of visual neural circuit development by GS homeobox 1. by Alexandra R Schmidt, Haiden J Placer, Ishmael M Muhammad, Rebekah Shephard, Regina L Patrick, Taylor Saurborn, Eric J Horstick, Sadie A Bergeron

“…This work is the first to implicate gsx1 in establishing cell identity and functional neural circuits in the visual system.…”
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A novel cuproptosis-related genes nomogram on the prognosis and immune microenvironment of breast invasive carcinoma by Guanmin Shang, Zhiwen Xu, Dengfu Peng, Xinghe Liao, Jiangang Zhao

“…These results may help illuminate the functions that CRGs perform in BRCA, which might improve our knowledge of cuproptosis and facilitate the implementation of more successful immunotherapy techniques.…”
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Genetic dissection of plant height-related traits by combined methods in wheat (Triticum aestivum L.) by Haiyan Zhang, Yue Li, Naicui Wei, Yuqiong Hao, Xiaohua Li, Bangbang Wu, Xingwei Zheng, Jiajia Zhao, Jun Zheng

“…Linkage analysis was applied to two populations: a doubled haploid (DH) population of 180 lines derived from the cross ‘Jinchun 7 × Jinmai 919’ and a recombinant inbred line (RIL) population of 165 F10 lines from the cross ‘DH 118 × Jinmai 919’ to verify the genetic effects of stable major loci. …”
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Innovation Ecosystem of Iran's Tourism Industry with Emphasis on Supply Chain by Azizolah Jafari, mahdi alaei kerahrudi

“…The tourism industry can also improve its performance by developing the ecosystem of innovation. …”
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MicroRNA-409-5p is upregulated in breast cancer and its downregulation inhibits cancer development through downstream target of RSU1 by Hong Yu, Hua Xing, Wei Han, Yali Wang, Tianyang Qi, Changlong Song, Zheli Xu, Hongjun Li, Yinghui Huang

“…We investigated the expression and function of miR-409-5p in human breast cancer. Quantitative real-time polymerase chain reaction was conducted to evaluate endogenous miR-409-5p expression in breast cancer tumors and breast cancer cell lines. …”
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The crucial role of neutrophil extracellular traps and IL-17 signaling in indomethacin-induced gastric injury in mice by Yujun Hou, Wen Wang, Jiangnan Ye, Luqiang Sun, Siyuan Zhou, Qianhua Zheng, Yunzhou Shi, Ying Chen, Junpeng Yao, Lu Wang, Xiangyun Yan, Renhong Wan, Shuai Chen, Ying Li

“…ELISA and immunofluorescence were performed to validate expression of IL-17 signaling pathway. …”
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In Vitro Study of Antiviral Properties of Compounds Based on 1,4-Dioxane Derivative of Closo-Decaborate Anion with Amino Acid Ester Residues Against Influenza Virus A/IIV-Orenburg/... by Timur M. Garaev, Ilya I. Yudin, Natalya V. Breslav, Tatyana V. Grebennikova, Evgenii Y. Matveev, Elizaveta A. Eshtukova-Shcheglova, Varvara V. Avdeeva, Konstantin Y. Zhizhin, Nikolay T. Kuznetsov

“…The studies performed for molecular docking of the anionic part of <b>1</b>²⁻ and <b>2</b>²⁻ with the transmembrane domain of viroporin M2 show some differences in the location of these two ligands inside the M2 canal pore.…”
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Mechanistic insights into promotion of non-small cell lung cancer by BAG5 using integrative multi-omics approaches by Jing-Shan Huang, Jing-Shan Huang, Jing-Shan Huang, Jia-Mei Wang, Ye Yuan, Ting Zhang, Bai-Qiang Li, Fu-Ying Zhao, Liang Hao, Zhan-Wu Yu, Hua-Qin Wang

