Biosimilars: development and investigation using achievements in modern biotechnology by R. R. Niyazov, M. A. Dranitsyna, A. N. Vasiliev, E. V. Gavrishina

“…The state-of-the-art methods of biotechnology and analytics, when applied in line with the appropriate scientific and regulatory requirements, can allow developing similar biologics where no difference in the clinical profile exists with the respective innovator product. …”
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Age-Related Effects on Future Mental Time Travel by Filomena Anelli, Elisa Ciaramelli, Shahar Arzy, Francesca Frassinetti

“…Aged individuals performed worse in both self-projection to the future and self-reference to future events compared to young individuals. …”
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Characteristics of the nitric oxide system indicators in the left ventricle myocardium in SHR by Yu. M. Kolesnyk, M. I. Isachenko, O. V. Melnikova, T. A. Hrekova

“…The aim was to determine the morpho-functional parameters of the left ventricular myocardium NO system in the rats with essential hypertension (SHR line). …”
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Downregulated PRNP Facilitates Cell Proliferation and Invasion and Has Effect on the Immune Regulation in Ovarian Cancer by Kuan Hu, Xiaofang Zhang, Lei Zhou, Juanni Li

“…Then, comprehensive evaluations concerning gene expression, clinical implication, in vitro validation of expression and functional experiments, prediction of downstream molecules and related signal pathways, and immune-modulating function were performed. …”
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Singlet Oxygen-Induced Mitochondrial Reset in Cancer: A Novel Approach for Ovarian Cancer Therapy by Jorgelindo da Veiga Moreira, Laurent Schwartz, Mario Jolicoeur

“…We aimed to examine the role of SO in modulating mitochondrial function, cellular metabolism, and proliferation in ovarian cancer cell lines compared to control cells. …”
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B Cell Activating Factor Induces Drug Resistance in Hairy Cell Leukemia Variant by Claire Fritz, Daniel Feinberg, Akshaya Radhakrishnan, Kayla Klatt, E. Ricky Chan, Philip Rock, Richard Burack, Reshmi Parameswaran

“…To test whether BAFF signaling promotes chemoresistance in HCL-v, we stimulated patient-derived HCL-v cells with BAFF and performed RNA sequencing. Lastly, to confirm the functional implications of BAFF signaling in HCL-v, we treated patient-derived HCL-v cells with exogenous BAFF before treatment with cladribine. …”
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Diaphragmatic curvature analysis using dynamic digital radiography by Takuya Hino, Akinori Tsunomori, Noriaki Wada, Akinori Hata, Taiki Fukuda, Yusei Nakamura, Yoshitake Yamada, Tomoyuki Hida, Mizuki Nishino, Masako Ueyama, Atsuko Kurosaki, Takeshi Kubo, Shoji Kudoh, Kousei Ishigami, Hiroto Hatabu

“…Methods: This retrospective study included healthy volunteers and COPD patients recruited from 2009 to 2014 at Fukujuji Hospital, who received DDR and pulmonary functional test. AUD was defined as an area under a hemidiaphragm and above the line connecting the ipsilateral costophrenic angle to the top of the hemidiaphragm on DDR image. …”
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Gene Editing Anxiety by Angelo Osofsky

“…Even if genes for anxiety could be edited with great predictive success, the line separating non-genetic anxiety from pathological versions is unclear. …”
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Cryo-EM structures of a pentameric ligand-gated ion channel in liposomes by Vikram Dalal, Brandon K Tan, Hanrui Xu, Wayland WL Cheng

“…To determine the structure of a pLGIC in a membrane environment that supports ion channel function, we performed single particle cryo-EM of ELIC in liposomes. …”
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ASF1B promotes gastric cancer progression by modulating H2AC20 and activating PI3K/AKT and ERK1/2 pathways by Mengyuan Zhao, Junchang Zhang, Yanjun He, Chongge You

“…We then constructed ASF1B knockout and overexpression cell lines, and conducted biological function tests on this basis, validated at mouse and organoid levels. …”
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Pericyte-mediated regulation of angiogenesis during cutaneous wound healing in adult zebrafish by Tomohiro Ishii, Shinya Yuge, Koji Ando, Weibin Zhou, Shigetomo Fukuhara

