INCREASE OF EFFICIENCY OF SUPPRESSION OF THE ACTIVE NOISE JAMMING IN RADAR INTERCEPTION OF AIR TARGETS IN THE REVIEW MODE by V. E. Markevich

“…The single estimation of straight line CMJ is formed as result dyad products of the instant vectors of noises in handling channels. …”
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Universal receptive system as a novel regulator of transcriptomic activity of Staphylococcus aureus by George Tetz, Kristina Kardava, Maria Vecherkovskaya, Alireza Khodadadi-Jamayran, Aristotelis Tsirigos, Victor Tetz

“…The results of this study add another line of evidence that the Universal Receptive System plays an important role in cell regulation, including cell responses to the environmental factors of clinically important pathogens, and that nucleic acid-based TezRs are functionally active parts of the extrabiome.…”
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ISOT position statement on the feasibility of an organ for transplantation from brain-dead deceased donors: a Delphi consensus by Manish R. Balwani, Vivek B. Kute, Jigar Shrimali, Bharat G. Jagiasi, Pradip Kumar Bhattacharya, Amit Pasari, Manoj Gumber, Sanjeev Gulati, Raj Kanwar Yadav, Shankar Prasad Nagaraju, Gomathy Narasimhan, Natarajan Gopalkrishnan, Divyesh Engineer, Tushar Dighe, Jamal Rizvi, Sanjay P. Kolte, Vishal Vasant Ramteke, Nishant Shantanu Deshpande, Priyanka Tolani, Georgi Abraham, Abhijit Patil, Anurag Gupta, Dhananjai Agarwal, Dinesh Khullar, Narayan Prasad, Pratik Das, Radhika Krishna Patil, Ravi Mohanka, Sandeep Mahajan, Sourabh Sharma, Subho Banerjee, Vinant Bhargava, Jyoti Patodia, Arpita Ray Chaudhury, Aneesh Srivastava

“…It encourages critical care and transplant teams to perform structured assessments of organ viability, apply ethical principles, and pursue informed consent in line with local regulations.…”
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Construction and validation of a prognostic model based on cuproptosis-related genes in patients with multiple myeloma by KANG Zhongmin, KANG Zhongmin, LI Licheng

“…Time-dependent receiver operating characteristic (ROC) and calibration curves were plotted to assess the predictive performance and accuracy of the model. The differences between the high- and low-risk cohorts were explored using Kaplan-Meier survival curve analysis and immune microenvironment correlation analysis. ② RT-qPCR and Western blotting were used to verify the expression of prognostic model genes in MM cell lines and normal bone marrow single-nucleated cells, and CCK-8 assay, flow cytometry, and Western blotting were applied to verify the biological function of UBE2D1 in MM cells. …”
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Relationship between retinol metabolism and hepatocellular carcinoma: a comprehensive analysis of Mendelian randomization, prognostic characteristic and experiment by Fuqing Chen, Yifan Cai, Jianyin Zhou

“…The expression level of RDH16 gene was detected in cell lines and clinical samples, and finally the function of RDH16 gene and its regulatory relationship with miR- 665 were verified by in vitro cell experiments. …”
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Light-regulated microRNAs shape dynamic gene expression in the zebrafish circadian clock. by Zuo Wang, Shuang Wang, Yi Bi, Alessandra Boiti, Shengxiang Zhang, Daniela Vallone, Xianyong Lan, Nicholas S Foulkes, Haiyu Zhao

“…Circadian clocks in zebrafish peripheral tissues and even zebrafish-derived cell lines are entrainable by direct light exposure thus providing unique insight into the function and evolution of light regulatory pathways. …”
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ORF1p promotes proliferation and invasion of esophageal squamous cell carcinoma cells by regulating AJUBA expression by YANG Fan, LI Jiangyang, DAI Xiaoyan

“…Results ① Western blot analysis demonstrated the expression of ORF1p was significantly higher in the ESCC cell lines than the normal esophageal squamous epithelial cells (P<0.05). ② IHC confirmed remarkable up-regulation of ORF1p in ESCC tissues than paired adjacent normal tissues (P<0.000 1). ③ Functional assays and experiments on xenograft tumor models revealed that ORF1p substantially enhanced the proliferation, migration, and invasion of ESCC cells, as well as tumorigenic potential in vivo (P<0.05). ④ Functional rescue experiments showed that ORF1p facilitated the proliferation, migration, and invasion of ESCC cells by modulating AJUBA expression (P<0.05). …”
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Multi-omics landscape of alternative splicing in diffuse midline glioma reveals immune- and neural-driven subtypes with implications for spliceosome-targeted therapy by Chaxian Liu, Chaxian Liu, Chaxian Liu, Chaxian Liu, Chaxian Liu, Yue Liu, Yue Liu, Yue Liu, Yue Liu, Yue Liu, Hao Lin, Hao Lin, Hao Lin, Hao Lin, Hao Lin, Chufan Zhang, Chufan Zhang, Chufan Zhang, Bilong Zhang, Bilong Zhang, Bilong Zhang, Haikun Song, Haikun Song, Haikun Song, Xiaomin Fan, Yi Lyu, Hui Yang, Hui Yang, Hui Yang, Hui Yang, Hui Yang, Ying Mao, Ying Mao, Ying Mao, Ying Mao

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An in‐cell helicase reporter system for quantifying DDX3X and DDX3Y activities by Zhi Sheng Poh, James Chia Wei Tan, Brandon Han Siang Wong, Kottaiswamy Amuthavalli, Holy Kristanti, Suat Hoon Tan, Nicholas Francis Grigoropoulos, Navin Kumar Verma

