Dissecting the multi-omics landscape of TEAD1 in hepatocellular carcinoma: cycle regulation and metastatic potential by Ruiping Huai, Ruiping Huai, Ruiping Huai, Canquan Mao, Lili Xiong

“…This study aims to clarify the function and potential mechanisms of action of TEAD1 in cancer.MethodsWe assessed pan-cancer expression, methylation, and mutation profiles of TEAD1 to determine its prognostic significance in clinical settings. …”
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SBDS-Deficient Cells Have an Altered Homeostatic Equilibrium due to Translational Inefficiency Which Explains their Reduced Fitness and Provides a Logical Framework for Interventio... by Piera Calamita, Annarita Miluzio, Arianna Russo, Elisa Pesce, Sara Ricciardi, Farhat Khanim, Cristina Cheroni, Roberta Alfieri, Marilena Mancino, Chiara Gorrini, Grazisa Rossetti, Ivana Peluso, Massimiliano Pagani, Diego L Medina, Johanna Rommens, Stefano Biffo

“…We then performed a comprehensive analysis of cellular functions including colony formation, translational and transcriptional RNA-seq, stress and drug sensitivity. …”
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NSUN4 Facilitates the Activity of Oncogenic Protein CDC20 to Promote NSCLC Development by Mediating m5C Modification of CDC20 mRNA by Zhilong Li, Xianzhen Wu

“…Subcutaneous xenograft studies were performed to analyze the function in vivo. Results In human NSCLC tumors and cell lines, NSUN4 and CDC20 levels were upregulated. …”
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LINC00534 promotes breast cancer progression by targeting the miR-139-5p/HMGB2 axis by Qiaomei Liu, Wei Xiong

“…Objective The purpose of this study was to explore the function of LINC00534 and miR-139-5p in breast cancer progression, as well as the mechanisms that underpin its actions. …”
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Genome-Wide Association Study Reveals Multiple Loci Influencing Normal Human Facial Morphology. by John R Shaffer, Ekaterina Orlova, Myoung Keun Lee, Elizabeth J Leslie, Zachary D Raffensperger, Carrie L Heike, Michael L Cunningham, Jacqueline T Hecht, Chung How Kau, Nichole L Nidey, Lina M Moreno, George L Wehby, Jeffrey C Murray, Cecelia A Laurie, Cathy C Laurie, Joanne Cole, Tracey Ferrara, Tracey Ferrara, Stephanie Santorico, Ophir Klein, Washington Mio, Eleanor Feingold, Benedikt Hallgrimsson, Richard A Spritz, Mary L Marazita, Seth M Weinberg

“…Numerous lines of evidence point to a genetic basis for facial morphology in humans, yet little is known about how specific genetic variants relate to the phenotypic expression of many common facial features. …”
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CLINICAL AND BIOCHEMICAL INDICATORS IN WHITE RATS IN THE TREATMENT OF EXPERIMENTAL GENERALIZED PARODONTITIS by Yu.I. Silenko, M.V. Khrebor, Y.M. Silenko, O.A. Pisarenko

“…Materials and methods of the research. Experiments were performed on 280 six-month-old of rats Wistar line of both sexes weighing 120-130 g. …”
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Protocadherin 7 inhibits cell migration and invasion through E-cadherin in gastric cancer by Hong-Fang Chen, Ran-Ran Ma, Jun-Yi He, Hui Zhang, Xiao-Ling Liu, Xiang-Yu Guo, Peng Gao

“…MTS ((3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium)) and transwell assays were performed to assess the effect of protocadherin 7 on proliferation, migration, and invasion in gastric cancer cell lines. …”
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Platelet-Derived Growth Factor has Context-Dependent Effects on Osteogenesis in Bone Marrow-Derived Cells by Nicholas Huffman, Julianne Gillis MD, Amogh Magesh, Sreedhara Sangadala MSc, PhD, Jay M. Patel PhD, Jason T. Bariteau MD

“…This work highlights the need for further studies to fully grasp how PDGF functions in an arthrodesis.…”
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Weighted Gene Co-Expression Network Analysis Uncovers Critical Genes and Pathways Involved in Soybean Response to Soybean Mosaic Virus by Hanhan Zhu, Ruiqiong Li, Yaoyao Fang, Xue Zhao, Weili Teng, Haiyan Li, Yingpeng Han

“…In addition, we performed non-targeted metabolomic sequencing of leaves from the treatment and control groups. …”
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Pathway activation model for personalized prediction of drug synergy by Quang Thinh Trac, Yue Huang, Tom Erkers, Päivi Östling, Anna Bohlin, Albin Osterroos, Mattias Vesterlund, Rozbeh Jafari, Ioannis Siavelis, Helena Backvall, Santeri Kiviluoto, Lukas Orre, Mattias Rantalainen, Janne Lehtiö, Soren Lehmann, Olli Kallioniemi, Yudi Pawitan, Trung Nghia Vu