“…These results suggest that pericytes play an active role for generating functional blood vessels during wound angiogenesis.…”
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A variable metric proximal stochastic gradient method: An application to classification problems by Pasquale Cascarano, Giorgia Franchini, Erich Kobler, Federica Porta, Andrea Sebastiani

“…Further, we utilize a non-monotone line search to automatize step size selection. Convergence results are provided for both convex and non-convex objective functions. …”
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GAN-based image prediction of maize growth across varieties and developmental stages by Xinyi Wang, Shilong Liu, Zhihao Wang, Zedong Geng, Weikun Li, Chengxiu Wu, Yingjie Xiao, Wanneng Yang, Lingfeng Duan

“…Results This article proposed a visualized growth prediction method based on an improved Pix2PixHD network, incorporating spatial attention mechanisms, an improved loss function, and a modified dropout strategy to enhance prediction accuracy and visual fidelity. …”
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Paediatric Obstructive Sleep Apnoea: Pathophysiology and the Role of Myofunctional Therapy by Yan Kiu Li

“…The pathophysiology of obstructive sleep apnoea (OSA) is well studied in the adult population, but not in the paediatric population, although it can be generally classified into anatomical, functional, and pathological factors, with the most common aetiology being adenotonsillar hypertrophy and a reduced neuromuscular tone of the upper airway (UA) muscles. …”
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Reconstructing spectral cues for sound localization from responses to rippled noise stimuli. by A John Van Opstal, Joyce Vliegen, Thamar Van Esch

“…The reconstructed spectral cues resulted to be invariant to the considerable variation in ripple bandwidth, and for each listener they had a remarkable resemblance to the idiosyncratic head-related transfer functions (HRTFs). These results are not in line with models that rely on the detection of a single peak or notch in the amplitude spectrum, nor with a local analysis of first- and second-order spectral derivatives. …”
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Exploring the binding pathways of the 14-3-3ζ protein: Structural and free-energy profiles revealed by Hamiltonian replica exchange molecular dynamics with distancefield distance r... by Gabor Nagy, Chris Oostenbrink, Jozef Hritz

“…The 14-3-3 protein family performs regulatory functions in eukaryotic organisms by binding to a large number of phosphorylated protein partners. …”
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Polyaspectivity of the Compositional Structure of the Rhetorical Text by L. A. Golyshkina

“…The concept of the argumentation complex is introduced that is the union of register units that perform certain functions in the argumentation. The formal-pragmatic aspect demonstrates the formation of the superstructure of the text by incorporating argumentative complexes into the main part of the rhetorical text, as well as its communicative-pragmatic framework - introduction and conclusion. …”
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SONOELASTOGRAPHY IN DIAGNOSTICS AND SURGICAL TREATMENT OF PATIENTS WITH RECTOCELE by A. G. Khitar’Yan, R. N. Zavgorodnyaya, K. A. Dul’Erov, D. V. Stagniev, S. A. Kovalev, A. S. Bolotskov

“…The surgery included a sacrospinal fixation of cupula of the vagina, colporrhaphy supplemented by transrectal «11-hour» mucopecsia on the hight up to 5 cm from dentate line. There was stated that the major diagnostic criteria of functional insufficiency of pelvic floor were the sonoelastometric study of stiffness of the perineum muscles and tonometric research of gradient of vagina pressure in case of rest and tension. …”
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Localized and Excimer Triplet Electronic States of Naphthalene Dimers: A Computational Study by Lara Martínez-Fernández, Roberto Improta

“…We perform DFT calculations with different hybrid (ωB97X-D and M05-2X) and double hybrid (B2PLYP-D3 and ωB2PLYP) functionals to characterize the lowest energy triplet excited states of naphthalene monomer and dimers in different stacking arrangements and to simulate their absorption spectra. …”
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A framework for personal protective equipment use in laboratories: regulatory compliance and employee protection by Segaran P. Pillai, Sarah Bradberry, Marisa Newcomer, Tanya Pittas, Kelsey Mathern

“…The Occupational Safety and Health Administration (OSHA) Personal Protective Equipment (PPE) Standard, outlined in 29 CFR 1910 Subpart I states that Protective gear - including personal protective clothing, respiratory equipment, and barriers or shields- must be supplied, properly used, and kept clean and functional whenever there are hazards present. These hazards may arise from processes, environmental conditions, chemicals, radiation, or mechanical sources that could potentially cause injury or harm bodily functions through skin contact, inhalation, or absorption. …”
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