Integrative Analysis of scRNA-Seq and Bulk RNA-Seq Identifies Plasma Cell Related Genes and Constructs a Prognostic Model for Hepatocellular Carcinoma by Tang M, Xu Y, Pan M

“…Finally, SSR3’s biological function was validated in vitro in HCC cell lines.Conclusion: Plasma cells are key clusters in HCC development. …”
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Effects of normal stress on shear properties and acoustic emission characteristics of bonded rock-concrete interfaces by Yan Chen, Jiangfan Yang, Jintao Wang, Shuai Heng, Zhiqiang Hou

“…Abstract Direct laboratory shear tests, accompanied by acoustic emission (AE) monitoring, were performed to examine the influence of normal stress (ranging from 4 to 16 MPa) on the shear behavior and acoustic emission characteristics of bonded granite-concrete interfaces. …”
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Bioinformatic analysis of maize gene encoding starch branching enzyme SBEIIb. by Г. І. Сліщук, Т. Ю. Жернаков, Н. Е. Волкова

“…For the polymorphic sites design primers were developed that allowed to differentiate the maize lines. It was determined that the detection of polymorphism in theory can influence the enzyme function and, as a result, change the concentration of amylopectin in maize grain.…”
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Metrology of metasurfaces: optical properties by Nicolas Kossowski, Yanel Tahmi, Amir Loucif, Martin Lepers, Benoit Wattellier, Guillaume Vienne, Samira Khadir, Patrice Genevet

“…However, manufacturing metasurfaces with higher levels of complexity in foundries, and assembling them in production lines, still requires comprehensive optical metrology solutions, associated with established standardized measurements, that can validate their functionalities during and after integration into a system. …”
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Should Steroid Therapy Be Necessarily Needed for Autoimmune Pancreatitis Patients with Lesion Resected due to Misdiagnosed or Suspected Malignancy? by Wenchuan Wu, Xiuzhong Yao, Chao Lin, Dayong Jin, Dansong Wang, Wenhui Lou, Xinyu Qin

“…All patients underwent liver function, CA19-9, and contrast-enhanced CT and/or MRI. …”
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JNK pathway suppression mediates insensitivity to combination endocrine therapy and CDK4/6 inhibition in ER+ breast cancer by Sarah Alexandrou, Christine S. Lee, Kristine J. Fernandez, Celine E. Wiharja, Leila Eshraghi, John Reeves, Daniel A. Reed, Neil Portman, Zoe Phan, Heloisa H. Milioli, Iva Nikolic, Antonia L. Cadell, David R. Croucher, Kaylene J. Simpson, Elgene Lim, Theresa E. Hickey, Ewan K. A. Millar, Carla L. Alves, Henrik J. Ditzel, C. Elizabeth Caldon

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Prostaglandin endoperoxide synthase 2 regulates neuroinflammation to mediate postoperative cognitive dysfunction in mice by Xuelian Li, Xuemei Li, Qixin Zhang, Yiyun Li, Yingshun Zhou, Jun Zhou, Xiaoxia Duan

“…In vitro, PTGS2 was silenced in BV2 microglial cell lines, and oxygen-glucose deprivation/reoxidation (OGD/R) was performed. …”
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STRONG II trial: stereotactic body radiation therapy following chemotherapy for unresectable perihilar cholangiocarcinoma – a single-arm multicentre phase II study by Derk Jan de Groot, Luisa Vonghia, Bas Groot Koerkamp, Lydi M J W van Driel, Alejandra Méndez Romero, Anne Demols, Erik van Werkhoven, Dirk De Ruysscher, Christelle Bouchart, Marjolein Y V Homs, Joris I Erdmann, Martijn Intven, Ferry Eskens, Harm Westdorp, Timon Vandamme, Suus Y van Loosbroek, Maaike T W Milder, Rianne D W Vaes, Wilhelm den Toom, François Willemssen, Yvette Seppenwoolde, Nadia Haj Mohammad, Joep de Bruijne, Eva Versteijne, Anna M Bruynzeel, Freek Brandts, Pètra M Braam, Eric T T L Tjwa, Akos Gulyban, Jeroen Buijsen, Judith de Vos-Geelen, Maxime Dewulf, Ines Joye, Margriet Dieters, Fred J F Ubbels, Frederik J H Hoogwater, Ben Heijmen

“…Unfortunately, the majority of patients present with unresectable tumours or are excluded from surgical treatment due to complications like cholangitis affecting their performance status. In the Netherlands, recommended first-line treatment for patients with unresectable pCCA is palliative chemotherapy with gemcitabine and cisplatin. …”
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SLIT3-mediated intratumoral crosstalk induces neuroblastoma differentiation via a spontaneous regression-like program by Meiling Liu, Dekang Lv, Wenjing Yan, Yi Wu, Shulan Wang, Luoxuan Wang, Jie Lei, Deshun Zeng, Zifeng Wang, Fang Liu, Bing Deng, Quentin Liu, Bin He, Min Yan

“…Orthotopic and subcutaneous xenograft models were established to verify SLIT3's in vivo function. Cellular bulk RNA-seq analysis was performed with or without SLIT3 recombinant protein treatment to discover the downstream pathways activated by SLIT3, followed by validation with specific pathway inhibitors. …”
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Development of an Efficient and Generalized MTSCAM Model to Predict Liquid Chromatography Retention Times of Organic Compounds by Mengdie Fan, Chenhui Sang, Hua Li, Yue Wei, Bin Zhang, Yang Xing, Jing Zhang, Jie Yin, Wei An, Bing Shao