“…The Spearman’s correlation coefficients between predicted and observed drug synergy were 0.50 (95% CI: 0.47–0.53) in Test Set 1 and 0.26 (95% CI: 0.22–0.30) in Test Set 2, compared to 0.38 (95% CI: 0.34–0.42) and 0.18 (95% CI: 0.16–0.20), respectively, for the best performing method in the Challenge. We show evidence that higher synergy is associated with higher functional interaction between the drug targets, and this functional interaction information is captured by PAS. …”
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Exosomal miR-6126 as a novel therapeutic target for overcoming resistance of anti-cancer effect in hepatocellular carcinoma by Hyemin Hwang, Jimin Kim, Tae-Hun Kim, Yeonju Han, Dayoung Choi, Sua Cho, Seunghwan Kim, Sanghee Park, Taehyun Park, Filippo Piccinini, Won Jong Rhee, Jae-Chul Pyun, Misu Lee

“…Methods Sorafenib-resistant cells were generated by culturing the human HCC cell line Huh7 in a medium containing 20 µM sorafenib for six months. …”
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Knee-Sparing Resection and Reconstruction Surgery for Bone Sarcoma Using 3D-Surgical Approach: Average of 5-Year Follow-Up by Amit Benady, Noy Yehiel, Ortal Segal, Omri Merose, Amir Sterenheim, Osnat Sher, Ben Efrima, Eran Golden, Yair Gortzak, Solomon Dadia

“…In cases where the tumor arises in the distal femur or proximal tibia near the joint line, knee-sacrificing surgery is typically performed, followed by reconstruction with oncological megaprostheses. …”
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Ultrasound examination of swallowing disorder characteristics in patients with oncopathology of the oral cavity by A. O. Kushta

“…B-mode was the main one in all the studied areas where one image frame was vertically lined up. The swallowing act was assessed in M-mode (a length of the axial movement). …”
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On the Measurement of Electric Resistance of Liquid Electrolytes of Accumulator Battery by N. N. Grinchik, K. V. Dobrego, M. A. Chumachenko

“…The measurements of specific resistance of some electrolytes were performed. The advantages of the proposed method and measuring device are their simplicity, cheapness, reliability and, consequently, wider possibility to utilize it at technological lines and processes, even at such sites of production processes where such a control was impractical earlier. …”
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Effect of polystyrene micro/nanoplastics on mesenchymal phenotypic transformation in testicular Sertoli cells by CAI Jing, WEN Yixian, ZHANG Huilian

“…Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed to identify functions and signaling pathways enriched in the testicular transcriptome. …”
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Endothelial cells nurture stem cell-like characteristics of osteosarcoma cells in a perivascular niche by CXCL12/CXCR4 pathway by CAO Ya, LIU Yang, WANG Yang

“…Methods‍　‍A co-culture model was established in vitro using SV40T- human umbilical vein endothelial cells (HUVEC-T1) and osteosarcoma stem cells (OSCs) derived from the human osteosarcoma cell line 143B. Thus, there were 2 groups of cells, OSCs and co-cultured OSCs. …”
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Neuroprotective Activity of 5-ethoxy-2-ethylthiobenzimidazole (Etomerzol) and 2-ethylthiobenzimidazole (Bemitil) in a Model of Middle Cerebral Artery Occlusion by E. Yu. Zavarina, E. K. Krasova, I. A. Titovich, A. N. Kimaev

“…On the 1st, 3rd, and 7th days after the operation, the "Limb Stimulation" (SC) test was performed. On the 7th day, the tests "Open field" (OP) and "Elevated plus maze" (EPM) were performed. …”
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Increased antitumor efficacy of PD-1-deficient melanoma-specific human lymphocytes by Nathalie Labarrière, Lucine Marotte, Sylvain Simon, Virginie Vignard, Emilie Dupre, Malika Gantier, Jonathan Cruard, Jean-Baptiste Alberge, Melanie Hussong, Cecile Deleine, Jean-Marie Heslan, Jonathan Shaffer, Tiffany Beauvais, Joelle Gaschet, Emmanuel Scotet, Delphine Fradin, Anne Jarry, Tuan Nguyen

“…Extensive characterization of a panel of T cell clones expressing the same TCR and exhibiting similar functional avidity demonstrated superior antitumor reactivity against a PD-L1 expressing melanoma cell line. …”
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Integrative QTL Mapping and Transcriptomic Profiling to Identify Growth-Associated QTL and Candidate Genes in Hong Kong Catfish (<i>Clarias fuscus</i>) by Yian Zhu, Dayan Zhou, Yijun Shen, Chuanhao Pan, Yu Chen, Yulei Zhang, Binlan Yang, Guangli Li, Huapu Chen, Changxu Tian

“…This study aimed to identify the candidate genes associated with the growth of <i>C. fuscus</i> by integrating QTL mapping for growth traits and the RNA-seq analysis of differentially expressed genes (DEGs) between two extreme body size groups (big-sized group and small-sized group). QTL mapping was performed on eight growth traits—body weight, body height, body length, body width, orbital diameter, caudal peduncle length, caudal peduncle height, and pre-dorsal length—using 200 individuals from a full-sibling line. …”
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MYB/AKT3 axis is a key driver of ovarian cancer growth, aggressiveness, and chemoresistance by Kunwar Somesh Vikramdeo, Orlandric Miree, Shashi Anand, Amod Sharma, Sanjeev Kumar Srivastava, Seema Singh, Rodney P Rocconi, Ajay Pratap Singh

“…Methods MYB expression was evaluated in a panel of OC cell lines by immunoblotting. Gain and loss of function studies were performed by developing stable control and forced-MYB-expressing and -silenced cell lines, respectively. …”
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