Scientific and Technical Tools for Enhancement of Special Treatment Devices by V. V. Mahniboroda, A. A. Gorjachev, A. E. Krasnov

“…Highlights- nowadays it is impossible to maintain contaminated vehicles and equipment in special decontamination centers nearthe battle line due to far-ranging precision weapons and drones;- promising on-board sets and special treatment devices should be more independent and powerful than previous ones(IDTS, SST, DK-4) and be able to work directly at the lines of combat contact.Relevance. …”
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Autism spectrum disorder related phenotypes in a mouse model lacking the neuronal actin binding protein profilin 2 by Walter Witke, Marina Di Domenico, Laura Maggi, Alessia Di Nardo, Valentin Stein, Pietro Pilo Boyl

“…It has been shown in vitro and in vivo that in neurons it functions both post-synaptically to shape and maintain dendritic arborizations and spine density and plasticity, as well as pre-synaptically to regulate vesicle exocytosis. …”
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Diagnostic Advances in Leptospirosis: A Comparative Analysis of Paraclinical Tests with a Focus on PCR by Elena Ciurariu, Catalin Prodan-Barbulescu, Diana-Maria Mateescu, Paul Tutac, Virgiliu-Bogdan Sorop, Monica Susan, Norberth-Istvan Varga

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Exploring potential therapeutic targets for colorectal tumors based on whole genome sequencing of colorectal tumors and paracancerous tissues by Yufan Sheng, Sen Niu, Da Li, Chunyuan Meng, Tong Wang

“…Whole genome sequencing was performed on these two groups of samples to obtain somatic and germ line mutation data of the two groups of samples, and then based on the data of the two groups, we screened and analyzed the mutation spectra and mutation characteristics, high-frequency copy number variations, and high-frequency mutated genes of tumor and paraneoplastic samples, thus mapping the genomic map of tumor and cancer susceptibility genes of paraneoplastic samples. …”
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Dimensional stability of brake pads reinforced with calcined eggshell particles under exposed to engine lubricating oil by Sunardi Sunardi, Ariawan Dody, Surojo Eko, Prabowo Aditya Rio, Wibowo Cahyo Hadi, Akbar Hammar Ilham, Sudrajad Agung, Seputro Harjo

“…Exposure to a humid environment can affect the behavior of brake lining composites. Considering the vital function of brake linings in controlling vehicle speed, environmental influences must receive serious attention. …”
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SNORA13 antisense oligonucleotides enhances the therapeutical effects of 5-fluorouracil in colon adenocarcinoma by Yanzhi Wang, Huihui An, Yaou Zhang, Yaou Zhang, Qing Rex Lyu, Zhe Zhang

“…To investigate the role of SNORA13 in CRC, loss-of-function (LoF) study was conducted using transient antisense oligonucleotides (ASOs) transfection and SNORA13 knockout with CRISPR-Cas9 genome editing in HT29 colon adenocarcinoma cell line. …”
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A CASE REPORT OF SUCCESSFUL TREATMENT OF STAGE IV EWING’S SARCOMA IN AN ADOLESCENT PATIENT by O. I. Kit, D. Yu. Yurchenko, D. V. Burtsev, S. A. Kuznetsov, O. P. Popovyan, A. A. Barashev, P. V. Chernogorov, E. M. Frantsiyants, A. B. Sagakyants, L. B. Kushtova, G. A. Mkrtchyan, A. I. Bespalova, M. V. Starzhetskaya

“…The patient received 6 cycles of neoadjuvant chemotherapy according to EURO EWING 2008 protocol; tumor progression and lung metastasis were registered. Two cycles of second-line chemotherapy were performed; by the decision of the doctors’ council, the first stage of surgical treatment was performed: resection of the left ilium and the defect replacement with a temporary cement spacer. …”
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THE EUROPEAN COURT ON HUMAN RIGHTS: THE PROBLEM OF UNENFORCEABLE JUDGMENTS by Stanislav V. Chernichenko

“…The paper demonstrates that the problem of implementing judgments of the European Court of Human Rights does exist if such a judgment is not in line with the Constitution of the Russian Federation. …”
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Comprehensive evaluation of phosphoproteomic-based kinase activity inference by Sophia Müller-Dott, Eric J. Jaehnig, Khoi Pham Munchic, Wen Jiang, Tomer M. Yaron-Barir, Sara R. Savage, Martin Garrido-Rodriguez, Jared L. Johnson, Alessandro Lussana, Evangelia Petsalaki, Jonathan T. Lei, Aurelien Dugourd, Karsten Krug, Lewis C. Cantley, D. R. Mani, Bing Zhang, Julio Saez-Rodriguez

“…Additionally, in the tumor-based evaluation, adding predicted targets from NetworKIN further boosts the performance. We then demonstrate how kinase activity inference aids characterize kinase inhibitor responses in cell lines. …”
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A method for benchmarking genetic screens reveals a predominant mitochondrial bias by Mahfuzur Rahman, Maximilian Billmann, Michael Costanzo, Michael Aregger, Amy H Y Tong, Katherine Chan, Henry N Ward, Kevin R Brown, Brenda J Andrews, Charles Boone, Jason Moffat, Chad L Myers