“…BAG5, a unique member of this family, contains multiple BAG domains, yet its role in non-small cell lung cancer (NSCLC) remains largely unexplored.MethodsIn this study, we employed a multi-omics approach, integrating single-cell transcriptomics, proteomics, interactomics, and phosphoproteomics data to comprehensively investigate BAG5 function in NSCLC. Functional analyses were performed using cell lines and patient-derived organoids (PDOs) to validate our findings.ResultsOur results demonstrate that BAG5 plays a critical role in the regulation of RNA metabolism, mitochondrial dynamics, and metabolic reprogramming. …”
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Targeting TUBB2B inhibits triple-negative breast cancer growth and brain-metastatic colonization by Qingling He, Jianyang Hu, Fung-Yin Ngo, Huiqi Zhang, Lin He, Hao Huang, Tan Wu, Yilin Pan, Zihan Yang, Yuanyuan Jiang, William C. Cho, Wah Cheuk, Gary M. Tse, Julia Y. Tsang, Mengsu Yang, Liang Zhang, Xin Wang, Pui-Chi Lo, C. Geoffrey Lau, Y. Rebecca Chin

“…Mechanistically, we identify eukaryotic translation elongation factor 1 alpha 1 (eEF1A1) as a novel interacting partner of TUBB2B, revealing a previously unexplored role of TUBB2B in translational regulation. In line with its neural-related functions, TUBB2B overexpression in TNBC cells activates astrocytes, which in turn upregulate TUBB2B in tumor cells. …”
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ARHGAP42 promotes cell migration and invasion involving PI3K/Akt signaling pathway in nasopharyngeal carcinoma by Qian Hu, Xiao Lin, Linxiaoxiao Ding, Yinduo Zeng, Danmei Pang, Nengtai Ouyang, Yanqun Xiang, Herui Yao

“…Western blot and immunohistochemical staining were used for detecting the expression of ARHGAP42 protein in nasopharyngeal carcinoma tissues and cell lines. The overexpression and silence experiments of ARHGAP42 were performed in NPC cell lines using siRNA and expressive plasmid for evaluating cancer cell migration and invasion in vitro. …”
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Reconstruction of the Tibial Stump After Fibulectomy by Bezsmertnyi YO, Veremii OA, Shevchuk VI, Bezsmertnyi OY

“…The result is a highly functional stump with the possibility of using end support and full prosthetics. …”
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APPLICATION OF THE CRIMINAL LAW IN CONTRACTING SYSTEM AND STATE DEFENSE ORDER VIOLATIONS by V. N. Borkov

“…It is necessary to proceed from the existence of two lines of activity of the customer. The first is the acceptance of the delivered goods, the work performed, the ser-vices rendered. …”
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Lung ultrasound outperforms symptom-based screening to detect interstitial lung disease associated with rheumatoid arthritis by Wim Wuyts, Joseph Jacob, Patrick Verschueren, Veerle Taelman, Barbara Neerinckx, Heleen Cypers, Alexandros Kalkanis, Nico De Crem, Marie Vermant, Tinne Goos, Emanuela Elsa Cortesi, Tine Follet, Stefan Gogaert, Nathalie Veyt, Laurens J De Sadeleer

“…Sensitivity and specificity analyses were performed to assess symptom-based questionnaires and the number of B-lines to detect RA-ILD. …”
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Clinical and cost-effectiveness of lithium versus quetiapine augmentation for treatment-resistant depression in adults: LQD a pragmatic randomised controlled trial by Jess Kerr-Gaffney, Zohra Zenasni, Kimberley Goldsmith, Nahel Yaziji, Huajie Jin, Alessandro Colasanti, John Geddes, David Kessler, R Hamish McAllister-Williams, Allan H Young, Alvaro Barrera, Lindsey Marwood, Rachael W Taylor, Helena Tee, Anthony J Cleare

“…Background Lithium and several atypical antipsychotics are the recommended first-line augmentation options for treatment-resistant depression; however, few studies have compared them directly, and none for longer than 8 weeks. …”
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