“…Next, an innovative classification system was implemented, classifying 10,905 compounds into a 3-tier hierarchy across 141 classes, based on functional group weighting. Then, data augmentation was performed within each category using simplified molecular input line entry system (SMILES) enumeration combined with structural similarity expansion. …”
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Disentangling the roles of approach, activation and valence in instrumental and pavlovian responding. by Quentin J M Huys, Roshan Cools, Martin Gölzer, Eva Friedel, Andreas Heinz, Raymond J Dolan, Peter Dayan

“…These influences come in two main groups, defined along anatomical, pharmacological, behavioural and functional lines. Investigations of the influences have so far concentrated on the groups as a whole; here we take the critical step of looking inside each group, using a detailed reinforcement learning model to distinguish effects to do with value, specific actions, and general activation or inhibition. …”
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3D Printed Swordfish‐Like Wireless Millirobot by Xingcheng Ou, Yu Sheng, Jiaqi Huang, Dantong Huang, Xiaohong Li, Ran Bi, Guoliang Chen, Weijie Hu, Shuang‐Zhuang Guo

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An Adiabatic-Expansion-Induced Perturbation Study on Gas–Aerosol Partitioning in Ambient Air—Formation of NH₄NO₃ and Microdroplet Nitrogen Fixation (2) by Yating Gao, Qinchu Fan, Yujiao Zhu, Hengqing Shen, Qi Yuan, Yang Gao, Huiwang Gao, Xiaohong Yao

“…We investigate these questions based on adiabatic-expansion-induced perturbation observations performed in various atmospheres over the last decade. …”
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Phenotyping, genome‐wide dissection, and prediction of maize root architecture for temperate adaptability by Weijun Guo, Fanhua Wang, Jianyue Lv, Jia Yu, Yue Wu, Hada Wuriyanghan, Liang Le, Li Pu

“…Here, we obtained 16 root morphology‐related traits (R‐traits), 7 weight‐related traits (W‐traits), and 108 slice‐related microphenotypic traits (S‐traits) from the meristem, elongation, and mature zones by cross‐sectioning primary, crown, and lateral roots from 316 maize lines. Significant differences were observed in some root traits between tropical/subtropical and temperate lines, such as primary and total root diameters, root lengths, and root area. …”
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INFLUENCE OF ANODIC ALUMINA USED AS SEPARATING DIELECTRIC OF SILICON AVALANCHE LEDs ON DIODE CHARACTERISTICS by Vi Le Dinh, A. Yu. Klutsky, A. A. Dolbik, A. A. Leshok, S. K. Lazarouk

“…An explanation of this effect is presented on the basis that the built-in negative electric charge inside the anode oxide also creates a space charge region in silicon, which helps to reduce the effect of the concentration of field lines at the edges of diode structures, performing the function of protecting the Schottky contact from edge effects as well as protective areas do. …”
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Identifying the mitochondrial ribosomal protein MRPL13 as an oncogenic RBP that promotes proliferation, migration, and anti-apoptotic effects in esophageal cancer cells by Yaxi Song, Hui Wang, Shiyao Li, Weili Tao, Chunqing Li, Bin Wang, Caifeng Gong

“…Gene enrichment variation analysis (GSVA) was performed to analyze molecular differences. EdU, transwell and flow cytometry assays were performed to detected proliferation, migration and apoptosis level of ESCA cell lines. …”
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Special Issue on Contemporary Research Studies in Operations Research, Business Analytics, and Business Intelligence by Viswanath Kumar Ganesan, S. Vinodh, Malolan Sundararaman, M. Vimala Rani, M. Mathirajan

“…Optimization Algorithms: Developing efficient algorithms to solve linear fractional transshipment problem with multi-objective linear fractional functions. 4. AI in Business Intelligence: Investigating long-term impacts of AI-enabled Business Intelligence tools on data-driven decision-making and organizational performance. 5. …”
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Investigating the differential microRNAs expression in young and aged Drosophila melanogaster following Flock House Virus infection by Amber Thibeaux, Max Yang Lu, Marshall Martin, Michael Rodwell, Victoria Faber, Lakbira Sheffield, Janna L. Fierst, Stanislava Chtarbanova

“…For 17 candidate miRNAs, we tested Drosophila lines with in vivo miRNA knockdown for their survival of systemic FHV challenge. …”
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Effect of testosterone treatment during puberty in boys with Klinefelter syndrome (The TIPY Study): protocol for a nationwide randomised, double-blinded, placebo-controlled study by Gary Butler, Anders Juul, Judith L Ross, Jørgen Holm Petersen, Kurt Kristensen, Ann-Margrethe Rønholt Christensen, Ida Dyhr Caspersen, Andrés Felipe Østergaard Fritzbøger, Niels Birkebæk, Anders Jørgen Schou, Shanlee Davis, Sophie van Rijn, Lise Aksglaede

“…Additionally, individuals with KS often experience mental health challenges and functional impairments that significantly impact their quality of life. …”
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A novel NFKB1 agonist remodels tumor microenvironment and activates dendritic cells to promote anti-tumor immunity in colorectal cancer by Ying Chen, Qiaoming Li, Zixiang Wang, Ling V. Sun, Steven X. Hou

“…Methods We conducted an in vivo chemical screen to identify F1929-1458, which is capable of eliciting an organism-wide response to destroy stem cell tumors in Drosophila. We then performed functional validation using a mouse colorectal cancer graft tumor model established with the CT26 cell line characterized by its high content of CSCs. …”
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