“…Abstract Genome sequencing has identified numerous mutations in the DEAD‐box RNA helicases, DDX3X and DDX3Y, associated with cancer and other diseases, but monitoring of their functional consequences remains a challenge. Conventional helicase assays are laborious, often technically difficult, and are performed in cell‐free systems that do not address biologically relevant questions. …”
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Elevated SGO2 expression in lung adenocarcinoma promotes migration and invasion via MAD2 and correlates with poor prognosis by Min Sun, Wenzheng Zhou, Guohao Wei, Mengyao Lv, Yan Sun, Huihui Zhao, Chuandong Zhu

“…Subsequently, we validated our findings through immunohistochemical staining in a subset of 21 Lung adenocarcinoma cases from Nanjing Second Hospital. Furthermore, the functional role of SGO2 in the H1299 cell line was assessed through a series of experiments including Western blotting, CCK-8 assays, Transwell assays for invasion, wound healing assays, and flow cytometric analysis. …”
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Lactylation Modification as a Promoter of Bladder Cancer: Insights from Multi-Omics Analysis by Yipeng He, Lingyan Xiang, Jingping Yuan, Honglin Yan

“…The Lasso algorithm was used to establish a prognostic model related to lactylation modification, and its predictive ability was tested with a validation cohort. Functional enrichment analysis, tumor microenvironment analysis, and treatment response evaluation were performed on the high- and low-risk groups. …”
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External calibration with Drosophila whole-cell spike-ins delivers absolute mRNA fold changes from human RNA-Seq and qPCR data by Franziska Taruttis, Maren Feist, Phillip Schwarzfischer, Wolfram Gronwald, Dieter Kube, Rainer Spang, Julia C. Engelmann

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Middle term results of tantalum acetabular cups in total hip arthroplasty following pelvic irradiation by Massimiliano De Paolis, Riccardo Zucchini, Carlo Romagnoli, Matteo Romantini, Federica Mariotti, Davide Maria Donati

“…Radiographic signs of loosening were investigated by X-rays looking for radiolucent lines. We used the Harris hip score for the clinical and functional evaluation. …”
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SfDredd, a Novel Initiator Caspase Possessing Activity on Effector Caspase Substrates in Spodoptera frugiperda. by Zhouning Yang, Ke Zhou, Hao Liu, Andong Wu, Long Mei, Qingzhen Liu

“…Sf9, a cell line derived from Spodoptera frugiperda, is an ideal model organism for studying insect apoptosis. …”
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Mutations in the transcriptional regulator MAB_2885 confer tedizolid and linezolid resistance through the MmpS-MmpL efflux pump MAB_2302-MAB_2303 in Mycobacterium abscessus. by Huiyun Zhang, Shiyong Wang, Yu Zhang, Wenya Hua, Siran Lin, Xinchang Chen, Tao Xu, Jiazhen Chen, Wenhong Zhang

“…Tedizolid (TZD), an oxazolidinone-class antibacterial drug, has been recommended as an alternative treatment for MAB-infected patients who are intolerant to or whose isolate is resistant to first-line drugs including linezolid (LZD). To investigate the TZD resistance mechanisms in MAB, we isolated 23 TZD-resistant MAB mutants and performed whole-genome sequencing (WGS) to identify resistance-associated genes. …”
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Visual biofeedback for paradoxical vocal fold motion (PVFM) by Rachelle Alyce LeBlanc, Daniel Aalto, Caroline C. Jeffery

“…We aimed to examine the efficacy of surgeon performed visual biofeedback as first-line treatment for PVFM. …”
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Glypican-3 regulated epithelial mesenchymal transformation-related genes in osteosarcoma: based on comprehensive tumor microenvironment profiling by Jiaming Zhang, Wei Wang

“…Single-cell RNA-Seq (scRNA-Seq) analysis was conducted on OS samples to identify cell populations expressing model genes. Functional validation was performed using si-GPC3 in the MG-63 cell line.ResultsThe EMT-based prognostic model demonstrated strong predictive capacity across several validation cohorts. …”
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PCK1 and SLC22A2 gene variants associated with response to metformin treatment in type 2 diabetes. by Sophie St-Amour, Laurence Tessier, Janie Harnois, Catherine Allard, Alexandre Lavoie, Philippe Caron, Luigi Bouchard, Patrice Perron, Karine Tremblay

“…Type 2 diabetes (T2D) is a chronic disorder affecting 462 million worldwide, often managed with metformin as first-line treatment. However, metformin's response varies among individuals, including up to 30% experiencing serious adverse drug reactions (ADRs) and 20-50% inefficacy. …”
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Application of Multimodal Anesthesia in Surgical Interventions for Lung Cancer by S. V. Kachur, V. T. Dolgikh, O. V. Korpacheva, O. V. Leonov

“…It is more expedient to perform surgeries to remove malignant tumors in the lungs under the multimodal anesthesia, because these interventions are distinguished by high traumatic rate and having a «fine line» between compensation and decompensation of the basic vital functions in the perioperative period.…”
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Design Optimization of an Innovative Instrumental Single-Sided Formwork Supporting System for Retaining Walls Using Physics-Constrained Generative Adversarial Network by Wei Liu, Lin He, Jikai Liu, Xiangyang Xie, Ning Hao, Cheng Shen, Junyong Zhou

“…By supporting the formwork from one side, an SFSS can minimize its spatial footprint, enabling its closer placement to boundary lines without compromising structural integrity. …”
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