Protocol to identify proteins as regulators of gene expression noise by Óscar García-Blay, Maike M.K. Hansen

“…Here, we present a protocol for identifying novel candidate proteins with noise regulatory functions. We describe steps for inhibiting translation in cells, performing single-cell RNA sequencing and liquid chromatography-tandem mass spectrometry (LC-MS/MS), and utilizing known regulator-target interactions to integrate obtained data in a regulator enrichment analysis. …”
Get full text

The Naso-labial and lateral forehead flaps as a single stage: A case report and review of literature by Adigun I, Oladele A, Olabanji J

“…If the principles concerning cover, support, and lining are adhered to, excellent functional and aesthetic results can be achieved as we have obtained in our patient.…”
Get full text

Surgical correction of unilateral and bilateral congenital macrostomia: a case report and literature review by Guilherme Gurgel do Amaral Teles, Daniel Marques Perfeito

“…CONCLUSION: The technique used is easily reproducible, and aesthetically and functionally corrects macrostomia.…”
Get full text

Elaboración, validez de contenido y fiabilidad del instrumento de observación SOCTOD-BSR para el análi-sis de acciones en baloncesto en silla de ruedas (Development, content validi... by Adrián García-Fresneda, Verónica Muñoz-Arroyave, Xavier Iglesias, Apostolos Theodorou, David Suárez Iglesias, Alba Pardo Fernández

“…Keywords: psychometric properties, observational methodology, functional classification, line-up formations, parasport. …”
Get full text

Systems-level modeling of cancer-fibroblast interaction. by Raymond C Wadlow, Ben S Wittner, S Aidan Finley, Henry Bergquist, Rabi Upadhyay, Stephen Finn, Massimo Loda, Umar Mahmood, Sridhar Ramaswamy

“…We have taken a mathematical approach to begin defining these rules by performing the first large-scale quantitative analysis of fibroblast effects on cancer cell proliferation across more than four hundred heterotypic cell line pairings. …”
Get full text

Global Factors of World Statistic System Transformation by M. D. Simonova, E. A. Yarnykh

“…Within the frames of science about data statistic performs functions of the central bearing structural block, fosters the development of methods for processing and analyzing quantitative and non-quantitative information aimed at making effective decisions on all levels of management. …”
Get full text

Landslide Susceptibility Assessment Using the Geographical-Optimal-Similarity Model by Yonghong Xiao, Guolong Li, Lu Wei, Jing Ding, Zhen Zhang

“…This demonstrates superior performance and confirms the effectiveness and accuracy of the method in landslide susceptibility assessment. …”
Get full text

From infection to autoimmunity: can COVID-19 spark new auto-immune conditions? by Mourad Elghali, Mariem Mhiri, Imen Chaabene, Ines Bayar, Bilel Ben Amor, Imen Jaziri, Maha Changuel, Rihab Ben Dhia, Narjes Gouta, Jamel Saad, Rym Hadhri, Ahmed Zrig, Soumaya Boudokhane, Hela Marmouche, Mahbouba Jguirim, Nabil Sakly

“…Typing was performed using ELISA (Biosystems, Spain) or line blot (Euroimmun, Germany). …”
Get full text

COMPARATIVE EVALUATION OF OSTEOTROPIC ACTION OF ENDODONTIC FILLING MATERIALS ON THE MODEL OF EXPERIMENTAL DESTRUCTION OF BONE TISSUE OF THE JAW OF RATS by I. Han

“…The experiment was conducted on 120 white rats Wistar line, aged 9-10 weeks, herd breeded. To create a bone defect intervention was performed under general anesthesia (0.5 ml 4% solution of sodium thiopental into the peritoneum). …”
Get full text

Dissecting the transcriptional regulatory properties of human chromosome 16 highly conserved non-coding regions. by José Luis Royo, Carmen Hidalgo, Yolanda Roncero, María Angeles Seda, Altuna Akalin, Boris Lenhard, Fernando Casares, José Luis Gómez-Skarmeta

“…However, only a few systematic analyses of the function of these highly conserved non-coding regions (HCNRs) have been performed. …”
Get full text

Enhancing T cell anti-tumor efficacy with a PD1-TIGIT chimeric immune-checkpoint switch receptor by Jingjing Zhao, Jiebin Dong, Changwen Deng, Qianjing Zhang, Shicheng Sun, Honggang Li, Yun Bai, Hongkui Deng

“…In addition to neutralizing PDL1 and CD155, this chimeric receptor is engineered with the transmembrane region and intracellular domain of CD28, thereby effectively enhancing T cell survival and tumor-targeting functions. Notably, under simultaneous stimulation of PDL1 and CD155, CISR-CAR T cells demonstrate superior performance in terms of cell survival, proliferation, cytokine release, and cytotoxicity in vitro, compared with conventional CAR T cells. …”
Get full text

Intraoperative assesment of spinal cord conduction during surgical decompression in patients with cervical spondylotic myelopathy by M. A. Hit’, E. M. Troshina, S. S. Nikitin, A. O. Gushcha

“…The aim of this case was to study the on‑line assessment of the functions of corticospinal and somatosensory pathways changed due to surgical decompression of cervical spinal cord. …”
Get full text