“…Abstract We present FLEX (Functional evaluation of experimental perturbations), a pipeline that leverages several functional annotation resources to establish reference standards for benchmarking human genome‐wide CRISPR screen data and methods for analyzing them. …”
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Eliminating lead-exposure in nebulization therapy by lead-free piezoelectric by Fang-Zhou Yao, Wenying Fan, Yunfan Zhang, Bing Han, Zimin Feng, Binjie Chen, Zhongshang Dou, Jia Jiang, Ziyun Li, Haihan Gao, Chaofeng Wu, Naixin Liang, Yan Wei, Ke Wang, Xin Ma, Wen Gong

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Impact of personalized alignment technique on implant components position in total knee arthroplasty by Viktor V. Kuzin, Anton V. Kuzin, Aleksey V. Germanov, Maria A. Shpak

“…Introduction Due to substantial rates of dissatisfaction in patients with mechanical alignment in total knee replacement, surgeons began searching for alternative techniques to improve functional outcome. In the recent decade, kinematic alignment that is not based on the mechanical axis of the femur has become the most popular alternative to mechanical alignment. …”

Influence of Ordinary Cigarettes and Their Substitute IQOS^® on Secretory Immunoglobulin A in Unstimulated Saliva by Niкolai Pavlov, Ivelina Popova-Sotirova, Nina Musurlieva, Ralitsa Raycheva, Konstantin Trifonov, Maria Atanasova, Radka Cholakova

“…<b>Background</b>: Secretory immunoglobulin A (sIgA) plays a key role in oral and mucosal immunity, serving as a first-line defense against pathogens. Smoking is known to negatively affect immune function, but data on the impact of heated tobacco products such as IQOS^® on sIgA levels are limited. …”
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Assessing the Validity of the AASLD Surgical Treatment Algorithm in Patients with Early-Stage Hepatocellular Carcinoma by Aryoung Kim, Byeong Geun Song, Wonseok Kang, Geum-Youn Gwak, Yong-Han Paik, Moon Seok Choi, Joon Hyeok Lee, Myung Ji Goh, Dong Hyun Sinn

“…Analyses were separately performed for individuals recommended for resection (single lesion, CTP A and no clinically significant portal hypertension) and those recommended for LT (single lesion with impaired liver function such as CTP B or clinically significant portal hypertension or multiple lesions). …”
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SIX transcription factors are necessary for the activation of DUX4 expression in facioscapulohumeral muscular dystrophy by Amelia Fox, Jonathan Oliva, Rajanikanth Vangipurapu, Francis M. Sverdrup

“…Staining for SIX1 and SIX2 with specific antibodies was performed in FSHD myoblasts and myotubes. To assess reciprocal effects of DUX4 on SIX1, 2, and 4 expression, we utilized a doxycycline-inducible DUX4 myoblast cell line. …”
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Preserving inferior right hepatic vein enabled bisegmentectomy 7 and 8 without venous congestion: a case report by Masayoshi Terayama, Kyoji Ito, Nobuyuki Takemura, Fuyuki Inagaki, Fuminori Mihara, Norihiro Kokudo

“…Abstract Background In hepatectomy, the preservation of portal perfusion and venous drainage in the remnant liver is important for securing postoperative hepatic function. Right hepatectomy is generally indicated when a hepatic tumor involves the right hepatic vein (RHV). …”
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In vitro models of microglia: a comparative study by Zoe Woolf, Taylor J. Stevenson, Kevin Lee, Blake Highet, Jena Macapagal Foliaki, Ramona Ratiu, Justin Rustenhoven, Jason Correia, Patrick Schweder, Peter Heppner, Maria Weinert, Natacha Coppieters, Thomas Park, Johanna Montgomery, Amy M. Smith, Michael Dragunow

“…Abstract Microglia perform key homeostatic functions to protect the central nervous system (CNS). …”
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Women-specific reference ranges for serum TSH in Liguria: the impact of age and year of collection in a single-center cross-sectional study by Massimo Giusti, Marilena Sidoti

“…Abstract Background TSH is the first-line test of thyroid function, and the normal TSH references provided by manufacturers are generally used in diagnoses. …”
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LL-37 Attenuates Sepsis-Induced Lung Injury by Alleviating Inflammatory Response and Epithelial Cell Oxidative Injury via ZBP1-Mediated Autophagy by Hu Gao, Fajuan Tang, Bin Chen, Xihong Li

“…LL-37 can improve the survival of septic mice. Nevertheless, its function and underlying mechanism in sepsis-evoked ALI is elusive. …”
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Hydroxyurea blunts mitochondrial energy metabolism and osteoblast and osteoclast differentiation exacerbating trabecular bone loss in sickle cell mice by Ashish Kumar Tripathi, Sadaf Dabeer, Jun Song, Tatyana Vikulina, Susanne Roser-Page, Jessica A. Alvarez, David. R. Archer, M. Neale Weitzmann

“…Whether hydroxyurea (HU), a front-line therapy for SCD ameliorates bone disease has not been established. …”
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