Case Report: Post-operative mitral valve replacement complicating with a large cardiac mass and the role of TEE in Imaging [version 2; peer review: 2 approved] by Deepa Noronha, Chaithra Nayak, Syed Waleem Pasha, Padmanabh Kamath, Narasimha Pai D

“…Following stabilization,the patient was discharged considering optimal INR values and prosthetic valve function assessed by echocardiography. The patient’s symptoms improved during the first follow-up. …”
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Effectiveness of SGLT2 inhibitors compared to sulphonylureas for long-term glycemic control in type 2 diabetes: A meta-analysis by Zhouhong Zhan, Jialiang Wang, Nannan Shen, Xinwen Liu, Lihong Wang

“…However, their long-term effectiveness is often limited due to declining β-cell function. Sodium-glucose co-transporter 2 (SGLT2) inhibitors act independently of insulin, potentially providing more sustained glycemic control. …”
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Active peptides of TSP-1 inhibit retinal angiogenesis through the CD36 pathway in a rat model of choroidal neovascularization. by Yadi Li, Aiping Deng, Kangwei Jiao, Jie Yan, Wandong Zuo, Yujie Dong, Wenrong Xu, Yuting Li, Chunming Guo, Maorong Chen, Run Tian, Zhulin Hu

“…CRISPR-Cas9 technology was utilized to establish CD36 knockdown cell lines, alongside the conduction of qPCR to verify the efficiency of gene knockdown. …”
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The minor allele rs2295613(A), protective against systemic lupus erythematosus, makes a differential contribution to the activity of the <i>SLAMF1</i> gene promoter in T helpers an... by A. N. Uvarova, L. V. Putlyaeva, E. A. Zheremyan, E. M. Stasevich, M. M. Murashko, E. A. Bogomolova, K. V. Korneev, D. E. Demin, A. M. Schwartz, D. V. Kuprash

“…In the present work, we performed a functional analysis of single nucleotide promoter polymorphisms rs2295614(A&gt;T) and rs2295613(G&gt;A) of the SLAMF1 gene in the models of T-regulatory lymphocytes (MT-2 cell line) and T helpers (Jurkat cell line). …”
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Effect of Cyclic Loading on Bending Stiffness of Glued Laminated Pieces by Clara Gaspar Fossi de Souza, Giovana Gobatto Balanco, Leonor da Cunha Mastela, André Luis Christoforo, Francisco Antonio Rocco Lahr

“…NC and frequency explained E variations for Marupá; for Pequiá, only NC. Glue lines were evaluated, in function of NC, without problems identified, enabling both species for Glulam manufacture.…”
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Patient-centered group psychotherapy for depression and negative emotions: a systematic review and meta-analysis by Yang-yang Yin, Zhen-zhen Wan, Bo Wang

“…PCGP showed significant positive effects on overall effectiveness (RR = 1.10, 95% CI: 1.01-1.19, p = 0.03), symptom reduction (Positive and Negative Syndrome Scale (PANSS) scores, SMD = -1.96, 95% CI: -2.31 to -1.61, p &lt; 0.001), and functional outcomes (Personal and Social Performance (PSP) scores, SMD = 1.96, 95% CI: 1.41-2.51, p &lt; 0.001). …”
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Engineering novel CRISPRi repressors for highly efficient mammalian gene regulation by Andrew Kristof, Krithika Karunakaran, Christopher Allen, Paula Mizote, Sophie Briggs, Zixin Jian, Patrick Nash, John Blazeck

“…CRISPRi platforms can often have incomplete knockdown, performance variability across cell lines and gene targets, and inconsistencies dependent on the guide RNA sequence employed. …”
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Lightweight Insulating Geopolymer/Phase-Change Materials Applied Using an Innovative Spray Method by Agnieszka Przybek, Paulina Romańska, Jakub Piątkowski, Michał Łach

“…Tests performed on approximately 200 m² of surface confirmed the functionality of the process. …”
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Study on Deformation Characteristics of Surrounding Rock in Deep-Buried Tunnels of Plateau Railroads by Ziguang Zhang, Meng Zhang, Yahui Wang, Lin Wei, Lei Zhang, Biao Leng, Yong He

“…The results demonstrate that: the final deformation of the surrounding rock increased exponentially or power function with increasing burial depth. The rate of deformation increased significantly after the burial depth exceeded 1000 m. …”
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Inhibition of platelet activation alleviates diabetes-associated cognitive dysfunction via attenuating blood-brain barrier injury by Fuxing Xu, Juan Hu, Xuying Li, Lan Yang, Shiqiu Jiang, Tao Jiang, Bo Cheng, Hailiang Du, Ruiduo Wang, Yingying Deng, Wei Gao, Yansong Li, Yaomin Zhu