Machine learning-based prognostic model of lactylation-related genes for predicting prognosis and immune infiltration in patients with lung adenocarcinoma by Mingjun Gao, Mengmeng Wang, Siding Zhou, Jiaqi Hou, Wenbo He, Yusheng Shu, Xiaolin Wang

“…Finally, we analyzed the expression of KRT81 in LUAD tissues and cell lines using qRT-PCR, WB, and IHC. Changes in KRT81 function in LUAD cells were detected by CCK-8, colony formation, wound healing, transwell, and flow cytometry. …”
Get full text

A revision of the Ni-Zn phase diagram based on vapor-solid diffusion experiments by Daniel Garstenauer, Klaus W. Richter

Get full text

Integrated analysis reveals that EGR1 promotes epithelial IL33 production in T2 asthma by Yan Zhao, Jenil Patel, Jinhua Fan, Xinyang Wang, Lin Chen, Yuanyuan Li, Zhengxiu Luo

“…The functional experiments of EGR1 were investigated in vitro via siRNA knockdown and over-expressed plasmid. …”
Get full text

Novel Sonoguided Digital Palpation and Ultrasound-Guided Hydrodissection of the Long Thoracic Nerve for Managing Serratus Anterior Muscle Pain Syndrome: A Case Report with Technica... by Nunung Nugroho, King Hei Stanley Lam, Theodore Tandiono, Teinny Suryadi, Anwar Suhaimi, Wahida Ratnawati, Daniel Chiung-Jui Su, Yonghyun Yoon, Kenneth Dean Reeves

“…Physical examination revealed tenderness along the anterior axillary line and a positive hyperirritable spot at the mid axillary line at the 5th rib level. …”
Get full text

Оrgan-preserving operations in the abdominal gun-shot penetrating woundings of large bowel. Experience of the medical help delivery in military environment Аntiterroristic operatio... by O. Yu. Usenko, I. A. Lurin, K. V. Gumenuk, V. V. Nehoduiko, R. M. Mykhaylusov, R. V. Saliutin

“…Selecting the surgical treatment method for the gun-shot woundings of large bowel, it is necessary to base on complex analysis of the battle trauma character, the patient’s state and the risk for іntra- and postoperative complications. The first-line application of organ-preserving interventions as more physiological and those, which permit mostly rapid come back to the service duties functioning, is expedient. …”
Get full text

Dissecting the genetic architecture of key agronomic traits in lettuce using a MAGIC population by Hongyun Chen, Jiongjiong Chen, Ruifang Zhai, Dean Lavelle, Yue Jia, Qiwei Tang, Ting Zhu, Menglu Wang, Zedong Geng, Jianzhong Zhu, Hui Feng, Junru An, Jiansheng Liu, Weibo Li, Shenzhao Deng, Wandi Wang, Weiyi Zhang, Xiaoyan Zhang, Guangbao Luo, Xin Wang, Sunil Kumar Sahu, Huan Liu, Richard Michelmore, Wanneng Yang, Tong Wei, Hanhui Kuang

“…To address this challenge, we develop the first multi-parent, advanced generation inter-cross (MAGIC) population for lettuce using 16 diverse founder lines. Results Whole-genome sequencing of the 16 founder lines and 381 inbred progeny reveal minimal population structure, enabling informative genome-wide association studies (GWAS). …”
Get full text

Post-registration experience of nivolumab in advanced hepatocellular carcinoma: an international study by Dominik Bettinger, Bo Yu, David Szafron, Yinghong Wang, Mahvish Muzaffar, Thomas Marron, Uqba Khan, Yi-Hsiang Huang, David J Pinato, Ahmed Kaseb, Anwaar Saeed, Tomi Jun, Sirish Dharmapuri, Musharraf Navaid, ChiehJu Lee, Anushi Bulumulle, Sonal Paul, Petros Fessas, Neil Nimkar, Hannah Hildebrand, Tiziana Pressiani, Yehia I Abugabal, Nicola Personeni, Lorenza Rimassa, Celina Ang, Abdul Rafeh Naqash, Francesca Benevento

“…Post-registration data of treatment in a real-world setting is lacking.Patients and methods We performed an international, multicenter observational study to confirm safety and efficacy of nivolumab in 233 patients treated outside clinical trials from eight centers in North America, Europe and Asia.Results Patients received nivolumab for Barcelona Clinic Liver Cancer stage C (n=191, 92.0%) and Child-Pugh (CP) A (n=158, 67.8%) or B (n=75, 32.2%) HCC as first (n=85, 36.5%) or second to fourth systemic therapy line (n=148, 63.5%). …”
Get full text

Quantitative Structure Activity Relationship Studies of Topoisomerase I Inhibitors as Potent Antibreast Cancer Agents by Supriya Singh, Sucheta Das, Anubhuti Pandey, Sarvesh Paliwal, Rajeev Singh

“…So, with an aim to elucidate the important features responsible for their activity, QSAR studies on breast cancer cell line using stepwise multiple linear regressions, partial least square, and neural network were performed. …”
Get full text