“…We performed inhibition of platelet activation on diabetic and non-diabetic mice, with or without cilostazol treatment, and then compared cognitive function, platelet activation, BBB structure and permeability. …”
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Efficacy and safety of combination therapy with lenvatinib and pembrolizumab in elderly patients with advanced endometrial cancer by M. V. Volkonskiy, A. A. Akopyan, T. A. Zhelezkova, R. S. Zhikhorev, E. P. Krasnorutskaya, N. R. Abidova, T. A. Makarkina, M. O. Skorina, V. M. Filippova, I. A. Luev, Yu. V. Vasilyeva, G. D. Malina, L. P. Veshkina, B. L. Nersesyan

“…The median number of prior treatment lines was 3 (2–6). The objective response rate reached 25 %, and the disease control rate was 75 %. …”
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Seditious Spaces by Nurul Azreen Azlan

“…Protest provided a direct line for the interrogation of just how democratic postcolonial public space actually is. …”
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Non‐Volatile Resistive Switching in Nanoscaled Elemental Tellurium by Vapor Transport Deposition on Gold by Sara Ghomi, Christian Martella, Yoonseok Lee, Penny Hui‐Ping Chang, Paolo Targa, Andrea Serafini, Davide Codegoni, Chiara Massetti, Sepideh Gharedaghi, Alessio Lamperti, Carlo Grazianetti, Deji Akinwande, Alessandro Molle

“…This study reports the first memristor design based on nanoscaled tellurium synthesized by vapor transport deposition (VTD) at a temperature as low as 100 °C fully compatible with back‐end‐of‐line processing. The resistive switching behavior of tellurium nanosheets is studied by conductive atomic force microscopy, providing valuable insights into its memristive functionality, supported by microscale device measurements. …”
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Role of interleukin-21 in primary knee osteoarthritis: a clinical, laboratory and radiological study in Assiut Governorate by Mohamed I.M. Abdelkareem, Awad S. Abbas, Ahmed M. Salem, Rehab A.E. Elsayed

“…The serum concentration of IL-21 was significantly elevated in the group of cases with tenderness in the line of knee joint compared with those without knee joint line tenderness (P≤0.001). …”
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Non-enzymatic SETD1A activity drives breast cancer cell proliferation via cyclin K by Kanako Hayashi, Takayuki Hoshii, Meng Ning, Makoto Matsumoto, Shintaro Izumi, Masaki Fukuyo, Bahityar Rahmutulla, Masahiko Tanabe, Atsushi Kaneda

“…A CRISPR knockout of SETD1A was performed in a doxycycline-inducible Cas9-expressing KPL-1 breast cancer cell line. …”
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Effectiveness assessment of sulfur-containing amino acids in rats with experimental “alcohol withdrawal syndrome” with modified zoosocial interaction methods by V. I. Petrov, N. A. Osadchenko, A. S. Tarasov, A. M. Dotsenko, E. I. Morkovin

“…A zoosocial interaction test was performed 30 min after the administration.Results. …”
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Rotor Location During Atrial Fibrillation: A Framework Based on Data Fusion and Information Quality by Miguel A. Becerra, Diego H. Peluffo-Ordoñez, Johana Vela, Cristian Mejía, Juan P. Ugarte, Catalina Tobón

“…The proposed framework outperformed existing EGM-based rotor detection methods, demonstrating superior functionality and performance compared to existing EGM-based rotor detection methods. …”
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A DNA alteration and methylation co-detection method for clinical purpose by Jiyan Yu, Chunhe Yang, Xintao Zhu, Zhankun Wang, Boping Xu, Ye Cai, Jingbo Zhao, Ruijian Guo, Wuzhou Yuan, Jianqing Wang, Bohao Dong, Frank Ron Zheng, Shuang Yang

“…To address these challenges, we introduce a streamlined approach combining mutation and methylation profiling via mutation-protective strand synthesis with modified deoxycytidine triphosphates, demonstrating high concordance with standard enzymatic methyl-seq and DNA-seq in both whole-genome sequencing of cell lines and targeted sequencing of clinical samples. …”
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Space-Time-Intensity Online Early-Warning of Transmission Tower Faults by Caused Rainfall-Induced Landslides by Yi TANG, Xiangxiang XU, Bin CHEN, Tao YI

“…Finally, by taking the impact force of landslide as disaster-causing intensity and the bending deformation energy corresponding to the tower’s limit deflection as anti-disaster performance, a quantitative function relationship is obtained, which can reflect the damage degree of transmission towers from work-energy aspect. …”
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The ‘Reading the mind in the Eyes' test and emotional intelligence by Alberto Megías-Robles, María José Gutiérrez-Cobo, Rosario Cabello, Raquel Gómez-Leal, Simon Baron-Cohen, Pablo Fernández-Berrocal

“…Limitations and future lines of investigation are discussed.…”
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